Diklofenamid

Diklofenamid
(IUPAC) ime
	4,5-dihlorobenzen-1,3-disulfonamid
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
MedlinePlus	a601233
Identifikatori
CAS broj	120-97-8
ATC kod	S01EC02
PubChem	3038
DrugBank	DB01144
ChemSpider	2930
UNII	VVJ6673MHY
KEGG	D00518
ChEBI	CHEBI:101085
ChEMBL	CHEMBL17
Hemijski podaci
Formula	C6H6Cl2N2O4S2
Mol. masa	305,16 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) ; Key: GJQPMPFPNINLKP-UHFFFAOYSA-N
Farmakokinetički podaci
Vezivanje za proteine plazme	55%
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Diklofenamid (dihlorfenamid) je sulfonamid i inhibitor karbonske anhidraze iz meta-disulfamoilbenzenske klase.^[6]^[7]

Upotreba

Diklofenamid se često koristi za tretiranje epolepsije.^[8]

References

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Tawil R, McDermott M, Brown R, Shapiro B, Ptacek L, McManis P, Dalakas M, Spector S, Mendell J, Hahn A, Griggs R (2000). „Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis.”. Ann Neurol 47 (1): 46–53. DOI:10.1002/1531-8249(200001)47:1<46::AID-ANA9>3.0.CO;2-H. PMID 10632100.
↑ Okada S, Izumi W, Murai M, Komatsu H, Ishimitsu S (1991). „[Diclofenamide Reference Standard (Control 891) of National Institute of Hygienic Sciences]”. Eisei Shikenjo Hokoku 109 (109): 148–50. PMID 1364383.
↑ Rucquoy M.; Sorel L.. „Diclofenamide in the treatment of therapy-resistant epilepsy.”. PubMed. Pristupljeno 13. 5. 2013.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Tawil R, McDermott M, Brown R, Shapiro B, Ptacek L, McManis P, Dalakas M, Spector S, Mendell J, Hahn A, Griggs R (2000). „Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis.”. Ann Neurol 47 (1): 46–53. DOI:10.1002/1531-8249(200001)47:1<46::AID-ANA9>3.0.CO;2-H. PMID 10632100.

[7] Okada S, Izumi W, Murai M, Komatsu H, Ishimitsu S (1991). „[Diclofenamide Reference Standard (Control 891) of National Institute of Hygienic Sciences]”. Eisei Shikenjo Hokoku 109 (109): 148–50. PMID 1364383.

[8] Rucquoy M.; Sorel L.. „Diclofenamide in the treatment of therapy-resistant epilepsy.”. PubMed. Pristupljeno 13. 5. 2013.

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