Methylphenidate (MPH), commonly prescribed for attention deficit hyperactivity disorder, is used recreationally by adolescents or adults. Women represent a risk group for abuse of psychostimulants because they respond more intensely,... more
Methylphenidate (MPH), commonly prescribed for attention deficit hyperactivity disorder, is used recreationally by adolescents or adults. Women represent a risk group for abuse of psychostimulants because they respond more intensely, probably due to sex hormones. BDNF is a neurotrophic factor that modulates several neuronal functions in the CNS and with important implications in memory. Studies show that female hormones, specially estrogen, influences neuroplasticity of the hippocampus. Objective: to evaluate the modulatory effects of female sex hormones in the mRNA levels of BDNF mRNA in the hippocampus of MPH sensitized rats. Female adult Wistar rats were assigned to the ovariectomized or intact groups and submitted to a sensitization protocol in subgroups: acute MPH (ACT), repeated MPH (RPT) and control (CTR). Two weeks after ovariectomy, for 5 consecutive days, RTP rats received MPH 2,5mg/Kg i.p. while ACTs Página 1 de 2 Abstract Print View 17/11/2014
Methylphenidate (MPH), commonly prescribed for attention deficit hyperactivity disorder, is used recreationally by adolescents or adults. Women represent a risk group for abuse of psychostimulants because they respond more intensely,... more
Methylphenidate (MPH), commonly prescribed for attention deficit hyperactivity disorder, is used recreationally by adolescents or adults. Women represent a risk group for abuse of psychostimulants because they respond more intensely, probably due to sex hormones. BDNF is a neurotrophic factor that modulates several neuronal functions in the CNS and with important implications in memory. Studies show that female hormones, specially estrogen, influences neuroplasticity of the hippocampus. Objective: to evaluate the modulatory effects of female sex hormones in the mRNA levels of BDNF mRNA in the hippocampus of MPH sensitized rats. Female adult Wistar rats were assigned to the ovariectomized or intact groups and submitted to a sensitization protocol in subgroups: acute MPH (ACT), repeated MPH (RPT) and control (CTR). Two weeks after ovariectomy, for 5 consecutive days, RTP rats received MPH 2,5mg/Kg i.p. while ACTs Página 1 de 2 Abstract Print View 17/11/2014