Fenformin
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(IUPAC) ime | |||
---|---|---|---|
2-(N-fenetilkarbamimidoil)guanidin | |||
Klinički podaci | |||
AHFS/Drugs.com | Internacionalno ime leka | ||
Identifikatori | |||
CAS broj | 114-86-3 | ||
ATC kod | A10BA01 | ||
PubChem[1][2] | 8249 | ||
DrugBank | DB00914 | ||
ChemSpider[3] | 7953 | ||
UNII | DD5K7529CE | ||
KEGG[4] | D08351 | ||
ChEBI | CHEBI:8064 | ||
ChEMBL[5] | CHEMBL170988 | ||
Hemijski podaci | |||
Formula | C10H15N5 | ||
Mol. masa | 205,26 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Phenformin je antidijabetesni lek iz biguanidne klase. On je bio u prodaji, ali je povučen sa tržišta tokom 1970-tih zbog povišenog rizika od laktacidoze, koja je fatalna u 50% slučajeva.
Phenformin je otkriven 1957. Klinička ispitivanja su počela 1958. i ustanovljeno je da je efektivan, ali da uzrokuje gastrointestinalne nuspojave.[6]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ McKendry JB, Kuwayti K, Rado PP (May 1959). „Clinical Experience with DBI (Phenformin) in the Management of Diabetes”. Can Med Assoc J 80 (10): 773–8. PMC 1831029. PMID 13652024.