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José Augusto Bragatti

Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Médicas, Post-Doc

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Graduated in Medicine at UFRGS in 1983.
Specialist in Neuroanatomy (UFRGS, 1987) .
Neurologist by ABN since 1988.
Clinical neurophysiologist by SBNC since 1991.
Master in Medical Sciences at UFRGS in 2009 .
PhD in Medical Sciences at UFRGS in 2013 .
Head of the Clinical Neurophysiology Unit at HCPA.
Epilepsy Group Coordinator at HMV .
Phone: 55 51 99985-7545
Address: Rua Ramiro Barcelos 2350 - sala 2040
90003-030
Porto Alegre, RS
Brasil

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Papers by José Augusto Bragatti

The optic radiations perspective under the white fiber dissection technique : the rule in epilepsy surgery

P789: Interictal EEG activity is associated with mood disorders in temporal lobe epilepsy

Clinical Neurophysiology, Jun 1, 2014

Methylation of BDNF and SLC6A4 Gene Promoters in Brazilian Patients With Temporal Lobe Epilepsy Presenting or Not Psychiatric Comorbidities

Frontiers in Integrative Neuroscience

The relationship between epilepsy and psychiatric comorbidities has been recognized for centuries... more The relationship between epilepsy and psychiatric comorbidities has been recognized for centuries, but its pathophysiological mechanisms are still misunderstood. It is biologically plausible that genetic or epigenetic variations in genes that codify important neurotransmitters involved in epilepsy as well as in psychiatric disorders may influence the development of the latter in patients with epilepsy. However, this possibility remains poorly investigated. The aim of this study was to evaluate the methylation profile of the BDNF and SLC6A4, two genes importantly involved in neuroplasticity, in patients with temporal lobe epilepsy (TLE) regarding the development or not of psychiatric comorbidities. One hundred and thirty-nine patients with TLE, 90 females and 45 males, were included in the study. The mean age of patients was 44.0 (+12.0) years, and mean duration of epilepsy was 25.7 (+13.3) years. The Structured Clinical Interview for DSM-IV shows that 83 patients (59.7%) had neurops...

Síndrome Do Duplo-Córtex: Aspectos De Neuroimagem e Relato De Caso

Revista Brasileira de Neurologia e Psiquiatria, Sep 24, 2021

Ritmo social em pacientes com diagnóstico de epilepsia mioclônica juvenil e transtorno depressivo

Idade de início de crises influencia nas características de cefaléia em pacientes portadores de epilepsia

Expressão da proteína Príon Celular no hipocampo no modelo de epilepsia do lobo temporal por pilocarpina

Associação entre alelos variantes do gene NTRK2 e epilepsia do lobo temporal

Epilepsia como fator de risco independente para cefaléia tensional, enxaqueca e outros tipos de cefaléia

Fatores de risco para enxaqueca em pacientes com epilepsia

Preditores independentes de transtornos de ansiedade na epilepsia do lobo temporal

The optic radiations perspective under the white fiber dissection technique : the rule in epilepsy surgery

Evidências clinicas dos ritmos biológicos nos mecanismos patológicos no cérebro

Temporal choroidal fissure cyst and temporal lobe epilepsy: report of two cases

Journal of Epilepsy and Clinical Neurophysiology, 2010

STUDY DESIGN: Two case reports of a choroidal fissure cyst in the temporal horn associated with c... more STUDY DESIGN: Two case reports of a choroidal fissure cyst in the temporal horn associated with complex partial seizure. OBJECTIVES: To describe the clinical course, image findings and literature review of choroidal fissure cysts. SUMMARY AND BACKGROUND DATA: there are few reported cases of choroidal fissure cysts. RESULTS: We report two patients with complex partial seizures and temporal choroidal fissure cysts. The seizures were controlled in both patients. CONCLUSION: The choroidal fissure cyst diagnosis must highlight the importance of considering this lesion in the differential diagnosis of temporal lobe cyst and temporal lobe seizure.

Musical hallucinations following insular glioma resection

Neurosurgical Focus, 2010

Hallucinations can be auditory, visual, tactile, gustatory, or olfactory, and can be caused by ps... more Hallucinations can be auditory, visual, tactile, gustatory, or olfactory, and can be caused by psychiatric (such as schizophrenia and depression), neurological (such as cerebrovascular accidents, neoplasia, and infection), or endocrine and metabolic disorders. Musical hallucinations related to neurological disorders are rare. The authors present a case of a patient with a right insular glioma who developed transient musical hallucinations after microsurgical resection of the tumor.

