International Journal of Adolescent Medicine and Health, 2019
Aim The reported incidence of isolated hemihyperplasia (IH) has a very wide range (from 1:13,000 ... more Aim The reported incidence of isolated hemihyperplasia (IH) has a very wide range (from 1:13,000 to 1:86,000 live births) and further clarification is needed. We hypothesized that a survey of the birth prevalence of IH among newborn infants may underestimate the incidence of IH by overlooking late-onset cases. Methods The prospective international multicenter study utilized the two-steps selection tool for an anonymous survey of volunteers of 15–18 years old. The initial step was “three measurements-three questions” screening, or “face-palms-calves survey”. The subsequent step was an in-depth assessment of selected cases to exclude localized, lesional and syndrome-related cases as well as body asymmetry within normative range and to select suspected cases of IH. This step included measurements of various anatomical regions and a subsequent questionnaire. The participants that were selected in a risk group were advised to refer to medical institutions for clinical, genetic and instru...
We conducted a prospective, randomized, double-blind pilot study of patients presenting with symp... more We conducted a prospective, randomized, double-blind pilot study of patients presenting with symptoms of obstructed nasal breathing to determine whether electrotherapy could provide nonsurgical symptom relief. Forty patients were divided into an electrotherapy group (n = 20) and a placebo group (n = 20). All selected patients demonstrated nasal valve stenosis with a positive Cottle maneuver and clinically evident nasal valve collapse. Treatment consisted of high-frequency transcutaneous and intranasal electric stimulation of nasal muscles for 15 minutes, 3 times a week for 10 weeks. Treated patients were followed for 10 to 12 months. Twelve patients in the electrotherapy group (60%) exhibited subjective improvement; in 8 cases (40%), the improvement was proved objectively. In the placebo group, 7 patients (35%) indicated subjective improvement; and in one case (5%), the improvement was proved objectively. Follow-up visits showed a rapid decline of positive results when treatment was...
Our purpose was to evaluate the diagnostic value of measuring diameters of optic nerve sheath (ON... more Our purpose was to evaluate the diagnostic value of measuring diameters of optic nerve sheath (ONSD), presence/absence of papilledema, tortuosity of the optic nerve, flattening of the posterior sclera, and intraocular protrusion of the prelaminar optic nerve for intracranial pressure assessment in cases of Chiari I malformation. In a retrospective study, MRI data of 37 consecutive pediatric patients with Chiari malformation and data of 400 patients without intracranial pathology were compared and analyzed. ONSDs were measured at the point where the ophthalmic artery crosses the optic nerve (anatomical landmark). The correlation analysis was performed with clinical findings, gender, age, papilledema, and other neuro-ophthalmological findings. ONSD was enlarged in 38 % of cases of Chiari malformation. The enlargement was bilateral, no correlation with age or gender was found (p = 0.67 and p = 0.76, respectively). The presence of papilledema was detected in 19 % of cases presenting less valuable diagnostic sign if compared with ONSD. The tortuosity of the optic nerve was found in 22 % of cases, but in three patients, it was unilateral. All patients with enlarged ONSD and other neuro-ophthalmological signs present were treated surgically, while most of the patients without these signs (20/23) were treated conservatively. In majority of pediatric cases of Chiari malformation, the ONSD is not enlarged and other neuro-ophthalmological signs are not present. Detecting the enlarged ONSD and other neuro-ophthalmological signs in cases of Chiari malformation may indicate the elevated intracranial pressure and necessity for urgent surgical intervention.
