The journals of gerontology. Series A, Biological sciences and medical sciences, Jan 22, 2015
Over the past decade, a large number of discoveries have shown that interventions (genetic, pharm... more Over the past decade, a large number of discoveries have shown that interventions (genetic, pharmacological, and nutritional) increase the lifespan of invertebrates and laboratory rodents. Therefore, the possibility of developing antiaging interventions for humans has gone from a dream to a reality. However, it has also become apparent that we need more information than just lifespan to evaluate the translational potential of any proposed antiaging intervention to humans. Information is needed on how an intervention alters the "healthspan" of an animal, that is, how the physiological functions that change with age are altered. In this report, we describe the utility and the limitations of assays in mice currently available for measuring a wide range of physiological functions that potentially impact quality of life. We encourage investigators and reviewers alike to expect at minimum an overall assessment of health in several domains across several ages before an interventi...
Science of aging knowledge environment : SAGE KE, Jan 26, 2004
Despite their higher metabolic rates and lifetime energy expenditures, birds generally outlive si... more Despite their higher metabolic rates and lifetime energy expenditures, birds generally outlive similar-sized mammals even in the wild, often reaching maturity and aging considerably more slowly. Wild populations of many bird species have been monitored for years using banding-and-recapture methods, allowing field ornithologists to document age-related declines in survival and reproductive success. Although elderly birds rarely reach advanced stages of senescence in nature, many show other signs of physiological deterioration. In this Perspective, we review recent reports of aging-related changes in the immune response of two small European songbirds, the barn swallow and the collared flycatcher. Researchers in both studies challenged birds' humoral immune response by administering antigen to free-ranging adults during the breeding season. Older barn swallows--particularly breeding females--showed lower antibody responses (both primary and secondary) to vaccination with Newcastle...
As part of a coordinated effort to expand our research activity at the interface of Aging and Ene... more As part of a coordinated effort to expand our research activity at the interface of Aging and Energetics a team of investigators at The University of Alabama at Birmingham systematically assayed and catalogued the top research priorities identified in leading publications in that domain, believing the result would be useful to the scientific community at large. To identify research priorities and opportunities in the domain of aging and energetics as advocated in the 40 most cited papers related to aging and energetics in the last 4 years. The investigators conducted a search for papers on aging and energetics in Scopus, ranked the resulting papers by number of times they were cited, and selected the ten most-cited papers in each of the four years that include 2010 to 2013, inclusive. Ten research categories were identified from the 40 papers. These included: (1) Calorie restriction (CR) longevity response, (2) role of mTOR (mechanistic target of Rapamycin) and related factors in...
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2013
Comparing biological processes in closely related species with divergent life spans is a powerful... more Comparing biological processes in closely related species with divergent life spans is a powerful approach to study mechanisms of aging. The oxidative stress hypothesis of aging predicts that longer-lived species would have lower reactive oxygen species (ROS) generation and/or an increased antioxidant capacity, resulting in reduced oxidative damage with age than in shorter-lived species. In this study, we measured ROS generation in the young adult animals of the long-lived white-footed mouse, Peromyscus leucopus (maximal life span potential, MLSP = 8 yr) and the common laboratory mouse, Mus musculus (C57BL/6J strain; MLSP = 3.5 yr). Consistent with the hypothesis, our results show that skeletal muscle mitochondria from adult P. leucopus produce less ROS (superoxide and hydrogen peroxide) compared with M. musculus. Additionally, P. leucopus has an increase in the activity of antioxidant enzymes superoxide dismutase 1, catalase, and glutathione peroxidase 1 at young age. P. leucopus c...
The journals of gerontology. Series A, Biological sciences and medical sciences, Jan 22, 2015
Over the past decade, a large number of discoveries have shown that interventions (genetic, pharm... more Over the past decade, a large number of discoveries have shown that interventions (genetic, pharmacological, and nutritional) increase the lifespan of invertebrates and laboratory rodents. Therefore, the possibility of developing antiaging interventions for humans has gone from a dream to a reality. However, it has also become apparent that we need more information than just lifespan to evaluate the translational potential of any proposed antiaging intervention to humans. Information is needed on how an intervention alters the "healthspan" of an animal, that is, how the physiological functions that change with age are altered. In this report, we describe the utility and the limitations of assays in mice currently available for measuring a wide range of physiological functions that potentially impact quality of life. We encourage investigators and reviewers alike to expect at minimum an overall assessment of health in several domains across several ages before an interventi...
Science of aging knowledge environment : SAGE KE, Jan 26, 2004
Despite their higher metabolic rates and lifetime energy expenditures, birds generally outlive si... more Despite their higher metabolic rates and lifetime energy expenditures, birds generally outlive similar-sized mammals even in the wild, often reaching maturity and aging considerably more slowly. Wild populations of many bird species have been monitored for years using banding-and-recapture methods, allowing field ornithologists to document age-related declines in survival and reproductive success. Although elderly birds rarely reach advanced stages of senescence in nature, many show other signs of physiological deterioration. In this Perspective, we review recent reports of aging-related changes in the immune response of two small European songbirds, the barn swallow and the collared flycatcher. Researchers in both studies challenged birds' humoral immune response by administering antigen to free-ranging adults during the breeding season. Older barn swallows--particularly breeding females--showed lower antibody responses (both primary and secondary) to vaccination with Newcastle...
As part of a coordinated effort to expand our research activity at the interface of Aging and Ene... more As part of a coordinated effort to expand our research activity at the interface of Aging and Energetics a team of investigators at The University of Alabama at Birmingham systematically assayed and catalogued the top research priorities identified in leading publications in that domain, believing the result would be useful to the scientific community at large. To identify research priorities and opportunities in the domain of aging and energetics as advocated in the 40 most cited papers related to aging and energetics in the last 4 years. The investigators conducted a search for papers on aging and energetics in Scopus, ranked the resulting papers by number of times they were cited, and selected the ten most-cited papers in each of the four years that include 2010 to 2013, inclusive. Ten research categories were identified from the 40 papers. These included: (1) Calorie restriction (CR) longevity response, (2) role of mTOR (mechanistic target of Rapamycin) and related factors in...
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2013
Comparing biological processes in closely related species with divergent life spans is a powerful... more Comparing biological processes in closely related species with divergent life spans is a powerful approach to study mechanisms of aging. The oxidative stress hypothesis of aging predicts that longer-lived species would have lower reactive oxygen species (ROS) generation and/or an increased antioxidant capacity, resulting in reduced oxidative damage with age than in shorter-lived species. In this study, we measured ROS generation in the young adult animals of the long-lived white-footed mouse, Peromyscus leucopus (maximal life span potential, MLSP = 8 yr) and the common laboratory mouse, Mus musculus (C57BL/6J strain; MLSP = 3.5 yr). Consistent with the hypothesis, our results show that skeletal muscle mitochondria from adult P. leucopus produce less ROS (superoxide and hydrogen peroxide) compared with M. musculus. Additionally, P. leucopus has an increase in the activity of antioxidant enzymes superoxide dismutase 1, catalase, and glutathione peroxidase 1 at young age. P. leucopus c...
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Papers by Steven Austad