No major clinical impact of Val66Met BDNF gene polymorphism on temporal lobe epilepsy

Epilepsy Research, 2010

To report the frequencies of Val66Met polymorphism in patients with temporal lobe epilepsy (TLE) ... more To report the frequencies of Val66Met polymorphism in patients with temporal lobe epilepsy (TLE) compared to normal controls. We also investigated whether Val66Met promoted differences in major clinical variables of TLE. A case-control study comparing the frequencies of Val66Met polymorphism in 101 Caucasian TLE patients and in 104 Caucasian normal matching controls. In the second step, we evaluated the patient group in terms of the major clinical and electrographic variables related to the epileptogenic process. The frequency of Val66Met polymorphism did not differ between epileptic patients and normal controls. Moreover, the Val66Met polymorphisms did not influence age of epilepsy onset, duration of epilepsy, control of seizures, or extension of the irritative zone. Also, the groups did not differ in terms of family history of epilepsy and presence of aura. In spite of abundant evidence that Val66Met BDNF polymorphism has an impact on several different neurological or psychiatric disorders, we conclude that a major clinical impact of Val66Met polymorphism as a disease modifier in temporal lobe epilepsy is probably unlikely.

Serotonin gene polymorphisms and psychiatry comorbidities in temporal lobe epilepsy

Epilepsy Research, 2012

Impact of the chronic use of benzodiazepines prescribed for seizure control on the anxiety levels of patients with epilepsy

Epilepsy & Behavior, 2012

Topiramate is effective for status epilepticus and seizure control in neuraminidase deficiency

Arquivos de Neuro-Psiquiatria, 2011

Prevalence of psychiatric comorbidities in temporal lobe epilepsy in a Southern Brazilian population

Arquivos de Neuro-Psiquiatria, 2011

A great prevalence of psychiatric disorders in epilepsy is well demonstrated, although most studi... more A great prevalence of psychiatric disorders in epilepsy is well demonstrated, although most studies have used unstructured psychiatric interviews for diagnosis. Here we present a study evaluating the prevalence of psychiatric comorbidities in a cohort of Southern Brazilian patients with temporal lobe epilepsy (TLE) using a structured clinical interview. We analyzed 166 patients with TLE regarding neuropsychiatric symptoms through the Structured Clinical Interview for DSM-IV. One hundred-six patients (63.9%) presented psychiatric comorbidities. Mood disorders were observed in 80 patients (48.2%), anxiety disorders in 51 patients (30.7%), psychotic disorders in 14 (8.4%), and substance abuse in 8 patients (4.8%) respectively. Our results agree with literature data where most authors detected mental disorders in 10 to 60% of epileptic patients. This wide variation is probably attributable to different patient groups investigated and to the great variety of diagnostic methods. Structure...

The optic radiations perspective under the white fiber dissection technique : the rule in epilepsy surgery

P789: Interictal EEG activity is associated with mood disorders in temporal lobe epilepsy

Clinical Neurophysiology, Jun 1, 2014

Methylation of BDNF and SLC6A4 Gene Promoters in Brazilian Patients With Temporal Lobe Epilepsy Presenting or Not Psychiatric Comorbidities

Frontiers in Integrative Neuroscience

The relationship between epilepsy and psychiatric comorbidities has been recognized for centuries... more The relationship between epilepsy and psychiatric comorbidities has been recognized for centuries, but its pathophysiological mechanisms are still misunderstood. It is biologically plausible that genetic or epigenetic variations in genes that codify important neurotransmitters involved in epilepsy as well as in psychiatric disorders may influence the development of the latter in patients with epilepsy. However, this possibility remains poorly investigated. The aim of this study was to evaluate the methylation profile of the BDNF and SLC6A4, two genes importantly involved in neuroplasticity, in patients with temporal lobe epilepsy (TLE) regarding the development or not of psychiatric comorbidities. One hundred and thirty-nine patients with TLE, 90 females and 45 males, were included in the study. The mean age of patients was 44.0 (+12.0) years, and mean duration of epilepsy was 25.7 (+13.3) years. The Structured Clinical Interview for DSM-IV shows that 83 patients (59.7%) had neurops...

