BACKGROUND:The aim of this study was to assess the association of single-nucleotide polymorphisms (SNPs) in IL1R1 with the risk of lumbar disc herniation (LDH) in the Han population in northwest China. MATERIAL AND METHODS:To estimate the association...

Yong Zhu; Shunan Li; Yao Sun; Jiamin Wu; Zichao Xiong; Tianbo Jin; Haiyu Jia; Xuejun Yang. IL1R1 Polymorphisms are Associated with Lumbar Disc Herniation Risk in the Northwestern Chinese Han Population. Medical Science Monitor 2019, 25, 3728 -3738.

Yong Zhu, Shunan Li, Yao Sun, Jiamin Wu, Zichao Xiong, Tianbo Jin, Haiyu Jia, Xuejun Yang. IL1R1 Polymorphisms are Associated with Lumbar Disc Herniation Risk in the Northwestern Chinese Han Population. Medical Science Monitor. 2019; 25 ():3728-3738.

Yong Zhu; Shunan Li; Yao Sun; Jiamin Wu; Zichao Xiong; Tianbo Jin; Haiyu Jia; Xuejun Yang. 2019. "IL1R1 Polymorphisms are Associated with Lumbar Disc Herniation Risk in the Northwestern Chinese Han Population." Medical Science Monitor 25, no. : 3728-3738.

刘辉兰刘辉兰; Huilan Liu Huilan Liu; 孙尧 孙尧; Yao Sun Yao Sun; 张帅一张帅一; Shuaiyi Zhang Shuaiyi Zhang; 李涛 李涛; Tao Li Tao Li; 李健 李健; Jian Li Jian Li. 5.1-ps passively mode-locked Nd:Gd0.42Y0.58VO4 laser with a LT-GaAs absorber. Chinese Optics Letters 2008, 6, 361 -363.

刘辉兰刘辉兰, Huilan Liu Huilan Liu, 孙尧 孙尧, Yao Sun Yao Sun, 张帅一张帅一, Shuaiyi Zhang Shuaiyi Zhang, 李涛 李涛, Tao Li Tao Li, 李健 李健, Jian Li Jian Li. 5.1-ps passively mode-locked Nd:Gd0.42Y0.58VO4 laser with a LT-GaAs absorber. Chinese Optics Letters. 2008; 6 (5):361-363.

刘辉兰刘辉兰; Huilan Liu Huilan Liu; 孙尧 孙尧; Yao Sun Yao Sun; 张帅一张帅一; Shuaiyi Zhang Shuaiyi Zhang; 李涛 李涛; Tao Li Tao Li; 李健 李健; Jian Li Jian Li. 2008. "5.1-ps passively mode-locked Nd:Gd0.42Y0.58VO4 laser with a LT-GaAs absorber." Chinese Optics Letters 6, no. 5: 361-363.

BACKGROUND: Studies implicate that angiotensin 1–7 (Ang1-7) imparts protective effects in the kidney. However, its relevance in hypertensive kidney disease is not fully understood. The purpose of this study was to explore the role of Ang1-7 on renal damage/remodeling during hypertension and its potential underlying molecular–cellular mechanisms. METHODS: Hypertension was induced in adult Sprague–Dawley rats by infusion of aldosterone (ALDO; 0.75 μg/hour) for 4 weeks with or without co-treatment of Ang1-7 (1 mg/kg/day). Untreated rats served as controls. Systolic blood pressure was monitored by tail-cuff technique. Renal fibrosis was evaluated by picrosirius red staining and renal collagen volume fraction was quantitated using imaging analyzing system. The expression of profibrotic factors [transforming growth factor-β1 (TGF-β1), platelet-derived growth factor-D (PDGF-D), fibroblast growth factor-1 (FGF-1), vascular endothelial growth factor-D (VEGF-D), and tissue inhibitors of metalloproteinases (TIMPs)] and free radical producing enzymes (inducible nitric oxide synthase and nicotinamide adenine dinucleotide phosphate [NADPH] oxidase) in the kidney were examined by reverse transcription–polymerase chain reaction and western blot. Renal oxidative stress was assessed by malondialdehyde (MDA) measurement. RESULTS: Chronic ALDO infusion caused hypertension and hypertensive renal disease represented as glomerular damage/sclerosis. Ang1-7 co-treatment did not affect blood pressure in ALDO-treated rats, but significantly attenuated the glomerular damage/fibrosis. ALDO treatment significantly elevated renal expression of profibrogenic factors, including TGF-β1, TIMP-1/TIMP-2, FGF-1, PDGF-D, and VEGF-D, whereas Ang1-7 co-treatment significantly reduced renal TGF-β1, TIMP-1/TIMP-2, and FGF-1, but not PDGF-D and VEGF-D. Furthermore, ALDO infusion elevated NADPH oxidase (gp91phox) and MDA in the kidney, which was attenuated by Ang1-7 co-treatment. CONCLUSIONS: Ang1-7 plays a protective role in the hypertensive kidney disease independent of blood pressure. The beneficial effects of Ang1-7 are likely mediated via suppressing TGF-β/FGF-1 pathways and oxidative stress.

