This study aimed to introduce new composites, containing polyamide-6 (PA6) and lead monoxide (PbO... more This study aimed to introduce new composites, containing polyamide-6 (PA6) and lead monoxide (PbO), to protect against ionizing photon sources used for diagnostic and therapeutic purposes. Five composites, containing various weight percentages of PbO filler (0, 5, 10, 20, and 50%), were developed in this study. Initially, the numerical attenuation value was estimated using the XMuDat program by calculating the mass attenuation coefficients at different energy levels. Next, the samples were synthesized based on the melt-mixing method in a laboratory mixing extruder. Their characteristics were also determined by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis, X-ray diffraction (XRD), and thermogravimetric analysis (TGA). Finally, experimental radiation attenuation tests were carried out. Based on the SEM results, the acceptable filler weight percentage was up to 20%. However, substantial aggregates were formed at the highest weight percentage. The results of XRD analysis showed a higher tendency for crystallization by decreasing the amorphous area while increasing the filler weight percentage. Moreover, the mass loss rate was monitored at different temperatures, revealing that the filler incorporation improved the thermal durability of the samples. The radiation results showed a good agreement between the experimental and computational data, except when aggregates formation was substantial. The experimental data revealed that when the lead weight percentage increased from 0% (crude PA6) to 50%, the halfvalue layer decreased from 3.13 to 0.17 cm at an energy level of 59 keV and from 7.28 to 4.97 cm at an energy level of 662 keV. Following the studied mechanism, the superiority of lead/polyamide composites can be found in the high adsorption of photon radiation at low energies (E < 0.20 MeV) and significant attenuation at medium and higher energies. Considering these promising results, the shielding properties of these composites can be further analyzed via more practical investigations.
Journal of Biomedical Physics and Engineering, 2019
Background : In recent years, there has been an increased interest toward non-lead radiation shie... more Background : In recent years, there has been an increased interest toward non-lead radiation shields consisting of small-sized filler particles doped into polymer matrices. In this paper, we study a new polyvinyl alcohol (PVA)/WO3 composite in the presence of high-energy gamma photons through simulation via the Monte Carlo N-Particle (MCNP) simulation code.Materials and Methods: An MCNP geometry was first designed in the software based on real-life conditions, and the generated geometry was validated by calculating the mass attenuation coefficient and making relative comparisons with standard tables. Using the lattice card in the MCNP input file, WO3 was considered as a filler dispersed in a PVA polymer at sizes of 10 µm and 30 nm with a weight concentration of 50 wt%. By defining 106-photons emitted from point sources corresponding to 662, 778, 964, 1112, 1170, 1130 and 1407 keV energy levels, and the F4 tally used to estimate the cell average flux, the values for mass attenuation ...
Journal of Biomedical Physics and Engineering, Sep 1, 2015
Airport workers are continuously exposed to different levels of radiofrequency microwave (RF/MW) ... more Airport workers are continuously exposed to different levels of radiofrequency microwave (RF/MW) radiation emitted by radar equipments. Radars are extensively used in military and aviation industries. Over the past several years, our lab has focused on the health effects of exposure to different sources of electromagnetic fields such as cellular phones, mobile base stations, mobile phone jammers, laptop computers, radars, dentistry cavitrons and MRI. The main goal of this study was to investigate if occupational exposure of Shahid Dastghieb international airport workers to radiofrequency radiation affects their short term memory and reaction time. Thirty two airport workers involved in duties at control and approach tower (21 males and 11 females), with the age range of 27-67 years old (mean age of 37.38), participated voluntary in this study. On the other hand, 29 workers (13 males, and 16 females) whose offices were in the city with no exposure history to radar systems were also p...
MRI workers are occupationally exposed to static and time-varying gradient magnetic fields. While... more MRI workers are occupationally exposed to static and time-varying gradient magnetic fields. While the 24-hour time-averaged exposure to static magnetic fields is about a few mT, the maximum static field strength can be as high as 500 mT during patient setup. Over the past several years, our laboratory has performed extensive experiments on the health effects of exposure of animal models and humans to different sources of electromagnetic fields such as cellular phones, mobile base stations, mobile phone jammers, laptop computers, radars, dentistry cavitrons and MRI. This study is to investigate the adverse health effects in MRI workers and also to assess the effect of exposure of MRI workers to static magnetic fields on their cognitive functions. In the first phase of this study a questionnaire was designed to collect information from 120 MRI personnel. The collection of data about the adverse health effects was based on self-reporting by the participants. In the second phase, 47 vol...
