Background: Exaggerated cardiovascular reactivity for blood pressure (BP) and heart rate (HR) to ... more Background: Exaggerated cardiovascular reactivity for blood pressure (BP) and heart rate (HR) to laboratory stress tests has been proposed as a predictor of cardiovascular disease. Subjects and Methods: The study was conducted in normal subject; 262 males and 280 females (mean age 30 ± 9 years, BMI 23.5 ± 4 years), from five large and highly consanguineous homogeneous Arab families of OFS. Hemodynamic parameters: Heart rate (HR), systolic, diastolic, mean BP (mmHg), Stroke index (SI, SI (ml/beat/m 2 ), cardiac index (CI,L/min/m 2 ) ), total peripheral resistance index (TPRI, yne*s*/cm 2 )), left ventricular ejection time (LVET, ms) and cardiac contractility (IC, 1000/sec ) were computed from beat-to-beat BP, ECG and impedance cardiography (TFM, CNSystems). Autonomic parameters ( LF; sympathetic , HF; parasympathetic, normalized) and baroreceptor sensitivity (BRS, ms/mmHg) were computed using spectral analysis and the sequence method, respectively. Hemodynamic and autonomic eactivity...
Technology and health care : official journal of the European Society for Engineering and Medicine, 2013
Obstructive Sleep Apnea (OSA) is the cessation of breathing during sleep due to the collapse of u... more Obstructive Sleep Apnea (OSA) is the cessation of breathing during sleep due to the collapse of upper airway. Polysomnographic recording is a conventional method for detection of OSA. Although it provides reliable results, it is expensive and cumbersome. Thus, an advanced non-invasive signal processing based technique is needed. The main purpose of this work is to predict the severity of sleep apnea using an efficient wavelet-based spectral analysis method of the heart rate variability (HRV) to classify sleep apnea into three different levels (mild, moderate, and severe) according to its severity and to distinguish them from normal subjects. The standard FFT spectrum analysis method and the soft-decision wavelet-based technique are to be used in this work in order to rank patients to full polysomnography. Data of 20 normal subjects and 20 patients with mild apnea and 20 patients with moderate apnea and 20 patients of severe apnea are used in this study. The data is obtained from the...
Background: Heart rate variability (HRV) is a reliable, non-invasive, economical reflection of ma... more Background: Heart rate variability (HRV) is a reliable, non-invasive, economical reflection of many physiological and psychological factors regulating the normal heart rhythm. It is often used as an index of cardiac parasympathetic system activity. In the general population decreased HRV is an independent risk factor for morbidity and mortality. Individual differences of HRV can be attributed to genetic factors and are found to be more pronounced in subjects during stress tests. However, most published studies on the genetic influence on HRV have focused on subjects of European and African-Americans descent. In Oman Family Study (OFS) we aim to (a) estimate and quantify the contribution of genes to the variance of HRV; (b) calculate the overlap in genetic and environmental influences on HRV at rest and under stress using uni-and bivariate analyses; and (c) multipoint variance component-based linkage analysis for all HRV parameters. Methods: The OFS consists of five large, multigener...
Obstructive sleep apnoea/hypopnoea syndrome (OSAHS) is a disorder characterised by repetitive upp... more Obstructive sleep apnoea/hypopnoea syndrome (OSAHS) is a disorder characterised by repetitive upper airway collapse during sleep in association with daytime sleepiness. It has an estimated prevalence of 2% and 4% among middle-aged women and men respectively. The aim of the study was to look at the association of body mass index (BMI), age and gender and prevalence of OSAHS in the Omani population. Polysomnography reports and hospital medical records of all patients who took part in the Sleep Study at the Sleep Laboratory of the Clinical Physiology Department, Sultan Qaboos University Hospital, between January 1995 and December 2006, were retrospectively reviewed. Data from both sources was gathered and analysed. A total of 1,042 sleep studies were conducted with 608 valid studies for analysis. The study showed that the apnoea/hypopnoea index (AHI) >15 was more prevalent in men compared to women (47.9% versus 33.5%, P = 0.001). There was significant correlation of AHI with BMI (P ...
