This is the true raw data of my transcript with my 17 most trusted yet also most disappointing Go... more This is the true raw data of my transcript with my 17 most trusted yet also most disappointing Google voice chat
My very urgent but unfortunately until now discredited and ignored message to the American govern... more My very urgent but unfortunately until now discredited and ignored message to the American government that I was unable to submit at https://www.whitehouse.gov/contact/ due to an unidentified data error.============= Ever since sometimes before 10 a.m. on 06/03/23 when I realized that it is more important to connect to the Biden Administration instead of clocking in for my regular Walmart (https://www.walmart.com/store/126-little-rock-ar) shift at 10 a.m. a Russian computer virus slowed down my laptop with Windows 7 and Zoomtext 10. My rational reasons to fear for my life, health safety and the immanent violation of freedoms and rights granted to me by the American Constitution have been discredited or ignored by everyone with whom I shared them (more than 1000 people) ever since I was deported to Cancun on an Interjet flight that departed from Havana at 5 p.m. on 12/09/19. Someone told me that 911 was preventable if the email by which the terrorists shared critical details about their immanent attack had not only been captured by the CIA but were also translated from Arabic into English before the 911 attack occurred. Since about 11 a.m. when I started trying to verify this fact on Google I am suddenly overwhelmed with many crazy computer and internet problems I can’t handle because I am visually impaired due to Albinism. Like 911 was preventable the problems forcing me now to connect to the Biden Administration ASAP were preventable if my Walmart had continued encouraging me to keep sharing any concerns after the former store manager Carlos Santiago, who hired me in July 2202 stopped working at my Walmart last winter. Refer to my 1st unsolicited email to him 1 day before Walmart started paying me as evidence below:
From: Thomas Friedbert Hahn <thomas.fried.hahn@gmail.com> Date: Mon, Jul 11, 2022 at 10:26 PM Subject: Please find my employment authorization for the orientation tomorrow attached. To: Carlos Santiago - cas00k9.s00126 <cas00k9.s00126.us@Walmart.com>
My very urgent but unfortunately until now discredited and ignored message to the American govern... more My very urgent but unfortunately until now discredited and ignored message to the American government that I was unable to submit at https://www.whitehouse.gov/contact/ due to an unidentified data error. Ever since sometimes before 10 a.m. on 06/03/23 when I realized that it is more important to connect to the Biden Administration instead of clocking in for my regular Walmart (https://www.walmart.com/store/126-little-rock-ar) shift at 10 a.m. a Russian computer virus slowed down my laptop with Windows 7 and Zoomtext 10. My rational reasons to fear for my life, health safety and the immanent violation of freedoms and rights granted to me by the American Constitution have been discredited or ignored by everyone with whom I shared them (more than 1000 people) ever since I was deported to Cancun on an Interjet flight that departed from Havana at 5 p.m. on 12/09/19. Someone told me that 911 was preventable if the email by which the terrorists shared critical details about their immanent attack had not only been captured by the CIA but were also translated from Arabic into English before the 911 attack occurred. Since about 11 a.m. when I started trying to verify this fact on Google I am suddenly overwhelmed with many crazy computer and internet problems I can’t handle because I am visually impaired due to Albinism. Like 911 was preventable the problems forcing me now to connect to the Biden Administration ASAP were preventable if my Walmart had continued encouraging me to keep sharing any concerns after the former store manager Carlos Santiago, who hired me in July 2202 stopped working at my Walmart last winter. Refer to my 1st unsolicited email to him 1 day before Walmart started paying me as evidence below:
From: Thomas Friedbert Hahn <thomas.fried.hahn@gmail.com> Date: Mon, Jul 11, 2022 at 10:26 PM Subject: Please find my employment authorization for the orientation tomorrow attached. To: Carlos Santiago - cas00k9.s00126 <cas00k9.s00126.us@Walmart.com>
Can prolonged unemployment lead to labor law revolutions?, 2022
Generally, most positive and negative political revolutions and political changes are caused by u... more Generally, most positive and negative political revolutions and political changes are caused by unresolved underlying problems, such as the inability to become gainfully employed at least in the case of Adolf Hitler and Dr. Thomas Hahn.
What are some of the subjective psychological life circumstances undoubtedly shared by Adolf Hitler and Dr. Thomas Hahn that may have preposition them to have no other choice but to get into seriously and passionately opposing the political power structures messing up their lives at least from their often as unjustifiably subjective discredited individual personal perspective even though I can prove later that nothing can ever be considered “objective” since all our observations must inherently be always “subjective” anyway?
Generally, most positive and negative political revolutions and political changes are caused by u... more Generally, most positive and negative political revolutions and political changes are caused by unresolved underlying problems, such as the inability to become gainfully employed at least in the case of Adolf Hitler and Dr. Thomas Hahn.
What are some of the subjective psychological life circumstances undoubtedly shared by Adolf Hitler and Dr. Thomas Hahn that may have preposition them to have no other choice but to get into seriously and passionately opposing the political power structures messing up their lives at least from their often as unjustifiably subjective discredited individual personal perspective even though I can prove later that nothing can ever be considered “objective” since all our observations must inherently be always “subjective” anyway?
Every dedicated group can set up freelancing portals like www.guru.com, www.upwork.com, www.freel... more Every dedicated group can set up freelancing portals like www.guru.com, www.upwork.com, www.freelancer.com, etc., to secretly coordinate more activities than multinational global companies, such as Facebook, Microsoft, SAP, Google, etc. without raising suspicion for expanding indirect power and influence much further. This could lead to the creation of much more powerful invincible imperceptible virtual nations by anyone, who cares to understand why. This might be destined to happen eventually, because I have been forced to understand this, unless I can get help to end my life before others care to understand it too. If I must stay alive, I cannot avoid getting converted into the "bad" guy, I never wanted to be. Should anything be done about it? Why or why not?
How can all governments be overthrown simultaneously to reduce the lack of employment related sui... more How can all governments be overthrown simultaneously to reduce the lack of employment related suicide risk in only 20 years? The unmet prerequisite for this revolution is that international freelancer strangers decide to trust each other financially more than their own government because a few countries don't collect income tax. This attached writing violates the Community Standards of Facebook and is therefore only included in attached 144 pages long MS Word document draft complied of emails that nobody can understand yet. No government has the right to withhold prescription drugs and work authorizations from anybody because jobs belong to those, whose lives depends on them, instead of to any governmental authority! All authoritative actions must be minimized to their absolute necessity to prevent the harm of other. The attached file reveals how to work safely without work authorization as a freelancer worldwide at freelancer web portals like www.freelancer.com, www.guru.com, www.upwork.com, www.iindeed.com which require a single tax ID under which many different freelancers from different countries can hide their freelance earning from anywhere where freelancing is legal and the internet is fast. Huge enterprises, such as www.google.com, www.facebook.com, www.apple.com, www.sap.com, www.microsft.com, www.oracle.com, www.ibm.com and other software developer companies can be transformed from employment based to freelancer based software development because everything should be done remotely anyways because of COVID 19.. Thus, the software development giants can safe lots of money by letting freelancers compete for projects instead of hiring employees because freelancers don't receive employee benefits such as vacation, sick leave, 504K, health and job site insurance,, advanced notice of job termination, baby off time, etc. Why has nobody figured this out until now? Since www.Facebook.com is trying to keep censoring me by removing my option to attach files that violate Facebook's Community Standards, you can click at the link below to download the same file from www.academia.edu https://www.academia.edu/s/9d561fce59.
How can all governments be overthrown simultaneously to reduce the lack of employment related sui... more How can all governments be overthrown simultaneously to reduce the lack of employment related suicide risk in only 20 years? The unmet prerequisite for this revolution is that international freelancer strangers decide to trust each other financially more than their own government because a few countries don't collect income tax. This attached writing violates the Community Standards of Facebook and is therefore only included in attached 144 pages long MS Word document draft complied of emails that nobody can understand yet. No government has the right to withhold prescription drugs and work authorizations from anybody because jobs belong to those, whose lives depends on them, instead of to any governmental authority! All authoritative actions must be minimized to their absolute necessity to prevent the harm of other. The attached file reveals how to work safely without work authorization as a freelancer worldwide at freelancer web portals like www.freelancer.com, www.guru.com, www.upwork.com, www.iindeed.com which require a single tax ID under which many different freelancers from different countries can hide their freelance earning from anywhere where freelancing is legal and the internet is fast. Huge enterprises, such as www.google.com, www.facebook.com, www.apple.com, www.sap.com, www.microsft.com, www.oracle.com, www.ibm.com and other software developer companies can be transformed from employment based to freelancer based software development because everything should be done remotely anyways because of COVID 19.. Thus, the software development giants can safe lots of money by letting freelancers compete for projects instead of hiring employees because freelancers don't receive employee benefits such as vacation, sick leave, 504K, health and job site insurance,, advanced notice of job termination, baby off time, etc. Why has nobody figured this out until now? Since www.Facebook.com is trying to keep censoring me by removing my option to attach files that violate Facebook's Community Standards, you can click at the link below to download the same file from www.academia.edu https://www.academia.edu/s/9d561fce59.
How can all governments be overthrown simultaneously to reduce the lack of employment related sui... more How can all governments be overthrown simultaneously to reduce the lack of employment related suicide risk in only 20 years? The unmet prerequisite for this revolution is that international freelancer strangers decide to trust each other financially more than their own government because a few countries don't collect income tax. This attached writing violates the Community Standards of Facebook and is therefore only included in attached 144 pages long MS Word document draft complied of emails that nobody can understand yet.
Now it has become a self-fulfilling prophecy that I am a threat because I keep getting punished b... more Now it has become a self-fulfilling prophecy that I am a threat because I keep getting punished by being unfairly deprived of my Constitutional Rights, especially freedom of speech. But I am like a rubber band that feels angry when authorities abuse their power and overstretch it to the point that it hurts. It takes too much energy and efforts to keep me stretched and I will snap back eventually unless I will be given the opportunity to legally request euthanasia in Belgium of I should ever get deported back into the European Union (EU).
Actually, I became a threat because while I was hospitalized at the 10th floor in the suicide psych ward at www.lcmh.com from June 24th until July 3rd, 2020 because my mind had no other choice than to spin until it found at least a theoretical remedy for this conundrum in the future described at the now blocked link
Belgian law allows euthanasia for patients who suffer from severe and incurable distress including psychological disorders.
Belgian law allows euthanasia for patients who suffer from severe and incurable distress, including psychological disorders.Photograph Courtesy Tom Mortier
My research is about violation of freedom of speech, Constitutional Rights, human behavior, ignor... more My research is about violation of freedom of speech, Constitutional Rights, human behavior, ignorance, fear, suicide, isolation, lack of communication and understanding, Anarchy, Politics, Social Science, Economy, Discrimination, Equality, Competition, Immigration, Employment, human behavior prediction, Revolutions, mind control, machine learning, modeling, crisis prevention, trust, safety, causal relationships, dimensions, changes over time, manipulations, intuition, mental illness, belonging, psychology, psychiatry, medicine, science, authority, grouping, similarities, dissimilarities, inductive and deductive reasoning, conspiracy theory, mind and though process control, immigration, intuition, fear, destiny, loss of freedom and how the consequences of the interplay between these example dimensions, especially of subjective feelings of regrets, will shape our future over time (social time series experiments) .
