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  1. Migraine is a debilitating neurological disorder that presents significant management challenges, resulting in underdiagnosis and inappropriate treatments, leaving patients at risk of medication overuse (MO). ...

    Authors: Teerapong Aramruang, Akshita Malhotra, Pawin Numthavaj, Panu Looareesuwan, Thunyarat Anothaisintawee, Charungthai Dejthevaporn, Nat Sirirutbunkajorn, John Attia and Ammarin Thakkinstian
    Citation: The Journal of Headache and Pain 2024 25:165
    Content type: Review Published on:

  2. Migraine-related perfusion changes are documented but inconsistent across studies due to limited sample size and insufficient phenotyping. The phasic and spatial dynamics across migraine subtypes remains poorl...

    Authors: Chia-Hung Wu, Pei-Lin Lee, Yen-Feng Wang, Jiing-Feng Lirng, Shu-Ting Chen, Chung-Jung Lin, Shuu-Jiun Wang, Kun-Hsien Chou and Shih-Pin Chen
    Citation: The Journal of Headache and Pain 2024 25:167
    Content type: Research Published on:

  3. Patients with migraine are vulnerable to insufficient sleep, but the impact of sleep restriction is largely unknown. In addition, the importance of sleep may be different in patients with migraine who mostly h...

    Authors: Jan Petter Neverdahl, Martin Uglem, Dagfinn Matre, Kristian Bernhard Nilsen, Knut Hagen, Gøril Bruvik Gravdahl, Trond Sand and Petter Moe Omland
    Citation: The Journal of Headache and Pain 2024 25:166
    Content type: Research Published on:

  4. Patients with migraine are typically advised to avoid passive smoking because it may aggravate headaches and other health conditions. However, there is insufficient high-quality evidence on the association bet...

    Authors: Tsubasa Takizawa, Keiko Ihara, Miyuki Unekawa, Chisato Iba, Shizuko Kagawa, Narumi Watanabe, Shingo Nakayama, Kaori Sakurai, Naoki Miyazaki, Noriyuki Ishida, Ryo Takemura, Mamoru Shibata, Yoshikane Izawa, Shotaro Chubachi, Koichi Fukunaga and Jin Nakahara
    Citation: The Journal of Headache and Pain 2024 25:162
    Content type: Brief Report Published on:

  5. Headache disorders are among the most prevalent neurological disorders worldwide. However, whether groups differing in socioeconomic position (SEP) are disproportionately affected by headache disorders has not...

    Authors: Britta Müller, Charly Gaul, Olaf Reis, Tim P. Jürgens, Peter Kropp, Ruth Ruscheweyh, Andreas Straube, Elmar Brähler, Stefanie Förderreuther, Florian Rimmele and Thomas Dresler
    Citation: The Journal of Headache and Pain 2024 25:164
    Content type: Research Published on:

  6. Chronic migraine is closely related to the dysregulation of neurochemical substances in the brain, with metabolic imbalance being one of the proposed causes of chronic migraine. This study aims to evaluate the...

    Authors: Jinggui Gao, Da Wang, Chenlu Zhu, Jian Wang, Tianxiao Wang, Yunhao Xu, Xiao Ren, Kaibo Zhang, Cheng Peng, Jisong Guan and Yonggang Wang
    Citation: The Journal of Headache and Pain 2024 25:163
    Content type: Research Published on:

  7. Recent meta-analyses estimated 14.6% and 11.2% SNP-based heritability of migraine, compared to twin-heritability estimates of 30–60%. This study aimed to investigate heritability estimates in “migraine-first” ...

    Authors: Dora Torok, Peter Petschner, Daniel Baksa and Gabriella Juhasz
    Citation: The Journal of Headache and Pain 2024 25:161
    Content type: Brief Report Published on:

  8. Rimegepant, a small molecule calcitonin gene-related peptide (CGRP) receptor antagonist, is indicated for acute and preventive migraine treatment in the United States and other countries. However, there is a l...

    Authors: Zhao Yang, Xiaodan Wang, Mengyue Niu, Qiao Wei, Huizhu Zhong, Xiaoyan Li, Weihong Yuan, Wenli Xu, Shuo Zhu, Shengyuan Yu, Jun Liu, Jianzhou Yan, Wenyan Kang and Peijian Huang
    Citation: The Journal of Headache and Pain 2024 25:160
    Content type: Research Published on:

  9. Migraine and insomnia are prevalent conditions that often co-occur, each exacerbating the other and substantially impacting the quality of life. The locus coeruleus (LC), a brainstem region responsible for nor...