Silica nanoparticles (SNPs) are known as intrinsic radiolabeling agents and offer a fast and reli... more Silica nanoparticles (SNPs) are known as intrinsic radiolabeling agents and offer a fast and reliable approach to deliver theranostic agents into targeted organs. Radiolabeled amorphous silica nanoparticles are of great interest to radiation oncology communities. In order to improve the performance of these nano materials in cancer diagnosis and treatment, their inherent properties, such as surface area and the ability to accumulate in cancer cells, should be enhanced. Pyridine functionalized mesoporous silica MCM-41 is known as a potential anticancer-drug delivery system with high suface area. In thiswork, in order to produce an image-guided drug delivery system for diagnostic applications, [68Ga] radionuclide was grafted on pyridine functionalized MCM-41. The nanoparticles were assessed with atomic force microscopy (AFM), paper chromatography, X-ray diffraction, FTIR spectroscopy, CHN and TGA/DTA analyses. The pharmacokinetic profile evaluation of the radiolabeled nano silica, [68...
The design of organic/inorganic polymer nanoparticles-based hybrids is promising for gamma ray se... more The design of organic/inorganic polymer nanoparticles-based hybrids is promising for gamma ray sensor systems. Here, we design semiconducting nanocomposite system for efficient gamma ray harvesting system where cadmium telluride (CdTe) quantum dots act as dopant and poly(N-vinyl carbazole) (PVK) polymer acts as host. Highly crystalline 1-dodecanethiol (1-DDT) decorated CdTe quantum dots with average diameter of ~ 3 nm were synthesized and characterized with high-resolution transmission electron microscopy (HR-TEM) analysis. Nearly monodispersed CdTe/PVK nanocomposite was subsequently prepared by addition of CdTe quantum dots (QDs) in poly(N-vinyl carbazole) matrix. The photophysical interactions between polymer host and QDs have been investigated by preparing an ohmic contact detector using a conductive cell with two gold-coated walls. Gamma detecting properties of the CdTe QDs/PVK nanocomposite such as sensitivity, repeatability, and the linearity of dose rate response were assessed. Significant enhancement in photoconductivity induced by the gamma radiation in CdTe QDs/PVK nanocomposite has been demonstrated.
Background: It has been shown that short-wavelength blue component of the visible light spectrum ... more Background: It has been shown that short-wavelength blue component of the visible light spectrum can alter the circadian rhythm and suppress the level of melatonin hormone. The short-wavelength light emitted by smartphones’ screens can affect the sleep quality of the people who use these devices at night through suppression of melatonin.Objectives: In this study, we examined the effects of covering the screens of smartphones with different filters (changing the effective wavelength of the light) on sleep delay time in 43 healthy students.Materials and Methods: Volunteer students were asked to go to bed at 23:00 and to use their mobile phones in bed for watching a natural life documentary movie for 60 minutes. No filter was used for one night while amber and blue filters were used for other 2 nights. Photospectrometry method was used to determine the output spectrum of the light passing through the filters used for covering the screens of the mobile phones. The order for utilizing a...
This study explored the feasibility to produce 198Au in the Isfahan miniature neutron source reac... more This study explored the feasibility to produce 198Au in the Isfahan miniature neutron source reactor (MNSR). To estimate production level, we used the MCNP simulation method, validated through empirical data. Role of different irradiation and cooling periods to maximize the produced yield was also studied. The results of our study showed that after 30 cycles, the maximum production was 812.3 mCi g−1 in the maximum flux and irradiation time. However, after the 15th cycle it reached its maximum production of 90% (740.3 mCi g−1). Also, the role of irradiation and cooling periods in the optimum fuel management was shown. Our results showed that producing 198Au is feasible in MNSRs.
Porphyrins and 68Ga have emerged as novel synergic options for PET applications so the idea of pr... more Porphyrins and 68Ga have emerged as novel synergic options for PET applications so the idea of preparation of a novel porphyrin complex using this nuclide was targeted. Herein, [68Ga(III)] labeled 5, 10, 15, 20-Tetrakis(2, 4, 6-trimethoxy phenyl) porphyrin ([68Ga(III)]-TTMPP) was developed in this work. The biodistribution of the [68Ga(III)]-TTMPP complex among vital organs of mice bearing Fibrosarcoma tumors was studied using scarification. Due to the short half-life of 68Ga, high tumor avidity and fast excretion of [68Ga(III)]-TTMPP complex, this labeled compound is demonstrated to be a potential bioprobe for positron emission tomography (PET) and photodynamic therapy (PDT).
