The dysembryoplastic neuroepithelial tumor is a benign central nervous system neoplasm of childre... more The dysembryoplastic neuroepithelial tumor is a benign central nervous system neoplasm of children and young adults manifesting almost exclusively in complex partial seizures. The authors report the case of an 8-year-old boy presenting with characteristic clinical and radiologic features who subsequently underwent surgery. Light microscopic, immunohistochemical and ultrastructural traits of the tumor are described demonstrating pluripotential differentiation of tumor cells and architectural features suggesting a dysontogenic lesion. A brief literature review on the biology and histologic diagnosis of the dysembryoplastic neuroepithelial tumor is provided. Although this uncommon tumor accounts for only a minority of intracranial neoplasms, its pathogenetic role has to be considered in the differential diagnosis of temporal lobe epilepsies. This is the first report on this recently described, rare neoplastic condition in Hungary.
Kutatasaink celja a rubeolavirus (RV), a vesicularis stomatitis virus (VSV) es a herpes simplex v... more Kutatasaink celja a rubeolavirus (RV), a vesicularis stomatitis virus (VSV) es a herpes simplex virus (HSV) sejtkarosito es teratogen hatasanak jobb megertese volt, ezert azt tanulmanyoztuk, hogy ezen virusok befolyasoljak-e a p63 es a Bcl-2 csaladba tarozo feherjek expressziojat. RV fertőzes hatasara, mindegyik TAp63 izoforma szintje emelkedett, mig a deltaNp63alfa szintje csokkent Vero sejtekben. VSV fertőzes hatasara, a Bcl-2 es a Bax-alfa szintje csokkent, a p53 es a p63 szintje nem valtozott, mig a p18 Bax expresszioja jelentős mertekben emelkedett WK sejtekben. VSV-vel fertőzott HaCaT sejtekben a deltaNp63alfa es a mutans p53 szintje csokkent, a Bcl-2 nem valtozott, mig a Bax-alfa es a p18 Bax expresszioja fokozodott. HSV fertőzes hatasara, a deltaNp63alfa szintje csokkent, mig nehany mas p63 izoforma expresszioja fokozodott. Tovabba, a HSV fertőzes a Bax-beta szintjenek emelkedeset valtotta ki. Eredmenyeink azt mutatjak, hogy mindharom virus befolyasolja a p63 izoformak es a ...
The entorhinal cortex (EC) provides the predominant excitatory drive to the hippocampal CA1 and s... more The entorhinal cortex (EC) provides the predominant excitatory drive to the hippocampal CA1 and subicular neurones in chronic epilepsy. Here we analysed the effects of one-sided lateral EC (LEC) and temporoammonic (alvear) path lesion on the development and properties of 4-aminopyridine-induced seizures. Electroencephalography (EEG) analysis of freely moving rats identified that the lesion increased the latency of the hippocampal seizure significantly and decreased the number of brief convulsions. Seizure-induced neuronal c-fos expression was reduced in every hippocampal area following LEC lesion. Immunocytochemical analysis 40 days after the ablation of the LEC identified sprouting of cholinergic and calretinin-containing axons into the dentate molecular layer. Region and subunit specific changes in the expression of ionotropic glutamate receptors (iGluRs) were identified. Although the total amount of AMPA receptor subunits remained unchanged, GluR1(flop) displayed a significant decrease in the CA1 region. An increase in NR1 and NR2B N-methyl-d-aspartate (NMDA) receptor subunits and KA-2 kainate receptor subunit was identified in the deafferented layers of the hippocampus. These results further emphasize the importance of the lateral entorhinal area in the spread and regulation of hippocampal seizures and highlight the potential role of the rewiring of afferents and rearrangement of iGluRs in the dentate gyrus in hippocampal convulsive activity.
ABSTRACT We present a case of a 23-year-old man who suffered a facial assault. An intracranial fo... more ABSTRACT We present a case of a 23-year-old man who suffered a facial assault. An intracranial foreign body, a socket from a socket wrench, was introduced into the cranial cavity via a medial conjunctival entry wound which presented with minimal physical signs. The entry wound and the foreign body were missed during the patient’s first presentation to an emergency department leading to a delay in diagnosis. Subsequent periorbital swelling and visual blurring prompted delayed investigation leading to detection of the foreign body. This case report highlights the need for a high index of suspicion of intracranial complications when assessing ocular injuries. The mechanism of the penetrating injury, the ophthalmological findings and the surgical and antibiotic management are discussed.
