Introduction: We aimed in the present study to investigate the effects of pulmonary rehabilitation on the respiratory parameters and effort capacity, quality of life (QoL), anxiety, depression, and sleepiness in the patients with... more
Introduction: We aimed in the present study to investigate the effects of pulmonary rehabilitation on the respiratory parameters and effort capacity, quality of life (QoL), anxiety, depression, and sleepiness in the patients with Parkinson's disease (PD). Methods: The study included 34 mobilized patients with PD. Patients underwent a 12-week pulmonary physiotherapy (PPT). Pulmonary function tests (PFT), six-minute walk test (6mWT), Hoehn and Yahr Scale (HYS), Unified Parkinson's Disease Rating Scale (UPDRS), QoL, Parkinson's Disease Questionnaire (PDQ), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Epworth Sleepiness Scale (ESS) scores were evaluated before and after PPT. Results: PPT improved parameters of PFT significantly, and caused an increase of about 35 m in the 6mWT (p<0.001). HYS (p=0.002), UPDRS, QoL, PDQ, BAI, BDI and ESS scores were found to improve significantly after the PPT (p<0.001 for all). Conclusion: Results of our study indi...
Objective: The aim of this study was to investigate the efficacy of favipiravir (FVP) in severe COVID-19. Materials and methods: This is a retrospective study of 142 COVID-19 patients with severe pneumonia signs, who received inpatient... more
Objective: The aim of this study was to investigate the efficacy of favipiravir (FVP) in severe COVID-19. Materials and methods: This is a retrospective study of 142 COVID-19 patients with severe pneumonia signs, who received inpatient treatment between March 15 and May 20, 2020. The patients were divided into two groups according to the use of FVP treatment; group 1 (n = 99) included patients who treated with FVP and group 2 (n = 43) who didn’t receive FVP. Results: Mean age was 66.47 ± 11.89 in group 1, and 68.58 ± 14.78 in group 2. Forty patients (40.4%) in group 1 and 22 (51.2%) in group 2 were treated in the intensive care unit (P > 0.05). The proportion of eosinophil, tendency of increasing thrombocyte counts and eosinophil/neutrophil ratio in FVP group was significantly higher than non-FVP group (p 0.05). The mortality rates in Group 1 (n = 26 [26.3%]) were lower than those in group 2 (n = 16 [37.2%]), but it was not statistically significant. Conclusion: While the treatme...
Research Interests: Medicine and Favipiravir
Acute desending necrotizing mediastinitis(DNM) is a fulminant process that occurs as a complication of cervical necrotizing faciitis that spreads along the fascial planes without involvement of primary skin and muscle with high mortality... more
Acute desending necrotizing mediastinitis(DNM) is a fulminant process that occurs as a complication of cervical necrotizing faciitis that spreads along the fascial planes without involvement of primary skin and muscle with high mortality rates. It is a clinical condition characterized by high mortality despite intense treatment. We present a case of DNM in 30-year-old girl suffering from a dental abscess. A-30-year-old woman admitted with fever, exhaustion neck distendion for a week. He had a tooth abscess one week ago.female patient who admitted to our department with the diagnosis of DNM underwent Neck insision, and the abscess in her neck was drained with transcervical initiative. Necrotic tissue in the area was debrided. Since thorax computerized tomography revealed formation of empyema pouches and emission of pus content from the retropharyngeal area into the mediastinum, decortication and empyemectomy were performed. The mediastinal pleura was resected and the mediastinum was ...
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Ectopic adrenocorticotropic hormone (ACTH) syndrome is a rare cause of the Cushing's syndrome. The occurrence of the ectopic ACTH syndrome presenting with severe hypokalaemia, metabolic alkalosis, and hypertension has been highlighted... more
Ectopic adrenocorticotropic hormone (ACTH) syndrome is a rare cause of the Cushing's syndrome. The occurrence of the ectopic ACTH syndrome presenting with severe hypokalaemia, metabolic alkalosis, and hypertension has been highlighted in case reports. However, presentation with lower gastrointestinal perforation is not known. We report the case of a 70-year-old male patient with severe hypokalaemia, metabolic alkalosis, hypertension, and colonic perforation as manifestations of an ACTH-secreting small cell lung carcinoma. Ectopic ACTH syndrome should be kept in mind as a cause of hypokalaemia, hypertension, and intestinal perforation in patients with lung carcinoma.