Background:We performed a genome-wide scan in a homogeneous Arab population to identify genomic r... more Background:We performed a genome-wide scan in a homogeneous Arab population to identify genomic regions linked to blood pressure (BP) and its intermediate phenotypes during mental and physical stress tests.Methods:The Oman Family Study subjects (N= 1277) were recruited from five extended families of ~10 generations. Hemodynamic phenotypes were computed from beat-to-beat BP, electrocardiography and impedance cardiography. Multi-point linkage was performed for resting, mental (word conflict test, WCT) and cold pressor (CPT) stress and their reactivity scores (s), using variance components decomposition-based methods implemented in SOLAR.Results:Genome-wide scans for BP phenotypes identified quantitative trait loci (QTLs) with significant evidence of linkage on chromosomes 1 and 12 for WCT-linked cardiac output (LOD = 3.1) and systolic BP (LOD = 3.5). Evidence for suggestive linkage for WCT was found on chromosomes 3, 17 and 1 for heart rate (LOD = 2.3), DBP (LOD = 2.4) and left ventri...
Objective: To estimate the heritability of ambulatory blood pressure (BP), heart rate (HR), and b... more Objective: To estimate the heritability of ambulatory blood pressure (BP), heart rate (HR), and beat-to-beat office BP and HR in an isolated, environmentally and genetically homogeneous Omani Arab population. Methods: Ambulatory BP measurements were recorded in 1,124 subjects with a mean age of 33.8 ± 16.2 years, using the auscultatory mode of the validated Schiller ambulatory BP Monitor. Beat-to-beat BP and HR were recorded by the Task Force Monitor. Heritability was estimated using quantitative genetic analysis. This was achieved by applying the maximum-likelihood-based variance decomposition method implemented in SOLAR software. Results: We detected statistically significant heritability estimates for office beat-to-beat, 24-hour, daytime, and sleep HR of 0.31, 0.21, 0.20, and 0.07, respectively. Heritability estimates in the abovementioned conditions for systolic BP (SBP)/diastolic BP (DBP)/mean BP (MBP) were all significant and estimated at 0.19/0.19/0.19, 0.30/0.44/0.41, 0.28/...
Background: Exaggerated cardiovascular reactivity for blood pressure (BP) and heart rate (HR) to ... more Background: Exaggerated cardiovascular reactivity for blood pressure (BP) and heart rate (HR) to laboratory stress tests has been proposed as a predictor of cardiovascular disease. Subjects and Methods: The study was conducted in normal subject; 262 males and 280 females (mean age 30 ± 9 years, BMI 23.5 ± 4 years), from five large and highly consanguineous homogeneous Arab families of OFS. Hemodynamic parameters: Heart rate (HR), systolic, diastolic, mean BP (mmHg), Stroke index (SI, SI (ml/beat/m 2 ), cardiac index (CI,L/min/m 2 ) ), total peripheral resistance index (TPRI, yne*s*/cm 2 )), left ventricular ejection time (LVET, ms) and cardiac contractility (IC, 1000/sec ) were computed from beat-to-beat BP, ECG and impedance cardiography (TFM, CNSystems). Autonomic parameters ( LF; sympathetic , HF; parasympathetic, normalized) and baroreceptor sensitivity (BRS, ms/mmHg) were computed using spectral analysis and the sequence method, respectively. Hemodynamic and autonomic eactivity...
Technology and health care : official journal of the European Society for Engineering and Medicine, 2013
Obstructive Sleep Apnea (OSA) is the cessation of breathing during sleep due to the collapse of u... more Obstructive Sleep Apnea (OSA) is the cessation of breathing during sleep due to the collapse of upper airway. Polysomnographic recording is a conventional method for detection of OSA. Although it provides reliable results, it is expensive and cumbersome. Thus, an advanced non-invasive signal processing based technique is needed. The main purpose of this work is to predict the severity of sleep apnea using an efficient wavelet-based spectral analysis method of the heart rate variability (HRV) to classify sleep apnea into three different levels (mild, moderate, and severe) according to its severity and to distinguish them from normal subjects. The standard FFT spectrum analysis method and the soft-decision wavelet-based technique are to be used in this work in order to rank patients to full polysomnography. Data of 20 normal subjects and 20 patients with mild apnea and 20 patients with moderate apnea and 20 patients of severe apnea are used in this study. The data is obtained from the...
