Communications

Indoline-containing alkaloids 1 have long been the subjects of intense interest because of their wide-ranging biological activities and also because of the challenge posed by their complex structures. The complexity arises from three factors: (i) the polycyclic nature of the ...

PergamonTetrahedron Letters 40 (1999) 161-164TETRAHEDRONLETTERSA Novel Route to ( )-Aspidospermidine: First Application of"Radical-Polar Crossover" Reactions to Total SynthesisOwen Callaghan, Christopher Lampard#, Alan R. Kennedy and John A. Murphy*Department of ...

One of the classical syntheses of benzo[b]thiophenes starts from commercially available thiophenols, reacting with bromoacetaldehyde dimethyl acetal, followed by cyclisation using strong acid. The reaction steps are generally high yielding but when starting with 3-...

1. Rat liver 100,000 g pellet microsomal fraction p-hydroxylate phenylethylamine to tyramine in a relatively slow proceeding, NADPH-requiring reaction; Km 2.1 x 10(-5) M and Vmax 0.32 nmol/mg protein/20 min. 2. This reaction is inhibited, either competitively, noncompetitively or uncompetitively by a number of behaviorally active monomethylated and monohalogenated derivatives of phenylethylamine. 3. Whereas formation of tyramine was not significantly affected by L-phenylalanine or its p-chloro derivative, it was competitively inhibited by imipramine, iprindole and alprazolam. 4. It is suggested that at least some of the effects of these drugs may result from their ability to interfere with phenylethylamine metabolism.