1-Amino-5-fosfonoindan-1-karboksilna kiselina (APICA) je lek koji se koristi u neurološkim istraživanjima. on je selektivni antagonist za grupu II metabotropnih glutamatnih receptora (mGluR2/3), i bio je koristan u istraživanju te receptorske potfamilije.[1][2][3][4][5]
^Ma D, Tian H, Sun H, Kozikowski AP, Pshenichkin S, Wroblewski JT. Bioorganic & Medicinal Chemistry Letters. 1997 May 6;7(9):1195-1198. „Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists”. doi:10.1016/S0960-894X(97)00177-7.
^Ma D, Tian H, Zou G. Asymmetric Strecker-Type Reaction of alpha-Aryl Ketones. Synthesis of (S)-alphaM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the Antagonists of Metabotropic Glutamate Receptors. Journal of Organic Chemistry. 1999 Jan 8;64(1):120-125. PMID11674092
^Xi ZX, Baker DA, Shen H, Carson DS, Kalivas PW. Journal of Pharmacology and Experimental Therapeutics. 2002 Jan;300(1):162-71. „Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens”. PMID11752112. doi:10.1124/jpet.300.1.162.
^Baker DA, Xi ZX, Shen H, Swanson CJ, Kalivas PW. The origin and neuronal function of in vivo nonsynaptic glutamate. Journal of Neuroscience. 2002 Oct 15;22(20):9134-41. PMID12388621
^Zhou F, Yao HH, Wu JY, Yang YJ, Ding JH, Zhang J, Hu G. Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake. Journal of Neuroscience Research. 2006 Aug 1;84(2):268-77. PMID16752416