Síndrome Do Duplo-Córtex: Aspectos De Neuroimagem e Relato De Caso

Revista Brasileira de Neurologia e Psiquiatria, Sep 24, 2021

Ritmo social em pacientes com diagnóstico de epilepsia mioclônica juvenil e transtorno depressivo

Idade de início de crises influencia nas características de cefaléia em pacientes portadores de epilepsia

Expressão da proteína Príon Celular no hipocampo no modelo de epilepsia do lobo temporal por pilocarpina

Associação entre alelos variantes do gene NTRK2 e epilepsia do lobo temporal

Epilepsia como fator de risco independente para cefaléia tensional, enxaqueca e outros tipos de cefaléia

Fatores de risco para enxaqueca em pacientes com epilepsia

Preditores independentes de transtornos de ansiedade na epilepsia do lobo temporal

The optic radiations perspective under the white fiber dissection technique : the rule in epilepsy surgery

Evidências clinicas dos ritmos biológicos nos mecanismos patológicos no cérebro

Temporal choroidal fissure cyst and temporal lobe epilepsy: report of two cases

Journal of Epilepsy and Clinical Neurophysiology, 2010

STUDY DESIGN: Two case reports of a choroidal fissure cyst in the temporal horn associated with c... more STUDY DESIGN: Two case reports of a choroidal fissure cyst in the temporal horn associated with complex partial seizure. OBJECTIVES: To describe the clinical course, image findings and literature review of choroidal fissure cysts. SUMMARY AND BACKGROUND DATA: there are few reported cases of choroidal fissure cysts. RESULTS: We report two patients with complex partial seizures and temporal choroidal fissure cysts. The seizures were controlled in both patients. CONCLUSION: The choroidal fissure cyst diagnosis must highlight the importance of considering this lesion in the differential diagnosis of temporal lobe cyst and temporal lobe seizure.

Musical hallucinations following insular glioma resection

Neurosurgical Focus, 2010

Hallucinations can be auditory, visual, tactile, gustatory, or olfactory, and can be caused by ps... more Hallucinations can be auditory, visual, tactile, gustatory, or olfactory, and can be caused by psychiatric (such as schizophrenia and depression), neurological (such as cerebrovascular accidents, neoplasia, and infection), or endocrine and metabolic disorders. Musical hallucinations related to neurological disorders are rare. The authors present a case of a patient with a right insular glioma who developed transient musical hallucinations after microsurgical resection of the tumor.

No major clinical impact of Val66Met BDNF gene polymorphism on temporal lobe epilepsy

Epilepsy Research, 2010

To report the frequencies of Val66Met polymorphism in patients with temporal lobe epilepsy (TLE) ... more To report the frequencies of Val66Met polymorphism in patients with temporal lobe epilepsy (TLE) compared to normal controls. We also investigated whether Val66Met promoted differences in major clinical variables of TLE. A case-control study comparing the frequencies of Val66Met polymorphism in 101 Caucasian TLE patients and in 104 Caucasian normal matching controls. In the second step, we evaluated the patient group in terms of the major clinical and electrographic variables related to the epileptogenic process. The frequency of Val66Met polymorphism did not differ between epileptic patients and normal controls. Moreover, the Val66Met polymorphisms did not influence age of epilepsy onset, duration of epilepsy, control of seizures, or extension of the irritative zone. Also, the groups did not differ in terms of family history of epilepsy and presence of aura. In spite of abundant evidence that Val66Met BDNF polymorphism has an impact on several different neurological or psychiatric disorders, we conclude that a major clinical impact of Val66Met polymorphism as a disease modifier in temporal lobe epilepsy is probably unlikely.

Serotonin gene polymorphisms and psychiatry comorbidities in temporal lobe epilepsy

Epilepsy Research, 2012

Impact of the chronic use of benzodiazepines prescribed for seizure control on the anxiety levels of patients with epilepsy

Epilepsy & Behavior, 2012

Topiramate is effective for status epilepticus and seizure control in neuraminidase deficiency

Arquivos de Neuro-Psiquiatria, 2011

Prevalence of psychiatric comorbidities in temporal lobe epilepsy in a Southern Brazilian population

Arquivos de Neuro-Psiquiatria, 2011

A great prevalence of psychiatric disorders in epilepsy is well demonstrated, although most studi... more A great prevalence of psychiatric disorders in epilepsy is well demonstrated, although most studies have used unstructured psychiatric interviews for diagnosis. Here we present a study evaluating the prevalence of psychiatric comorbidities in a cohort of Southern Brazilian patients with temporal lobe epilepsy (TLE) using a structured clinical interview. We analyzed 166 patients with TLE regarding neuropsychiatric symptoms through the Structured Clinical Interview for DSM-IV. One hundred-six patients (63.9%) presented psychiatric comorbidities. Mood disorders were observed in 80 patients (48.2%), anxiety disorders in 51 patients (30.7%), psychotic disorders in 14 (8.4%), and substance abuse in 8 patients (4.8%) respectively. Our results agree with literature data where most authors detected mental disorders in 10 to 60% of epileptic patients. This wide variation is probably attributable to different patient groups investigated and to the great variety of diagnostic methods. Structure...