To measure optic nerve sheath diameters (ONSD) in different locations by computer tomography (CT)... more To measure optic nerve sheath diameters (ONSD) in different locations by computer tomography (CT) and to recommend the best location for cases when ONSD is used for intracranial pressure monitoring. In a prospective cohort study, CT data of 300 healthy adults were analyzed (600 eyes). In all cases, the CT investigation was performed at the Emergency Department because of the various conditions that proved not to be connected with ophthalmological or neurological pathology. The ONSD were measured at 3 mm and 8 mm distance from the globe, and 3 mm from the anterior opening of the optic canal. The correlation analysis was performed with gender, age, and ethnic background. The right/left ONSD are 4.94±1.51/5.17±1.34 mm at 3 mm, 4.35±0.76/4.45±0.62 mm at 8 mm from the globe, and 3.55±0.82/3.65±0.7 mm at 3 mm from the optic canal. No significant differences correlated with gender of the patients, their age, and ethnic background were found. In healthy persons, the ONSD varies from 5.17±1....
To confirm our clinical impression that intra--abdominal handlebar injuries are progressively inc... more To confirm our clinical impression that intra--abdominal handlebar injuries are progressively increasing in number and severity in the latest years. A retrospective analysis of data concerning 132 patients admitted to our department of pediatric surgery during a 10--year period (between 2003 and 2012), following bicycle--related blunt abdominal trauma, was performed. Patients were divided into two groups: those who fall from their bicycle (n = 43) and those who sustained direct impact from the handlebars (n = 89) and compared. Number of admitted patients due to bike related injury was increased during a 10--year period. The bikes used by 91.6% of the participants were the high quality BMX, with rigid and strong handlebars. The average age for both groups was 10.3 years (4--16 years). Boys were injured more than girls. Thirty patients from both groups sustained severe abdominal visceral injuries, 25 from the handlebar group and 6 from the fall group (p=0.018). The overall average len...
Patients suspected of having swallowing disorders, could highly benefit from simple diagnostic sc... more Patients suspected of having swallowing disorders, could highly benefit from simple diagnostic screening before being referred to specialist evaluations. The article analyzes various instrumental methods of dysphagia assessment, introduces surface electromyography (sEMG) to carry out rapid assessment of such patients, and debates proposed suggestions for sEMG screening protocol in order to identify abnormal deglutition. Subject related books and articles from 1813 to 2007 were obtained through library search, MEDLINE (1949-2007) and EMBASE (1975-2007). Specifics steps for establishing the protocol for applying the technique for screening purposes (e.g., evaluation of specific muscles), the requirements for diagnostic sEMG equipment, the sEMG technique itself, and defining the tests suitable for assessing deglutition (e.g., saliva, normal, and excessive swallows and uninterrupted drinking of water) are presented in detail. SEMG is compared with other techniques in terms of cost, timi...
International journal of pediatric otorhinolaryngology, 2006
Surface electromyography (sEMG) studies were performed on 80 children with acute tonsillitis (AT)... more Surface electromyography (sEMG) studies were performed on 80 children with acute tonsillitis (AT) and 110 children with recurrent tonsillitis (RT), age 4-12 years, to trace sEMG changes of duration and amplitude of muscle activity during swallowing and continuous drinking. Prospective observational study of randomly chosen patients compared to normative database. Timing and amplitude (in muV) of activity of masseter, submental and infrahyoid muscles were evaluated during voluntary single swallows of saliva ("dry" swallow), water swallows, swallows of excessive amount of water (up to 15 ml), and continuous drinking of 50 ml of water. These parameters were measured for two age groups for both conditions: 4-8 and 9-12 years old. The previously established normative database was taken for control. AT presents prolonged duration of swallowing and electric hyperactivity of infrahyoid muscles but this activity returns to normal after recovery. RT affects masseter and infrahyoid m...
