Epithelia can adjust the permeability of their paracellular permeation route to physiological req... more Epithelia can adjust the permeability of their paracellular permeation route to physiological requirements, pathological conditions, and pharmacological challenges. This is reflected by a transepithelial electrical resistance (TER) ranging from a few tenth to several thousands Ω·cm2, depending on the degree of sealing of the tight junction (TJ). The present work is part of an effort to understand the causes and mechanisms underlying these adaptations. We observed that an extract of human urine (hDLU) increases TER in a concentration- and time-dependent manner and is more effective when added from the basolateral side of cultured monolayers of Madin-Darby canine kidney cells than from the apical one. We found that its main TER-increasing component is epidermal growth factor (hEGF), as depletion of this peptide with specific antibodies, or inhibition of its receptor with PD153035, abolishes its effect. Since the permeability of the TJ depends on the expression of several species of me...
Crystal structure of trans-dibromobis(triphenylphosphine)platinum(II) was determined by X-ray-cry... more Crystal structure of trans-dibromobis(triphenylphosphine)platinum(II) was determined by X-ray-crystallography. The complex crystallizes on an inversion center in distorted square planar coordination around platinum with triphenylphosphine ligands in trans positions to each other and with two molecules of dichloromethane as solvate.
KEYWORDS Polymarker; PM-PCR; population genetics; Latin American populations ... ABSTRACT We have... more KEYWORDS Polymarker; PM-PCR; population genetics; Latin American populations ... ABSTRACT We have analyzed the allele and phenotype frequencies in five DNA loci: LDLR, GYPA, HBGG, GC, and D7S8 in a sample from Uruguay. All the loci were in Hardy-Weinberg ...
Epithelia can adjust the permeability of their paracellular permeation route to physiological req... more Epithelia can adjust the permeability of their paracellular permeation route to physiological requirements, pathological conditions, and pharmacological challenges. This is reflected by a transepithelial electrical resistance (TER) ranging from a few tenth to several thousands Ω·cm2, depending on the degree of sealing of the tight junction (TJ). The present work is part of an effort to understand the causes and mechanisms underlying these adaptations. We observed that an extract of human urine (hDLU) increases TER in a concentration- and time-dependent manner and is more effective when added from the basolateral side of cultured monolayers of Madin-Darby canine kidney cells than from the apical one. We found that its main TER-increasing component is epidermal growth factor (hEGF), as depletion of this peptide with specific antibodies, or inhibition of its receptor with PD153035, abolishes its effect. Since the permeability of the TJ depends on the expression of several species of me...
Crystal structure of trans-dibromobis(triphenylphosphine)platinum(II) was determined by X-ray-cry... more Crystal structure of trans-dibromobis(triphenylphosphine)platinum(II) was determined by X-ray-crystallography. The complex crystallizes on an inversion center in distorted square planar coordination around platinum with triphenylphosphine ligands in trans positions to each other and with two molecules of dichloromethane as solvate.
KEYWORDS Polymarker; PM-PCR; population genetics; Latin American populations ... ABSTRACT We have... more KEYWORDS Polymarker; PM-PCR; population genetics; Latin American populations ... ABSTRACT We have analyzed the allele and phenotype frequencies in five DNA loci: LDLR, GYPA, HBGG, GC, and D7S8 in a sample from Uruguay. All the loci were in Hardy-Weinberg ...
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Papers by A. Ruiz-Cabrera