Aprindin

Aprindin
(IUPAC) ime
	{3-[2,3-dihidro-1H-inden-2-il(fenil)amino]propil}dietilamin
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	37640-71-4
ATC kod	C01BB04
PubChem	2218
DrugBank	DB01429
ChemSpider	2132
UNII	5Y48085P9Q
KEGG	D02969
ChEMBL	CHEMBL1213033
Hemijski podaci
Formula	C22H30N2
Mol. masa	322,487 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3 ; Key: NZLBHDRPUJLHCE-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Aprindin je antiaritmički agens klase 1b.^[6]

U jednoj studiji, on je odložio atrijalnu fibirlaciji duže od digoksina.^[7]

Aprindin je efektivan pri oralnoj administraciji.^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Sato R, Hisatome I, Tanaka Y, et al. (September 1991). „Aprindine blocks the sodium current in guinea-pig ventricular myocytes”. Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. PMID 1660104.
↑ Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). „Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation”. Circ. J. 66 (6): 553–6. DOI:10.1253/circj.66.553. PMID 12074271. Arhivirano iz originala na datum 2013-10-17. Pristupljeno 2014-04-05.
↑ Reid PR, Greene HL, Varghese PJ (December 1977). „Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome”. Br Heart J 39 (12): 1353–60. DOI:10.1136/hrt.39.12.1353. PMC 483421. PMID 603737.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid1660104-6] Sato R, Hisatome I, Tanaka Y, et al. (September 1991). „Aprindine blocks the sodium current in guinea-pig ventricular myocytes”. Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. PMID 1660104.

[pmid12074271-7] Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). „Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation”. Circ. J. 66 (6): 553–6. DOI:10.1253/circj.66.553. PMID 12074271. Arhivirano iz originala na datum 2013-10-17. Pristupljeno 2014-04-05.

[pmid603737-8] Reid PR, Greene HL, Varghese PJ (December 1977). „Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome”. Br Heart J 39 (12): 1353–60. DOI:10.1136/hrt.39.12.1353. PMC 483421. PMID 603737.

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