1 Laboratório de Solos da Universidade do Estado de Mato Grosso (UNEMAT), Cáceres, MT. 2 Universidade do Estado de Mato Grosso (UNEMAT), Departamento de Agronomia, Av. São João, s/n, Cavalhada - Cáceres, MT, CEP 78200-000. E-mail:... more
1 Laboratório de Solos da Universidade do Estado de Mato Grosso (UNEMAT), Cáceres, MT. 2 Universidade do Estado de Mato Grosso (UNEMAT), Departamento de Agronomia, Av. São João, s/n, Cavalhada - Cáceres, MT, CEP 78200-000. E-mail: winintonmendes@ ...
Research Interests:
There is increasing evidence suggesting that oxidative stress plays an important role in the development of many chronic and degenerative conditions such as diabetic encephalopathy and depression. Considering that diabetic rats and mice... more
There is increasing evidence suggesting that oxidative stress plays an important role in the development of many chronic and degenerative conditions such as diabetic encephalopathy and depression. Considering that diabetic rats and mice present higher depressive-like behaviour when submitted to the forced swimming test and that treatment with insulin and/or clonazepam is able to reverse the behavioural changes of the diabetic rats, the present work investigated the antioxidant status, specifically total antioxidant reactivity and antioxidant potential of insulin and clonazepam, as well as the effect of this drugs upon protein oxidative damage and reactive species formation in cortex, hippocampus and striatum from diabetic rats submitted to forced swimming test. It was verified that longer immobility time in diabetic rats and insulin plus clonazepam treatment reversed this depressive-like behaviour. Moreover, data obtained in this study allowed to demonstrate through different parame...