Diego Carrilho

Universidade Federal do Rio Grande do Sul, Escola De Enfermagem, Undergraduate

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Papers by Diego Carrilho

Relato De Experiência Do Pet Redes Da Ufrgs - Rede De Atenção Psicossocial (Raps) – Cuidados Em Saúde Mental e Álcool e Outras Drogas a Jovens e Adultos

11O Congresso Internacional Da Rede Unida, Apr 30, 2014

Mitochondrial and Oxidative Stress Aspects in Hippocampus of Rats Submitted to Dietary n-3 Polyunsaturated Fatty Acid Deficiency After Exposure to Early Stress

by Natividade S Couto-Pereira, Diego Carrilho, and Carla Dalmaz

Chronic dietary long-chain polyunsaturated fatty acids (PUFAs) deficiency may lead to changes in ... more Chronic dietary long-chain polyunsaturated fatty acids (PUFAs) deficiency may lead to changes in cortex and hippocampus neuronal membrane phospho-lipids, and may be linked to impaired central nervous system function. Particularly docosahexaenoic acid deficiency appears to be involved in neuropsychiatric disorders. On the other hand, adverse events early in life may also profoundly affect brain development, leading to long-lasting effects on neurophysiology, neurobiology and behavior. This research assessed if neonatal stress and a dietary n-3 PUFAs deficiency could interact to produce hippocampal alterations related to mitochondrial functions in adult rats. There were no effects of diet, neonatal intervention or interactions on superoxide dismutase or catalase enzymatic activities, mitochondrial membrane potential and respiratory chain complexes. Rats fed n-3 PUFAs deficient diet displayed higher levels of glutathione peroxidase and catalase activity, higher free radicals

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