Ernest Mario School of Pharmacy

Neuropathic pain is a chronic pain condition seen in patients with diabetic neuropathy, cancer chemotherapy-induced neuropathy, idiopathic neuropathy as well as other diseases affecting the nervous system. Only a small percentage of people with neuropathic pain benefit from current medications. The complexity of the disease, poor identification/lack of diagnostic and prognostic markers limit current strategies for the management of neuropathic pain. Multiple genes and pathways involved in human diseases can be regulated by microRNA (miRNA) which are small non-coding RNA. Several miRNAs are found to be dysregulated in neuropathic pain. These miRNAs regulate expression of various genes associated with neuroinflammation and pain, thus, regulating neuropathic pain. Some of these key players include adenylate cyclase (Ac9), toll-like receptor 8 (Tlr8), suppressor of cytokine signaling 3 (Socs3), signal transducer and activator of transcription 3 (Stat3) and RAS p21 protein activator 1 (R...

In April 2006, the Michigan State Board of Educaon and Michigan Legislatures adopted a rigorous package of high school graduaon requirements, one of which made Michigan the first state that incorporated an online learning graduaon requirement into the K‐12 curriculum. All Michigan's students entering high school during 2008‐2009 school year were required to complete online learning during their course of high school studies in order to graduate. Michigan Virtual School helped the schools in Michigan to fulfill this requirement by developing a 20‐hour online learning course called " Career Forward ". In December 2008, the Michigan Virtual University provided the Naonal Repository of Online Courses access to the CareerForward course content, allowing students from anywhere in the United States, the ability to access CareerForward free of charge. This evaluaon study was conducted to provide Michigan Virtual School with informaon to improve the design and delivery of the Career Forward course, in order to improve the learning experiences of the future students and to improve the overall efficiency of the course. Analysis of data from this research indicated that, CareerForward in its current format had very lile impact on student atude towards career planning. Recommendaons for changes in design and delivery opons of the course for future offerings are suggested in order to make the course more effecve and to meet its objecves.