Asthma is a chronic inflammatory disease characterized by airway obstruction and hyper-responsive... more Asthma is a chronic inflammatory disease characterized by airway obstruction and hyper-responsiveness. It is a complex disorder influenced by genetic and environmental factors, which contribute to the clinical manifestations of asthma. Asthma may affect the lower respiratory tract, causing epithelial damage, mucus hyper-secretion, edema, bronchospasm, and airway remodeling. Genetic studies have uncovered single nucleotide polymorphisms (SNPs) associated with asthma. However, knowledge of the functional impact of these SNPs is lacking. Several genes associated with asthma have been well characterized on a functional level: ORMDL3, S1PR1, PHF11, F3, and ADAM33. Epigenetic modifications, which include DNA methylation, histone modification, and miRNA, affect transcriptional activity in multiple genetic pathways associated with the development of asthma. The aim of this paper is to describe the pathophysiology, etiology, genetics, and epigenetics of asthma and the factors contributing to...
Journal of International Dental and Medical Research, 2019
Children with Down Syndrome are developmentally delayed, particularly in cognitive ability and fi... more Children with Down Syndrome are developmentally delayed, particularly in cognitive ability and fine motor skills, and this affects oral health care comprehension. The educational toy busy book, Ayo Sikat Gigi, can be used as a special approach to educate them regarding the oral health care. We evaluated the cognitive comprehension scores of dental health education using this busy book. This experimental clinical study included 25 Down Syndrome children (17 males, 8 females; age 7–12 years) from special primary schools in Jakarta. This age range was chosen after adjustment of mental age of children without Down Syndrome. The scores before and after dental health education using the busy book, Ayo Sikat Gigi, were analyzed and their differences measured. Scores were obtained from the objective test from the busy book, which is a picturematching test on dental health education that is obtained from the book contents. The scores after dental health education using the busy book were hig...
Asthma is a chronic inflammatory disease characterized by airway obstruction and hyper-responsive... more Asthma is a chronic inflammatory disease characterized by airway obstruction and hyper-responsiveness. It is a complex disorder influenced by genetic and environmental factors, which contribute to the clinical manifestations of asthma. Asthma may affect the lower respiratory tract, causing epithelial damage, mucus hyper-secretion, edema, bronchospasm, and airway remodeling. Genetic studies have uncovered single nucleotide polymorphisms (SNPs) associated with asthma. However, knowledge of the functional impact of these SNPs is lacking. Several genes associated with asthma have been well characterized on a functional level: ORMDL3, S1PR1, PHF11, F3, and ADAM33. Epigenetic modifications, which include DNA methylation, histone modification, and miRNA, affect transcriptional activity in multiple genetic pathways associated with the development of asthma. The aim of this paper is to describe the pathophysiology, etiology, genetics, and epigenetics of asthma and the factors contributing to...
Journal of International Dental and Medical Research, 2019
Children with Down Syndrome are developmentally delayed, particularly in cognitive ability and fi... more Children with Down Syndrome are developmentally delayed, particularly in cognitive ability and fine motor skills, and this affects oral health care comprehension. The educational toy busy book, Ayo Sikat Gigi, can be used as a special approach to educate them regarding the oral health care. We evaluated the cognitive comprehension scores of dental health education using this busy book. This experimental clinical study included 25 Down Syndrome children (17 males, 8 females; age 7–12 years) from special primary schools in Jakarta. This age range was chosen after adjustment of mental age of children without Down Syndrome. The scores before and after dental health education using the busy book, Ayo Sikat Gigi, were analyzed and their differences measured. Scores were obtained from the objective test from the busy book, which is a picturematching test on dental health education that is obtained from the book contents. The scores after dental health education using the busy book were hig...
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Papers by Astrinia Putri