Background: Heart rate variability (HRV) is a reliable, non-invasive, economical reflection of ma... more Background: Heart rate variability (HRV) is a reliable, non-invasive, economical reflection of many physiological and psychological factors regulating the normal heart rhythm. It is often used as an index of cardiac parasympathetic system activity. In the general population decreased HRV is an independent risk factor for morbidity and mortality. Individual differences of HRV can be attributed to genetic factors and are found to be more pronounced in subjects during stress tests. However, most published studies on the genetic influence on HRV have focused on subjects of European and African-Americans descent. In Oman Family Study (OFS) we aim to (a) estimate and quantify the contribution of genes to the variance of HRV; (b) calculate the overlap in genetic and environmental influences on HRV at rest and under stress using uni-and bivariate analyses; and (c) multipoint variance component-based linkage analysis for all HRV parameters. Methods: The OFS consists of five large, multigener...
Obstructive sleep apnoea/hypopnoea syndrome (OSAHS) is a disorder characterised by repetitive upp... more Obstructive sleep apnoea/hypopnoea syndrome (OSAHS) is a disorder characterised by repetitive upper airway collapse during sleep in association with daytime sleepiness. It has an estimated prevalence of 2% and 4% among middle-aged women and men respectively. The aim of the study was to look at the association of body mass index (BMI), age and gender and prevalence of OSAHS in the Omani population. Polysomnography reports and hospital medical records of all patients who took part in the Sleep Study at the Sleep Laboratory of the Clinical Physiology Department, Sultan Qaboos University Hospital, between January 1995 and December 2006, were retrospectively reviewed. Data from both sources was gathered and analysed. A total of 1,042 sleep studies were conducted with 608 valid studies for analysis. The study showed that the apnoea/hypopnoea index (AHI) >15 was more prevalent in men compared to women (47.9% versus 33.5%, P = 0.001). There was significant correlation of AHI with BMI (P ...
Background:We performed a genome-wide scan in a homogeneous Arab population to identify genomic r... more Background:We performed a genome-wide scan in a homogeneous Arab population to identify genomic regions linked to blood pressure (BP) and its intermediate phenotypes during mental and physical stress tests.Methods:The Oman Family Study subjects (N= 1277) were recruited from five extended families of ~10 generations. Hemodynamic phenotypes were computed from beat-to-beat BP, electrocardiography and impedance cardiography. Multi-point linkage was performed for resting, mental (word conflict test, WCT) and cold pressor (CPT) stress and their reactivity scores (s), using variance components decomposition-based methods implemented in SOLAR.Results:Genome-wide scans for BP phenotypes identified quantitative trait loci (QTLs) with significant evidence of linkage on chromosomes 1 and 12 for WCT-linked cardiac output (LOD = 3.1) and systolic BP (LOD = 3.5). Evidence for suggestive linkage for WCT was found on chromosomes 3, 17 and 1 for heart rate (LOD = 2.3), DBP (LOD = 2.4) and left ventri...
Objective: To estimate the heritability of ambulatory blood pressure (BP), heart rate (HR), and b... more Objective: To estimate the heritability of ambulatory blood pressure (BP), heart rate (HR), and beat-to-beat office BP and HR in an isolated, environmentally and genetically homogeneous Omani Arab population. Methods: Ambulatory BP measurements were recorded in 1,124 subjects with a mean age of 33.8 ± 16.2 years, using the auscultatory mode of the validated Schiller ambulatory BP Monitor. Beat-to-beat BP and HR were recorded by the Task Force Monitor. Heritability was estimated using quantitative genetic analysis. This was achieved by applying the maximum-likelihood-based variance decomposition method implemented in SOLAR software. Results: We detected statistically significant heritability estimates for office beat-to-beat, 24-hour, daytime, and sleep HR of 0.31, 0.21, 0.20, and 0.07, respectively. Heritability estimates in the abovementioned conditions for systolic BP (SBP)/diastolic BP (DBP)/mean BP (MBP) were all significant and estimated at 0.19/0.19/0.19, 0.30/0.44/0.41, 0.28/...
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Papers by Deepali Jaju