There have been reports, mainly retrospective, of pancreatitis and hyperamylasemia after anterogr... more There have been reports, mainly retrospective, of pancreatitis and hyperamylasemia after anterograde double-balloon enteroscopy (DBE). Our aim was to report the incidence of pancreatitis and hyperamylasemia after DBE and investigate possible risk factors associated with its occurrence. In this single-center prospective cohort study, serum samples were taken for amylase and lipase before and 3 hours after anterograde DBE in consecutive patients. Multiple variables were recorded, including total procedure time, insertion depth, and number of passes. Patients were evaluated to 24 hours later for signs of pancreatitis. The main outcome measures were the occurrence of hyperamylasemia and pancreatitis. 92 patients were included in the analysis (58 women, 34 men; mean age 54 years, range 18-89). The mean total procedure time was 62 minutes (range 30-120). The mean post-procedure amylase and lipase levels were significantly higher in comparison with the baseline levels (165 U/L vs. 69 U/L and 144 U/L vs. 28 U/L respectively, P<.05); 36 patients (39%) showed hyperamylasemia after the procedure and three patients developed acute mild pancreatitis. Hyperamylasemia was associated more frequently with procedure duration greater than 60 minutes ( P<.001) and insertion depth greater than 25 cm ( P<.013). The incidence of hyperamylasemia after anterograde DBE is common and particularly associated with longer procedure time and insertion depth. The cumulative incidence of pancreatitis was 3%. We recommend the avoidance of both unnecessarily lengthy procedures and deep insertion distances in patients who undergo anterograde DBE.
Helicobacter pylori virulence determinants have not previously been studied in detail in Latin Am... more Helicobacter pylori virulence determinants have not previously been studied in detail in Latin Americans with H. pylori infections. We characterized the vacA (vacuolating cytotoxin gene A) and cagA (cytotoxin-associated gene A) types of more than 400 single-colony isolates from 20 patients in Mexico City. For 17 patients H. pylori strains of two or more different vacA genotypes were isolated from gastric biopsy specimens, indicating infection with two or more strains of H. pylori. The most frequent vacA genotype was s1b/m1. vacA diversity was more marked than that described previously, in that isolates from seven patients had untypeable vacA midregions and isolates from nine patients had type s1 signal sequence coding regions which could not be further subtyped. Previously undescribed vacA type s2/m1 strains were found in five patients. All patients were infected with cagA-positive strains, but occasionally, these coexisted with small numbers of cagA-negative strains. In conclusion,...
Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
Although rigid rectosigmoidoscopy has been gradually replaced by the use of flexible rectosigmoid... more Although rigid rectosigmoidoscopy has been gradually replaced by the use of flexible rectosigmoidoscopy in recent years, it remains an effective, economic and widely available diagnostic tool. The aim of this study was to determine the type and magnitude of symptoms during rigid rectosigmodoscopy. Prospective evaluation of patients who underwent diagnostic rigid rectosigmoidoscopy. The main complaints were recorded, and their magnitude quantified using a visual analogue scale. A total of 134 patients (mean age = 48 years) were examined. The prone jackknife position was used in 54% of them and left lateral decubitus in 46%. A complete (full length) examination was achieved in 68%. There were no complications. Sixty percent of patients referred complaints: pain (33%), discomfort by rectal preparation (13%), uncomfortable defecation desire (8%), and discomfort by the position (4%). Median values determined by visual analogue scale for pain, discomfort by rectal preparation, uncomfortab...
There have been reports, mainly retrospective, of pancreatitis and hyperamylasemia after anterogr... more There have been reports, mainly retrospective, of pancreatitis and hyperamylasemia after anterograde double-balloon enteroscopy (DBE). Our aim was to report the incidence of pancreatitis and hyperamylasemia after DBE and investigate possible risk factors associated with its occurrence. In this single-center prospective cohort study, serum samples were taken for amylase and lipase before and 3 hours after anterograde DBE in consecutive patients. Multiple variables were recorded, including total procedure time, insertion depth, and number of passes. Patients were evaluated to 24 hours later for signs of pancreatitis. The main outcome measures were the occurrence of hyperamylasemia and pancreatitis. 92 patients were included in the analysis (58 women, 34 men; mean age 54 years, range 18-89). The mean total procedure time was 62 minutes (range 30-120). The mean post-procedure amylase and lipase levels were significantly higher in comparison with the baseline levels (165 U/L vs. 69 U/L and 144 U/L vs. 28 U/L respectively, P<.05); 36 patients (39%) showed hyperamylasemia after the procedure and three patients developed acute mild pancreatitis. Hyperamylasemia was associated more frequently with procedure duration greater than 60 minutes ( P<.001) and insertion depth greater than 25 cm ( P<.013). The incidence of hyperamylasemia after anterograde DBE is common and particularly associated with longer procedure time and insertion depth. The cumulative incidence of pancreatitis was 3%. We recommend the avoidance of both unnecessarily lengthy procedures and deep insertion distances in patients who undergo anterograde DBE.
Helicobacter pylori virulence determinants have not previously been studied in detail in Latin Am... more Helicobacter pylori virulence determinants have not previously been studied in detail in Latin Americans with H. pylori infections. We characterized the vacA (vacuolating cytotoxin gene A) and cagA (cytotoxin-associated gene A) types of more than 400 single-colony isolates from 20 patients in Mexico City. For 17 patients H. pylori strains of two or more different vacA genotypes were isolated from gastric biopsy specimens, indicating infection with two or more strains of H. pylori. The most frequent vacA genotype was s1b/m1. vacA diversity was more marked than that described previously, in that isolates from seven patients had untypeable vacA midregions and isolates from nine patients had type s1 signal sequence coding regions which could not be further subtyped. Previously undescribed vacA type s2/m1 strains were found in five patients. All patients were infected with cagA-positive strains, but occasionally, these coexisted with small numbers of cagA-negative strains. In conclusion,...
Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
Although rigid rectosigmoidoscopy has been gradually replaced by the use of flexible rectosigmoid... more Although rigid rectosigmoidoscopy has been gradually replaced by the use of flexible rectosigmoidoscopy in recent years, it remains an effective, economic and widely available diagnostic tool. The aim of this study was to determine the type and magnitude of symptoms during rigid rectosigmodoscopy. Prospective evaluation of patients who underwent diagnostic rigid rectosigmoidoscopy. The main complaints were recorded, and their magnitude quantified using a visual analogue scale. A total of 134 patients (mean age = 48 years) were examined. The prone jackknife position was used in 54% of them and left lateral decubitus in 46%. A complete (full length) examination was achieved in 68%. There were no complications. Sixty percent of patients referred complaints: pain (33%), discomfort by rectal preparation (13%), uncomfortable defecation desire (8%), and discomfort by the position (4%). Median values determined by visual analogue scale for pain, discomfort by rectal preparation, uncomfortab...
Uploads