Metionin-tRNK ligaza
| Metionin-tRNK ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Metionin-tRNK ligaza monomer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 6.1.1.10 | ||||||||
| CAS broj | 9033-22-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Metionin-tRNK ligaza (EC 6.1.1.10, metionil-tRNK sintetaza, metionil-transferna ribonukleinsko kiselinska sintetaza, metionil-transferna ribonukleatna sintetaza, metionil-transferna RNK sintetaza, metioninska translaza, MetRS) je enzim sa sistematskim imenom L-metionin:tRNKMet ligaza (formira AMP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
U organizmima koji formiraju N-formilmetionil-tRNKfMet za inicijaciju translacije, ovaj enzim takođe prepoznaje initiator tRNKfMet i katalizuje formiranje L-metionil-tRNKfMet.
Reference
[уреди | уреди извор]- ^ Bergmann, F.H., Berg, P. and Dieckmann, M. (1961). „The enzymic synthesis of amino acyl derivatives of ribonucleic acid. II. The preparation of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid synthetases from Escherichia coli”. J. Biol. Chem. 236: 1735—1740.
- ^ Lee, C.P., Dyson, M.R., Mandal, N., Varshney, U., Bahramian, B. and RajBhandary, U.L. (1992). „Striking effects of coupling mutations in the acceptor stem on recognition of tRNAs by Escherichia coli Met-tRNA synthetase and Met-tRNA transformylase”. Proc. Natl. Acad. Sci. USA. 89: 9262—9266. PMID 1409632.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Methionine---tRNA+ligase на US National Library of Medicine Medical Subject Headings (MeSH)
