MK-0249

MK-0249
	2-Metil-3-[4-(3-pirolidin-1-ilpropoksi)fenil]-5-(trifluorometil)quinazolin-4-on
Identifikacija
CAS registarski broj	1167574-41-5
PubChem	11697697
ChemSpider	9872422
ChEMBL	CHEMBL476323
Jmol-3D slike	Slika 1
SMILES
	CC1=NC2=CC=CC(=C2C(=O)N1C3=CC=C(C=C3)OCCCN4CCCC4)C(F)(F)F
InChI
	InChI=1S/C23H24F3N3O2/c1-16-27-20-7-4-6-19(23(24,25)26)21(20)22(30)29(16)17-8-10-18(11-9-17)31-15-5-14-28-12-2-3-13-28/h4,6-11H,2-3,5,12-15H2,1H3; Kod: DDDZBLNULGDPGA-UHFFFAOYSA-N
Svojstva
Molekulska formula	C23H24F3N3O2
Molarna masa	431.45 g mol−1
	; ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

MK-0249 je histaminski antagonist koji je selektiv za H₃ receptor.^[5] Ovo jedinjenje je razvila kompanija Abot laboratorije. Ono može da bude potencijalni lek za kognitivne poremećaje.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Esbenshade TA, Browman KE, Bitner RS, Strakhova M, Cowart MD, Brioni JD (July 2008). „The histamine H3 receptor: an attractive target for the treatment of cognitive disorders”. Br. J. Pharmacol. 154 (6): 1166–81. DOI:10.1038/bjp.2008.147. PMC 2483387. PMID 18469850.