My research is about violation of freedom of speech, Constitutional Rights, human behavior, ignor... more My research is about violation of freedom of speech, Constitutional Rights, human behavior, ignorance, fear, suicide, isolation, lack of communication and understanding, Anarchy, Politics, Social Science, Economy, Discrimination, Equality, Competition, Immigration, Employment, human behavior prediction, Revolutions, mind control, machine learning, modeling, crisis prevention, trust, safety, causal relationships, dimensions, changes over time, manipulations, intuition, mental illness, belonging, psychology, psychiatry, medicine, science, authority, grouping, similarities, dissimilarities, inductive and deductive reasoning, conspiracy theory, mind and though process control, immigration,intuition, fear, destiny, loss of freedom and how the consequences of the interplay between these example dimensions, especially of subjective feelings of regrets, will shape our future over time (social time series experiments) .
My research is about violation of freedom of speech, Constitutional Rights, human behavior, ignor... more My research is about violation of freedom of speech, Constitutional Rights, human behavior, ignorance, fear, suicide, isolation, lack of communication and understanding, Anarchy, Politics, Social Science, Economy, Discrimination, Equality, Competition, Immigration, Employment, human behavior prediction, Revolutions, mind control, machine learning, modeling, crisis prevention, trust, safety, causal relationships, dimensions, changes over time, manipulations, intuition, mental illness, belonging, psychology, psychiatry, medicine, science, authority, grouping, similarities, dissimilarities, inductive and deductive reasoning, conspiracy theory, mind and though process control, immigration,intuition, fear, destiny, loss of freedom and how the consequences of the interplay between these example dimensions, especially of subjective feelings of regrets, will shape our future over time (social time series experiments) . Today is a sad day because I can no longer deny that we never had any freedom of speech to begin with.
Many people experience too much stress caused by uncertain work visa issues. How would it feel i... more Many people experience too much stress caused by uncertain work visa issues. How would it feel if the governments compete for you to have your freelance earnings taxed by them instead of you begging and praying for your work visa to get approved? This proposed economic scenario might be a solution that will come like a self-fulfilling prophecy if everybody simply does what I propose without fear of punishment because as a consistently disobedient group we are stronger than any authority can ever be.
Newest not yet shared unpreventable risk development awareness in progress.
Every dedicated grou... more Newest not yet shared unpreventable risk development awareness in progress. Every dedicated group can set up freelancing portals like www.guru.com, www.upwork.com, www.freelancer.com, etc., to secretly coordinate more activities than multinational global companies, such as Facebook, Microsoft, SAP, Google, etc. without raising suspicion for expanding indirect power and influence much further. This could lead to the creation of much more powerful invincible imperceptible virtual nations by anyone, who cares to understand why. This might be destined to happen eventually, because I have been forced to understand this, unless I can get help to end my life before others care to understand it too. If I must stay alive, I cannot avoid getting converted into the "bad" guy, I never wanted to be. Should anything be done about it? Why or why not?
================================================================
Newest still unshared unpreventa... more ================================================================ Newest still unshared unpreventable risk developments in progress. Every dedicated group, that can set up freelancing portals like www.guru.com, www.upwork.com, www.freelancer.com, etc., can secretly coordinate the same activities as multinational global companies, such as Facebook, Microsoft, SAP, Google, etc. without raising suspicion to expand its indirect power and influence much further than any government or company can. This could lead to the creation of more powerful invincible imperceptible virtual nations by anyone, who cares to understand why. This might be destined to happen eventually, because I have been forced to understand this, unless I can get help to end my life before others care to understand it too. If I must stay alive, I cannot avoid to get converted into the "bad" guy, I never wanted to be. What should I do to stop it? =================================================================
This is the true raw data of my transcript with my 17 most trusted yet also most disappointing Go... more This is the true raw data of my transcript with my 17 most trusted yet also most disappointing Google voice chat
My very urgent but unfortunately until now discredited and ignored message to the American govern... more My very urgent but unfortunately until now discredited and ignored message to the American government that I was unable to submit at https://www.whitehouse.gov/contact/ due to an unidentified data error.============= Ever since sometimes before 10 a.m. on 06/03/23 when I realized that it is more important to connect to the Biden Administration instead of clocking in for my regular Walmart (https://www.walmart.com/store/126-little-rock-ar) shift at 10 a.m. a Russian computer virus slowed down my laptop with Windows 7 and Zoomtext 10. My rational reasons to fear for my life, health safety and the immanent violation of freedoms and rights granted to me by the American Constitution have been discredited or ignored by everyone with whom I shared them (more than 1000 people) ever since I was deported to Cancun on an Interjet flight that departed from Havana at 5 p.m. on 12/09/19. Someone told me that 911 was preventable if the email by which the terrorists shared critical details about their immanent attack had not only been captured by the CIA but were also translated from Arabic into English before the 911 attack occurred. Since about 11 a.m. when I started trying to verify this fact on Google I am suddenly overwhelmed with many crazy computer and internet problems I can’t handle because I am visually impaired due to Albinism. Like 911 was preventable the problems forcing me now to connect to the Biden Administration ASAP were preventable if my Walmart had continued encouraging me to keep sharing any concerns after the former store manager Carlos Santiago, who hired me in July 2202 stopped working at my Walmart last winter. Refer to my 1st unsolicited email to him 1 day before Walmart started paying me as evidence below:
From: Thomas Friedbert Hahn <thomas.fried.hahn@gmail.com> Date: Mon, Jul 11, 2022 at 10:26 PM Subject: Please find my employment authorization for the orientation tomorrow attached. To: Carlos Santiago - cas00k9.s00126 <cas00k9.s00126.us@Walmart.com>
My very urgent but unfortunately until now discredited and ignored message to the American govern... more My very urgent but unfortunately until now discredited and ignored message to the American government that I was unable to submit at https://www.whitehouse.gov/contact/ due to an unidentified data error. Ever since sometimes before 10 a.m. on 06/03/23 when I realized that it is more important to connect to the Biden Administration instead of clocking in for my regular Walmart (https://www.walmart.com/store/126-little-rock-ar) shift at 10 a.m. a Russian computer virus slowed down my laptop with Windows 7 and Zoomtext 10. My rational reasons to fear for my life, health safety and the immanent violation of freedoms and rights granted to me by the American Constitution have been discredited or ignored by everyone with whom I shared them (more than 1000 people) ever since I was deported to Cancun on an Interjet flight that departed from Havana at 5 p.m. on 12/09/19. Someone told me that 911 was preventable if the email by which the terrorists shared critical details about their immanent attack had not only been captured by the CIA but were also translated from Arabic into English before the 911 attack occurred. Since about 11 a.m. when I started trying to verify this fact on Google I am suddenly overwhelmed with many crazy computer and internet problems I can’t handle because I am visually impaired due to Albinism. Like 911 was preventable the problems forcing me now to connect to the Biden Administration ASAP were preventable if my Walmart had continued encouraging me to keep sharing any concerns after the former store manager Carlos Santiago, who hired me in July 2202 stopped working at my Walmart last winter. Refer to my 1st unsolicited email to him 1 day before Walmart started paying me as evidence below:
From: Thomas Friedbert Hahn <thomas.fried.hahn@gmail.com> Date: Mon, Jul 11, 2022 at 10:26 PM Subject: Please find my employment authorization for the orientation tomorrow attached. To: Carlos Santiago - cas00k9.s00126 <cas00k9.s00126.us@Walmart.com>
Can prolonged unemployment lead to labor law revolutions?, 2022
Generally, most positive and negative political revolutions and political changes are caused by u... more Generally, most positive and negative political revolutions and political changes are caused by unresolved underlying problems, such as the inability to become gainfully employed at least in the case of Adolf Hitler and Dr. Thomas Hahn.
What are some of the subjective psychological life circumstances undoubtedly shared by Adolf Hitler and Dr. Thomas Hahn that may have preposition them to have no other choice but to get into seriously and passionately opposing the political power structures messing up their lives at least from their often as unjustifiably subjective discredited individual personal perspective even though I can prove later that nothing can ever be considered “objective” since all our observations must inherently be always “subjective” anyway?
Generally, most positive and negative political revolutions and political changes are caused by u... more Generally, most positive and negative political revolutions and political changes are caused by unresolved underlying problems, such as the inability to become gainfully employed at least in the case of Adolf Hitler and Dr. Thomas Hahn.
What are some of the subjective psychological life circumstances undoubtedly shared by Adolf Hitler and Dr. Thomas Hahn that may have preposition them to have no other choice but to get into seriously and passionately opposing the political power structures messing up their lives at least from their often as unjustifiably subjective discredited individual personal perspective even though I can prove later that nothing can ever be considered “objective” since all our observations must inherently be always “subjective” anyway?
Every dedicated group can set up freelancing portals like www.guru.com, www.upwork.com, www.freel... more Every dedicated group can set up freelancing portals like www.guru.com, www.upwork.com, www.freelancer.com, etc., to secretly coordinate more activities than multinational global companies, such as Facebook, Microsoft, SAP, Google, etc. without raising suspicion for expanding indirect power and influence much further. This could lead to the creation of much more powerful invincible imperceptible virtual nations by anyone, who cares to understand why. This might be destined to happen eventually, because I have been forced to understand this, unless I can get help to end my life before others care to understand it too. If I must stay alive, I cannot avoid getting converted into the "bad" guy, I never wanted to be. Should anything be done about it? Why or why not?
How can all governments be overthrown simultaneously to reduce the lack of employment related sui... more How can all governments be overthrown simultaneously to reduce the lack of employment related suicide risk in only 20 years? The unmet prerequisite for this revolution is that international freelancer strangers decide to trust each other financially more than their own government because a few countries don't collect income tax. This attached writing violates the Community Standards of Facebook and is therefore only included in attached 144 pages long MS Word document draft complied of emails that nobody can understand yet. No government has the right to withhold prescription drugs and work authorizations from anybody because jobs belong to those, whose lives depends on them, instead of to any governmental authority! All authoritative actions must be minimized to their absolute necessity to prevent the harm of other. The attached file reveals how to work safely without work authorization as a freelancer worldwide at freelancer web portals like www.freelancer.com, www.guru.com, www.upwork.com, www.iindeed.com which require a single tax ID under which many different freelancers from different countries can hide their freelance earning from anywhere where freelancing is legal and the internet is fast. Huge enterprises, such as www.google.com, www.facebook.com, www.apple.com, www.sap.com, www.microsft.com, www.oracle.com, www.ibm.com and other software developer companies can be transformed from employment based to freelancer based software development because everything should be done remotely anyways because of COVID 19.. Thus, the software development giants can safe lots of money by letting freelancers compete for projects instead of hiring employees because freelancers don't receive employee benefits such as vacation, sick leave, 504K, health and job site insurance,, advanced notice of job termination, baby off time, etc. Why has nobody figured this out until now? Since www.Facebook.com is trying to keep censoring me by removing my option to attach files that violate Facebook's Community Standards, you can click at the link below to download the same file from www.academia.edu https://www.academia.edu/s/9d561fce59.