Yuanjian Chen; Wenyuan Zhao; Chang Liu; Weixin Meng; Tieqiang Zhao; Syamal K Bhattacharya; Yao Sun. Molecular and Cellular Effect of Angiotensin 1–7 on Hypertensive Kidney Disease. American Journal of Hypertension 2019, 32, 460 -467.

Yuanjian Chen, Wenyuan Zhao, Chang Liu, Weixin Meng, Tieqiang Zhao, Syamal K Bhattacharya, Yao Sun. Molecular and Cellular Effect of Angiotensin 1–7 on Hypertensive Kidney Disease. American Journal of Hypertension. 2019; 32 (5):460-467.

Yuanjian Chen; Wenyuan Zhao; Chang Liu; Weixin Meng; Tieqiang Zhao; Syamal K Bhattacharya; Yao Sun. 2019. "Molecular and Cellular Effect of Angiotensin 1–7 on Hypertensive Kidney Disease." American Journal of Hypertension 32, no. 5: 460-467.

Meng-Yao Sun; Di-Ming Chen; Cong Li-Gao. Solvent-Dependent Assembly of Two New 3d–4f Heterometal-Organic Frameworks Based on a Bifunctional Ligand. Journal of Cluster Science 2018, 29, 593 -598.

Meng-Yao Sun, Di-Ming Chen, Cong Li-Gao. Solvent-Dependent Assembly of Two New 3d–4f Heterometal-Organic Frameworks Based on a Bifunctional Ligand. Journal of Cluster Science. 2018; 29 (4):593-598.

Meng-Yao Sun; Di-Ming Chen; Cong Li-Gao. 2018. "Solvent-Dependent Assembly of Two New 3d–4f Heterometal-Organic Frameworks Based on a Bifunctional Ligand." Journal of Cluster Science 29, no. 4: 593-598.

Feng Deng; Ying Wang; Huiyuan Huang; Meiqi Niu; Shuming Zhong; Ling Zhao; Zhangzhang Qi; Xiaoyan Wu; Yao Sun; Chen Niu; Yuan He; Li Huang; Ruiwang Huang. Abnormal segments of right uncinate fasciculus and left anterior thalamic radiation in major and bipolar depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2017, 81, 340 -349.

Feng Deng, Ying Wang, Huiyuan Huang, Meiqi Niu, Shuming Zhong, Ling Zhao, Zhangzhang Qi, Xiaoyan Wu, Yao Sun, Chen Niu, Yuan He, Li Huang, Ruiwang Huang. Abnormal segments of right uncinate fasciculus and left anterior thalamic radiation in major and bipolar depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017; 81 ():340-349.

Feng Deng; Ying Wang; Huiyuan Huang; Meiqi Niu; Shuming Zhong; Ling Zhao; Zhangzhang Qi; Xiaoyan Wu; Yao Sun; Chen Niu; Yuan He; Li Huang; Ruiwang Huang. 2017. "Abnormal segments of right uncinate fasciculus and left anterior thalamic radiation in major and bipolar depression." Progress in Neuro-Psychopharmacology and Biological Psychiatry 81, no. : 340-349.