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Conventional methods for the aetiological diagnosis of community-acquired pneumonia (CAP) are often insufficient owing to low sensitivity and the long wait for the results of culture and particularly serology, and it often these methods... more
Conventional methods for the aetiological diagnosis of community-acquired pneumonia (CAP) are often insufficient owing to low sensitivity and the long wait for the results of culture and particularly serology, and it often these methods establish a diagnosis in only half of cases. To evaluate the most common bacterial and viral agents in CAP using a fast responsive PCR method and investigate the relationship between clinical/laboratory features and aetiology, thereby contributing to empirical antibiotic selection and reduction of treatment failure. In children aged 4-15 years consecutively admitted with a diagnosis of CAP, the 10 most commonly detected bacterial and 12 most commonly detected viral agents were investigated by induced sputum using bacterial culture and multiplex PCR methods. Clinical and laboratory features were compared between bacterial and viral pneumonia. In 78 patients, at least one virus was detected in 38 (48.7%) and at least one bacterium in 32 (41%). In addition, both bacteria and viruses were detected in 16 (20.5%) patients. Overall, the agent detection rate was 69.2%. The most common viruses were respiratory syncytial virus and influenza and the most frequently detected bacteria were S. pneumoniae and H. influenzae. PCR was superior to culture for bacterial isolation (41% vs 13%, respectively). Fever, wheezing and radiological features were not helpful in differentiating between bacterial and viral CAP. White blood cell count, CRP and ESR values were significantly higher in the bacterial/mixed aetiology group than in the viral aetiology group. In CAP, multiplex PCR is highly reliable, superior in detecting multiple pathogens and rapidly identifies aetiological agents. Clinical features are poor for differentiation between bacterial and viral infections. The use of PCR methods allow physicians to provide more appropriate antimicrobial therapy, resulting in a better response to treatment, and it may be possible for use as a routine service if costs can be reduced.
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Tracheobronchomegaly or Mounier-Kuhn syndrome is a rare disorder characterized by marked dilatation of the trachea and main bronchi, bronchiectasis, and recurrent respiratory tract infections. The etiology of this disorder is uncertain.... more
Tracheobronchomegaly or Mounier-Kuhn syndrome is a rare disorder characterized by marked dilatation of the trachea and main bronchi, bronchiectasis, and recurrent respiratory tract infections. The etiology of this disorder is uncertain. It is thought to be due to defective development of elastic and muscle tissues in the upper airways. Patients usually present with symptoms related to infection and bronchiectasis. Symptoms can range from chronic cough to severe respiratory failure requiring mechanical ventilation. However, some patients may be asymptomatic. The diagnosis is usually made on the basis of the characteristic computerized thomography scan findings. Treatment was mainly supportive with chest physiotherapy and antibiotics during infectious exacerbations. 19 years old and 36 kg weigh male patient was admitted with shortness of breath and recurrent lung infections. Chest X-ray showed marked tracheal widening, bilateral pneumothorax, and bronchiectasis. Trachea diameter was measured of 27 mm in the thoracic tomography. Because of the rarity, we report the case of a patient who was diagnosed with Mounier-Kuhn syndrome with bilateral pneumothorax (a previously non reported association) and developing respiratory failure even with simple exercise.
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Inhaler devices used for the treatment of chronic respiratory diseases are frequently incorrectly used by the patients. The effects of training on the correct use of these devices are unquestionable. However, despite the training provided... more
Inhaler devices used for the treatment of chronic respiratory diseases are frequently incorrectly used by the patients. The effects of training on the correct use of these devices are unquestionable. However, despite the training provided on the correct technique of using the inhaler device, some patients still continue using the device incorrectly. The aims of the present study are to determine the rate of incorrect use of the inhaler devices, assess the parameters that affect the incorrect use, demonstrate the contribution of training, and determine the characteristics of the patients who use the devices incorrectly despite training. 342 consecutive patients were included in the study. The patients' ability to use the devices correctly was scored before and after face-to-face trainings. The parameters affecting incorrect use, the impact of training, and characteristics of the patients who continued the incorrect usage after training were evaluated. The rate of correct usage wa...