How can all governments be overthrown simultaneously to reduce the lack of employment related sui... more How can all governments be overthrown simultaneously to reduce the lack of employment related suicide risk in only 20 years? The unmet prerequisite for this revolution is that international freelancer strangers decide to trust each other financially more than their own government because a few countries don't collect income tax. This attached writing violates the Community Standards of Facebook and is therefore only included in attached 144 pages long MS Word document draft complied of emails that nobody can understand yet. No government has the right to withhold prescription drugs and work authorizations from anybody because jobs belong to those, whose lives depends on them, instead of to any governmental authority! All authoritative actions must be minimized to their absolute necessity to prevent the harm of other. The attached file reveals how to work safely without work authorization as a freelancer worldwide at freelancer web portals like www.freelancer.com, www.guru.com, www.upwork.com, www.iindeed.com which require a single tax ID under which many different freelancers from different countries can hide their freelance earning from anywhere where freelancing is legal and the internet is fast. Huge enterprises, such as www.google.com, www.facebook.com, www.apple.com, www.sap.com, www.microsft.com, www.oracle.com, www.ibm.com and other software developer companies can be transformed from employment based to freelancer based software development because everything should be done remotely anyways because of COVID 19.. Thus, the software development giants can safe lots of money by letting freelancers compete for projects instead of hiring employees because freelancers don't receive employee benefits such as vacation, sick leave, 504K, health and job site insurance,, advanced notice of job termination, baby off time, etc. Why has nobody figured this out until now? Since www.Facebook.com is trying to keep censoring me by removing my option to attach files that violate Facebook's Community Standards, you can click at the link below to download the same file from www.academia.edu https://www.academia.edu/s/9d561fce59.
How can all governments be overthrown simultaneously to reduce the lack of employment related sui... more How can all governments be overthrown simultaneously to reduce the lack of employment related suicide risk in only 20 years? The unmet prerequisite for this revolution is that international freelancer strangers decide to trust each other financially more than their own government because a few countries don't collect income tax. This attached writing violates the Community Standards of Facebook and is therefore only included in attached 144 pages long MS Word document draft complied of emails that nobody can understand yet.
Now it has become a self-fulfilling prophecy that I am a threat because I keep getting punished b... more Now it has become a self-fulfilling prophecy that I am a threat because I keep getting punished by being unfairly deprived of my Constitutional Rights, especially freedom of speech. But I am like a rubber band that feels angry when authorities abuse their power and overstretch it to the point that it hurts. It takes too much energy and efforts to keep me stretched and I will snap back eventually unless I will be given the opportunity to legally request euthanasia in Belgium of I should ever get deported back into the European Union (EU).
Actually, I became a threat because while I was hospitalized at the 10th floor in the suicide psych ward at www.lcmh.com from June 24th until July 3rd, 2020 because my mind had no other choice than to spin until it found at least a theoretical remedy for this conundrum in the future described at the now blocked link
Belgian law allows euthanasia for patients who suffer from severe and incurable distress including psychological disorders.
Belgian law allows euthanasia for patients who suffer from severe and incurable distress, including psychological disorders.Photograph Courtesy Tom Mortier
My research is about violation of freedom of speech, Constitutional Rights, human behavior, ignor... more My research is about violation of freedom of speech, Constitutional Rights, human behavior, ignorance, fear, suicide, isolation, lack of communication and understanding, Anarchy, Politics, Social Science, Economy, Discrimination, Equality, Competition, Immigration, Employment, human behavior prediction, Revolutions, mind control, machine learning, modeling, crisis prevention, trust, safety, causal relationships, dimensions, changes over time, manipulations, intuition, mental illness, belonging, psychology, psychiatry, medicine, science, authority, grouping, similarities, dissimilarities, inductive and deductive reasoning, conspiracy theory, mind and though process control, immigration, intuition, fear, destiny, loss of freedom and how the consequences of the interplay between these example dimensions, especially of subjective feelings of regrets, will shape our future over time (social time series experiments) .
My research is about violation of freedom of speech, Constitutional Rights, human behavior, ignor... more My research is about violation of freedom of speech, Constitutional Rights, human behavior, ignorance, fear, suicide, isolation, lack of communication and understanding, Anarchy, Politics, Social Science, Economy, Discrimination, Equality, Competition, Immigration, Employment, human behavior prediction, Revolutions, mind control, machine learning, modeling, crisis prevention, trust, safety, causal relationships, dimensions, changes over time, manipulations, intuition, mental illness, belonging, psychology, psychiatry, medicine, science, authority, grouping, similarities, dissimilarities, inductive and deductive reasoning, conspiracy theory, mind and though process control, immigration,intuition, fear, destiny, loss of freedom and how the consequences of the interplay between these example dimensions, especially of subjective feelings of regrets, will shape our future over time (social time series experiments) .
My research is about violation of freedom of speech, Constitutional Rights, human behavior, ignor... more My research is about violation of freedom of speech, Constitutional Rights, human behavior, ignorance, fear, suicide, isolation, lack of communication and understanding, Anarchy, Politics, Social Science, Economy, Discrimination, Equality, Competition, Immigration, Employment, human behavior prediction, Revolutions, mind control, machine learning, modeling, crisis prevention, trust, safety, causal relationships, dimensions, changes over time, manipulations, intuition, mental illness, belonging, psychology, psychiatry, medicine, science, authority, grouping, similarities, dissimilarities, inductive and deductive reasoning, conspiracy theory, mind and though process control, immigration,intuition, fear, destiny, loss of freedom and how the consequences of the interplay between these example dimensions, especially of subjective feelings of regrets, will shape our future over time (social time series experiments) . Today is a sad day because I can no longer deny that we never had any freedom of speech to begin with.
Many people experience too much stress caused by uncertain work visa issues. How would it feel i... more Many people experience too much stress caused by uncertain work visa issues. How would it feel if the governments compete for you to have your freelance earnings taxed by them instead of you begging and praying for your work visa to get approved? This proposed economic scenario might be a solution that will come like a self-fulfilling prophecy if everybody simply does what I propose without fear of punishment because as a consistently disobedient group we are stronger than any authority can ever be.
Newest not yet shared unpreventable risk development awareness in progress.
Every dedicated grou... more Newest not yet shared unpreventable risk development awareness in progress. Every dedicated group can set up freelancing portals like www.guru.com, www.upwork.com, www.freelancer.com, etc., to secretly coordinate more activities than multinational global companies, such as Facebook, Microsoft, SAP, Google, etc. without raising suspicion for expanding indirect power and influence much further. This could lead to the creation of much more powerful invincible imperceptible virtual nations by anyone, who cares to understand why. This might be destined to happen eventually, because I have been forced to understand this, unless I can get help to end my life before others care to understand it too. If I must stay alive, I cannot avoid getting converted into the "bad" guy, I never wanted to be. Should anything be done about it? Why or why not?
================================================================
Newest still unshared unpreventa... more ================================================================ Newest still unshared unpreventable risk developments in progress. Every dedicated group, that can set up freelancing portals like www.guru.com, www.upwork.com, www.freelancer.com, etc., can secretly coordinate the same activities as multinational global companies, such as Facebook, Microsoft, SAP, Google, etc. without raising suspicion to expand its indirect power and influence much further than any government or company can. This could lead to the creation of more powerful invincible imperceptible virtual nations by anyone, who cares to understand why. This might be destined to happen eventually, because I have been forced to understand this, unless I can get help to end my life before others care to understand it too. If I must stay alive, I cannot avoid to get converted into the "bad" guy, I never wanted to be. What should I do to stop it? =================================================================
The Program of All-Inclusive Care for the Elderly (PACE) (2013)[6] study aimed to find out if the... more The Program of All-Inclusive Care for the Elderly (PACE) (2013)[6] study aimed to find out if the program we designed for the 11 month treatment can efficiently help people lose weight, and even can keep tracking of weight loss and body fat by checking some of the parameters we measured during the 11 months. We worked on the potentially significant parameters for weight loss in 11 months, such as age, height, weight, body size and body fat. We used association rule mining and classification rule mining to discover which parameters are significant for weight loss and what are the associations between weight loss and those significant parameters. Experimental results showed that weight loss with support from 0.2 to 0.9 and confidence from 0.7 to 1.0 is related to body weight and the changes of chest size, arm size, waist size, thigh size and hip size. In future, we will discover the associations among body weight, body size, body fat, heart beat and blood pressure.
This research pertains to the applications of data mining of microarray databases for large-B-cel... more This research pertains to the applications of data mining of microarray databases for large-B-cell Lymphoma and metastasis cancer, the latter of which little has been known about the genomic events that regulate the transformation of a tumor into a metastatic phenotype.
Named Entity Recognition (NER) in biomedical literature is a very active research area. NER is a ... more Named Entity Recognition (NER) in biomedical literature is a very active research area. NER is a crucial component of biomedical text mining because it allows for information retrieval, reasoning and knowledge discovery. Much research has been carried out in this area using semantic type categories, such as “DNA”, “RNA”, “proteins” and “genes”. However, disease NER has not received its needed attention yet, specifically human disease NER. Traditional machine learning approaches lack the precision for disease NER, due to their dependence on token level features, sentence level features and the integration of features, such as orthographic, contextual and linguistic features. In this paper a method for disease NER is proposed which utilizes sentence and token level features based on Conditional Random Fields using the NCBI disease corpus. Our system utilizes rich features including orthographic, contextual, affixes, bigrams, part of speech and stem based features. Using these feature ...