    Authors: Changlin Wang, Sishi Chen, Zihan Cheng, Shiyong Xia, Chang jun Fei, Li Ye, Liang Gong, Chunhua Xi and Yu Wang
    Citation: The Journal of Headache and Pain 2024 25:159
    Content type: Research Published on:

  11. Efficacy and safety of human monoclonal antibody erenumab used for migraine prophylaxis have been shown in clinical studies. APOLLON is an open-label, multi-center, single arm study, which permits dose adjustm...

    Authors: Hartmut Göbel, Eugen Schlegel, Kathrin Jaeger, Sonja Ortler and Lea Leist
    Citation: The Journal of Headache and Pain 2024 25:157
    Content type: Research Published on:

  12. Chronic migraine is a severe and common neurological disorder, yet its precise physiological mechanisms remain unclear. The IGF1/IGF1r signaling pathway plays a crucial role in pain modulation. Studies have sh...

    Authors: Tianxiao Wang, Chenlu Zhu, Kaibo zhang, Jinggui Gao, Yunhao Xu, Chenyang Duan, Shouyi Wu, Cheng Peng, Jisong Guan and Yonggang Wang
    Citation: The Journal of Headache and Pain 2024 25:156
    Content type: Research Published on:

  13. New daily persistent headache (NDPH) is a continuous, unremitting headache from onset that yields suboptimal results with traditional medicines. Repetitive transcranial magnetic stimulation (rTMS) has emerged ...

    Authors: M.M. Bharath, Vimal Kumar Paliwal, Swansu Batra, Prabhakar Mishra, Naina Mishra and Romil Saini
    Citation: The Journal of Headache and Pain 2024 25:155
    Content type: Research Published on:

  14. The pathophysiology of migraine remains poorly understood, yet a growing number of studies have shown structural connectivity disruptions across large-scale brain networks. Although both structural and functio...

    Authors: Ana Matoso, Ana R. Fouto, Inês Esteves, Amparo Ruiz-Tagle, Gina Caetano, Nuno A. da Silva, Pedro Vilela, Raquel Gil-Gouveia, Rita G. Nunes and Patrícia Figueiredo
    Citation: The Journal of Headache and Pain 2024 25:154
    Content type: Research Published on:

  15. Idiopathic intracranial hypertension (IIH) is a cause of chronic headaches that are probably driven by raised intracranial pressure (ICP). Cerebral venous sinus pressure is thought to play a role in the underl...

    Authors: Federico Cagnazzo, Max Villain, Liesjet EH van Dokkum, Răzvan Alexandru Radu, Riccardo Morganti, Gregory Gascou, Cyril Dargazanli, Pierre-Henri Lefevre, Emmanuelle Le Bars, Gaetano Risi, Nicola Marchi, Anne Ducros and Vincent Costalat
    Citation: The Journal of Headache and Pain 2024 25:153
    Content type: Research Published on:

  17. Artificial intelligence (AI) is revolutionizing the field of biomedical research and treatment, leveraging machine learning (ML) and advanced algorithms to analyze extensive health and medical data more effici...

    Authors: Igor Petrušić, Woo-Seok Ha, Alejandro Labastida-Ramirez, Roberta Messina, Dilara Onan, Claudio Tana and Wei Wang
    Citation: The Journal of Headache and Pain 2024 25:151
    Content type: Review Published on:

  18. Most real-world data on CGRP mAbs have been published from high-income countries such as the USA, Western countries, Japan, Korea, and Singapore. However, data from low- and middle-income countries in Southeas...

    Authors: Prakit Anukoolwittaya, Akarin Hiransuthikul, Thanakit Pongpitakmetha, Sekh Thanprasertsuk and Wanakorn Rattanawong
    Citation: The Journal of Headache and Pain 2024 25:150
    Content type: Brief Report Published on:

  19. Anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies have emerged as promising therapeutic options for the treatment of chronic migraine. However, treatment response varies considerably among indi...

    Authors: Yu-Chin An, Kuo-Sheng Hung, Chih-Sung Liang, Chia-Kuang Tsai, Chia-Lin Tsai, Sy-Jou Chen, Yu-Kai Lin, Guan-Yu Lin, Po-Kuan Yeh and Fu-Chi Yang
    Citation: The Journal of Headache and Pain 2024 25:149
    Content type: Research Published on:

  20. Migraine is a highly prevalent and complex neurovascular disease. However, the currently available therapeutic drugs often fall to adequately meet clinical needs due to limited effectiveness and numerous undes...