The Israel Medical Association journal : IMAJ, 2005
Endonasal operations such as septoplasty, rhinoplasty, nasal septal reconstruction and conchotomy... more Endonasal operations such as septoplasty, rhinoplasty, nasal septal reconstruction and conchotomy, as well as endoscopic sinus surgery, especially when combined with turbinectomy and/or submucous resection of the septum, may produce bleeding and postoperative hematoma requiring postoperative hemostatic measures. Since nasal packing may cause pain, rhinorrhea and inconvenience, a more effective and less uncomfortable hemostatic technique is needed. To compare the hemostatic efficacy of the second-generation surgical sealant (Quixil in Europe and Israel, Crosseal in the USA) to that of nasal packing in endonasal surgery. We conducted a prospective randomized trial that included 494 patients (selected from 529 using exclusion and inclusion criteria and completed follow-up) undergoing the above-mentioned endonasal procedures. Patients were assigned to one of three surgical groups: septoplasty + conchotomy + nasal packing or fibrin sealant (Group 1); ESS + nasal packing or fibrin sealant...
The Annals of otology, rhinology, and laryngology, 2005
Endoscopic sinus surgery (ESS), especially when combined with turbinectomy and/or with submucous ... more Endoscopic sinus surgery (ESS), especially when combined with turbinectomy and/or with submucous resection of the septum, may involve postoperative bleeding that might end with nasal packing. Nasal packing causes pain, rhinorrhea, and inconvenience and may not stop the postoperative bleeding. The aim of our study was to compare the hemostatic properties of the second-generation surgical sealant Quixil (Crosseal) with those of nasal packing in ESS. We performed a prospective randomized trial in 64 consecutive patients who underwent ESS and presented excessive intraoperative and/or postoperative bleeding. They were allocated by the sealed-envelope method into two groups. A routine ESS procedure was ended with Merocel nasal packing in group 1, and with aerosol application of Quixil sealant at the operative site in group 2. The hemostatic effects were evaluated objectively in the clinic by anterior rhinoscopy and endoscopy and assessed subjectively by the patients at follow-up visits. I...
The purpose of this paper is to describe the outcome of muscle-building therapy for nasal muscles... more The purpose of this paper is to describe the outcome of muscle-building therapy for nasal muscles in cases of nasal valve stenosis or collapse. The present study was performed to investigate the best way to combine transcutaneous and intranasal surface electromyography (sEMG) biofeedback training of muscles involved in nasal valve function with a home exercise program and electric stimulation of nasal muscles. A randomized pilot study of 3 groups of patients (n1=12, n2=12, n3=10; total 34 patients) presenting with symptoms of obstructed nasal breathing was conducted. All selected patients demonstrated nasal valve stenosis with a positive Cottler maneuver and clinically evident nasal valve collapse. Follow-up ranged from 8 to 12 months. Treatment for Group 1 included transcutaneous and intranasal electric stimulation of nasal muscles only. Treatment for Group 2 included biofeedback training and home exercise program of specific nasal movements, and treatment for Group 3 included surf...
The Israel Medical Association journal : IMAJ, 2004
The external approach is the golden standard for sinonasal tumor removal but is associated with s... more The external approach is the golden standard for sinonasal tumor removal but is associated with several side effects, including facial scars, intracranial and extracranial complications, a long hospitalization period and high costs. Endoscopic sinus surgery enables resection of benign and selected malignant sinonasal tumors and has the advantages of no facial scars, better functional and structural preservation of the sinonasal complex, minimal trauma to surrounding tissue, a shorter hospitalization stay and lower costs. To evaluate the advantages and limitations of endoscopic resection of benign and malignant sinonasal tumors, their recurrence and complication rates. The medical and radiology records of 56 patients who underwent endonasal endoscopic resection of benign and malignant sinonasal tumors between 1996 and 2003 were retrospectively reviewed. Tumors located in the center of the nose and sinuses were endoscopically resected. Six cases of malignant tumor and 50 cases of beni...