Hiring decisions can be risky. How much can employers save by better understanding the motivation... more Hiring decisions can be risky. How much can employers save by better understanding the motivations and objectives of each applicant? How much time and expertise should be invested in getting to know each applicant? Will such efforts raise the return on investment? What are the shortcomings and deficits of the criteria to evaluate, compare and rank applicants? How do they need to get changed to reflect the shift in the relative order of job skills between employees when the composition of the team (total of all employees) changes by hiring, firing or replacing? A job description combines tasks and steps to a random set of job responsibilities. But could there be better ways to bundle tasks together and to look for the most qualified applicant for this particular arbitrarily defined task bundle? Could the employer benefit from regrouping all small tasks, which a company must perform, by changing which and how many small job tasks will be bundled together in different job descriptions? And if so, how can reassigning each little tasks from different jobs to the most suitable employee (task-centered approach) instead of looking for the most qualified applicant for a particular job (job-centered approach) help in improving productivity and profitability? How and why will the new task-centered approach help to increase the workforce diversity more than the job-centered approach? How can reassigning tasks help disabled and handicapped lacking essential job functions to get hired anyways? How can employers benefit from not only looking for the most qualified applicant for any particular job (i.e. arbitrarily bundle of tasks and steps) Why does the task-centered based hiring decision benefit employees, employees, applicants and disabled job-seekers more than job-centered based hiring decisions? What are the benefits to seek the best employee for each task (task-centered) instead of the most qualified applicant for a particular job? How can employers benefit from a paradigm shift replacing the job-centered with the task-centered hiring perspective? How can the multi-dimensional effects, which different combinations of employees (i.e. teams) on the overall productivity and profitability be measured? How much welfare and unemployment benefits could be saved if employers were aware of the additional benefits when making task or employee based hiring decisions instead of exclusively looking for the most qualified applicant? How can reassigning job-tasks to different employees help applicants to become the most qualified job-seeker despite lacking essential job functions? How could employers be convinced that they'd benefit most from reassigning tasks from different jobs to the employee most qualified for a particular task instead of only looking for the best applicant for a particular job consisting of an arbitrary bundle of tasks?
Update from Donald Trump and the Equal Employment Opportunity Commission (EOEC) uploaded on Sunda... more Update from Donald Trump and the Equal Employment Opportunity Commission (EOEC) uploaded on Sunday 11/19/2017
I received the email below already 4 days ago. I was glad when I read that somebody understands at least parts of my long writings. I know now that my property or attribute of being classified as a foreigner overwrites my disability attributes, which make all other disabled job-seekers eligible for Schedule A. I was hoping that my disability attributes and the need for Schedule A to become gainfully employed would overwrite my foreign student status because both are mutually exclusive.
Thank you for your letter to President Donald Trump which was forwarded to the Office of Disability Employment Policy (ODEP) at the U.S. Department of Labor (DOL) for a response.
We appreciate you sharing your thoughts on the current hiring practices used by employers in the United States, your desire to find employment, and your concerns about your visa status. As you may know, ODEP fulfills its mission by promoting the adoption and implementation of ODEP policy strategies and effective practices — meaning those that ODEP has developed and/or validated — that will positively impact the employment of people with disabilities. ODEP is a non-regulatory agency and does not assist job seekers in finding employment.
While we do not enforce employment policies, we do promote and encourage the adoption of strategies and practices that increase the employment of people with disabilities. The concept of employers leveraging an individual job seeker’s skills and abilities rather than relying on a standard list of tasks or job description to determine whether an individual is qualified for a position is an approach ODEP has supported for many years.
Through an approach ODEP has termed customized employment, the relationship between the employer and potential employee is customized in such a way as to meet the needs of both parties. For many years, ODEP has promoted customized employment as an additional workplace flexibility policy (also known as flexible work arrangements) and/or practice within the workforce. ODEP has evidence-based research data showing that customized employment leads to positive employment outcomes for individuals with disabilities and continues to promote the strategies and data through education, outreach, and collaboration with other federal agencies and private organizations. You can find out more about customized employment at: https://www.dol.gov/odep/topics/CustomizedEmployment.htm
Any questions related to your visa status and its impact on potential employment opportunities should be directed to the Department of Homeland’s Security U.S. Citizenship and Immigration Services (DHS/USCIS). This link describes all the ways you may contact the agency: https://www.uscis.gov/about-us/contact-us
We hope this information is helpful.
Sincerely,
Michael Reardon Supervisory Manager Employment-related Supports Team
General and comparative endocrinology, Jan 28, 2016
Medullary bone, a non-structural osseous tissue, serves as a temporary storage site for calcium t... more Medullary bone, a non-structural osseous tissue, serves as a temporary storage site for calcium that is needed for eggshell production in a number of avian species. Previous research focusing primarily on domesticated species belonging to the Anseriformes, Galliformes, and Columbiformes has indicated that rising estrogen levels are a key signal stimulating medullary bone formation; Passeriformes (which constitute over half of extant bird species and are generally small) have received little attention. In the current study, we examined the influence of estrogen on medullary bone and cortical bone in two species of Passeriformes: the Pine Siskin (Spinus pinus) and the House Finch (Haemorhous mexicanus). Females of these species received either an estradiol implant or were untreated as a control. After 4.5-5months, reproductive condition was assessed and leg (femora) and wing (humeri) bones were collected for analysis using high-resolution (10μm) micro-computed tomography scanning. We ...
We present a simple package for distributing evaluations of a Mathematica function for many argum... more We present a simple package for distributing evaluations of a Mathematica function for many arguments on a cluster of computers. After setting up the hosts, the only change is to replace Map[f,points] by MapCore[f,points].
... al [6], they have already provided an algorithm for real-time natural hand gesture detection ... more ... al [6], they have already provided an algorithm for real-time natural hand gesture detection in their ... So they are using for there whole communica-tion with the computer a simple webcam for the ... This ranking is based on the fact that multi-touch devices with the iPad as a cutting ...
Why should the concept of Imperatively Hidden Elements (IHE) become common knowledge, especially ... more Why should the concept of Imperatively Hidden Elements (IHE) become common knowledge, especially in machine learning and feature selection? Did everyone, except for me, knew all along that our scientific progress-rate limiting bottlenecking factor is proper feature selection but not the lack of advances in improving our machine learning algorithms? I assumed that this could not be the case because most publications present improvements in machine learning algorithms, but neglect to even mention that lack of progress in better feature selection is preventing us from making any significant progress but not poorly performing machine learning algorithms. I thought that if I did not know that until my defense, then most others, especially those who don't know much about machine learning yet, i.e. most of our wet-lab biologists, who need to design their experiments accordingly, are not aware of this problem either. Then I thought I must tell them or else they keep mistakenly misinterpreting unpredictable outcomes as unavoidable noise instead of correctly realizing that still imperatively hidden elements (IHE) affect our predicted outcome in manner, which we cannot yet explain, unless we start observing the last temporal visible object/observation/event, after which we can no longer correctly predict the chain of subsequent events or observations, from many different perspectives and angles in order to really scrutinize it legitimacy, because most likely, it is composed of more than a single visible object (VO), of which we are already aware, because an undetermined number of distinctly different, but yet still imperatively hidden; thus inevitably for us still imperceptible, but nevertheless fully legitimate and truly existing yet invisible objects look too similar to our only visible object, which tricks us into the illusion of erroneously believing that it's only a single object. But the truth is that it is actually 2 or more objects, between which we cannot yet distinguish. Nevertheless, the number of possible outcomes depends on the number of truly existing objects, regardless whether or not we can distinguish them from their background. For example, until this morning, I was not aware of the difference between Python and Cython. Cython was for me in imperatively hidden object, which to me looked exactly like Python, because Cython is almost identical to Python, except for, that its variables must be of a specified type, e.g. string, vector, list, numeric, data frame, etc., which is not the case in Python. This led to my observation that some Python packages run fine on Windows whereas other never worked. Since the PyAffy.py library must have been written in Cython, it tricked me into the illusion that the only way to use a Python package, which fails to run under Windows, is to use Linux. It took us 3 months to set up a Linux laptop I could see. Now I discovered that we could have copied the Cython code and save it as a Python file by omitting specifying the variable type and run it just like a Python file. If we had used machine learning to discover the reason for some Python packages, specifically the PyAffy-package not running under Windows, could machine learning figure out that the feature " variable type selection " , which is a Boolean of present or absent, can be used to distinguish between Python and Cython? If we just gave the programming code of Python libraries and the outcome of running and not running as training data for supervised machine learning, could it figure out without any prior knowledge about Cython, that a programming language other than Python is causing problems under Windows? Can machine learning learn programming? Can it learn to conceptually understand the differences between variable types, If the concept of IHE is true, then most graduates are not well prepared to deal with imperatively hidden elements (IHE), because they appear to be totally left in the dark about this dangerously unnecessarily very time-consuming temporary progress-preventing nettlesome barrier, which can halt progress for many years, because nobody ever shared with them (i.e. our future wet-lab scientists, who must choose wisely, which data they collect for the computational analysts, to reach valid conclusions) the concept that the risk for misinterpreting poor outcome predictability as unavoidable background noise instead of getting alerted that a still imperatively hidden element (IHE), which we cannot perceive yet, creates a much bigger and more dangerous obstacle, than any visible element, which has at least one feature that causes it
I found Osh6 at a very high rank of lifespan extending genes. That is why I want to take all the genes that are part of the same molecular function as Osh6 and run an expression similarity analysis on SPELL (Serial Pattern of Expression Levels Locator) (see spell.yeastgenome.org/).
I hope to find genes of unknown functions that could be involved in the same molecular function. If I find this, I'll validate with my time series plots and TFBS similarity analysis. That way I hope to predict the function of an unknown gene in lipid metabolism. I will also try the opposite approach, i.e. I'll take genes of unknown function and look for a group of similarly expressed genes, which belong to the same GO term.
I added 19 pages to the second chapter. I was able to further improve the accuracy of my yeast lifespan predicting machine learning algorithm by adding more features about lipids. My last draft had an average prediction error of +/-5 replications. Now it is less than +/-3 replication for the 50th percentile of the replicative lifespan. To my knowledge nobody has published any research on about using machine learning and feature selection to predict the replicative age.
If you have any more ideas how I could make my dissertation look better, I'd be very thankful for any new feasible ideas and inspirations. I have mainly been using Python and R for all my analysis.
I found that ribosomal RNA and proteins are most closely follow the cell cycle and that if knocked out the yeast's lifespan can be extended significantly. I want to use the different cyclical periodically recurring and highly fluctuating gene expression oscillation pattern to discover the functions of genes we have not yet discovered. I am interested in this because a friend of mine showed me a cancer dataset that looked very similar. Since cancer is very similar to the yeast in that it keeps constantly dividing and hence its age can be expressed in replication we could use the same guilt-by-association approach to infer the functions or at least the way their expression is controlled by TFs from genes with similar temporal expression patterns of genes with already known functions.
When analyzing the time series plots of the 62 yeast chaperons I discovered that their expression plot trajectories can easily be clustered into 7 expression patterns, which are consisted with the 7 classes of yeast chaperons. If I had only taken the average centroid of all 62 chaperons I would have been misled because using this approach could not be applied to potentially discover more new currently still unknown chaperons because no unknown chaperon would have time series trajectories, which would highly correlate with the average chaperon expression pattern of all 7 classes since their in-group expression pattern is very homogeneous but between the 7 different chaperon classes the expression pattern is very different.
I intended to elucidate the different ways by which we age by a very similar clustering algorithm, which I have developed based on time series curves over three subsequent yeast cell cycle consisting of 36 mRNA measures each about 25 minutes apart; thus, allowing to measure very steep mRNA expression fluctuation periods by manifold within the only 90 minutes of the cell cycle because even very brief but rapid expression changes that last not much longer than 1/12th of a cell cycle, of which I found surprisingly many.