    Authors: Zhonghua Xiong, Lei Zhao, Yanliang Mei, Dong Qiu, Xiaoshuang Li, Peng Zhang, Mantian Zhang, Jin Cao and Yonggang Wang
    Citation: The Journal of Headache and Pain 2024 25:148
    Content type: Research Published on:

  21. Magnetoencephalography/electroencephalography (M/EEG) can provide insights into migraine pathophysiology and help develop clinically valuable biomarkers. To integrate and summarize the existing evidence on cha...

    Authors: Paul Theo Zebhauser, Henrik Heitmann, Elisabeth S. May and Markus Ploner
    Citation: The Journal of Headache and Pain 2024 25:147
    Content type: Review Published on:

  22. Having previously shown headache disorders to be prevalent in Mongolia, here we elaborate on headache as a public-health concern in this country, reporting symptom burden and headache-attributed impaired parti...

    Authors: Otgonbayar Luvsannorov, Byambasuren Tsenddorj, Dorjkhand Baldorj, Selenge Enkhtuya, Delgermaa Purev, Andreas Husøy and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2024 25:146
    Content type: Research Published on:

  23. Idiopathic intracranial hypertension (IIH) is a neurological disorder characterized by increased intracranial pressure. Whilst lumbar puncture (LP) is necessary for the diagnosis of IIH, its therapeutic effect...

    Authors: Sina Zaic, Nik Krajnc, Stefan Macher, Martin Michl, Nina Müller, Christoph Mitsch, Wolfgang Marik, Klaus Novak, Christian Wöber, Berthold Pemp and Gabriel Bsteh
    Citation: The Journal of Headache and Pain 2024 25:145
    Content type: Research Published on:

  24. There have been limited data on idiopathic intracranial hypertension (IIH) in Asians and there remain uncertainties whether a cerebrospinal fluid (CSF) pressure of 250 mm CSF is an optimum diagnostic cutoff. T...

    Authors: Hsiang-Ting Hsu, Hui-Chen Cheng, Tsung-Wei Hou, Yi-Shiang Tzeng, Jong-Ling Fuh, Shih-Pin Chen, Wei-Ta Chen, Wei-Ju Lee, Yen-Wei Pai, Yi-Chung Lee, Jiing-Feng Lirng, Shuu-Jiun Wang and Yen-Feng Wang
    Citation: The Journal of Headache and Pain 2024 25:144
    Content type: Research Published on:

  25. About a quarter of migraine cases among women have menstrual migraine (MM), which is usually more severe, longer lasting, and less responsive to treatment than typical migraine. Randomized controlled trials (R...

    Authors: Cindy Ciat-Wuah Khoo, Chan-Cheng Liu, Michael Lu, Yu-Chen Huang and Hsing-Yu Weng
    Citation: The Journal of Headache and Pain 2024 25:143
    Content type: Research Published on:

  26. Magnetic resonance spectroscopy (MRS) studies have indicated that the imbalance between gamma-aminobutyric acid (GABA) and glutamate/glutamine (Glx) levels was the potential cause of migraine development. Howe...

    Authors: Tong Chen, Xiaoyan Bai, Wei Wang, Xue Zhang, Xun Pei, Xueyan Zhang, Ziyu Yuan, Yuanbin Zhao, Qi Yang, Yonggang Wang and Binbin Sui
    Citation: The Journal of Headache and Pain 2024 25:142
    Content type: Research Published on:

  27. Orally administered second-generation gepants are effective for the treatment of migraine. The intranasal administration of the third-generation gepant zavegepant might have additional benefits including a rap...

    Authors: Deirdre M. Boucherie, Ruben Dammers, Arnaud Vincent, A. H. Jan Danser and Antoinette MaassenVanDenBrink
    Citation: The Journal of Headache and Pain 2024 25:141
    Content type: Research Published on:

  28. Widespread neuropathic pain usually affects a wide range of body areas and inflicts huge suffering on patients. However, little is known about how it happens and effective therapeutic interventions are lacking.

    Authors: Yu Du, Shi-Da Lin, Xue-Qing Wu, Bao-Yu Xue, Yi-La Ding, Jia-Hang Zhang, Bei Tan, Guo-Dong Lou, Wei-Wei Hu, Zhong Chen and Shi-Hong Zhang
    Citation: The Journal of Headache and Pain 2024 25:140
    Content type: Research Published on:

  29. miR-155 is involved in the generation and maintenance of inflammation and pain, endothelial function and immune system homeostasis, all functions that are relevant for migraine. The present study aims to asses...

