Roni Zemet

To assess the utility of a detailed early fetal anatomy scan prior to karyotyping in the management of pregnancies with an increased nuchal translucency (NT). The study included fetuses with NT above the 99(th) centile. These women were offered the option of an early detailed fetal anatomy scan prior to genetic evaluation. The presence or absence of major sonographic findings was analyzed for its predictive value for fetal aneuploidy. An increased NT >99(th) centile was detected in 43 fetuses (1.8%). Mean NT was 4.5 mm (range 3.4-9.0) and gestational age at the early fetal anatomy survey was 12.4 weeks (12-13.6). Major sonographic findings were present in 30 fetuses (69.8%); 24 of them underwent karyotyping and it was abnormal in 14. Among the 13 fetuses without major sonographic findings, 12 had normal karyotype results and 1 had aneuploidy, yielding a positive predictive value of 58.3% of early fetal anatomy scan for abnormal karyotype results. Multivariate logistic regression ...

The purposes of this study were to assess the feasibility of fetal thymus measurement between 13 and 16 weeks' gestation, to evaluate the potential difference using color Doppler sonography with the thy-box technique, and to construct normal percentile ranges. This retrospective study included 287 healthy singleton pregnancies. The fetal thymus was shown in an axial plane of the upper mediastinum. Color Doppler imaging was applied to outline the thy-box: ie, the area between the brachiocephalic artery posteriorly and internal mammary arteries laterally. Measurements of the lateral and anteroposterior diameters of the thymus with and without color Doppler imaging were compared. The thymus was shown in 95% of the cases (273 of 287) between 13 and 16 weeks' gestation. The mean lateral thymus diameter ± SD with color Doppler imaging (5.30 ± 0.7 mm) was significantly longer in comparison to the measurement without color Doppler imaging (5.06 ± 0.8 mm; P < .001), whereas the an...