Aging is one of the chief biomedical problems of the 21st century. After decades of basic researc... more Aging is one of the chief biomedical problems of the 21st century. After decades of basic research on biogerontology (the science of aging), the aging process still remains an enigma. Although hundreds of "theories" on aging have been formulated and many fundamental insights about age-related changes and genetic as well as environmental interventions that change the pace of aging have been discovered, the actual why and how we age remain enigmatic. In the post-genomic era there is an exponential increase in data. As a consequence it is a challenge to utilize all information based on it and derive meaningful knowledge about biological phenomena. No individual scientist, no group, nor consortium is capable of keeping up within their own field and are overwhelmed by the explosion of data increase. Machine learning applied on biological data has the potential to solve this and cause a paradigm shift from hypothesis-driven research (which predominates biological research including biogerontology) to data-driven research. This dissertation addresses this problem. In particular it proposes and executes the use of machine learning on current existing data to predict drivers of aging (and therefore helps to distinguish causes from consequences), interventions to counteract aging, and specific hypotheses to fill in research gaps that require experimental validation. The objective of this project is therefore to build computational models that are based on data relevant to the phenomenon of aging and to predict as many of its aspects and dimensions as possible (thus elucidate their relations to each other). For converting between and sorting within dimensions which are relevant to aging, different machine learning models are evaluated. Ones models are built, it can be determined how much they can explain different aspects of aging. Those models will also be capable of specifying which features are most relevant for prediction (in both classification or regression). It is possible to train models that incorporate age-related changes based on transcriptomic, proteomic, metabolomic, epigenomic as well as morphological data and their combinations. Machine learning is further used to convert between and within them. This work focuses on three types of predictors. Subsequently, discoveries are made with the statistical and learning algorithms. The first model (lifespan predictor) is trained on predicting the lifespan based on genotype, environment and combinations thereof. It is useful for predicting lifespan extending interventions on the population level. The second model (age predictor) is trained on predicting the age given features measured on individuals. This is useful for identifying biomarkers of aging and to determine the effects of interventions on the level of individuals. The third model predicts functions/regulations of biological entities in regard to the aging process based on heterogeneous data such as ontologies and diverse omics including time-series gene expression profiles (which can be visualized as plots), and linked data. It is used to understand the role of genes and proteins as well as perhaps other entities such as small molecules including lipids and other metabolites. Functions of proteins, which are still unknown, especially those involved in yeast lipid metabolism and its regulation, can be predicted. For this purpose we use primarily yeast as model organism as well as data on humans. Other biomedical model organisms might be added if found beneficial. The novel aspects of this research are for instance that 1) aging is investigated systematically in an unbiased data-driven approach, 2) lifespan is predicted as continuous values, 3) age is predicted by combining multiple omics data, 4) functions and regulations of biological entities like genes are predicted with high confidence from heterogeneous data sources. This thesis discovered that genetics is the most important feature of lifespan determination. Phenotypic features related to lipid and membranes such as vacuolar morphology and autophagy activity are important for lifespan determination according to the best performing models. A age predictor based on transcriptomics and proteomics can highly accurately determine the age. It selected features are associated with both translation and lipid metabolism. Among the top selected features are transcripts of genes when deleted exhibit abnormal vacuolar morphology as well as targets of Opi1. Opi1 itself and its regulators were found to be differentially regulated post-transcriptional or post-translational. Lastly, a function predictor for genes was created that achieved exceptional accuracy of classifying aging genes. It learned for instance that piecemeal autophagy of the nucleus is strongly predictive for aging-suppressor genes while cytoplasmic translation is strongly predictive for gerontogenes
Why some ideas survive and others die?
Talk Nerdy to Me: Making Connections for Audience Enga... more Why some ideas survive and others die?
Talk Nerdy to Me: Making Connections for Audience Engagement Adapted from Heath, C., & Heath, D. (2007). Made to stick: Why some ideas survive and others die. New York: Random House?
Directions: Working with your research, brainstorm connection ideas for the following.
WHAT is the core idea of your research? (the most important idea) (Give others the bigger picture and connect it) ex. The Helicopter View
In no more than two sentences, state the big picture (core idea) of your research:
The core idea of my research is that if we cannot find the secret for aging by looking only where data may point us, we must start looking somewhere else, even if no data points in this direction. To accomplish this we must change perspectives and need to spend time reading my long comparative analogy narratives.
Compare: What “common” things/ideas is your core idea like?
If you cannot find your favorite sweater in your closet, there is no point to keep looking for it in your closet over and over again; but instead, you may need to start looking elsewhere, e.g. in your drawers, even if you may not recall to ever have put it there, but somebody else might. So if for certain, the item or answer you are looking for cannot be found in its most likely place, then its better to start looking at less likely places despite lacking any logically seeming connections or explanations.
Contrast: What “common” things/ideas is your core idea NOT like?
The answers are not obvious because crucial concepts are still missing. We can only find them by trying to generate new experimental data aiming to exclude initially crazy hypotheses, which may not be crazy after all, as long as they remain internally consistent.
WHY is your research important? WHY should the audience care?
After I graduate people will forget about my intuitive insights. We may lose more than 50 years in anti-aging research and will lose billions of people unnecessarily due to aging before data may point us to look in the same directions as I am trying to propose despite the lack of reproducible evidence due to the lack of suitable datasets.
How does your research impact the everyday person? (Be creative here)
It’s our very survival, which most of us have not yet realized lies within our hands if we’ll reach out and grab it hard enough, long enough and creatively enough.
What are better way to create undetectable global economic monopolies, 2022
Creating Undetectable Economic Monopolies (CUEM) helps people without work authorization to earn ... more Creating Undetectable Economic Monopolies (CUEM) helps people without work authorization to earn an income on a global level. It will lead to a revolution in the globalization of the virtual workforce. When my OPT work authorization expired on 10/7/19 because I have faced too much discrimination by employers, I was forced to start thinking about how to make a living without work authorization. My past freelancing experiences helped me to realize that it is impossible to detect, who adds value by performing virtual freelancing at freelancing websites, such as www.upwork.com, www.guru.com, www.freelancer.com, www.indeed.com, etc. This allows undocumented workers to perform freelancing work under other people's tax ID, globally. Interestingly, countries like Bangladesh, Oman, the United Arabic Emirates (UAE) do not collect income tax resulting from virtual online freelancing work. The decision not to tax freelancing earnings gives those countries a competitive economic adantage because this tempts freelancers, who must pay high taxes on their freelancing earnings, to register their freelancing earnings under them for - let’s say 1% - to avoid getting taxed much higher for them by their own governments. This contributes to the wealth accumulation in those countries that have chosen not to tax incomes earned by freelancing. Furthermore, it is possible to substitute regular job descriptions to which traditional employees or contractors can apply with project descriptions for which freelancers can bit online. Moreover, it is possible to operate huge companies by posting freelancing projects, for which freelancers are invited to bit, instead of job descriptions, for which aspiring employees are invited to apply to get hired for a particular job. This will save the company lots of money because, unlike employees, freelancers are not entitled for employment benefits, such as health insurance, sick leave, paid vacations, child leave, retirement, etc. Moreover, the boundaries of companies using this trick become blurred and eventually undetectable because nobody can suspect that all the posted freelancing projects together add up to the business operations of huge companies (i.e. much bigger than they are today) because other people post their freelancing projects, which have nothing to do with the secret large company as well. This will prevent the still very powerful American Antitrust laws to split up companies that have succeeded in establishing national or even global economic monopolies. Over time, this can stop national governments from enforcing employment restrictions within their jurisdiction if more people have the courage to circumvent them than can get punished for it. This will hopefully contribute towards dissolving the traditional nation state as we know it because its governments tend to restrict employment opportunities unfairly and arbitrarily Even though this may sound frightening at first, I expect it to have an overall beneficial instead of harmful effect, because every secret consortium is free to use the same trick to establish its secret undetectable monopoly in order to maximize its profits. Over time this might make national governments obsolete. I hope that this will result in those secret global economic consortiums to pay more attention to the needs of their freelancers than national governments to the needs for their citizen. Controlling secretly multiple companies that everyone else believes compete against one another can have many still unrecognized economic advantages with the inherent risk that those, who decide to use this trick, can - over time - run every organization, which does not, out of business. This may be harder to put into practice in our democracies with our free market economies than in dictatorships with planned economies. This is a big risk factor that should not get ignored any longer. For example, lets imagine that the Iranian and Cuban secret service form a secret consortium to secretly manipulate cell phone battery manufacturing companies without them being aware of it. Let’s say that the Iranian cell phone battery manufacturer develops a new battery that lasts 5 days and starts marketing it globally. Let’s say that the secret consortium decides to steal this technology from the Iranian cell phone battery company to the Cuban cell phone battery company. If the Cubans suddenly start to compete against the Iranians with its own technology despite lacking the funds for Research and Development, this creates fear in the Iranian company to get run out of business by its underestimated Cuban competitor. This will cause the Iranians to invest more in their Research and Development to stay ahead of its underestimated Cuban competitor. Over time, this secret Iranian / Cuban consortium can learn what business factors they must change within the companies, which they are secretly controlling, to make them more competitive against one another over time. By doing so, they will eventually succeed in running every competitor, who cannot use the same trick, out of business.
¿Cuáles son los beneficios no reconocidos para luchar por una independencia incondicionalmente responsable individualmente para todos (es decir, la anarquía)?
¡Proponer la revolución para la independencia incondicional, incluidos los enfermos mentales, por... more ¡Proponer la revolución para la independencia incondicional, incluidos los enfermos mentales, porque nuestros conceptos actuales de enfermedad y el propósito de nuestro sistema legal son defectuosos!
Es esencial para nuestro bienestar individual subjetivo exigir agresivamente un control completo sobre todos los aspectos subjetivamente relevantes de nuestras vidas, p. autorizaciones de trabajo, trabajos, visas, medicamentos recetados, etc. de cada gobierno, médico, ley, juez, policía, policía, parientes, amigos, superiores, militares, etc. en todo el mundo simultáneamente para recuperar el control total sobre un individuo nivel.
Por lo tanto, la autoridad final sobre drogas, empleos, visas, libertad de expresión, actividades comerciales, tratamientos médicos, etc. pertenece a todos, que subjetivamente se sienten afectados negativamente sin ella, en lugar de cualquier tipo de gobierno, aplicación de la ley, profesionales, expertos, médicos, instituciones, etc.
Por ejemplo, cualquier paciente que necesite estimulantes para el TDAH en los EE. UU. También los necesita en cualquier otro país, independientemente de sus leyes.
La gente como yo necesita un propósito en la vida para mantenerse con vida. Un trabajo significativo me daría un propósito tan esencial para la vida sin el cual ya no puedo seguir con vida por mucho más tiempo. En consecuencia, ningún gobierno tiene ningún derecho legítimo de determinar quién está permitido y quién tiene prohibido trabajar en un país en particular.
