<p>The figure displays the mean and standard deviation of the CCT (in seconds) by gender in... more <p>The figure displays the mean and standard deviation of the CCT (in seconds) by gender in MS patients and control group.</p
<p>Upper panels: the CCT measurements at the right and left side ICA across the subjects in... more <p>Upper panels: the CCT measurements at the right and left side ICA across the subjects in the control group evaluated by first rater (left panel) and second rater (right panel).</p
<p>The blue colour, shown only in MS patients, demonstrates a prolonged CCT. The veins are ... more <p>The blue colour, shown only in MS patients, demonstrates a prolonged CCT. The veins are in green and not blue in the control.</p
<p>The control group showed significant lower CCT. The difference between the CCT mean in M... more <p>The control group showed significant lower CCT. The difference between the CCT mean in MS and CTR was 2.09 s with a confidence interval of 95% [1.77 s: 2.41 s].</p
Multiple sclerosis (Ms) is a chronic, disabling condition with severe clinical and social consequ... more Multiple sclerosis (Ms) is a chronic, disabling condition with severe clinical and social consequences. glatiramer acetate (gA) has been widely used for more than 15 years as a first-line disease-modifying agent in the treatment of relapsingremitting Ms (rrMs). it appears to have multiple modes of action, including the induction of gA-reactive T-helper 2 (Th2) immunoregulatory cells and the stimulation of neurotrophin secretion in the central nervous system, which may promote neuronal repair. clinical trial data show that gA reduces the relapse rate in rrMs, can delay or halt disability progression, and brings about improvement in magnetic resonance imaging (Mri) measures of disease activity, including reduction of brain atrophy. early treatment with gA can reduce the risk of developing clinically definite Ms in patients with clinically isolated syndrome. furthermore, it has an excellent safety and tolerability profile. recent data from patients treated for 15 years have indicated ...
Experiments were made on 188 white rats. Immunoreactive aldosterone, sodium and calcium excretion... more Experiments were made on 188 white rats. Immunoreactive aldosterone, sodium and calcium excretion with urine were determined. Administration of the polypeptide drug epithalamine to intact animals promoted sodium excretion reduction, immunoreactive aldosterone elevation in the blood plasma. On the contrary, during epithalamine administration following aldosterone secretion stimulation (by shock reproduction) there was an increase in sodium excretion and a decrease in the aldosterone level. It is concluded that the epiphysis produces a different action on adrenal mineralocorticoids, depending on their initial function.
Literature has suggested that changes in brain flow circulation occur in patients with multiple s... more Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the ab-solute CCT value in MS patients and to correlate its value to age at disease onset and dura-tion, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27s) and control group (mean = 2.8s; sd = 0.51s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly...
Literature has suggested that changes in brain flow circulation occur in patients with multiple s... more Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27s) and control group (mean = 2.8s; sd = 0.51s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.
Literature has suggested that changes in brain flow circulation occur in patients with multiple s... more Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27s) and control group (mean = 2.8s; sd = 0.51s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.
Literature has suggested that changes in brain flow circulation occur in patients with multiple s... more Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27s) and control group (mean = 2.8s; sd = 0.51s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.
Literature has suggested that changes in brain flow circulation occur in patients with multiple s... more Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27s) and control group (mean = 2.8s; sd = 0.51s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.
<p>The figure displays the mean and standard deviation of the CCT (in seconds) by gender in... more <p>The figure displays the mean and standard deviation of the CCT (in seconds) by gender in MS patients and control group.</p
<p>Upper panels: the CCT measurements at the right and left side ICA across the subjects in... more <p>Upper panels: the CCT measurements at the right and left side ICA across the subjects in the control group evaluated by first rater (left panel) and second rater (right panel).</p
<p>The blue colour, shown only in MS patients, demonstrates a prolonged CCT. The veins are ... more <p>The blue colour, shown only in MS patients, demonstrates a prolonged CCT. The veins are in green and not blue in the control.</p
<p>The control group showed significant lower CCT. The difference between the CCT mean in M... more <p>The control group showed significant lower CCT. The difference between the CCT mean in MS and CTR was 2.09 s with a confidence interval of 95% [1.77 s: 2.41 s].</p
Multiple sclerosis (Ms) is a chronic, disabling condition with severe clinical and social consequ... more Multiple sclerosis (Ms) is a chronic, disabling condition with severe clinical and social consequences. glatiramer acetate (gA) has been widely used for more than 15 years as a first-line disease-modifying agent in the treatment of relapsingremitting Ms (rrMs). it appears to have multiple modes of action, including the induction of gA-reactive T-helper 2 (Th2) immunoregulatory cells and the stimulation of neurotrophin secretion in the central nervous system, which may promote neuronal repair. clinical trial data show that gA reduces the relapse rate in rrMs, can delay or halt disability progression, and brings about improvement in magnetic resonance imaging (Mri) measures of disease activity, including reduction of brain atrophy. early treatment with gA can reduce the risk of developing clinically definite Ms in patients with clinically isolated syndrome. furthermore, it has an excellent safety and tolerability profile. recent data from patients treated for 15 years have indicated ...
Experiments were made on 188 white rats. Immunoreactive aldosterone, sodium and calcium excretion... more Experiments were made on 188 white rats. Immunoreactive aldosterone, sodium and calcium excretion with urine were determined. Administration of the polypeptide drug epithalamine to intact animals promoted sodium excretion reduction, immunoreactive aldosterone elevation in the blood plasma. On the contrary, during epithalamine administration following aldosterone secretion stimulation (by shock reproduction) there was an increase in sodium excretion and a decrease in the aldosterone level. It is concluded that the epiphysis produces a different action on adrenal mineralocorticoids, depending on their initial function.
Literature has suggested that changes in brain flow circulation occur in patients with multiple s... more Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the ab-solute CCT value in MS patients and to correlate its value to age at disease onset and dura-tion, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27s) and control group (mean = 2.8s; sd = 0.51s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly...
Literature has suggested that changes in brain flow circulation occur in patients with multiple s... more Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27s) and control group (mean = 2.8s; sd = 0.51s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.
Literature has suggested that changes in brain flow circulation occur in patients with multiple s... more Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27s) and control group (mean = 2.8s; sd = 0.51s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.
Literature has suggested that changes in brain flow circulation occur in patients with multiple s... more Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27s) and control group (mean = 2.8s; sd = 0.51s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.
Literature has suggested that changes in brain flow circulation occur in patients with multiple s... more Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27s) and control group (mean = 2.8s; sd = 0.51s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.
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