To give a description of normal surface electromyography (sEMG) aspects of uninterrupted (continu... more To give a description of normal surface electromyography (sEMG) aspects of uninterrupted (continuous) drinking and to establish normal sEMG values for swallowing 100 mL of water. Prospective observational study of healthy volunteers. Four hundred twenty apparently healthy male and female volunteers divided into three age groups (18-40, 41-65, 66+ years). The evaluated parameters included the total duration, number of swallows, amount of water per swallow, and voltage of the EMG activity of the orbicularis oris, masseter, and submental-submandibular muscles and the infrahyoid muscle groups covered by the m. platysma. The overall normal mean values for duration, number of swallows, and amplitude of muscle activity during continuous drinking were compiled. The age-related increase in duration of swallows and of total drinking time was significant only in the older group (95% confidence interval, P < .05). There were no significant sex-related differences for any age group (P > or = .05). The mean electric activity (in muV) varied insignificantly among the age groups. The activity of the m. orbicularis oris was the least informative. An unexpectedly significant number of healthy subjects (14.25%, P < .05) performed a dry swallow after drinking. The establishment of normal sEMG levels now makes this modality applicable for evaluating the swallowing mechanism among adults for potentially identifying and ruling out abnormalities. Its simplicity, noninvasiveness, and low level of discomfort also make it highly suitable for screening purposes.
OBJECTIVE: Surface electromyographic studies were performed on 440 normal adults to describe and ... more OBJECTIVE: Surface electromyographic studies were performed on 440 normal adults to describe and evaluate different types of normal swallows clinically useful for ENT department. STUDY DESIGN: Prospective observational study of healthy volunteers. METHODS: EMG recordings were made using stick-on surface electrodes. Rectified and filtered EMG signals were evaluated. Parameters evaluated include the graphic configuration of activity of the orbicularis oris, masseter, submental group, and infrahyoid muscles, the last 2 covered by platysma, during single swallowing and continuous drinking. Four tests were examined: voluntary saliva swallows, voluntary separate swallows as normal, voluntary separate swallows of excessive amount of water (20 mL), drinking of 100 mL of water. Graphic recording of activity of the above-mentioned muscles during swallowing and drinking were evaluated for groups of adults of different ages. RESULTS: There are several types of normal swallows as seen at the sur...
OBJECTIVE: To provide a description of surface electromyography (sEMG) of spontaneous saliva swal... more OBJECTIVE: To provide a description of surface electromyography (sEMG) of spontaneous saliva swallowing (SSS) and monitoring of swallow rate in patients with salivary gland diseases. STUDY DESIGN: Numbers of SSS obtained during 2 hours of sEMG monitoring were compared with sialometry data for healthy volunteers (n = 100), patients with Sjögren syndrome (n = 10), and patients after parotid gland (n = 15) and submandibular gland (n = 16) surgery. RESULTS: Normative: 1 SSS every 2 minutes and 15 seconds; Sjögren: 1 SSS every 13 minutes ( P < 0.001); parotid gland surgery: 1 SSS every 3 minutes and 24 seconds ( P = 0.26); submandibular gland surgery: 1 SSS every 5 minutes and 04 seconds ( P < 0.05). Sjögren patients and patients after submandibular surgery had hyposalivation correlated with less SSS. CONCLUSION: The established normal rate of SSS makes this modality applicable for evaluating salivary flow for potentially identifying and ruling out abnormalities. Parotid gland surg...
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 2009
In this study, the objective was to evaluate the presence of estrogen receptors alpha and beta (E... more In this study, the objective was to evaluate the presence of estrogen receptors alpha and beta (ERalpha and ERbeta) in cases of papillary carcinoma of the thyroid gland and to assess the practicality of this test. Immunohistochemical stains were performed for both ERalpha and ERbeta, for evaluation of immunoreactivity in 90 papillary carcinomas. Three variables were evaluated in each sample: the intensity of the staining both nuclear and cytoplasmatic, and the spread of the stain over the sample. None of the histological samples showed immunoreactivity for ERalpha. Positive immunoreactivity results for ERbeta were found in tissue samples in 66.6% (60 cases). The study shows that ERbeta has no significant specification for differentiation between papillary carcinoma and other malignant lesions of the thyroid, while ERalpha is undetectable in this lesion. The ER testing in cases of papillary carcinoma of the thyroid gland is nonspecific and might be not necessary.