Solo dos personas son lo suficientemente poderosas como para dominar a cualquier gobierno del mundo. Una persona debe ocultar en secreto a un inmigrante ilegal bajo su identificación fiscal. Esto se puede hacer fácilmente configurando perfiles independientes, p. en www.indeed.com, www.guru.com, www.upwork.com, etc.
Además, esta forma de ocultar a los inmigrantes ilegales permitiéndoles trabajar sin autorización de trabajo hace posible el desarrollo gradual e indetectable de los monopolios del mercado económico, e incluso probable, con el tiempo.
Esto es esencial para gradualmente ser indetectable y dominar simultáneamente a todas las autoridades actuales en todo el mundo con el fin de transferir el poder absoluto absoluto y el control completo sobre todos los aspectos relevantes de la vida a todos, que subjetivamente sienten que su propia vida estaría en riesgo o afectada negativamente de lo contrario. Por lo tanto, todos deben esforzarse por quitarle cualquier autoridad a alguien que afecte negativamente cualquier aspecto relevante de la vida, p. medicamentos recetados, tratamientos médicos, trabajos, residencia, actividades sociales y políticas, libertad ilimitada de expresión y expresión, etc.
Todos los que luchan con cualquier tipo de desafío están automáticamente más calificados para determinar la mejor manera de superar su desafío individual que cualquier otra persona. Los amigos pueden ayudar escuchando, entendiendo y haciendo sugerencias, pero la solución final a cualquier problema individual en particular siempre debe estar bajo el control total de aquellos afectados negativamente por él. No debe haber tabú para responder a problemas, incluido el suicidio.
No hay autoridades, gobiernos, jueces, médicos, policías, agentes del orden, médicos, padres, amigos, profesionales, expertos, etc. que puedan estar más calificados para tomar la determinación final sobre responder a un problema en particular que la persona en particular, que está luchando subjetivamente con sus consecuencias adversas directamente!
Esto parece ser inesperadamente difícil para cualquiera de comprender y estar de acuerdo. Desafortunadamente, eso no lo hace menos cierto si realmente se aplica subjetivamente a la vida de alguien, que subjetivamente se siente de esta manera, ¡por cualquier razón o sin razón alguna!
Por lo tanto, me refiero a este tipo de revolución para la independencia responsable incondicional para todos a la "Revolución Anarquista Responsable".
Honestamente, todavía no puedo entender la razón por la cual mi propia vida es obviamente mucho menos importante que mi estatus migratorio y las leyes que rigen su determinación.
En lugar de orientarnos a procedimientos y reglas, debemos actuar orientados a objetivos para reducir el riesgo creciente de suicidio.
What are the generally unrecognized benefits to strive for complete unconditional individually re... more What are the generally unrecognized benefits to strive for complete unconditional individually responsible independence for all (i.e. anarchy)? Proposing the revolution for unconditional independence, including the mentally ill, because our current concepts of illness and the purpose of our legal system are flawed! It is essential for our subjective individual well-being to aggressively demand complete control over all subjectively relevant aspects of our lives, e.g. work authorizations, jobs, visas, prescription medications,, etc. from every government, physician, law, judge, police, law enforcement, relatives, friends, superiors, military, etc. everywhere in the world simultaneously to regain full control on an individual level.
The key to the keys to immortality and eternal youth lies in the correct answer to the main quest... more The key to the keys to immortality and eternal youth lies in the correct answer to the main question: How to naively discover new essential – but still hidden – features required for properly training novel adaptive supervised machine learning algorithms (SMLA)
The evil mistress of Satan put me under her spell to test if she could do the same that she could... more The evil mistress of Satan put me under her spell to test if she could do the same that she could do to the American President Joe Biden. And even it is most embarrassing for me to confess that she succeeded I must put it here so that somebody else can warn the Biden Administration from the realistic scenario she exposed me to described below
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Ever since sometimes before 10 a.m. on 06/03/23 when I realized that it is more important to connect to the Biden Administration instead of clocking in for my regular Walmart (https://www.walmart.com/store/126-little-rock-ar) shift at 10 a.m. a Russian computer virus slowed down my laptop with Windows 7 and Zoomtext 10. My rational reasons to fear for my life, health safety and the immanent violation of freedoms and rights granted to me by the American Constitution have been discredited or ignored by everyone with whom I shared them (more than 1000 people) ever since I was deported to Cancun on an Interjet flight that departed from Havana at 5 p.m. on 12/09/19. Someone told me that 911 was preventable if the email by which the terrorists shared critical details about their immanent attack had not only been captured by the CIA but were also translated from Arabic into English before the 911 attack occurred. Since about 11 a.m. when I started trying to verify this fact on Google I am suddenly overwhelmed with many crazy computer and internet problems I can’t handle because I am visually impaired due to Albinism. Like 911 was preventable the problems forcing me now to connect to the Biden Administration ASAP were preventable if my Walmart had continued encouraging me to keep sharing any concerns after the former store manager Carlos Santiago, who hired me in July 2202 stopped working at my Walmart last winter. Refer to my 1st unsolicited email to him 1 day before Walmart started paying me as evidence below:
From: Thomas Friedbert Hahn <thomas.fried.hahn@gmail.com>
Date: Mon, Jul 11, 2022 at 10:26 PM
Subject: Please find my employment authorization for the orientation tomorrow attached.
To: Carlos Santiago - cas00k9.s00126 <cas00k9.s00126.us@Walmart.com>
It is now 6:51 p.m. CST.
Skype ID is TFH002
Google Voice: 501 301 4890
Straight Talk: 501 515 9794
HahnT4@gmail.com
https://www.researchgate.net/profile/Thomas-Hahn-18
https://www.linkedin.com/in/thomas-hahn-a764a5ab/
Ever since sometimes before 10 a.m. on 06/03/23 when I realized that it is more important to connect to the Biden Administration instead of clocking in for my regular Walmart (https://www.walmart.com/store/126-little-rock-ar) shift at 10 a.m. a Russian computer virus slowed down my laptop with Windows 7 and Zoomtext 10. My rational reasons to fear for my life, health safety and the immanent violation of freedoms and rights granted to me by the American Constitution have been discredited or ignored by everyone with whom I shared them (more than 1000 people) ever since I was deported to Cancun on an Interjet flight that departed from Havana at 5 p.m. on 12/09/19. Someone told me that 911 was preventable if the email by which the terrorists shared critical details about their immanent attack had not only been captured by the CIA but were also translated from Arabic into English before the 911 attack occurred. Since about 11 a.m. when I started trying to verify this fact on Google I am suddenly overwhelmed with many crazy computer and internet problems I can’t handle because I am visually impaired due to Albinism. Like 911 was preventable the problems forcing me now to connect to the Biden Administration ASAP were preventable if my Walmart had continued encouraging me to keep sharing any concerns after the former store manager Carlos Santiago, who hired me in July 2202 stopped working at my Walmart last winter. Refer to my 1st unsolicited email to him 1 day before Walmart started paying me as evidence below:
From: Thomas Friedbert Hahn <thomas.fried.hahn@gmail.com>
Date: Mon, Jul 11, 2022 at 10:26 PM
Subject: Please find my employment authorization for the orientation tomorrow attached.
To: Carlos Santiago - cas00k9.s00126 <cas00k9.s00126.us@Walmart.com>
It is now 6:51 p.m. CST.
Skype ID is TFH002
Google Voice: 501 301 4890
Straight Talk: 501 515 9794
HahnT4@gmail.com
https://www.researchgate.net/profile/Thomas-Hahn-18
https://www.linkedin.com/in/thomas-hahn-a764a5ab/
What are some of the subjective psychological life circumstances undoubtedly shared by Adolf Hitler and Dr. Thomas Hahn that may have preposition them to have no other choice but to get into seriously and passionately opposing the political power structures messing up their lives at least from their often as unjustifiably subjective discredited individual personal perspective even though I can prove later that nothing can ever be considered “objective” since all our observations must inherently be always “subjective” anyway?
What are some of the subjective psychological life circumstances undoubtedly shared by Adolf Hitler and Dr. Thomas Hahn that may have preposition them to have no other choice but to get into seriously and passionately opposing the political power structures messing up their lives at least from their often as unjustifiably subjective discredited individual personal perspective even though I can prove later that nothing can ever be considered “objective” since all our observations must inherently be always “subjective” anyway?
https://www.academia.edu/s/9d561fce59.
https://www.academia.edu/s/9d561fce59.
Actually, I became a threat because while I was hospitalized at the 10th floor in the suicide psych ward at www.lcmh.com from June 24th until July 3rd, 2020 because my mind had no other choice than to spin until it found at least a theoretical remedy for this conundrum in the future described at the now blocked link
http://www.researchgate.net/post/How_can_20_000_people_overthrow_all_governments_simultaneously_to_transition_from_a_work_visa_limited_into_an_HR_and_listening_limited_economy
If I end up getting misclassified as a threat, would euthanasia according to Belgium law be a legally acceptable option?
ye clicking on https://www.newyorker.com/magazine/2015/06/22/the-death-treatment the following text will appear
The Death Treatment
When should people with a non-terminal illness be helped to die?
https://media.newyorker.com/photos/59097b702179605b11ad8f02/1:1/w_270%2Cc_limit/undefined
By Rachel Aviv
June 15, 2015
Belgian law allows euthanasia for patients who suffer from severe and incurable distress including psychological disorders.
Belgian law allows euthanasia for patients who suffer from severe and incurable distress, including psychological disorders.Photograph Courtesy Tom Mortier
Every dedicated group can set up freelancing portals like www.guru.com, www.upwork.com, www.freelancer.com, etc., to secretly coordinate more activities than multinational global companies, such as Facebook, Microsoft, SAP, Google, etc. without raising suspicion for expanding indirect power and influence much further. This could lead to the creation of much more powerful invincible imperceptible virtual nations by anyone, who cares to understand why. This might be destined to happen eventually, because I have been forced to understand this, unless I can get help to end my life before others care to understand it too. If I must stay alive, I cannot avoid getting converted into the "bad" guy, I never wanted to be. Should anything be done about it? Why or why not?
Newest still unshared unpreventable risk developments in progress.
Every dedicated group, that can set up freelancing portals like www.guru.com, www.upwork.com, www.freelancer.com, etc., can secretly coordinate the same activities as multinational global companies, such as Facebook, Microsoft, SAP, Google, etc. without raising suspicion to expand its indirect power and influence much further than any government or company can. This could lead to the creation of more powerful invincible imperceptible virtual nations by anyone, who cares to understand why. This might be destined to happen eventually, because I have been forced to understand this, unless I can get help to end my life before others care to understand it too. If I must stay alive, I cannot avoid to get converted into the "bad" guy, I never wanted to be. What should I do to stop it?