Research Interests: Demography, Medication Adherence, Asthma, Allergic asthma, Inhaled drugs, and 15 moreInhalers, Humans, COPD, Female, Male, Inhalation Therapy, Dry Powder Inhalers, Bronchial Asthma Control in General Practice, Clinical Sciences, Aged, Adult, Inhaled corticosteroid therapy, Cross Sectional Studies, Equipment failure, and Cardiovascular medicine and haematology
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Kronik obstruktif Akciger Hastaligi (KOAH), tum dunyada ve ulkemizde sikligi giderek artan bir kuresel saglik sorunudur. Acil servis basvurulari ve hastane yatislarinin onemli bir nedeni olan akut alevlenmeler, bu sorunun en buyuk... more
Kronik obstruktif Akciger Hastaligi (KOAH), tum dunyada ve ulkemizde sikligi giderek artan bir kuresel saglik sorunudur. Acil servis basvurulari ve hastane yatislarinin onemli bir nedeni olan akut alevlenmeler, bu sorunun en buyuk bilesenidir. Akut alevlenmeler, agir solunum yetmezligine gidis surecini hizlandirir, yuksek oranda mortalite ve morbidite nedenidir ve ulkelerin saglik harcamalarinda ciddi bir yuk olusturur. Alevlenmelerin etyolojisi ve tedavisi ozellikle acil servis-aile hekimleri, evde saglik hizmeti sunuculari ve gogus hastaliklari ile ilgilenen hekimlerce iyi bilinmelidir.
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Uzun yillardir, kultur temelli arastirmalarin sonuclarina dayanilarak, akcigerlerin steril olduguna inaniliyordu. Hatta bu yuzden akcigerler, Insan Mikrobiyom Projesi’ne dâhil edilmedi.Bununla birlikte, son zamanlarda gelistirilen... more
Uzun yillardir, kultur temelli arastirmalarin sonuclarina dayanilarak, akcigerlerin steril olduguna inaniliyordu. Hatta bu yuzden akcigerler, Insan Mikrobiyom Projesi’ne dâhil edilmedi.Bununla birlikte, son zamanlarda gelistirilen kulturden bagimsiz yontemler ile saglikli insanlarin akcigerlerinde, sayi bakimindan az, ancak cesitliligi fazla bakteri turlerininyasadigi gosterilmistir. Ancak, gunumuzde devam eden arastirmalarda onemli metodolojik ve teknik engeller bulunmaktadir.Akciger mikrobiyomundaki nicel ve/veya nitel degisiklikler hastalik olusumu, ilerlemesi ve alevlenmelere katkida bulunabilir.Akciger mikrobiyomunun bilesimi ve immunolojik etkileri hakkinda bilgi, ozellikle kistik fi broz, bronsektazi, astim ve kronik obstruktif akciger hastaligi gibi hastaliklarda onemli patojenik kazanimlar saglayacaktir.Gelecekte buyuk kohortlari icine alan, cok merkezli calismalarin akciger mikrobiyomu hakkindaki bilgimize ve anlayisimiza katkida bulunacagini dusunuyoruz.
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INTRODUCTION AND AIM: Community-acquired pneumonia (CAP), which is often seen in daily practice, is a lower respiratory tract and pulmonary parenchyma infection which develops in society and daily life with community-acquired pathogens in... more
INTRODUCTION AND AIM: Community-acquired pneumonia (CAP), which is often seen in daily practice, is a lower respiratory tract and pulmonary parenchyma infection which develops in society and daily life with community-acquired pathogens in individuals with no known immune failure. Delay in the treatment of pneumonia is known to increase morbidity and mortality. Various scoring systems are currently used in the identification of treatment groups in pneumonia. With the aim of evaluating the approach to CAP cases, the infection. MATERIALS AND METHODS: Working Group of the Turkish Respiratory Research Association (TUSAD) prepared a 22-item questionnaire. RESULTS: The survey was published on the TUSAD official website between July 2013 and June 2016. A total of 78 individuals responded to the questionnaire on the website. CONCLUSION: The responses to the questionnaire could indicate the way forward for new guidelines for physicians in respect of the approach to CAP.