Miniature neutron source reactors (MNSRs) and their challenges were investigated. Then, MNSRs str... more Miniature neutron source reactors (MNSRs) and their challenges were investigated. Then, MNSRs structure and operation were discussed, and conflicting usages of high enriched uranium fuel and its technical challenges were explored. By using low enriched uranium it is possible to produce 99Mo isotopes with similar quality, plus using low enriched uranium does not increase the potential risks and high does level. Furthermore, it is possible to produce several medical radioisotopes such as 99Mo/99mTc generator, 131I, 65Zn, and 177Lu. These reactors can be employed in Boron Neutron Capture Therapy. After conversion, these reactors can be used more frequently and effectively.
This paper describes the system for the dose delivery currently used at the Centro Nazionale di A... more This paper describes the system for the dose delivery currently used at the Centro Nazionale di Adroterapia Oncologica (CNAO) for ion beam modulated scanning radiotherapy. CNAO Foundation, Istituto Nazionale di Fisica Nucleare and University of Torino have designed, built, and commissioned a dose delivery system (DDS) to monitor and guide ion beams accelerated by a dedicated synchrotron and to distribute the dose with a full 3D scanning technique. Protons and carbon ions are provided for a wide range of energies in order to cover a sizable span of treatment depths. The target volume, segmented in several layers orthogonally to the beam direction, is irradiated by thousands of pencil beams which must be steered and held to the prescribed positions until the prescribed number of particles has been delivered. For the CNAO beam lines, these operations are performed by the DDS. The main components of this system are two independent beam monitoring detectors, called BOX1 and BOX2, interfa...
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2021
In this experimental work, Polyvinyl Alcohol-Tungsten oxide micro- and nanocomposites were fabric... more In this experimental work, Polyvinyl Alcohol-Tungsten oxide micro- and nanocomposites were fabricated in various weight percentages of 0, 10, 20, 30, and 40 wt%, through the solution method. The dispersion state of the inclusions into the polymeric matrix was studied through the SEM analyses. Then, the linear attenuation coefficient, mass attenuation coefficient, half-value layer, tenth-value layer, and mean free path of the samples were measured using a Geiger counter for different gamma-rays of 57Co, 201Tl, 67Ga, Tc, 133Ba, and 137Cs radioactive sources. It was shown that increasing the concentration of the WO3 fillers in the PVA matrix increased the attenuation coefficients of the composites significantly. Besides, the attenuation coefficients of the nanocomposites were significantly larger than those of the microcomposites due to high surface-to-volume ratio of the tungsten oxide nano-particles compared to the microcomposites.
Background Airport workers are continuously exposed to different levels of radiofrequency microwa... more Background Airport workers are continuously exposed to different levels of radiofrequency microwave (RF/MW) radiation emitted by radar equipments. Radars are extensively used in military and aviation industries. Over the past several years, our lab has focused on the health effects of exposure to different sources of electromagnetic fields such as cellular phones, mobile base stations, mobile phone jammers, laptop computers, radars, dentistry cavitrons and MRI. The main goal of this study was to investigate if occupational exposure of Shahid Dastghieb international airport workers to radiofrequency radiation affects their short term memory and reaction time. Methods Thirty two airport workers involved in duties at control and approach tower (21 males and 11 females), with the age range of 27-67 years old (mean age of 37.38), participated voluntary in this study. On the other hand, 29 workers (13 males, and 16 females) whose offices were in the city with no exposure history to radar ...
Introduction: Radiotherapy with heavy charged particles such as protons and carbon ions (hadron t... more Introduction: Radiotherapy with heavy charged particles such as protons and carbon ions (hadron therapy) has been recognized as an advanced technique for the treatment of various cancers. For some indications such as pediatric and radio-resistant tumors, it is considered the preferred method. However, despite its remarkable benefits, development of hadron therapy centers in the world has always been subject to major constraints due to a number of reasons including the high costs of constructing and maintaining the centers, the need for strong infrastructures, and the lack of adequate research on the estimation of the number of patients eligible for utilizing this technique. Therefore, this study aimed to investigate the initial estimation of the number of patients eligible for hadron therapy in the Fars Province and Iran as a whole. Materials and Methods: In the absence of comprehensive national cancer registry data, the information for the initial estimation of the number of patien...