=================================================================
Ever since sometimes before 10 a.m. on 06/03/23 when I realized that it is more important to connect to the Biden Administration instead of clocking in for my regular Walmart (https://www.walmart.com/store/126-little-rock-ar) shift at 10 a.m. a Russian computer virus slowed down my laptop with Windows 7 and Zoomtext 10. My rational reasons to fear for my life, health safety and the immanent violation of freedoms and rights granted to me by the American Constitution have been discredited or ignored by everyone with whom I shared them (more than 1000 people) ever since I was deported to Cancun on an Interjet flight that departed from Havana at 5 p.m. on 12/09/19. Someone told me that 911 was preventable if the email by which the terrorists shared critical details about their immanent attack had not only been captured by the CIA but were also translated from Arabic into English before the 911 attack occurred. Since about 11 a.m. when I started trying to verify this fact on Google I am suddenly overwhelmed with many crazy computer and internet problems I can’t handle because I am visually impaired due to Albinism. Like 911 was preventable the problems forcing me now to connect to the Biden Administration ASAP were preventable if my Walmart had continued encouraging me to keep sharing any concerns after the former store manager Carlos Santiago, who hired me in July 2202 stopped working at my Walmart last winter. Refer to my 1st unsolicited email to him 1 day before Walmart started paying me as evidence below:
From: Thomas Friedbert Hahn <thomas.fried.hahn@gmail.com>
Date: Mon, Jul 11, 2022 at 10:26 PM
Subject: Please find my employment authorization for the orientation tomorrow attached.
To: Carlos Santiago - cas00k9.s00126 <cas00k9.s00126.us@Walmart.com>
It is now 6:51 p.m. CST.
Skype ID is TFH002
Google Voice: 501 301 4890
Straight Talk: 501 515 9794
HahnT4@gmail.com
https://www.researchgate.net/profile/Thomas-Hahn-18
https://www.linkedin.com/in/thomas-hahn-a764a5ab/
Ever since sometimes before 10 a.m. on 06/03/23 when I realized that it is more important to connect to the Biden Administration instead of clocking in for my regular Walmart (https://www.walmart.com/store/126-little-rock-ar) shift at 10 a.m. a Russian computer virus slowed down my laptop with Windows 7 and Zoomtext 10. My rational reasons to fear for my life, health safety and the immanent violation of freedoms and rights granted to me by the American Constitution have been discredited or ignored by everyone with whom I shared them (more than 1000 people) ever since I was deported to Cancun on an Interjet flight that departed from Havana at 5 p.m. on 12/09/19. Someone told me that 911 was preventable if the email by which the terrorists shared critical details about their immanent attack had not only been captured by the CIA but were also translated from Arabic into English before the 911 attack occurred. Since about 11 a.m. when I started trying to verify this fact on Google I am suddenly overwhelmed with many crazy computer and internet problems I can’t handle because I am visually impaired due to Albinism. Like 911 was preventable the problems forcing me now to connect to the Biden Administration ASAP were preventable if my Walmart had continued encouraging me to keep sharing any concerns after the former store manager Carlos Santiago, who hired me in July 2202 stopped working at my Walmart last winter. Refer to my 1st unsolicited email to him 1 day before Walmart started paying me as evidence below:
From: Thomas Friedbert Hahn <thomas.fried.hahn@gmail.com>
Date: Mon, Jul 11, 2022 at 10:26 PM
Subject: Please find my employment authorization for the orientation tomorrow attached.
To: Carlos Santiago - cas00k9.s00126 <cas00k9.s00126.us@Walmart.com>
It is now 6:51 p.m. CST.
Skype ID is TFH002
Google Voice: 501 301 4890
Straight Talk: 501 515 9794
HahnT4@gmail.com
https://www.researchgate.net/profile/Thomas-Hahn-18
https://www.linkedin.com/in/thomas-hahn-a764a5ab/
What are some of the subjective psychological life circumstances undoubtedly shared by Adolf Hitler and Dr. Thomas Hahn that may have preposition them to have no other choice but to get into seriously and passionately opposing the political power structures messing up their lives at least from their often as unjustifiably subjective discredited individual personal perspective even though I can prove later that nothing can ever be considered “objective” since all our observations must inherently be always “subjective” anyway?
What are some of the subjective psychological life circumstances undoubtedly shared by Adolf Hitler and Dr. Thomas Hahn that may have preposition them to have no other choice but to get into seriously and passionately opposing the political power structures messing up their lives at least from their often as unjustifiably subjective discredited individual personal perspective even though I can prove later that nothing can ever be considered “objective” since all our observations must inherently be always “subjective” anyway?
https://www.academia.edu/s/9d561fce59.
https://www.academia.edu/s/9d561fce59.
Actually, I became a threat because while I was hospitalized at the 10th floor in the suicide psych ward at www.lcmh.com from June 24th until July 3rd, 2020 because my mind had no other choice than to spin until it found at least a theoretical remedy for this conundrum in the future described at the now blocked link
http://www.researchgate.net/post/How_can_20_000_people_overthrow_all_governments_simultaneously_to_transition_from_a_work_visa_limited_into_an_HR_and_listening_limited_economy
If I end up getting misclassified as a threat, would euthanasia according to Belgium law be a legally acceptable option?
ye clicking on https://www.newyorker.com/magazine/2015/06/22/the-death-treatment the following text will appear
The Death Treatment
When should people with a non-terminal illness be helped to die?
https://media.newyorker.com/photos/59097b702179605b11ad8f02/1:1/w_270%2Cc_limit/undefined
By Rachel Aviv
June 15, 2015
Belgian law allows euthanasia for patients who suffer from severe and incurable distress including psychological disorders.
Belgian law allows euthanasia for patients who suffer from severe and incurable distress, including psychological disorders.Photograph Courtesy Tom Mortier
Every dedicated group can set up freelancing portals like www.guru.com, www.upwork.com, www.freelancer.com, etc., to secretly coordinate more activities than multinational global companies, such as Facebook, Microsoft, SAP, Google, etc. without raising suspicion for expanding indirect power and influence much further. This could lead to the creation of much more powerful invincible imperceptible virtual nations by anyone, who cares to understand why. This might be destined to happen eventually, because I have been forced to understand this, unless I can get help to end my life before others care to understand it too. If I must stay alive, I cannot avoid getting converted into the "bad" guy, I never wanted to be. Should anything be done about it? Why or why not?
Newest still unshared unpreventable risk developments in progress.
Every dedicated group, that can set up freelancing portals like www.guru.com, www.upwork.com, www.freelancer.com, etc., can secretly coordinate the same activities as multinational global companies, such as Facebook, Microsoft, SAP, Google, etc. without raising suspicion to expand its indirect power and influence much further than any government or company can. This could lead to the creation of more powerful invincible imperceptible virtual nations by anyone, who cares to understand why. This might be destined to happen eventually, because I have been forced to understand this, unless I can get help to end my life before others care to understand it too. If I must stay alive, I cannot avoid to get converted into the "bad" guy, I never wanted to be. What should I do to stop it?
=================================================================
I received the email below already 4 days ago. I was glad when I read that somebody understands at least parts of my long writings. I know now that my property or attribute of being classified as a foreigner overwrites my disability attributes, which make all other disabled job-seekers eligible for Schedule A. I was hoping that my disability attributes and the need for Schedule A to become gainfully employed would overwrite my foreign student status because both are mutually exclusive.
---------- Forwarded message ----------
From: Reardon, Michael - ODEP <Reardon.Michael@dol.gov>
Date: Wed, Nov 15, 2017 at 1:19 PM
Subject: Response to Your Letter
To: "Hahn5Thomas@gmail.com" <Hahn5Thomas@gmail.com>
Dear Mr. Hahn:
Thank you for your letter to President Donald Trump which was forwarded to the Office of Disability Employment Policy (ODEP) at the U.S. Department of Labor (DOL) for a response.
We appreciate you sharing your thoughts on the current hiring practices used by employers in the United States, your desire to find employment, and your concerns about your visa status. As you may know, ODEP fulfills its mission by promoting the adoption and implementation of ODEP policy strategies and effective practices — meaning those that ODEP has developed and/or validated — that will positively impact the employment of people with disabilities. ODEP is a non-regulatory agency and does not assist job seekers in finding employment.
While we do not enforce employment policies, we do promote and encourage the adoption of strategies and practices that increase the employment of people with disabilities. The concept of employers leveraging an individual job seeker’s skills and abilities rather than relying on a standard list of tasks or job description to determine whether an individual is qualified for a position is an approach ODEP has supported for many years.
Through an approach ODEP has termed customized employment, the relationship between the employer and potential employee is customized in such a way as to meet the needs of both parties. For many years, ODEP has promoted customized employment as an additional workplace flexibility policy (also known as flexible work arrangements) and/or practice within the workforce. ODEP has evidence-based research data showing that customized employment leads to positive employment outcomes for individuals with disabilities and continues to promote the strategies and data through education, outreach, and collaboration with other federal agencies and private organizations. You can find out more about customized employment at:
https://www.dol.gov/odep/topics/CustomizedEmployment.htm
Any questions related to your visa status and its impact on potential employment opportunities should be directed to the Department of Homeland’s Security U.S. Citizenship and Immigration Services (DHS/USCIS). This link describes all the ways you may contact the agency: https://www.uscis.gov/about-us/contact-us
We hope this information is helpful.
Sincerely,
Michael Reardon
Supervisory Manager
Employment-related Supports Team
I plan to add the following:
I found Osh6 at a very high rank of lifespan extending genes. That is why I want to take all the genes that are part of the same molecular function as Osh6 and run an expression similarity analysis on SPELL (Serial Pattern of Expression Levels Locator) (see spell.yeastgenome.org/).
I hope to find genes of unknown functions that could be involved in the same molecular function. If I find this, I'll validate with my time series plots and TFBS similarity analysis. That way I hope to predict the function of an unknown gene in lipid metabolism. I will also try the opposite approach, i.e. I'll take genes of unknown function and look for a group of similarly expressed genes, which belong to the same GO term.
I added 19 pages to the second chapter. I was able to further improve the accuracy of my yeast lifespan predicting machine learning algorithm by adding more features about lipids. My last draft had an average prediction error of +/-5 replications. Now it is less than +/-3 replication for the 50th percentile of the replicative lifespan. To my knowledge nobody has published any research on about using machine learning and feature selection to predict the replicative age.
If you have any more ideas how I could make my dissertation look better, I'd be very thankful for any new feasible ideas and inspirations. I have mainly been using Python and R for all my analysis.
I found that ribosomal RNA and proteins are most closely follow the cell cycle and that if knocked out the yeast's lifespan can be extended significantly. I want to use the different cyclical periodically recurring and highly fluctuating gene expression oscillation pattern to discover the functions of genes we have not yet discovered. I am interested in this because a friend of mine showed me a cancer dataset that looked very similar. Since cancer is very similar to the yeast in that it keeps constantly dividing and hence its age can be expressed in replication we could use the same guilt-by-association approach to infer the functions or at least the way their expression is controlled by TFs from genes with similar temporal expression patterns of genes with already known functions.