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Amac Calismamiz; bir egitim ve arastirma hastanesinde, kronik solunum yolu ve kronik kalp hastaligi nedeniyle yatarak tedavi goren hastalarin emosyonel durumlarini degerlendirmek, sosyo-demografik ozellikler ve hastalik cesidi ile... more
Amac Calismamiz; bir egitim ve arastirma hastanesinde, kronik solunum yolu ve kronik kalp hastaligi nedeniyle yatarak tedavi goren hastalarin emosyonel durumlarini degerlendirmek, sosyo-demografik ozellikler ve hastalik cesidi ile depresyon ve anksiyete arasindaki iliskiyi arastirmak amaciyla yapildi. Materyal ve Metot: Calismaya, Agustos 2014 ile Mart 2015 tarihleri arasinda, gogus ve kardiyoloji kliniklerinde yatan, bilinen psikiyatrik hastaligi olmayan 144 hasta dâhil edildi. Hastalarin sosyo-demografik ozellikleri yuz yuze gorusme yontemi ile; emosyonel durumlari hastanin kendi doldurdugu 14 sorudan olusan Hastane Anksiyete ve Depresyon (HAD) Olcegi kullanilarak degerlendirildi. Bulgular: Calismaya alinan hastalarin 80’i (% 55,5) Kronik Solunum Yolu Hastaligina, 64’u (% 44,5) Kronik Kalp Hastaligina sahipti ve ortalama hastalik sureleri 7,1 yildi. Tum hastalarda anksiyete orani % 53,5, depresyon orani % 75 bulundu. Kronik Solunum Yolu Hastaligi olan grupta ortalama anksiyete s...
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Aim: The current study aimed to evaluate the factors affecting survival in non-small cell lung cancer invading the chest wall. Method: A total of 45 cases operated on for Non-Small Cell Lung Cancer invading the chest wall (NSCLC) were... more
Aim: The current study aimed to evaluate the factors affecting survival in non-small cell lung cancer invading the chest wall. Method: A total of 45 cases operated on for Non-Small Cell Lung Cancer invading the chest wall (NSCLC) were followed-up for five years. The effects of factors such as depth of tumor invasion of the chest wall (parietal pleura, extra pleural fatty tissue, intercostal muscles, and rib involvement), perinodal involvement, “N” involvement, surgical margin of the resection, and adjuvant chemotherapy on prognosis and survival were evaluated. Results and Discussion: The number of males and females among the cases was 38 (84%) and seven (16%), respectively, with a mean age of 55 ± 8 years (42-74). Chest wall resection and extra-pleural resection was performed in 36 (80%) and nine (20%) cases, respectively. In the multivariate analysis, factors positively affecting survival were depth of invasion, tumor dimension less than 5 cm, N0 lymph node status, complete resecti...
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Swyer-James Syndrome is a rare pulmonary disease, characterized by one-sided hyperlucency, smaller hilum shadow and lack of vascular structures in affected side. Although usually asymptomatic, can also be symptoms such as recurrent lung... more
Swyer-James Syndrome is a rare pulmonary disease, characterized by one-sided hyperlucency, smaller hilum shadow and lack of vascular structures in affected side. Although usually asymptomatic, can also be symptoms such as recurrent lung infection, exertional dyspnea and hemoptysis. 23-year-old male patient presented with exercise-induced dyspnea. On physical examination, decreased breath sounds on the left hemithoraxes. Chest x-ray showed right middle and lower lobe more prominent hyperlucency, mediastinal shift to the left and small hilar shadow. Ventilation-perfusion scintigraphy were determined consistent defect areas. Swyer-James Syndrome diagnosed by chest X-ray is possible, but it is unthinkable because of the rarity. Swyer-James syndrome diagnosed patient is presented with literature data.