A dedicated Dose Delivery System (DDS) was developed to implement the modulated spot scanning tec... more A dedicated Dose Delivery System (DDS) was developed to implement the modulated spot scanning technique at the Italian Hadrontherapy facility (CNAO). This is the highest conformal method in use with protons and carbon ions worldwide. The clinical 3 dimensional target is subdivided into several spots irradiated delivering a pencil beam for each spot. The right position of the beam is achieved using two orthogonal scanning magnets for X and Y displacements while the Z position of the Bragg peak (along the beam direction) is achieved by exploiting the ability of the synchrotron to provide the appropriate beam energy. Each spot of a slice is characterized by the number of particles and by the beam position which are managed and controlled by the DDS. The DDS drives the treatment spot by spot by exploiting the treatment planning data and the online measurements. The preliminary performances achieved by the system during clinical treatments are the object of this paper. The estimation of ...
This study aimed to introduce new composites, containing polyamide-6 (PA6) and lead monoxide (PbO... more This study aimed to introduce new composites, containing polyamide-6 (PA6) and lead monoxide (PbO), to protect against ionizing photon sources used for diagnostic and therapeutic purposes. Five composites, containing various weight percentages of PbO filler (0, 5, 10, 20, and 50%), were developed in this study. Initially, the numerical attenuation value was estimated using the XMuDat program by calculating the mass attenuation coefficients at different energy levels. Next, the samples were synthesized based on the melt-mixing method in a laboratory mixing extruder. Their characteristics were also determined by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis, X-ray diffraction (XRD), and thermogravimetric analysis (TGA). Finally, experimental radiation attenuation tests were carried out. Based on the SEM results, the acceptable filler weight percentage was up to 20%. However, substantial aggregates were formed at the highest weight percentage. The results of XRD analysis showed a higher tendency for crystallization by decreasing the amorphous area while increasing the filler weight percentage. Moreover, the mass loss rate was monitored at different temperatures, revealing that the filler incorporation improved the thermal durability of the samples. The radiation results showed a good agreement between the experimental and computational data, except when aggregates formation was substantial. The experimental data revealed that when the lead weight percentage increased from 0% (crude PA6) to 50%, the halfvalue layer decreased from 3.13 to 0.17 cm at an energy level of 59 keV and from 7.28 to 4.97 cm at an energy level of 662 keV. Following the studied mechanism, the superiority of lead/polyamide composites can be found in the high adsorption of photon radiation at low energies (E < 0.20 MeV) and significant attenuation at medium and higher energies. Considering these promising results, the shielding properties of these composites can be further analyzed via more practical investigations.
Journal of Biomedical Physics and Engineering, 2019
Background : In recent years, there has been an increased interest toward non-lead radiation shie... more Background : In recent years, there has been an increased interest toward non-lead radiation shields consisting of small-sized filler particles doped into polymer matrices. In this paper, we study a new polyvinyl alcohol (PVA)/WO3 composite in the presence of high-energy gamma photons through simulation via the Monte Carlo N-Particle (MCNP) simulation code.Materials and Methods: An MCNP geometry was first designed in the software based on real-life conditions, and the generated geometry was validated by calculating the mass attenuation coefficient and making relative comparisons with standard tables. Using the lattice card in the MCNP input file, WO3 was considered as a filler dispersed in a PVA polymer at sizes of 10 µm and 30 nm with a weight concentration of 50 wt%. By defining 106-photons emitted from point sources corresponding to 662, 778, 964, 1112, 1170, 1130 and 1407 keV energy levels, and the F4 tally used to estimate the cell average flux, the values for mass attenuation ...
