Alkohol dehidrogenaza (NADP+)
| Alkohol dehidrogenaza (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Alkohol dehidrogenaza (NADP+) tetramer, Clostridium beijerinckii | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.1.1.2 | ||||||||
| CAS broj | 9028-12-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Alkohol dehidrogenaza (NADP+) (EC 1.1.1.2, alkoholna dehidrogenaza (NADP+), aldehid reduktaza (NADPH2), NADP-alkohol dehidrogenaza, NADP+-aldehid reduktaza, NADP+-zavisni aldehid reduktaza, NADPH-aldehid reduktaza, NADPH-zavisni aldehid reduktaza, nonspecifična sukcinski semialdehid reduktaza, ALR 1, low-Km aldehid reduktaza, high-Km aldehid reduktaza, alkohol dehidrogenaza (NADP)) je enzim sa sistematskim imenom alkohol:NADP+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- alkohol + NADP+ aldehid + NADPH + H+
Alkoholna dehidrogenaza je protein cinka. Neki članovi ove grupe oksiduju samo primarne alkohole; drugi deluju takođe na sekundarne alkohole. Mogu da budu identični sa EC 1.1.1.19 (L-glukuronat reduktaza), EC 1.1.1.33 (mevaldat reduktaza (NADPH)) i EC 1.1.1.55 (laktaldehid reduktaza (NADPH)). Ovi enzimi su specifični u pogledu NADPH.
- ↑ Bosron, W.F. and Prairie, R.L. (1972). „Triphosphopyridine nucleotide-linked aldehyde reductase. I. Purification and properties of the enzyme from pig kidney cortex”. J. Biol. Chem. 247: 4480-4485. PMID 4402936.
- ↑ DeMoss, R. (1953). „Triphosphopyridine nucleotide-specific ethanol dehydrogenase from Leuconostoc mesenteroides”. Bacteriol. Proc.: 81-81.
- ↑ Reeves, R.E., Montalvo, F.E. and Lushbaugh, T.S. (1971). „Nicotinamide-adenine dinucleotide phosphate-dependent alcohol dehydrogenase. Enzyme from Entamoeba histolytica and some enzyme inhibitors”. Int. J. Biochem. 2: 55-64.
- ↑ Tabakoff, B. and Erwin, V.G. (1970). „Purification and characterization of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from brain”. J. Biol. Chem. 245: 3263-3268. PMID 4393513.
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