    Authors: Rosaria Greco, Federico Bighiani, Chiara Demartini, Annamaria Zanaboni, Miriam Francavilla, Sara Facchetti, Gloria Vaghi, Marta Allena, Daniele Martinelli, Elena Guaschino, Natascia Ghiotto, Sara Bottiroli, Michele Corrado, Francescantonio Cammarota, Alessandro Antoniazzi, Elena Mazzotta…
    Citation: The Journal of Headache and Pain 2024 25:138
    Content type: Research Published on:

  30. Cluster headache (CH) is a significant health concern due to its major socioeconomic consequences and most patients being refractory to conventional strategies. For treatment resistant CH, occipital nerve stim...

    Authors: Linda Kollenburg, H. Arnts, M. Heitkamp, S. Geerts, C. Robinson, M. Dominguez, W. Mulleners and E. Kurt
    Citation: The Journal of Headache and Pain 2024 25:139
    Content type: Research Published on:

  31. This commentary addresses the use of rimegepant for situational prevention in migraine management. While the approach of using prophylactic treatments during high-risk periods is not new, its application with ...

    Authors: Lanfranco Pellesi and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2024 25:137
    Content type: Comment Published on:

  32. A global schools-based programme within the Global Campaign against Headache is estimating the burden of headache in children (6–11 years) and adolescents (12–17 years), cluster-sampling the world by conductin...

    Authors: Mendinatou Agbetou Houessou, Thierry Adoukonou, Willy Tchuenga Fokom, Nelly Dovoedo, Tayyar Şaşmaz, Fatma Bozdağ, Derya Uluduz and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2024 25:135
    Content type: Research Published on:

  33. Migraine is a neurological disorder characterized by complex, widespread, and sudden attacks with an unclear pathogenesis, particularly in chronic migraine (CM). Specific brain regions, including the insula, a...

    Authors: Shaobo Xiao, Guangshuang Lu, Jiayi Liu, Wenjie Su, Chenhao Li, Yingyuan Liu, Fanchao Meng, Jinjing Zhao, Nan Gao, Yan Chang, Xinghao Guo, Shengyuan Yu and Ruozhuo Liu
    Citation: The Journal of Headache and Pain 2024 25:136
    Content type: Research Published on:

  34. To assess rates of traversing barriers to care to access optimal clinical outcomes in people with migraine internationally.

    Authors: Michel Lanteri-Minet, Elizabeth Leroux, Zaza Katsarava, Richard B. Lipton, Fumihiko Sakai, Manjit Matharu, Kristina Fanning, Aubrey Manack Adams, Katherine Sommer, Michael Seminerio and Dawn C. Buse
    Citation: The Journal of Headache and Pain 2024 25:134
    Content type: Research Published on:

  35. We have previously shown headache to be highly prevalent in Cameroon. Here we present the attributed burden. We also perform a headache-care needs assessment.

    Authors: Callixte Kuate Tegueu, Anastase Dzudie Tamdja, Franklin Kom, Blaise Forgwa Barche, Peter Ebasone, Mélanie Magnerou, Paul Mbonda, Yannick Fogang, Daniel Massi Gams, Jacques Doumbe, Andreas Husøy and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2024 25:133
    Content type: Research Published on:

  37. While growing evidence suggests a relationship between migraine and cardiovascular disease, the genetic evidence for a causal relationship between migraine and cardiovascular disease is still scarce. Investiga...

    Authors: Xirui Duan, Xiaolan Du, Guangrong Zheng, Xinyan Zhou, Na Tan, Guochen Li, Bin Liu, Mei Zhu, Tengfei Ke and Chengde Liao
    Citation: The Journal of Headache and Pain 2024 25:130
    Content type: Research Published on:

  38. Migraine, a widespread neurological condition, substantially affects the quality of life, particularly for adolescents and young adults. While its impact is significant, there remains a paucity of comprehensiv...

    Authors: Zhi-feng Chen, Xiang-meng Kong, Cheng-hao Yang, Xin-yu Li, Hong Guo and Zhao-wei Wang
    Citation: The Journal of Headache and Pain 2024 25:131
    Content type: Research Published on:

  39. Migraine, a primary headache disorder whose mechanism remains incompletely understood, appears to involve the activation of the trigeminovascular system (TS) during attacks. Research suggests that inflammatory...