Journal of Biomedical Physics and Engineering, Sep 1, 2015
Airport workers are continuously exposed to different levels of radiofrequency microwave (RF/MW) ... more Airport workers are continuously exposed to different levels of radiofrequency microwave (RF/MW) radiation emitted by radar equipments. Radars are extensively used in military and aviation industries. Over the past several years, our lab has focused on the health effects of exposure to different sources of electromagnetic fields such as cellular phones, mobile base stations, mobile phone jammers, laptop computers, radars, dentistry cavitrons and MRI. The main goal of this study was to investigate if occupational exposure of Shahid Dastghieb international airport workers to radiofrequency radiation affects their short term memory and reaction time. Thirty two airport workers involved in duties at control and approach tower (21 males and 11 females), with the age range of 27-67 years old (mean age of 37.38), participated voluntary in this study. On the other hand, 29 workers (13 males, and 16 females) whose offices were in the city with no exposure history to radar systems were also p...
MRI workers are occupationally exposed to static and time-varying gradient magnetic fields. While... more MRI workers are occupationally exposed to static and time-varying gradient magnetic fields. While the 24-hour time-averaged exposure to static magnetic fields is about a few mT, the maximum static field strength can be as high as 500 mT during patient setup. Over the past several years, our laboratory has performed extensive experiments on the health effects of exposure of animal models and humans to different sources of electromagnetic fields such as cellular phones, mobile base stations, mobile phone jammers, laptop computers, radars, dentistry cavitrons and MRI. This study is to investigate the adverse health effects in MRI workers and also to assess the effect of exposure of MRI workers to static magnetic fields on their cognitive functions. In the first phase of this study a questionnaire was designed to collect information from 120 MRI personnel. The collection of data about the adverse health effects was based on self-reporting by the participants. In the second phase, 47 vol...
Silica nanoparticles (SNPs) are known as intrinsic radiolabeling agents and offer a fast and reli... more Silica nanoparticles (SNPs) are known as intrinsic radiolabeling agents and offer a fast and reliable approach to deliver theranostic agents into targeted organs. Radiolabeled amorphous silica nanoparticles are of great interest to radiation oncology communities. In order to improve the performance of these nano materials in cancer diagnosis and treatment, their inherent properties, such as surface area and the ability to accumulate in cancer cells, should be enhanced. Pyridine functionalized mesoporous silica MCM-41 is known as a potential anticancer-drug delivery system with high suface area. In thiswork, in order to produce an image-guided drug delivery system for diagnostic applications, [68Ga] radionuclide was grafted on pyridine functionalized MCM-41. The nanoparticles were assessed with atomic force microscopy (AFM), paper chromatography, X-ray diffraction, FTIR spectroscopy, CHN and TGA/DTA analyses. The pharmacokinetic profile evaluation of the radiolabeled nano silica, [68...
The design of organic/inorganic polymer nanoparticles-based hybrids is promising for gamma ray se... more The design of organic/inorganic polymer nanoparticles-based hybrids is promising for gamma ray sensor systems. Here, we design semiconducting nanocomposite system for efficient gamma ray harvesting system where cadmium telluride (CdTe) quantum dots act as dopant and poly(N-vinyl carbazole) (PVK) polymer acts as host. Highly crystalline 1-dodecanethiol (1-DDT) decorated CdTe quantum dots with average diameter of ~ 3 nm were synthesized and characterized with high-resolution transmission electron microscopy (HR-TEM) analysis. Nearly monodispersed CdTe/PVK nanocomposite was subsequently prepared by addition of CdTe quantum dots (QDs) in poly(N-vinyl carbazole) matrix. The photophysical interactions between polymer host and QDs have been investigated by preparing an ohmic contact detector using a conductive cell with two gold-coated walls. Gamma detecting properties of the CdTe QDs/PVK nanocomposite such as sensitivity, repeatability, and the linearity of dose rate response were assessed. Significant enhancement in photoconductivity induced by the gamma radiation in CdTe QDs/PVK nanocomposite has been demonstrated.
Background: It has been shown that short-wavelength blue component of the visible light spectrum ... more Background: It has been shown that short-wavelength blue component of the visible light spectrum can alter the circadian rhythm and suppress the level of melatonin hormone. The short-wavelength light emitted by smartphones’ screens can affect the sleep quality of the people who use these devices at night through suppression of melatonin.Objectives: In this study, we examined the effects of covering the screens of smartphones with different filters (changing the effective wavelength of the light) on sleep delay time in 43 healthy students.Materials and Methods: Volunteer students were asked to go to bed at 23:00 and to use their mobile phones in bed for watching a natural life documentary movie for 60 minutes. No filter was used for one night while amber and blue filters were used for other 2 nights. Photospectrometry method was used to determine the output spectrum of the light passing through the filters used for covering the screens of the mobile phones. The order for utilizing a...