International Journal of Adolescent Medicine and Health, 2019
Aim The reported incidence of isolated hemihyperplasia (IH) has a very wide range (from 1:13,000 ... more Aim The reported incidence of isolated hemihyperplasia (IH) has a very wide range (from 1:13,000 to 1:86,000 live births) and further clarification is needed. We hypothesized that a survey of the birth prevalence of IH among newborn infants may underestimate the incidence of IH by overlooking late-onset cases. Methods The prospective international multicenter study utilized the two-steps selection tool for an anonymous survey of volunteers of 15–18 years old. The initial step was “three measurements-three questions” screening, or “face-palms-calves survey”. The subsequent step was an in-depth assessment of selected cases to exclude localized, lesional and syndrome-related cases as well as body asymmetry within normative range and to select suspected cases of IH. This step included measurements of various anatomical regions and a subsequent questionnaire. The participants that were selected in a risk group were advised to refer to medical institutions for clinical, genetic and instru...
We conducted a prospective, randomized, double-blind pilot study of patients presenting with symp... more We conducted a prospective, randomized, double-blind pilot study of patients presenting with symptoms of obstructed nasal breathing to determine whether electrotherapy could provide nonsurgical symptom relief. Forty patients were divided into an electrotherapy group (n = 20) and a placebo group (n = 20). All selected patients demonstrated nasal valve stenosis with a positive Cottle maneuver and clinically evident nasal valve collapse. Treatment consisted of high-frequency transcutaneous and intranasal electric stimulation of nasal muscles for 15 minutes, 3 times a week for 10 weeks. Treated patients were followed for 10 to 12 months. Twelve patients in the electrotherapy group (60%) exhibited subjective improvement; in 8 cases (40%), the improvement was proved objectively. In the placebo group, 7 patients (35%) indicated subjective improvement; and in one case (5%), the improvement was proved objectively. Follow-up visits showed a rapid decline of positive results when treatment was...
Our purpose was to evaluate the diagnostic value of measuring diameters of optic nerve sheath (ON... more Our purpose was to evaluate the diagnostic value of measuring diameters of optic nerve sheath (ONSD), presence/absence of papilledema, tortuosity of the optic nerve, flattening of the posterior sclera, and intraocular protrusion of the prelaminar optic nerve for intracranial pressure assessment in cases of Chiari I malformation. In a retrospective study, MRI data of 37 consecutive pediatric patients with Chiari malformation and data of 400 patients without intracranial pathology were compared and analyzed. ONSDs were measured at the point where the ophthalmic artery crosses the optic nerve (anatomical landmark). The correlation analysis was performed with clinical findings, gender, age, papilledema, and other neuro-ophthalmological findings. ONSD was enlarged in 38 % of cases of Chiari malformation. The enlargement was bilateral, no correlation with age or gender was found (p = 0.67 and p = 0.76, respectively). The presence of papilledema was detected in 19 % of cases presenting less valuable diagnostic sign if compared with ONSD. The tortuosity of the optic nerve was found in 22 % of cases, but in three patients, it was unilateral. All patients with enlarged ONSD and other neuro-ophthalmological signs present were treated surgically, while most of the patients without these signs (20/23) were treated conservatively. In majority of pediatric cases of Chiari malformation, the ONSD is not enlarged and other neuro-ophthalmological signs are not present. Detecting the enlarged ONSD and other neuro-ophthalmological signs in cases of Chiari malformation may indicate the elevated intracranial pressure and necessity for urgent surgical intervention.
