This paper discusses the utility of 4-(4-acetamidophenyl)-4-oxobut-2-enoic acid as a key starting... more This paper discusses the utility of 4-(4-acetamidophenyl)-4-oxobut-2-enoic acid as a key starting material for the preparation of a novel series of pyridazinones, thiazoles derivatives, and other heterocycles via interaction with nitrogen, sulfur, and carbon nucleophiles under Michael addition conditions and studies the antimicrobial activities of some of these compounds.
This research describe the reaction of 3-(1-naphthoyl)acrylic acid1with different Nitrogen nucleo... more This research describe the reaction of 3-(1-naphthoyl)acrylic acid1with different Nitrogen nucleophiles under Aza-Michael reaction conditions to afford the corresponding Aza-Michael adduct 2(a-h)which allowed to react with hydrazine hydrate, hydroxyl amine hydrochloride and acetic anhydride to form novelpyridazinone3(a-c),oxazinone4(a-c) and furanone5(a-c) derivatives respectively. Some of the new products showed antimicrobial activities.
This research describe the reaction of 3-(1-naphthoyl)acrylic acid1with different Nitrogen nucleo... more This research describe the reaction of 3-(1-naphthoyl)acrylic acid1with different Nitrogen nucleophiles under Aza-Michael reaction conditions to afford the corresponding Aza-Michael adduct 2(a-h)which allowed to react with hydrazine hydrate, hydroxyl amine hydrochloride and acetic anhydride to form novelpyridazinone3(a-c),oxazinone4(a-c) and furanone5(a-c) derivatives respectively. Some of the new products showed antimicrobial activities.
This paper discusses the utility of 4-(4-acetamidophenyl)-4-oxobut-2-enoic acid as a key starting... more This paper discusses the utility of 4-(4-acetamidophenyl)-4-oxobut-2-enoic acid as a key starting material for the preparation of a novel series of pyridazinones, thiazoles derivatives, and other heterocycles via interaction with nitrogen, sulfur, and carbon nucleophiles under Michael addition conditions and studies the antimicrobial activities of some of these compounds.
This research describe the reaction of 3-(1-naphthoyl)acrylic acid1with different Nitrogen nucleo... more This research describe the reaction of 3-(1-naphthoyl)acrylic acid1with different Nitrogen nucleophiles under Aza-Michael reaction conditions to afford the corresponding Aza-Michael adduct 2(a-h)which allowed to react with hydrazine hydrate, hydroxyl amine hydrochloride and acetic anhydride to form novelpyridazinone3(a-c),oxazinone4(a-c) and furanone5(a-c) derivatives respectively. Some of the new products showed antimicrobial activities.
This research describe the reaction of 3-(1-naphthoyl)acrylic acid1with different Nitrogen nucleo... more This research describe the reaction of 3-(1-naphthoyl)acrylic acid1with different Nitrogen nucleophiles under Aza-Michael reaction conditions to afford the corresponding Aza-Michael adduct 2(a-h)which allowed to react with hydrazine hydrate, hydroxyl amine hydrochloride and acetic anhydride to form novelpyridazinone3(a-c),oxazinone4(a-c) and furanone5(a-c) derivatives respectively. Some of the new products showed antimicrobial activities.
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