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COVID-19 hayatimiza girdigi tarihten beri sosyal hayatimizi, calisma hayatimizi, yasayisimizi, hastabakim hizmetlerini, arastirmalarimizi ve hatta davranis tarzimizi etkiledi. Ustelik bu oyle bir salgin kisadece bir ulkede degil, butun... more
COVID-19 hayatimiza girdigi tarihten beri sosyal hayatimizi, calisma hayatimizi, yasayisimizi, hastabakim hizmetlerini, arastirmalarimizi ve hatta davranis tarzimizi etkiledi. Ustelik bu oyle bir salgin kisadece bir ulkede degil, butun dunya ulkelerinde ayni zamanda ve benzer yogunlukta etkilendi. Adetaulkelerin saglik sistemleri bircok sorunla sinanmistir. Salgin sirasinda bircok bilinmeyen denklem ic iceidi. Salgin basinda o kadar cok bilinmeyenimiz vardi ki hastalara nasil yaklastigimizi, nasil tedavi verecegimizive hangi ilaclarin verilmesi gerektigini henuz net bir sekilde bilmiyorduk. Gecen sure zarfindabircok arastirma ve bircok deneyim bizim hastaliga karsi nasil davranmamiz gerektigini ogretti.Salgin sirasinda bilgi kirliliginin ne kadar zarar verebilir oldugunu yasayarak ogrendik. Ayrica, salginbize asi savaslarini gosterdi. Salgindan kurtulmak icin kullandigimiz asilarin ne kadar degerli oldugunu,gelismis ulkelerin nasil asi savaslarina girdigini ve asilama ile beraber sa...
OZET Amac: Akciger kanseri kotu prognozlu ve tedavi yaniti sinirli olan bir kanser turudur. Galektin akciger kanseri patogenezinde rol alabildigi dusunulen fakat akciger kanseri ile iliskisinin yeterli duzeyde gosterilemedigi potansiyel... more
OZET Amac: Akciger kanseri kotu prognozlu ve tedavi yaniti sinirli olan bir kanser turudur. Galektin akciger kanseri patogenezinde rol alabildigi dusunulen fakat akciger kanseri ile iliskisinin yeterli duzeyde gosterilemedigi potansiyel bir belirtectir. Amacimiz serumda basit bir yontem olan galektin 1 ve 3 olcumunun, akciger kanseri tanisal ya da prognostik belirteci olup olamayacagini arastirmaktir. Yontem: Calismaya 49 akciger kanseri ve 30 saglikli kontrol hastasi alindi. Serumlarinda galektin 1 ve 3 duzeyleri galektin olcum kiti ile calisildi. Akciger kanserli olgular ve saglikli kontrol hastalari galektin 1 ve 3’un tanisal ve prognostik belirtec olup olmayacagi ile ilgili parametreler istatistiksel olarak incelendi. Bulgular: Akciger kanserli hastada galektin 1 ve 3 degeri, kontrol grubuna gore daha dusuktu. Galektin 1 ve 3 duzeyleri ile sag kalim, evre ve tumor capi arasinda iliski saptanmazken, metastaz ve tumor tipi ile negatif iliskisi saptandi. Sonuc: Galektin 1 ve 3 dege...
Yogun bakim uniteleri (YBU), hastane kokenli enfeksiyonlarin en sik goruldugu ve mortalitesinin en fazla oldugu bolumlerdir. Mekanik ventilasyon, trakeostomi, kateter uygulanmasi gibi invaziv girisimler ve genis spektrumlu antibiyotik... more
Yogun bakim uniteleri (YBU), hastane kokenli enfeksiyonlarin en sik goruldugu ve mortalitesinin en fazla oldugu bolumlerdir. Mekanik ventilasyon, trakeostomi, kateter uygulanmasi gibi invaziv girisimler ve genis spektrumlu antibiyotik kullanimi, YBU’sinde direncli patojenlerin ortaya cikmasinin onemli nedenlerindendir. Bu calismada, hastanemiz YBU’lerinde, mekanik ventilator uygulanan hastalardan alinan endotrakeal aspirat (ETA) orneklerinde uretilen mikroorganizmalarin ve antibiyotik direnc oranlarinin belirlenmesi amaclanmistir. Bu calismada Mart 2015-Mart 2016 tarihleri arasinda Sakarya Egitim Arastirma Hastanesi Yogun Bakim unitelerinde yatan hastalardan laboratuvara gonderilen ETA orneklerinin kultur sonuclari geriye donuk olarak degerlendirilmistir. Antibiyotik duyarlilik sonuclari Clinical and Laboratory Standards Institute (CLSI) kriterlerine gore degerlendirilmistir. Calisma periyodu boyunca laboratuvara toplam 350 tane ETA ornegi gelmis bunlarin 130’unda toplam 141 etken s...