To measure optic nerve sheath diameters (ONSD) in different locations by computer tomography (CT)... more To measure optic nerve sheath diameters (ONSD) in different locations by computer tomography (CT) and to recommend the best location for cases when ONSD is used for intracranial pressure monitoring. In a prospective cohort study, CT data of 300 healthy adults were analyzed (600 eyes). In all cases, the CT investigation was performed at the Emergency Department because of the various conditions that proved not to be connected with ophthalmological or neurological pathology. The ONSD were measured at 3 mm and 8 mm distance from the globe, and 3 mm from the anterior opening of the optic canal. The correlation analysis was performed with gender, age, and ethnic background. The right/left ONSD are 4.94±1.51/5.17±1.34 mm at 3 mm, 4.35±0.76/4.45±0.62 mm at 8 mm from the globe, and 3.55±0.82/3.65±0.7 mm at 3 mm from the optic canal. No significant differences correlated with gender of the patients, their age, and ethnic background were found. In healthy persons, the ONSD varies from 5.17±1....
To confirm our clinical impression that intra--abdominal handlebar injuries are progressively inc... more To confirm our clinical impression that intra--abdominal handlebar injuries are progressively increasing in number and severity in the latest years. A retrospective analysis of data concerning 132 patients admitted to our department of pediatric surgery during a 10--year period (between 2003 and 2012), following bicycle--related blunt abdominal trauma, was performed. Patients were divided into two groups: those who fall from their bicycle (n = 43) and those who sustained direct impact from the handlebars (n = 89) and compared. Number of admitted patients due to bike related injury was increased during a 10--year period. The bikes used by 91.6% of the participants were the high quality BMX, with rigid and strong handlebars. The average age for both groups was 10.3 years (4--16 years). Boys were injured more than girls. Thirty patients from both groups sustained severe abdominal visceral injuries, 25 from the handlebar group and 6 from the fall group (p=0.018). The overall average len...
Patients suspected of having swallowing disorders, could highly benefit from simple diagnostic sc... more Patients suspected of having swallowing disorders, could highly benefit from simple diagnostic screening before being referred to specialist evaluations. The article analyzes various instrumental methods of dysphagia assessment, introduces surface electromyography (sEMG) to carry out rapid assessment of such patients, and debates proposed suggestions for sEMG screening protocol in order to identify abnormal deglutition. Subject related books and articles from 1813 to 2007 were obtained through library search, MEDLINE (1949-2007) and EMBASE (1975-2007). Specifics steps for establishing the protocol for applying the technique for screening purposes (e.g., evaluation of specific muscles), the requirements for diagnostic sEMG equipment, the sEMG technique itself, and defining the tests suitable for assessing deglutition (e.g., saliva, normal, and excessive swallows and uninterrupted drinking of water) are presented in detail. SEMG is compared with other techniques in terms of cost, timi...
International journal of pediatric otorhinolaryngology, 2006
Surface electromyography (sEMG) studies were performed on 80 children with acute tonsillitis (AT)... more Surface electromyography (sEMG) studies were performed on 80 children with acute tonsillitis (AT) and 110 children with recurrent tonsillitis (RT), age 4-12 years, to trace sEMG changes of duration and amplitude of muscle activity during swallowing and continuous drinking. Prospective observational study of randomly chosen patients compared to normative database. Timing and amplitude (in muV) of activity of masseter, submental and infrahyoid muscles were evaluated during voluntary single swallows of saliva ("dry" swallow), water swallows, swallows of excessive amount of water (up to 15 ml), and continuous drinking of 50 ml of water. These parameters were measured for two age groups for both conditions: 4-8 and 9-12 years old. The previously established normative database was taken for control. AT presents prolonged duration of swallowing and electric hyperactivity of infrahyoid muscles but this activity returns to normal after recovery. RT affects masseter and infrahyoid m...