    Authors: Tamás Körtési, Gábor Nagy-Grócz and László Vécsei
    Citation: The Journal of Headache and Pain 2024 25:129
    Content type: Review Published on:

  40. Cluster headache (CH) is associated with high disability. The Cluster Headache Impact Questionnaire (CHIQ) is a short, disease-specific disability questionnaire first developed and validated in German. Here, w...

    Authors: Katharina Kamm, Andreas Straube, Mark Burish and Ruth Ruscheweyh
    Citation: The Journal of Headache and Pain 2024 25:128
    Content type: Research Published on:

  41. Management of idiopathic intracranial hypertension (IIH) is complex requiring contributions from multiple specialized disciplines. In practice, this creates considerable organizational and communicational chal...

    Authors: Gabriel Bsteh, Stefan Macher, Nik Krajnc, Wolfgang Marik, Martin Michl, Nina Müller, Sina Zaic, Jürgen Harreiter, Klaus Novak, Christian Wöber and Berthold Pemp
    Citation: The Journal of Headache and Pain 2024 25:127
    Content type: Research Published on:

  43. Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide pivotal in migraine pathophysiology and is considered a promising new migraine drug target. Although intravenous PACAP triggers migraine...

    Authors: Song Guo, Rikke Holm Rasmussen, Anders Hay-Schmidt, Messoud Ashina, Ayodeji A. Asuni, Jeppe Møller Jensen, Anja Holm, Sabrina Prehn Lauritzen, Glenn Dorsam, Jens Hannibal, Birgitte Georg, David Møbjerg Kristensen, Jes Olesen and Sarah Louise Christensen
    Citation: The Journal of Headache and Pain 2024 25:126
    Content type: Research Published on:

  44. The initiation of migraine headaches and the involvement of neuroinflammatory signaling between parenchymal and meningeal cells remain unclear. Experimental evidence suggests that a cascade of inflammatory sig...

    Authors: Turgay Dalkara, Zeynep Kaya and Şefik Evren Erdener
    Citation: The Journal of Headache and Pain 2024 25:124
    Content type: Review Published on:

  46. The relationship between lifestyle and migraine is complex, as it remains uncertain which specific lifestyle factors play the most prominent role in the development of migraine, or which modifiable metabolic t...

    Authors: Quan Gan, Enfeng Song, Lily Zhang, Yanjie Zhou, Lintao Wang, Zhengming Shan, Jingjing Liang, Shanghua Fan, Songqing Pan, Kegang Cao and Zheman Xiao
    Citation: The Journal of Headache and Pain 2024 25:122
    Content type: Research Published on:

  47. Migraine is a neurological disorder characterized by episodes of severe headache. Cortical spreading depression (CSD), the electrophysiological equivalent of migraine aura, results in opening of pannexin 1 meg...

    Authors: Burak Uzay, Buket Donmez-Demir, Sinem Yilmaz Ozcan, Emine Eren Kocak, Muge Yemisci, Yasemin Gursoy Ozdemir, Turgay Dalkara and Hulya Karatas
    Citation: The Journal of Headache and Pain 2024 25:120
    Content type: Research Published on:

  48. The aim of this paper is to critically re-appraise the published trials assessing propranolol for migraine prophylaxis.

    Authors: Jan Versijpt, Christina Deligianni, Muizz Hussain, Faisal Amin, Uwe Reuter, Margarita Sanchez-del-Rio, Derya Uluduz, Deirdre Boucherie, Dena Zeraatkar, Antoinette MaassenVanDenBrink, Simona Sacco, Christian Lampl and Raquel Gil-Gouveia
    Citation: The Journal of Headache and Pain 2024 25:119
    Content type: Research Published on:

  49. Cluster headache is characterized by activation of the trigeminovascular pathway with subsequent pain signalling in the meningeal vessels, and inflammation has been suggested to play a role in the pathophysiol...

    Authors: Caroline Ran, Felicia Jennysdotter Olofsgård, Katrin Wellfelt, Anna Steinberg and Andrea Carmine Belin
    Citation: The Journal of Headache and Pain 2024 25:121
    Content type: Research Published on:

  50. The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) method has been used to evaluate glymphatic system function in patients with migraine. However, since the diffusion tensor model ca...

    Authors: Yungang Cao, Mei Huang, Fangwang Fu, Keyang Chen, Kun Liu, Jinming Cheng, Yan Li and Xiaozheng Liu
    Citation: The Journal of Headache and Pain 2024 25:118
    Content type: Research Published on:
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  • ISSN: 1129-2377 (electronic)
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ISSN: 1129-2377

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