Clinical microbacteriology laboratories play important roles in quicker recognition, identification, and detection of drug resistance which aid in preventing the spread of tuberculosis. Thus, it is recommended that laboratories conduct... more
Clinical microbacteriology laboratories play important roles in quicker recognition, identification, and detection of drug resistance which aid in preventing the spread of tuberculosis. Thus, it is recommended that laboratories conduct consecutive or concurrent and differential diagnostic studies of laboratory samples, that the studies be completed in 28 to 30 days, and that laboratories provide the results of sensitivity studies of Mycobacterium tuberculosis complex (MTC). In addition to MTC induced infections, the incidence of atypical or nontuberculous mycobacteria (NTM) tends to increase, especially in developed countries. NTM have been reported to be associated with the lungs, lymphatic system, skin and bone. Correct identification of the agent provides an adequate and appropriate treatment strategy, and correct management of the diagnostic process is important in distinguishing between the MTC and NTM. Moreover, accurate diagnosis increases the success of the treatment, decrea...
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Introduction: We aimed in the present study to investigate the effects of pulmonary rehabilitation on the respiratory parameters and effort capacity, quality of life (QoL), anxiety, depression, and sleepiness in the patients with... more
Introduction: We aimed in the present study to investigate the effects of pulmonary rehabilitation on the respiratory parameters and effort capacity, quality of life (QoL), anxiety, depression, and sleepiness in the patients with Parkinson's disease (PD). Methods: The study included 34 mobilized patients with PD. Patients underwent a 12-week pulmonary physiotherapy (PPT). Pulmonary function tests (PFT), six-minute walk test (6mWT), Hoehn and Yahr Scale (HYS), Unified Parkinson's Disease Rating Scale (UPDRS), QoL, Parkinson's Disease Questionnaire (PDQ), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Epworth Sleepiness Scale (ESS) scores were evaluated before and after PPT. Results: PPT improved parameters of PFT significantly, and caused an increase of about 35 m in the 6mWT (p<0.001). HYS (p=0.002), UPDRS, QoL, PDQ, BAI, BDI and ESS scores were found to improve significantly after the PPT (p<0.001 for all). Conclusion: Results of our study indi...
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BACKGROUND/AIM Oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Smoking is the leading source of oxidants in lungs. However, it is currently unknown why some individuals are... more
BACKGROUND/AIM Oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Smoking is the leading source of oxidants in lungs. However, it is currently unknown why some individuals are more resistant to the detrimental effects of smoking and do not develop COPD. The aim in this study is to measure and compare the oxidant/antioxidant balance between in non-COPD individuals who smoke and COPD patients who smoke. MATERIALS AND METHODS Included in the study were 137 patients with COPD and 102 healthy individuals. Participants were divided into groups as COPD patients (former and current smokers), non-COPD individuals who smoke and non-smokers healthy persons. In the following stage, the total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) levels were measured in serum for all participants. RESULTS In the current-smoker COPD group, the level of oxidant status were significantly higher than the former-smoker COPD group (p < 0.001). Similarly, oxidant levels were significantly high in current-smoker healthy group than never smoker healthy group. According to these results TOS was associated with especially smoking status rather than COPD. Antioxidant status were similar between former-smoker COPD group and current-smoker COPD group. The antioxidant levels were found significantly low in current-smoker COPD patients, compared to the current-smoker non-COPD individuals (p = 0.007). Nevertheless, no significant difference was found in OSI levels between two groups. Briefly, high TOS and OSI values were correlated with only smoking, independently from COPD. CONCLUSION It was concluded that there are complex pathogenetic mechanisms, including genetic and individual variations other than oxidant/antioxidant balance, involved in the development of smoking-related COPD. TOS and OSI values are not predictive parameters for the development of COPD, but high level of TAS in non-COPD smokers is promising for future studies.
