- Faisalabad, Pakistan
Cyclohexylcarbamodithioic acid has been synthesized by the reaction of cyclohexylamine with carbon disulfide at room temperature. Its complexes have been synthesized by the reaction of cyclohexylcarbamodithioic acid with organotin(IV)... more
Cyclohexylcarbamodithioic acid has been synthesized by the reaction of cyclohexylamine with carbon disulfide at room temperature. Its complexes have been synthesized by the reaction of cyclohexylcarbamodithioic acid with organotin(IV) chlorides in 1 : 1/1 : 2 molar ratio. The ligand and complexes have been characterized by elemental analysis, infrared (IR), and multinuclear (1H, 13C, and 119Sn) NMR spectroscopy. Elemental data show good agreement between calculated and found values of carbon, hydrogen, nitrogen, and sulfur. IR data show that the ligand is bidentate and complexes exhibit a five-coordinate geometry in the solid state, which is also confirmed by semi-empirical studies. NMR data show that the complexes exhibit tetrahedral geometry in solution state. The ligand and its complexes were screened for their in vitro mutagenic, antimicrobial, MIC, antioxidant activities, and cytotoxicity. Biological screening data demonstrate that complexes show significant activity against va...
Research Interests: Analytical Chemistry, Inorganic Chemistry, Coordination Chemistry, NMR Spectroscopy, Drug development, and 13 moreCytotoxicity, Ir, Organotin Compounds, Nmr, Nitrogen, Empirical Study, Antimicrobial, Antioxidant Activity, Infrared, Room Temperature, Menthol Mint, Biological activity, and Essential Oils and Natural Products
Research Interests:
In aromatic plants species, biosynthesis of essential oils oocurs through two complex natural biochemical pathways involving different enzymatic reactions. Isopentenyl diphosphate (IPP) and its isomer dimethylallyl diphosphate (DMAPP) are... more
In aromatic plants species, biosynthesis of essential oils oocurs through two complex natural
biochemical pathways involving different enzymatic reactions. Isopentenyl diphosphate (IPP)
and its isomer dimethylallyl diphosphate (DMAPP) are the universal precursors of essential oils
biosynthesis and are produced by the cytosolic enzymatic MVA (mevalonic acid) pathway or by
plastidic and enzymatic 1-deoxy-D-xylolose-5-phosphate (DXP), also called the 2-Cmethylerythritol
4-phosphate (MEP) pathway. In the particular plant cell part, prenyl
diphosphate synthases condense isopentenyl diphosphate (IPP) and dimethylallyl diphosphate
(DMAPP) further to form prenyl diphosphates, which are used as substrates for geranyl
diphosphate, C10 (GPP) or for fernesyl diphosphate, C15 (FPP). Essential oils are final terpenoid
products and are formed by a huge group of enzymes known as terpene synthases (TPS).
Essential oils are important secondary metabolites of plants and have been used not only in
different industries but also in ethnobotanical medicines for centuries. Hence, considerable
research has been undertaken to understand the essential oils biosynthetic pathways. This review
will be a valuable source of information in the field of natural products as we give detailed
insights about biosynthesis of essential oils in plants, and thus indicate also new unexplored
horizons for further research
biochemical pathways involving different enzymatic reactions. Isopentenyl diphosphate (IPP)
and its isomer dimethylallyl diphosphate (DMAPP) are the universal precursors of essential oils
biosynthesis and are produced by the cytosolic enzymatic MVA (mevalonic acid) pathway or by
plastidic and enzymatic 1-deoxy-D-xylolose-5-phosphate (DXP), also called the 2-Cmethylerythritol
4-phosphate (MEP) pathway. In the particular plant cell part, prenyl
diphosphate synthases condense isopentenyl diphosphate (IPP) and dimethylallyl diphosphate
(DMAPP) further to form prenyl diphosphates, which are used as substrates for geranyl
diphosphate, C10 (GPP) or for fernesyl diphosphate, C15 (FPP). Essential oils are final terpenoid
products and are formed by a huge group of enzymes known as terpene synthases (TPS).
Essential oils are important secondary metabolites of plants and have been used not only in
different industries but also in ethnobotanical medicines for centuries. Hence, considerable
research has been undertaken to understand the essential oils biosynthetic pathways. This review
will be a valuable source of information in the field of natural products as we give detailed
insights about biosynthesis of essential oils in plants, and thus indicate also new unexplored
horizons for further research