This study explored the feasibility to produce 198Au in the Isfahan miniature neutron source reac... more This study explored the feasibility to produce 198Au in the Isfahan miniature neutron source reactor (MNSR). To estimate production level, we used the MCNP simulation method, validated through empirical data. Role of different irradiation and cooling periods to maximize the produced yield was also studied. The results of our study showed that after 30 cycles, the maximum production was 812.3 mCi g−1 in the maximum flux and irradiation time. However, after the 15th cycle it reached its maximum production of 90% (740.3 mCi g−1). Also, the role of irradiation and cooling periods in the optimum fuel management was shown. Our results showed that producing 198Au is feasible in MNSRs.
Porphyrins and 68Ga have emerged as novel synergic options for PET applications so the idea of pr... more Porphyrins and 68Ga have emerged as novel synergic options for PET applications so the idea of preparation of a novel porphyrin complex using this nuclide was targeted. Herein, [68Ga(III)] labeled 5, 10, 15, 20-Tetrakis(2, 4, 6-trimethoxy phenyl) porphyrin ([68Ga(III)]-TTMPP) was developed in this work. The biodistribution of the [68Ga(III)]-TTMPP complex among vital organs of mice bearing Fibrosarcoma tumors was studied using scarification. Due to the short half-life of 68Ga, high tumor avidity and fast excretion of [68Ga(III)]-TTMPP complex, this labeled compound is demonstrated to be a potential bioprobe for positron emission tomography (PET) and photodynamic therapy (PDT).
Miniature neutron source reactors (MNSRs) and their challenges were investigated. Then, MNSRs str... more Miniature neutron source reactors (MNSRs) and their challenges were investigated. Then, MNSRs structure and operation were discussed, and conflicting usages of high enriched uranium fuel and its technical challenges were explored. By using low enriched uranium it is possible to produce 99Mo isotopes with similar quality, plus using low enriched uranium does not increase the potential risks and high does level. Furthermore, it is possible to produce several medical radioisotopes such as 99Mo/99mTc generator, 131I, 65Zn, and 177Lu. These reactors can be employed in Boron Neutron Capture Therapy. After conversion, these reactors can be used more frequently and effectively.
This paper describes the system for the dose delivery currently used at the Centro Nazionale di A... more This paper describes the system for the dose delivery currently used at the Centro Nazionale di Adroterapia Oncologica (CNAO) for ion beam modulated scanning radiotherapy. CNAO Foundation, Istituto Nazionale di Fisica Nucleare and University of Torino have designed, built, and commissioned a dose delivery system (DDS) to monitor and guide ion beams accelerated by a dedicated synchrotron and to distribute the dose with a full 3D scanning technique. Protons and carbon ions are provided for a wide range of energies in order to cover a sizable span of treatment depths. The target volume, segmented in several layers orthogonally to the beam direction, is irradiated by thousands of pencil beams which must be steered and held to the prescribed positions until the prescribed number of particles has been delivered. For the CNAO beam lines, these operations are performed by the DDS. The main components of this system are two independent beam monitoring detectors, called BOX1 and BOX2, interfa...
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2021
In this experimental work, Polyvinyl Alcohol-Tungsten oxide micro- and nanocomposites were fabric... more In this experimental work, Polyvinyl Alcohol-Tungsten oxide micro- and nanocomposites were fabricated in various weight percentages of 0, 10, 20, 30, and 40 wt%, through the solution method. The dispersion state of the inclusions into the polymeric matrix was studied through the SEM analyses. Then, the linear attenuation coefficient, mass attenuation coefficient, half-value layer, tenth-value layer, and mean free path of the samples were measured using a Geiger counter for different gamma-rays of 57Co, 201Tl, 67Ga, Tc, 133Ba, and 137Cs radioactive sources. It was shown that increasing the concentration of the WO3 fillers in the PVA matrix increased the attenuation coefficients of the composites significantly. Besides, the attenuation coefficients of the nanocomposites were significantly larger than those of the microcomposites due to high surface-to-volume ratio of the tungsten oxide nano-particles compared to the microcomposites.