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Introduction: One day point prevalence study to evaluate patient profile in ICUs was planned by Turkish Thoracic Society Respiratory Failure and Intensive Care Group. Methods: The study was cross-sectional and data were obtained by a... more
Introduction: One day point prevalence study to evaluate patient profile in ICUs was planned by Turkish Thoracic Society Respiratory Failure and Intensive Care Group. Methods: The study was cross-sectional and data were obtained by a questionnaire in participating ICUs on October 26th 2016 for 24 hours. A questionnaire evaluating characteristics of patients in ICU was prepared. A total of 78 units declared to participate in the survey. Results: Ten centers were excluded from the study because they couldn’t participate on study day. A total of 922 patients were enrolled from 68 units. The mean age was 64.8 ± 17.9 (17-99), 58.6% were male. The mean APACHE II, QSOFA and GCS scores on the study day were 18.5 ± 8.8, 1.4 ±1.4 and 10.2 ± 4.3, respectively, and mean length of stay (LOS) was 20 ± 70 days. The patients were admited from emergency room(44%[n=407]), clinics(39%[n=359]) and other ICUs(17%[n=156]).38.5% of patients had Type 1 respiratory failure(RF),35.6% had Type 2 RF. Comorbidity was seen in 80.6% and malignancy rate was 18.8%. On the study day it was found that 52.1% of the patients underwent invasive mechanical ventilation(IMV),12.3% of the patients had non-invasive ventilation(NIV) 29.1% of them had oxygen therapy. Tracheostomy was performed in 19.7% of patients. 70% of the patients had enteral, 20.7% had parenteral nutrition. The discharge rate was 7% while mortality was 1.1% on that day. Discussion: Most of the patients in ICUs are respiratory failure cases admited from emergency department and clinics. Advanced age, presence of comorbidities and cancer are thought to prolong LOS in ICU. For effective use of ICU beds further regulations for patient admission criteria is necessary.
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Oxidative stress is one of the major causes of methotrexate induced lung injury (MILI). Alpha-lipoic acid (ALA), which occurs naturally in human food, has antioxidative and anti-inflammatory activities. The aim of this study was to... more
Oxidative stress is one of the major causes of methotrexate induced lung injury (MILI). Alpha-lipoic acid (ALA), which occurs naturally in human food, has antioxidative and anti-inflammatory activities. The aim of this study was to research the potential protective role of ALA on MILI in rats. Twenty one rats were randomly subdivided into three groups: control (group I), methotrexate (MTX) treated (group II), and MTX+ALA treated (group III). Lung injury was performed with a single dose of MTX (20 mg/kg) to groups 2 and 3. On the sixth day, animals in all groups were sacrificed by decapitation and lung tissue and blood samples were removed for histological examination and also measurement the levels of interleukin-1-beta (IL-1β), malondialdehyde (MDA), glutathione (GSH), tumour necrosis factor-alpha (TNF-α), myeloperoxidase (MPO), and sodium potassium-adenosine triphosphatase (Na+/K+ATPase). In MTX group tissue GSH, Na+/K+ATPase activities were lower, tissue MDA, MPO and plasma IL-1?, TNF-? were significantly higher than the other groups. Histopathological examination showed that lung injury was less severe in group 2 according to group 3. Oxidative damage of MTX in rat lung is partially reduced when combined with ALA.
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Objectives. Exposure to ambient metals and air pollutants in urban environments has been associated with impaired lung health and inflammation in the lungs. Fractional exhaled nitric oxide (FeNO) is a reliable marker of airway... more
Objectives. Exposure to ambient metals and air pollutants in urban environments has been associated with impaired lung health and inflammation in the lungs. Fractional exhaled nitric oxide (FeNO) is a reliable marker of airway inflammation. In this study, we aimed to compare the FeNO levels of three schools that have different distances from iron and steel industry zone for assessing the effects of heavy metals and air pollution on their respiratory health. Methods. Pulmonary function test and FeNO measurements were evaluated in 387 adolescents in three schools which have different distance from plant. Results. FeNO levels were significantly higher in School I (n=142; 18.89±12.3 ppb) and School II (n=131; 17.68±7.7 ppb) than School III (n=114; 4.28±3.9 ppb). Increased FeNO concentration was related to the distance of iron and steel industry zone in young adults. Conclusion. The FeNO concentrations in school children were inversely proportional to the distance from the steel mill. Th...
