A novel series of twenty-seven cinnamides constituted by cinnamic acid derivatives liked to
1-aryl piperazines were synthesized and evaluated for their potential inhibitory diphenolase …

Two different series of fifty-two compounds, based on 3′,4′,5′-trimethoxyaniline (7a–ad)
and variably substituted anilines (8a–v) at the 7-position of the 2-substituted-[1,2,4]triazolo [1…

A new class of inhibitors of tubulin polymerization based on the 2-amino-3-(3′,4′,5′-trimethoxybenzoyl)benzo[b]furan
molecular scaffold was synthesized and evaluated for in vivo …

The clinical evidence for the success of tyrosine kinase inhibitors in combination with
microtubule-targeting agents prompted us to design and develop single agents that possess both …

A series of 3-(3′,4′,5′-trimethoxyphenyl)-4-substituted 1H-pyrazole and their related 3-aryl-4-(3′,4′,5′-trimethoxyphenyl)-1-H-pyrazole
regioisomeric derivatives, prepared as cis-…

A novel series of tubulin polymerization inhibitors, based on the 1-(3′,4′,5′-trimethoxyphenyl)-2-aryl-1H-imidazole
scaffold and designed as cis-restricted combretastatin A-4 …

The 2-oxindole nucleus is the central core to develop new anticancer agents and its substitution
at the 3-position can effect antitumor activity. Utilizing a pharmacophore hybridization …

A further investigation aiming to generate new potential antitumor agents led us to
synthesize a new series of twenty-two compounds characterized by the presence of the 7-(3′,4′,5′…

Three different series of cis-restricted analogues of combretastatin A-4 (CA-4), corresponding
to thirty-nine molecules that contained a pyrrole nucleus interposed between the two aryl …

The P2Y6 receptor (P2Y6R), a Gq-coupled receptor, is a potential drug discovery target for
various inflammatory and degenerative conditions. Antagonists have been shown to …