Background Airport workers are continuously exposed to different levels of radiofrequency microwa... more Background Airport workers are continuously exposed to different levels of radiofrequency microwave (RF/MW) radiation emitted by radar equipments. Radars are extensively used in military and aviation industries. Over the past several years, our lab has focused on the health effects of exposure to different sources of electromagnetic fields such as cellular phones, mobile base stations, mobile phone jammers, laptop computers, radars, dentistry cavitrons and MRI. The main goal of this study was to investigate if occupational exposure of Shahid Dastghieb international airport workers to radiofrequency radiation affects their short term memory and reaction time. Methods Thirty two airport workers involved in duties at control and approach tower (21 males and 11 females), with the age range of 27-67 years old (mean age of 37.38), participated voluntary in this study. On the other hand, 29 workers (13 males, and 16 females) whose offices were in the city with no exposure history to radar ...
Introduction: Radiotherapy with heavy charged particles such as protons and carbon ions (hadron t... more Introduction: Radiotherapy with heavy charged particles such as protons and carbon ions (hadron therapy) has been recognized as an advanced technique for the treatment of various cancers. For some indications such as pediatric and radio-resistant tumors, it is considered the preferred method. However, despite its remarkable benefits, development of hadron therapy centers in the world has always been subject to major constraints due to a number of reasons including the high costs of constructing and maintaining the centers, the need for strong infrastructures, and the lack of adequate research on the estimation of the number of patients eligible for utilizing this technique. Therefore, this study aimed to investigate the initial estimation of the number of patients eligible for hadron therapy in the Fars Province and Iran as a whole. Materials and Methods: In the absence of comprehensive national cancer registry data, the information for the initial estimation of the number of patien...
A dedicated Dose Delivery System (DDS) was developed to implement the modulated spot scanning tec... more A dedicated Dose Delivery System (DDS) was developed to implement the modulated spot scanning technique at the Italian Hadrontherapy facility (CNAO). This is the highest conformal method in use with protons and carbon ions worldwide. The clinical 3 dimensional target is subdivided into several spots irradiated delivering a pencil beam for each spot. The right position of the beam is achieved using two orthogonal scanning magnets for X and Y displacements while the Z position of the Bragg peak (along the beam direction) is achieved by exploiting the ability of the synchrotron to provide the appropriate beam energy. Each spot of a slice is characterized by the number of particles and by the beam position which are managed and controlled by the DDS. The DDS drives the treatment spot by spot by exploiting the treatment planning data and the online measurements. The preliminary performances achieved by the system during clinical treatments are the object of this paper. The estimation of ...
Due to the prominent diagnostic properties of gallium-68 radionuclide, for targeted delivery of t... more Due to the prominent diagnostic properties of gallium-68 radionuclide, for targeted delivery of this radionuclide to the cancerous cells, the nuclide was grafted on the pyridine functionalize MCM-41 nano-silica host. Detailed qualitative control tests including AFM, XRD, BET and DSC / TGA experiments were performed to accurately measure the amount of fixed functional groups on the resulting sample. Biodistribution data of the nanocomposite such as partition coefficient, tissue distribution studies in Bulbc mice and time/removal charts for labeled compound in living organs were compared with free gallium-68 cation. Key words: Gallium-68 Radionuclide, Biological Distribution, MCM-41 Nanosilica, PET Imaging
A novel complex of porphyrin and gallium-68 in the form of Tris(2,4,6-trimethoxyphenyl)phosphine ... more A novel complex of porphyrin and gallium-68 in the form of Tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP) gallium-68 ([68Ga]-TTMPP] was synthesized and the complex stability was checked under different radiochemical tests in human serum and invivo conditions. Then, the complex stability and distribution were analyzed by studying the distribution of the complex in the body of Balb/c mice at different sacrifice times. The results showed that the complex had a radiochemical purity of over 98% and acceptable stability in human serum up to 4 half-lives. The biodistribution of the complex in the mice body indicates high activity in the blood, liver, kidneys, skin, muscles, and lungs, and the capability of photodynamic therapy during proper excretion from the body. Keywords: [68Ga]-TTMPP complex, biodistribution, gallium-68 radionuclide, photodynamic therapy.
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Papers by MA Hosseini
Key words: Gallium-68 Radionuclide, Biological Distribution, MCM-41 Nanosilica, PET Imaging
Keywords: [68Ga]-TTMPP complex, biodistribution, gallium-68 radionuclide, photodynamic therapy.