The dysembryoplastic neuroepithelial tumor is a benign central nervous system neoplasm of childre... more The dysembryoplastic neuroepithelial tumor is a benign central nervous system neoplasm of children and young adults manifesting almost exclusively in complex partial seizures. The authors report the case of an 8-year-old boy presenting with characteristic clinical and radiologic features who subsequently underwent surgery. Light microscopic, immunohistochemical and ultrastructural traits of the tumor are described demonstrating pluripotential differentiation of tumor cells and architectural features suggesting a dysontogenic lesion. A brief literature review on the biology and histologic diagnosis of the dysembryoplastic neuroepithelial tumor is provided. Although this uncommon tumor accounts for only a minority of intracranial neoplasms, its pathogenetic role has to be considered in the differential diagnosis of temporal lobe epilepsies. This is the first report on this recently described, rare neoplastic condition in Hungary.
Kutatasaink celja a rubeolavirus (RV), a vesicularis stomatitis virus (VSV) es a herpes simplex v... more Kutatasaink celja a rubeolavirus (RV), a vesicularis stomatitis virus (VSV) es a herpes simplex virus (HSV) sejtkarosito es teratogen hatasanak jobb megertese volt, ezert azt tanulmanyoztuk, hogy ezen virusok befolyasoljak-e a p63 es a Bcl-2 csaladba tarozo feherjek expressziojat. RV fertőzes hatasara, mindegyik TAp63 izoforma szintje emelkedett, mig a deltaNp63alfa szintje csokkent Vero sejtekben. VSV fertőzes hatasara, a Bcl-2 es a Bax-alfa szintje csokkent, a p53 es a p63 szintje nem valtozott, mig a p18 Bax expresszioja jelentős mertekben emelkedett WK sejtekben. VSV-vel fertőzott HaCaT sejtekben a deltaNp63alfa es a mutans p53 szintje csokkent, a Bcl-2 nem valtozott, mig a Bax-alfa es a p18 Bax expresszioja fokozodott. HSV fertőzes hatasara, a deltaNp63alfa szintje csokkent, mig nehany mas p63 izoforma expresszioja fokozodott. Tovabba, a HSV fertőzes a Bax-beta szintjenek emelkedeset valtotta ki. Eredmenyeink azt mutatjak, hogy mindharom virus befolyasolja a p63 izoformak es a ...
The entorhinal cortex (EC) provides the predominant excitatory drive to the hippocampal CA1 and s... more The entorhinal cortex (EC) provides the predominant excitatory drive to the hippocampal CA1 and subicular neurones in chronic epilepsy. Here we analysed the effects of one-sided lateral EC (LEC) and temporoammonic (alvear) path lesion on the development and properties of 4-aminopyridine-induced seizures. Electroencephalography (EEG) analysis of freely moving rats identified that the lesion increased the latency of the hippocampal seizure significantly and decreased the number of brief convulsions. Seizure-induced neuronal c-fos expression was reduced in every hippocampal area following LEC lesion. Immunocytochemical analysis 40 days after the ablation of the LEC identified sprouting of cholinergic and calretinin-containing axons into the dentate molecular layer. Region and subunit specific changes in the expression of ionotropic glutamate receptors (iGluRs) were identified. Although the total amount of AMPA receptor subunits remained unchanged, GluR1(flop) displayed a significant decrease in the CA1 region. An increase in NR1 and NR2B N-methyl-d-aspartate (NMDA) receptor subunits and KA-2 kainate receptor subunit was identified in the deafferented layers of the hippocampus. These results further emphasize the importance of the lateral entorhinal area in the spread and regulation of hippocampal seizures and highlight the potential role of the rewiring of afferents and rearrangement of iGluRs in the dentate gyrus in hippocampal convulsive activity.
ABSTRACT We present a case of a 23-year-old man who suffered a facial assault. An intracranial fo... more ABSTRACT We present a case of a 23-year-old man who suffered a facial assault. An intracranial foreign body, a socket from a socket wrench, was introduced into the cranial cavity via a medial conjunctival entry wound which presented with minimal physical signs. The entry wound and the foreign body were missed during the patient’s first presentation to an emergency department leading to a delay in diagnosis. Subsequent periorbital swelling and visual blurring prompted delayed investigation leading to detection of the foreign body. This case report highlights the need for a high index of suspicion of intracranial complications when assessing ocular injuries. The mechanism of the penetrating injury, the ophthalmological findings and the surgical and antibiotic management are discussed.
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