The Israel Medical Association journal : IMAJ, 2005
Endonasal operations such as septoplasty, rhinoplasty, nasal septal reconstruction and conchotomy... more Endonasal operations such as septoplasty, rhinoplasty, nasal septal reconstruction and conchotomy, as well as endoscopic sinus surgery, especially when combined with turbinectomy and/or submucous resection of the septum, may produce bleeding and postoperative hematoma requiring postoperative hemostatic measures. Since nasal packing may cause pain, rhinorrhea and inconvenience, a more effective and less uncomfortable hemostatic technique is needed. To compare the hemostatic efficacy of the second-generation surgical sealant (Quixil in Europe and Israel, Crosseal in the USA) to that of nasal packing in endonasal surgery. We conducted a prospective randomized trial that included 494 patients (selected from 529 using exclusion and inclusion criteria and completed follow-up) undergoing the above-mentioned endonasal procedures. Patients were assigned to one of three surgical groups: septoplasty + conchotomy + nasal packing or fibrin sealant (Group 1); ESS + nasal packing or fibrin sealant...
The Annals of otology, rhinology, and laryngology, 2005
Endoscopic sinus surgery (ESS), especially when combined with turbinectomy and/or with submucous ... more Endoscopic sinus surgery (ESS), especially when combined with turbinectomy and/or with submucous resection of the septum, may involve postoperative bleeding that might end with nasal packing. Nasal packing causes pain, rhinorrhea, and inconvenience and may not stop the postoperative bleeding. The aim of our study was to compare the hemostatic properties of the second-generation surgical sealant Quixil (Crosseal) with those of nasal packing in ESS. We performed a prospective randomized trial in 64 consecutive patients who underwent ESS and presented excessive intraoperative and/or postoperative bleeding. They were allocated by the sealed-envelope method into two groups. A routine ESS procedure was ended with Merocel nasal packing in group 1, and with aerosol application of Quixil sealant at the operative site in group 2. The hemostatic effects were evaluated objectively in the clinic by anterior rhinoscopy and endoscopy and assessed subjectively by the patients at follow-up visits. I...
The purpose of this paper is to describe the outcome of muscle-building therapy for nasal muscles... more The purpose of this paper is to describe the outcome of muscle-building therapy for nasal muscles in cases of nasal valve stenosis or collapse. The present study was performed to investigate the best way to combine transcutaneous and intranasal surface electromyography (sEMG) biofeedback training of muscles involved in nasal valve function with a home exercise program and electric stimulation of nasal muscles. A randomized pilot study of 3 groups of patients (n1=12, n2=12, n3=10; total 34 patients) presenting with symptoms of obstructed nasal breathing was conducted. All selected patients demonstrated nasal valve stenosis with a positive Cottler maneuver and clinically evident nasal valve collapse. Follow-up ranged from 8 to 12 months. Treatment for Group 1 included transcutaneous and intranasal electric stimulation of nasal muscles only. Treatment for Group 2 included biofeedback training and home exercise program of specific nasal movements, and treatment for Group 3 included surf...
The Israel Medical Association journal : IMAJ, 2004
The external approach is the golden standard for sinonasal tumor removal but is associated with s... more The external approach is the golden standard for sinonasal tumor removal but is associated with several side effects, including facial scars, intracranial and extracranial complications, a long hospitalization period and high costs. Endoscopic sinus surgery enables resection of benign and selected malignant sinonasal tumors and has the advantages of no facial scars, better functional and structural preservation of the sinonasal complex, minimal trauma to surrounding tissue, a shorter hospitalization stay and lower costs. To evaluate the advantages and limitations of endoscopic resection of benign and malignant sinonasal tumors, their recurrence and complication rates. The medical and radiology records of 56 patients who underwent endonasal endoscopic resection of benign and malignant sinonasal tumors between 1996 and 2003 were retrospectively reviewed. Tumors located in the center of the nose and sinuses were endoscopically resected. Six cases of malignant tumor and 50 cases of beni...