When analyzing the time series plots of the 62 yeast chaperons I discovered that their expression plot trajectories can easily be clustered into 7 expression patterns, which are consisted with the 7 classes of yeast chaperons. If I had only taken the average centroid of all 62 chaperons I would have been misled because using this approach could not be applied to potentially discover more new currently still unknown chaperons because no unknown chaperon would have time series trajectories, which would highly correlate with the average chaperon expression pattern of all 7 classes since their in-group expression pattern is very homogeneous but between the 7 different chaperon classes the expression pattern is very different.
I intended to elucidate the different ways by which we age by a very similar clustering algorithm, which I have developed based on time series curves over three subsequent yeast cell cycle consisting of 36 mRNA measures each about 25 minutes apart; thus, allowing to measure very steep mRNA expression fluctuation periods by manifold within the only 90 minutes of the cell cycle because even very brief but rapid expression changes that last not much longer than 1/12th of a cell cycle, of which I found surprisingly many.
(the science of aging), the aging process still remains an enigma. Although hundreds of "theories" on aging have
been formulated and many fundamental insights about age-related changes and genetic as well as environmental
interventions that change the pace of aging have been discovered, the actual why and how we age remain enigmatic.
In the post-genomic era there is an exponential increase in data. As a consequence it is a challenge to utilize all
information based on it and derive meaningful knowledge about biological phenomena. No individual scientist, no
group, nor consortium is capable of keeping up within their own field and are overwhelmed by the explosion of data
increase. Machine learning applied on biological data has the potential to solve this and cause a paradigm shift from
hypothesis-driven research (which predominates biological research including biogerontology) to data-driven
research.
This dissertation addresses this problem. In particular it proposes and executes the use of machine learning on
current existing data to predict drivers of aging (and therefore helps to distinguish causes from consequences),
interventions to counteract aging, and specific hypotheses to fill in research gaps that require experimental
validation.
The objective of this project is therefore to build computational models that are based on data relevant to the
phenomenon of aging and to predict as many of its aspects and dimensions as possible (thus elucidate their relations
to each other). For converting between and sorting within dimensions which are relevant to aging, different machine
learning models are evaluated. Ones models are built, it can be determined how much they can explain different
aspects of aging. Those models will also be capable of specifying which features are most relevant for prediction (in
both classification or regression). It is possible to train models that incorporate age-related changes based on
transcriptomic, proteomic, metabolomic, epigenomic as well as morphological data and their combinations. Machine
learning is further used to convert between and within them.
This work focuses on three types of predictors. Subsequently, discoveries are made with the statistical and learning
algorithms. The first model (lifespan predictor) is trained on predicting the lifespan based on genotype, environment
and combinations thereof. It is useful for predicting lifespan extending interventions on the population level. The
second model (age predictor) is trained on predicting the age given features measured on individuals. This is useful
for identifying biomarkers of aging and to determine the effects of interventions on the level of individuals. The third
model predicts functions/regulations of biological entities in regard to the aging process based on heterogeneous data
such as ontologies and diverse omics including time-series gene expression profiles (which can be visualized as
plots), and linked data. It is used to understand the role of genes and proteins as well as perhaps other entities such as
small molecules including lipids and other metabolites. Functions of proteins, which are still unknown, especially
those involved in yeast lipid metabolism and its regulation, can be predicted.
For this purpose we use primarily yeast as model organism as well as data on humans. Other biomedical model
organisms might be added if found beneficial.
The novel aspects of this research are for instance that 1) aging is investigated systematically in an unbiased
data-driven approach, 2) lifespan is predicted as continuous values, 3) age is predicted by combining multiple omics
data, 4) functions and regulations of biological entities like genes are predicted with high confidence from
heterogeneous data sources.
This thesis discovered that genetics is the most important feature of lifespan determination. Phenotypic features
related to lipid and membranes such as vacuolar morphology and autophagy activity are important for lifespan
determination according to the best performing models. A age predictor based on transcriptomics and proteomics can
highly accurately determine the age. It selected features are associated with both translation and lipid metabolism.
Among the top selected features are transcripts of genes when deleted exhibit abnormal vacuolar morphology as well
as targets of Opi1. Opi1 itself and its regulators were found to be differentially regulated post-transcriptional or
post-translational. Lastly, a function predictor for genes was created that achieved exceptional accuracy of
classifying aging genes. It learned for instance that piecemeal autophagy of the nucleus is strongly predictive for
aging-suppressor genes while cytoplasmic translation is strongly predictive for gerontogenes
Talk Nerdy to Me: Making Connections for Audience Engagement
Adapted from Heath, C., & Heath, D. (2007). Made to stick: Why some ideas survive and others die. New York: Random House?
Directions: Working with your research, brainstorm connection ideas for the following.
WHAT is the core idea of your research? (the most important idea) (Give others the bigger picture and connect it) ex. The Helicopter View
In no more than two sentences, state the big picture (core idea) of your research:
The core idea of my research is that if we cannot find the secret for aging by looking only where data may point us, we must start looking somewhere else, even if no data points in this direction. To accomplish this we must change perspectives and need to spend time reading my long comparative analogy narratives.
Compare: What “common” things/ideas is your core idea like?
If you cannot find your favorite sweater in your closet, there is no point to keep looking for it in your closet over and over again; but instead, you may need to start looking elsewhere, e.g. in your drawers, even if you may not recall to ever have put it there, but somebody else might. So if for certain, the item or answer you are looking for cannot be found in its most likely place, then its better to start looking at less likely places despite lacking any logically seeming connections or explanations.
Contrast: What “common” things/ideas is your core idea NOT like?
The answers are not obvious because crucial concepts are still missing. We can only find them by trying to generate new experimental data aiming to exclude initially crazy hypotheses, which may not be crazy after all, as long as they remain internally consistent.
WHY is your research important? WHY should the audience care?
After I graduate people will forget about my intuitive insights. We may lose more than 50 years in anti-aging research and will lose billions of people unnecessarily due to aging before data may point us to look in the same directions as I am trying to propose despite the lack of reproducible evidence due to the lack of suitable datasets.
How does your research impact the everyday person? (Be creative here)
It’s our very survival, which most of us have not yet realized lies within our hands if we’ll reach out and grab it hard enough, long enough and creatively enough.
Es esencial para nuestro bienestar individual subjetivo exigir agresivamente un control completo sobre todos los aspectos subjetivamente relevantes de nuestras vidas, p. autorizaciones de trabajo, trabajos, visas, medicamentos recetados, etc. de cada gobierno, médico, ley, juez, policía, policía, parientes, amigos, superiores, militares, etc. en todo el mundo simultáneamente para recuperar el control total sobre un individuo nivel.
Por lo tanto, la autoridad final sobre drogas, empleos, visas, libertad de expresión, actividades comerciales, tratamientos médicos, etc. pertenece a todos, que subjetivamente se sienten afectados negativamente sin ella, en lugar de cualquier tipo de gobierno, aplicación de la ley, profesionales, expertos, médicos, instituciones, etc.
Por ejemplo, cualquier paciente que necesite estimulantes para el TDAH en los EE. UU. También los necesita en cualquier otro país, independientemente de sus leyes.
La gente como yo necesita un propósito en la vida para mantenerse con vida. Un trabajo significativo me daría un propósito tan esencial para la vida sin el cual ya no puedo seguir con vida por mucho más tiempo. En consecuencia, ningún gobierno tiene ningún derecho legítimo de determinar quién está permitido y quién tiene prohibido trabajar en un país en particular.
Solo dos personas son lo suficientemente poderosas como para dominar a cualquier gobierno del mundo. Una persona debe ocultar en secreto a un inmigrante ilegal bajo su identificación fiscal. Esto se puede hacer fácilmente configurando perfiles independientes, p. en www.indeed.com, www.guru.com, www.upwork.com, etc.
Además, esta forma de ocultar a los inmigrantes ilegales permitiéndoles trabajar sin autorización de trabajo hace posible el desarrollo gradual e indetectable de los monopolios del mercado económico, e incluso probable, con el tiempo.
Esto es esencial para gradualmente ser indetectable y dominar simultáneamente a todas las autoridades actuales en todo el mundo con el fin de transferir el poder absoluto absoluto y el control completo sobre todos los aspectos relevantes de la vida a todos, que subjetivamente sienten que su propia vida estaría en riesgo o afectada negativamente de lo contrario. Por lo tanto, todos deben esforzarse por quitarle cualquier autoridad a alguien que afecte negativamente cualquier aspecto relevante de la vida, p. medicamentos recetados, tratamientos médicos, trabajos, residencia, actividades sociales y políticas, libertad ilimitada de expresión y expresión, etc.
Todos los que luchan con cualquier tipo de desafío están automáticamente más calificados para determinar la mejor manera de superar su desafío individual que cualquier otra persona. Los amigos pueden ayudar escuchando, entendiendo y haciendo sugerencias, pero la solución final a cualquier problema individual en particular siempre debe estar bajo el control total de aquellos afectados negativamente por él. No debe haber tabú para responder a problemas, incluido el suicidio.
No hay autoridades, gobiernos, jueces, médicos, policías, agentes del orden, médicos, padres, amigos, profesionales, expertos, etc. que puedan estar más calificados para tomar la determinación final sobre responder a un problema en particular que la persona en particular, que está luchando subjetivamente con sus consecuencias adversas directamente!
Esto parece ser inesperadamente difícil para cualquiera de comprender y estar de acuerdo. Desafortunadamente, eso no lo hace menos cierto si realmente se aplica subjetivamente a la vida de alguien, que subjetivamente se siente de esta manera, ¡por cualquier razón o sin razón alguna!
Por lo tanto, me refiero a este tipo de revolución para la independencia responsable incondicional para todos a la "Revolución Anarquista Responsable".
Honestamente, todavía no puedo entender la razón por la cual mi propia vida es obviamente mucho menos importante que mi estatus migratorio y las leyes que rigen su determinación.
En lugar de orientarnos a procedimientos y reglas, debemos actuar orientados a objetivos para reducir el riesgo creciente de suicidio.
¿Solo los pacientes suicidas pueden entender esto?
________________________________________
Esta respuesta anterior refleja la opinión personal de Thomas Hahn, PhD
Identificación de Skype: TFH002
Correo electrónico: CIA101FBI@gmail.com
Teléfono Google Voice + 1 (501) 301 4890
Teléfono inteligente Android: + 1 (571) 839 0727
Perfil de Facebook: Thomas F Hahn
Manija de Twitter: Thomas Friedbert Hahn
@FriedbertHahn
Perfil en www.Researchgate.net:
https://www.researchgate.net/publication/309537991_Remote_Access_Programs_to_Better_Integrate_Individuals_with_Disabilities
https://dl.acm.org/doi/10.1145/2982142.2982182