Biochemical and Biophysical Research Communications, Jun 1, 1977
... IN NORMAL HUMAN LYMPHOCYTES Sheena M. Johnson' and Claude Nicolau+ Division of Immunolog... more ... IN NORMAL HUMAN LYMPHOCYTES Sheena M. Johnson' and Claude Nicolau+ Division of Immunological Medicine Clinical Research Centre Watford Road Harrow, UK +Institut flir Strahlenchemie im MaxPlanck Institut fur Kohlenforschung D4330 M1lheim ad Ruhr West ...
1. Cooperative State Transitions in Biomembranes: Spectroscopic Analyses.- 2. Domain Formation in... more 1. Cooperative State Transitions in Biomembranes: Spectroscopic Analyses.- 2. Domain Formation in Lipid Bilayers and Biological Membranes.- 3. Recent Studies of Lipid-Lipid and Lipid-Protein Interactions by Physical and Chemical Methods.- 4. Modulation of Plasma Membrane Architecture in Animal Cells.- 5. Protein-Lipid Interactions: Freeze-Fracture and Spin Label Studies.- 6. Shape and Solubilization of a Membrane Protein: Rhodopsin.- 7. Biological and Biochemical Changes in the Plasma Membrane of RNA Tumor Virus-Transformed Cells.- 8. Lipid Organization in Biological Membranes.- 9. Density-Dependent Growth Control and Lipid Mobilities in Normal and Tumor-Transformed Cell Membranes.- 10. Coupling Between ATP Hydrolysis and Sodium and Potassium Transport.- 11. Modulation of Some Membrane Enzymes Studied in Variant Cells.- 12. Vasopressin-sensitive Adenylate Cyclase from the Mammalian Kidney: Mechanisms of Activation.- 13. The Molecular Architecture of a Reconstituted Calcium Pump.
Publisher Summary This chapter reviews the biochemical and physiological effects of the incorpora... more Publisher Summary This chapter reviews the biochemical and physiological effects of the incorporation of allosteric effectors of hemoglobin in red blood cells. The amount of O2 that can be released in a particular organ depends on the critical O2 partial pressure characteristic for the organ and on the architecture of the microvasculature. This O2 release capacity is controlled by the microcirculation and molecular parameters of the intracellular Hb. The O2 release capacity can be enhanced by an increase in the co-operability of the Hb molecule; and/or by right shifting of the entire O2-binding curve toward higher O2 partial pressures. An abnormally high affinity of hemoglobin for oxygen shifts the O2-binding curve to the left and the P50 (O2 partial pressure at which 50% saturation of hemoglobin occurs) decreases causing a lower oxygen release to the tissues. In human RBC, the right-shift is controlled by several allosteric mechanisms, such as Bohr effect, 2, 3-bis-phosphoglycerate (DPG), and CO2-binding.
(partial) Some unique applications of erythrocytes as carrier systems, H O Alpar & W J Irwin ... more (partial) Some unique applications of erythrocytes as carrier systems, H O Alpar & W J Irwin In vitro drug release from human carrier erythrocytes, H C Eichler et al. Desferrioxamine loading of red cells for transfusion, A Zanella et al. Rheological approach to human red blood cell carriers desferrioxamine encapsulation, M Jrade et al. Optimisation of desferrioxamine loading in red blood cells, C Hurel et al. Transfusion of thalassemic patients with desferrioxamine loaded standard red blood cell units, G Fiorelli et al. Approach to the optimisation of inositol hexaphosphate entrapment into human red blood cells, M C Villereal et al. The nature and kinetics of red cell membrane changes during the osmotic pulse method of incorporating xenobiotics into viable red blood cells, R Franco et al. Isolated heart as a model to study the effects of the decrease in oxygen hemoglobin affinity, J F Baron et al. P50 shifts and tissue oxygen pressure, R Woodson et al. Arginase-loaded erythrocyte carriers: their fusion to host cells with viral fusogenic proteins and subcellular localization of arginase, C A Kruse et al. Encapsulation of rhodanese by mouse carrier erythrocytes, J Way et al. Antileishmanial activity of red-cell encapsulated drugs, J D Berman. IHP dramatically reduces Babesia microti and Plasmodium falciparum Parasitemias: observations of fluorescent red cells and fluorescent vacuoles, G M Ihler & P-F Tosi. The use of animal models in the encapsulation of drugs in erythrocytes, D A Lewis & J Desai. Towards cellular drug targeting and controlled release of drugs by magnetic fields, U Sprandel.