Research Interests: Metallurgy, Air pollution, Adolescent, Medicine, Schools, and 5 moreHeavy metals, Humans, Nitric oxide, Female, and Male
Tracheal tumors are very rare, and commonly malignant. Benign tracheal tumors, constitute only 1.9% of all lung tumors. Diagnosis of tracheal tumors is difficult. Clinical symptoms of asthma show similar characteristics due to easily... more
Tracheal tumors are very rare, and commonly malignant. Benign tracheal tumors, constitute only 1.9% of all lung tumors. Diagnosis of tracheal tumors is difficult. Clinical symptoms of asthma show similar characteristics due to easily mimic. In routine radiologic examinations is often inadequate the diagnosis. Those with airway obstruction caused is often incorrectly diagnosed with asthma and are treated in this direction. Our case 5 years from shortness of breath on exertion, complaints of wheezing and asthma medications are used. But had not seen for treatment despite receiving appropriate treatment and regular on the lack of improvement and tracheal obstruction was thought to evaluating the differential diagnosis. Bronchoscopic examination showed tracheal tumor. Tumor was removed endoscopically and complete clinical recovery was achieved. This article is not all wheezing respiratory asthma and not provided with appropriate treatment of patients with clinical improvement should be considered in the differential diagnosis of tracheal tumors and we present a case showing.
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... Dr. Yusuf AYDEMİR Konya Numune Hastanesi, Göğüs Hastalıkları Kliniği, Konya, TÜRKİYE/TURKEY; ÖZET: Amaç: Malign plevral effüzyonlarda, plevra sıvısı Prostaglandin E 2 (PGE 2 ) düzeyinin tanısal değerini saptamak. Gereç ve Yöntemler:... more
... Dr. Yusuf AYDEMİR Konya Numune Hastanesi, Göğüs Hastalıkları Kliniği, Konya, TÜRKİYE/TURKEY; ÖZET: Amaç: Malign plevral effüzyonlarda, plevra sıvısı Prostaglandin E 2 (PGE 2 ) düzeyinin tanısal değerini saptamak. Gereç ve Yöntemler: Selçuk Üniversitesi Meram ...
Research Interests:
zet Tüberküloz, farklı klinik ve radyolojik özelliklerle ortaya çıkabilir. Bu nedenle ayırı-cı tanıda zaman zaman güçlük çekilebilmektedir. Uyuşturucu madde kullanım öy-küsü olan 22 yaşında erkek hasta, yüksek ateş ile başvurduğu intaniye... more
zet Tüberküloz, farklı klinik ve radyolojik özelliklerle ortaya çıkabilir. Bu nedenle ayırı-cı tanıda zaman zaman güçlük çekilebilmektedir. Uyuşturucu madde kullanım öy-küsü olan 22 yaşında erkek hasta, yüksek ateş ile başvurduğu intaniye kliniğince nötropenik olması üzerine yatırılmıştı. Ampirik antibiyotik tedavisine yanıt alına-mayan hasta, radyolojik olarak akciğerde kitle görünümü olması üzerine kliniği-mize devralındı. Balgam ve bronş lavajında Asidorezistan bakteri negatif bulun-du. Aksiller lenf bezi eksizyonu ile tüberküloz tanısı konuldu. Antitüberküloz teda-vi ile ateşi düştü ve klinik düzelme sağlandı. Oldukça nadir görülmesi ve prevalan-sın yüksek olduğu bölgemizde, çok değişik klinik ve radyolojik bulgularla karşımı-za çıkabilen tüberkülozun, her zaman akılda tutulmasını vurgulamak amacıyla ol-guyu sunuyoruz. Abstract Tuberculosis may occur with very different clinical and radiological features.
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Swyer-James Syndrome is a rare pulmonary disease, characterized by one-sided hyperlucency, smaller hilum shadow and lack of vascular structures in affected side. Although usually asymptomatic, can also be symptoms such as recurrent lung... more
Swyer-James Syndrome is a rare pulmonary disease, characterized by one-sided hyperlucency, smaller hilum shadow and lack of vascular structures in affected side. Although usually asymptomatic, can also be symptoms such as recurrent lung infection, exertional dyspnea and hemoptysis. 23-year-old male patient presented with exercise-induced dyspnea. On physical examination, decreased breath sounds on the left hemithoraxes. Chest x-ray showed right middle and lower lobe more prominent hyperlucency, mediastinal shift to the left and small hilar shadow. Ventilation-perfusion scintigraphy were determined consistent defect areas. Swyer-James Syndrome diagnosed by chest X-ray is possible, but it is unthinkable because of the rarity. Swyer-James syndrome diagnosed patient is presented with literature data. Swyer-James Sendromu, tek taraflı saydamlık artışı, etkilenen bölgede vasküler yapıların azlığı ve küçük hilus gölgesi ile karakterize nadir bir akciğer hastalığıdır. Genellikle asemptomati...