Background. Bladder cancer is a common urinary system tumor. In the treatment of clinical patients, it is particularly important to find an effective treatment method to inhibit tumor growth. The worlds first PARP inhibitor olaparib is mainly used for the treatment of BRCA1/BRCA2 mutated tumors. Metformin, an antidiabetic drug, has been reported to reduce cancer incidence in humans and improve survival in cancer patients. Methods. Cell viability and proliferation were detected by CCK-8 assay and colony formation assay; cell apoptosis was detected by flow cytometry; cell migration and invasion abilities were detected by scratch assay and Transwell assay; STAT3/C-MYC signaling pathway protein were detected by western blotting. Results. Olaparib combined with metformin has better effects on the proliferation, clone formation, migration, invasion, and apoptosis of bladder cancer cells than single drug, indicating that metformin can enhance the inhibitory effect of olaparib on tumor growth and regulate the expression of STAT3/C-MYC signaling pathway proteins. Conclusion. The results of this study showed that metformin could significantly enhance the antitumor effect of olaparib on bladder cancer cells, and these effects were mediated by downregulating STAT3/C-MYC signaling pathway proteins. This finding may have potential clinical application in the treatment of bladder cancer.

Bao-Jin Chi; Yao Sun; Ling-Li Quan; Jin-Tao Zhao; Bo Wei; Shu-Qiu Wang. Metformin Can Enhance the Inhibitory Effect of Olaparib in Bladder Cancer Cells. Disease Markers 2022, 2022, 1 -10.

Bao-Jin Chi, Yao Sun, Ling-Li Quan, Jin-Tao Zhao, Bo Wei, Shu-Qiu Wang. Metformin Can Enhance the Inhibitory Effect of Olaparib in Bladder Cancer Cells. Disease Markers. 2022; 2022 ():1-10.

Bao-Jin Chi; Yao Sun; Ling-Li Quan; Jin-Tao Zhao; Bo Wei; Shu-Qiu Wang. 2022. "Metformin Can Enhance the Inhibitory Effect of Olaparib in Bladder Cancer Cells." Disease Markers 2022, no. : 1-10.

Geoneutrinos serve as a potent tool for comprehending the radiogenic power and composition of Earth. Although geoneutrinos have been observed in prior experiments, the forthcoming generation of experiments,such as JUNO, will be necessary for fully harnessing their potential. Precise prediction of the crustal contribution is vital for interpreting particlephysics measurements in the context of geo-scientific inquiries. Nonetheless, existing models such as JULOC and GIGJ have limitations in accurately forecasting the crustal contribution. This paper introduces JULOCI, the novel 3-D integrated crustal model of JUNO, which employs seismic, gravity, rock sample, and heat flow data to precisely estimate the geoneutrino signal of the lithosphere. The model indicates elevated concentrations of uranium and thorium in southern China, resulting in unexpectedly strong geoneutrino signals.The accuracy of JULOC-I, coupled with a decade of experimental data, affords JUNO the opportunity to test multiple mantle models. Once operational, JUNO can validate the model predictions and enhance the precision of mantle measurements. All in all, the improved accuracy ofJULOC-I represents a substantial stride towards comprehending the geochemical distribution of the South China crust, offering a valuable tool for investigating the composition and evolution of the Earth through geoneutrinos.

Ran Han; ZhiWei Li; Ruohan Gao; Yao Sun; Ya Xu; Yufei Xi; Guangzheng Jiang; Andong Wang; Yaping Cheng; Jie Pang; Qi Hua; Liangjian Wen; Liang Zhan; Yu-Feng Li. Expected geoneutrino signal at JUNO using local integrated 3-D refined crustal model. arXiv 2024 .

Ran Han, ZhiWei Li, Ruohan Gao, Yao Sun, Ya Xu, Yufei Xi, Guangzheng Jiang, Andong Wang, Yaping Cheng, Jie Pang, Qi Hua, Liangjian Wen, Liang Zhan, Yu-Feng Li. Expected geoneutrino signal at JUNO using local integrated 3-D refined crustal model. arXiv. 2024; ():.

Ran Han; ZhiWei Li; Ruohan Gao; Yao Sun; Ya Xu; Yufei Xi; Guangzheng Jiang; Andong Wang; Yaping Cheng; Jie Pang; Qi Hua; Liangjian Wen; Liang Zhan; Yu-Feng Li. 2024. "Expected geoneutrino signal at JUNO using local integrated 3-D refined crustal model." arXiv , no. : .