Biochemical and Biophysical Research Communications, Jun 1, 1977
... IN NORMAL HUMAN LYMPHOCYTES Sheena M. Johnson' and Claude Nicolau+ Division of Immunolog... more ... IN NORMAL HUMAN LYMPHOCYTES Sheena M. Johnson' and Claude Nicolau+ Division of Immunological Medicine Clinical Research Centre Watford Road Harrow, UK +Institut flir Strahlenchemie im MaxPlanck Institut fur Kohlenforschung D4330 M1lheim ad Ruhr West ...
1. Cooperative State Transitions in Biomembranes: Spectroscopic Analyses.- 2. Domain Formation in... more 1. Cooperative State Transitions in Biomembranes: Spectroscopic Analyses.- 2. Domain Formation in Lipid Bilayers and Biological Membranes.- 3. Recent Studies of Lipid-Lipid and Lipid-Protein Interactions by Physical and Chemical Methods.- 4. Modulation of Plasma Membrane Architecture in Animal Cells.- 5. Protein-Lipid Interactions: Freeze-Fracture and Spin Label Studies.- 6. Shape and Solubilization of a Membrane Protein: Rhodopsin.- 7. Biological and Biochemical Changes in the Plasma Membrane of RNA Tumor Virus-Transformed Cells.- 8. Lipid Organization in Biological Membranes.- 9. Density-Dependent Growth Control and Lipid Mobilities in Normal and Tumor-Transformed Cell Membranes.- 10. Coupling Between ATP Hydrolysis and Sodium and Potassium Transport.- 11. Modulation of Some Membrane Enzymes Studied in Variant Cells.- 12. Vasopressin-sensitive Adenylate Cyclase from the Mammalian Kidney: Mechanisms of Activation.- 13. The Molecular Architecture of a Reconstituted Calcium Pump.
Publisher Summary This chapter reviews the biochemical and physiological effects of the incorpora... more Publisher Summary This chapter reviews the biochemical and physiological effects of the incorporation of allosteric effectors of hemoglobin in red blood cells. The amount of O2 that can be released in a particular organ depends on the critical O2 partial pressure characteristic for the organ and on the architecture of the microvasculature. This O2 release capacity is controlled by the microcirculation and molecular parameters of the intracellular Hb. The O2 release capacity can be enhanced by an increase in the co-operability of the Hb molecule; and/or by right shifting of the entire O2-binding curve toward higher O2 partial pressures. An abnormally high affinity of hemoglobin for oxygen shifts the O2-binding curve to the left and the P50 (O2 partial pressure at which 50% saturation of hemoglobin occurs) decreases causing a lower oxygen release to the tissues. In human RBC, the right-shift is controlled by several allosteric mechanisms, such as Bohr effect, 2, 3-bis-phosphoglycerate (DPG), and CO2-binding.
(partial) Some unique applications of erythrocytes as carrier systems, H O Alpar & W J Irwin ... more (partial) Some unique applications of erythrocytes as carrier systems, H O Alpar & W J Irwin In vitro drug release from human carrier erythrocytes, H C Eichler et al. Desferrioxamine loading of red cells for transfusion, A Zanella et al. Rheological approach to human red blood cell carriers desferrioxamine encapsulation, M Jrade et al. Optimisation of desferrioxamine loading in red blood cells, C Hurel et al. Transfusion of thalassemic patients with desferrioxamine loaded standard red blood cell units, G Fiorelli et al. Approach to the optimisation of inositol hexaphosphate entrapment into human red blood cells, M C Villereal et al. The nature and kinetics of red cell membrane changes during the osmotic pulse method of incorporating xenobiotics into viable red blood cells, R Franco et al. Isolated heart as a model to study the effects of the decrease in oxygen hemoglobin affinity, J F Baron et al. P50 shifts and tissue oxygen pressure, R Woodson et al. Arginase-loaded erythrocyte carriers: their fusion to host cells with viral fusogenic proteins and subcellular localization of arginase, C A Kruse et al. Encapsulation of rhodanese by mouse carrier erythrocytes, J Way et al. Antileishmanial activity of red-cell encapsulated drugs, J D Berman. IHP dramatically reduces Babesia microti and Plasmodium falciparum Parasitemias: observations of fluorescent red cells and fluorescent vacuoles, G M Ihler & P-F Tosi. The use of animal models in the encapsulation of drugs in erythrocytes, D A Lewis & J Desai. Towards cellular drug targeting and controlled release of drugs by magnetic fields, U Sprandel.
Uploads