To give a description of normal surface electromyography (sEMG) aspects of uninterrupted (continu... more To give a description of normal surface electromyography (sEMG) aspects of uninterrupted (continuous) drinking and to establish normal sEMG values for swallowing 100 mL of water. Prospective observational study of healthy volunteers. Four hundred twenty apparently healthy male and female volunteers divided into three age groups (18-40, 41-65, 66+ years). The evaluated parameters included the total duration, number of swallows, amount of water per swallow, and voltage of the EMG activity of the orbicularis oris, masseter, and submental-submandibular muscles and the infrahyoid muscle groups covered by the m. platysma. The overall normal mean values for duration, number of swallows, and amplitude of muscle activity during continuous drinking were compiled. The age-related increase in duration of swallows and of total drinking time was significant only in the older group (95% confidence interval, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .05). There were no significant sex-related differences for any age group (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; or = .05). The mean electric activity (in muV) varied insignificantly among the age groups. The activity of the m. orbicularis oris was the least informative. An unexpectedly significant number of healthy subjects (14.25%, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .05) performed a dry swallow after drinking. The establishment of normal sEMG levels now makes this modality applicable for evaluating the swallowing mechanism among adults for potentially identifying and ruling out abnormalities. Its simplicity, noninvasiveness, and low level of discomfort also make it highly suitable for screening purposes.
OBJECTIVE: Surface electromyographic studies were performed on 440 normal adults to describe and ... more OBJECTIVE: Surface electromyographic studies were performed on 440 normal adults to describe and evaluate different types of normal swallows clinically useful for ENT department. STUDY DESIGN: Prospective observational study of healthy volunteers. METHODS: EMG recordings were made using stick-on surface electrodes. Rectified and filtered EMG signals were evaluated. Parameters evaluated include the graphic configuration of activity of the orbicularis oris, masseter, submental group, and infrahyoid muscles, the last 2 covered by platysma, during single swallowing and continuous drinking. Four tests were examined: voluntary saliva swallows, voluntary separate swallows as normal, voluntary separate swallows of excessive amount of water (20 mL), drinking of 100 mL of water. Graphic recording of activity of the above-mentioned muscles during swallowing and drinking were evaluated for groups of adults of different ages. RESULTS: There are several types of normal swallows as seen at the sur...
OBJECTIVE: To provide a description of surface electromyography (sEMG) of spontaneous saliva swal... more OBJECTIVE: To provide a description of surface electromyography (sEMG) of spontaneous saliva swallowing (SSS) and monitoring of swallow rate in patients with salivary gland diseases. STUDY DESIGN: Numbers of SSS obtained during 2 hours of sEMG monitoring were compared with sialometry data for healthy volunteers (n = 100), patients with Sjögren syndrome (n = 10), and patients after parotid gland (n = 15) and submandibular gland (n = 16) surgery. RESULTS: Normative: 1 SSS every 2 minutes and 15 seconds; Sjögren: 1 SSS every 13 minutes ( P < 0.001); parotid gland surgery: 1 SSS every 3 minutes and 24 seconds ( P = 0.26); submandibular gland surgery: 1 SSS every 5 minutes and 04 seconds ( P < 0.05). Sjögren patients and patients after submandibular surgery had hyposalivation correlated with less SSS. CONCLUSION: The established normal rate of SSS makes this modality applicable for evaluating salivary flow for potentially identifying and ruling out abnormalities. Parotid gland surg...
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 2009
In this study, the objective was to evaluate the presence of estrogen receptors alpha and beta (E... more In this study, the objective was to evaluate the presence of estrogen receptors alpha and beta (ERalpha and ERbeta) in cases of papillary carcinoma of the thyroid gland and to assess the practicality of this test. Immunohistochemical stains were performed for both ERalpha and ERbeta, for evaluation of immunoreactivity in 90 papillary carcinomas. Three variables were evaluated in each sample: the intensity of the staining both nuclear and cytoplasmatic, and the spread of the stain over the sample. None of the histological samples showed immunoreactivity for ERalpha. Positive immunoreactivity results for ERbeta were found in tissue samples in 66.6% (60 cases). The study shows that ERbeta has no significant specification for differentiation between papillary carcinoma and other malignant lesions of the thyroid, while ERalpha is undetectable in this lesion. The ER testing in cases of papillary carcinoma of the thyroid gland is nonspecific and might be not necessary.
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