Zinc is a structural constituent of many proteins, including Cu/Zn superoxide dismutase (SOD), an endogenous antioxidant enzyme. Hypozincemia has been found in patients hospitalized with congestive heart failure, where neurohormonal activation, including the renin-angiotensin-aldosterone system (RAAS), is expected and oxidative stress is present. This study was undertaken to elucidate potential pathophysiological mechanisms involved in Zn dyshomeostasis in aldosteronism. In rats receiving aldosterone/salt treatment (ALDOST) alone for 1 and 4 wk or in combination with spironolactone (Spiro), an ALDO receptor antagonist, we monitored 24-h urinary and fecal Zn excretion and tissue Zn levels in heart, liver, and skeletal muscle, together with tissue metallothionein (MT)-I, a Zn²⁺-binding protein, and Cu/Zn-SOD activities in plasma and tissues. When compared with unoperated, untreated, age-/sex-matched controls, urinary and, in particular, fecal Zn losses were markedly increased ( P < 0.05) at days 7 and 28 of ALDOST, leading to hypozincemia and a fall ( P < 0.05) in plasma Cu/Zn-SOD activity. Microscopic scars and perivascular fibrosis of intramural coronary arteries first appeared in the right and left ventricles at week 4 of ALDOST and were accompanied by increased ( P < 0.05) tissue Zn, MT-I, and Cu/Zn-SOD activity, which were not found in uninjured liver or skeletal muscle. Spiro cotreatment prevented cardiac injury and Zn redistribution to the heart. Thus increased urinary and fecal Zn losses, together with their preferential translocation to sites of cardiac injury, where MT-I overexpression and increased Cu/Zn-SOD activity appeared, contribute to Zn dyshomeostasis in rats with aldosteronism, which were each prevented by Spiro. These findings may shed light on Zn dyshomeostasis found in patients with decompensated heart failure.

Manesh Thomas; Alex Vidal; Syamal K. Bhattacharya; Robert A. Ahokas; Yao Sun; Ivan C. Gerling; Karl T. Weber. Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone. American Journal of Physiology-Heart and Circulatory Physiology 2007, 293, H2361 -H2366.

Manesh Thomas, Alex Vidal, Syamal K. Bhattacharya, Robert A. Ahokas, Yao Sun, Ivan C. Gerling, Karl T. Weber. Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone. American Journal of Physiology-Heart and Circulatory Physiology. 2007; 293 (4):H2361-H2366.

Manesh Thomas; Alex Vidal; Syamal K. Bhattacharya; Robert A. Ahokas; Yao Sun; Ivan C. Gerling; Karl T. Weber. 2007. "Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone." American Journal of Physiology-Heart and Circulatory Physiology 293, no. 4: H2361-H2366.

Qiusha Guo; Bing Xia; Simon Moshiach; Congfeng Xu; Yongde Jiang; Yuanjian Chen; Yao Sun; Jill M. Lahti; Xin A. Zhang. The microenvironmental determinants for kidney epithelial cyst morphogenesis. European Journal of Cell Biology 2008, 87, 251 -266.

Qiusha Guo, Bing Xia, Simon Moshiach, Congfeng Xu, Yongde Jiang, Yuanjian Chen, Yao Sun, Jill M. Lahti, Xin A. Zhang. The microenvironmental determinants for kidney epithelial cyst morphogenesis. European Journal of Cell Biology. 2008; 87 (4):251-266.

Qiusha Guo; Bing Xia; Simon Moshiach; Congfeng Xu; Yongde Jiang; Yuanjian Chen; Yao Sun; Jill M. Lahti; Xin A. Zhang. 2008. "The microenvironmental determinants for kidney epithelial cyst morphogenesis." European Journal of Cell Biology 87, no. 4: 251-266.

Karl T. Weber; Yao Sun; Ivan C. Gerling; Robert A. Ahokas. Aldosterone in Congestive Heart Failure. 2004, 151 -157.

Karl T. Weber, Yao Sun, Ivan C. Gerling, Robert A. Ahokas. Aldosterone in Congestive Heart Failure. . 2004; ():151-157.

Karl T. Weber; Yao Sun; Ivan C. Gerling; Robert A. Ahokas. 2004. "Aldosterone in Congestive Heart Failure." , no. : 151-157.