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    Elizaveta Kon

    Various types of platelet (PLT) products, such as Platelet Rich Plasma (PRP) and Platelet Gel (PG), derived from autologous peripheral blood, have been used for tissue repair. The good clinical outcomes, due mainly to their safety and... more
    Various types of platelet (PLT) products, such as Platelet Rich Plasma (PRP) and Platelet Gel (PG), derived from autologous peripheral blood, have been used for tissue repair. The good clinical outcomes, due mainly to their safety and Growth Factor (GF) content, have led to a wide use of PLT products in many fields of medicine. However, until now the existing literature adds controversies to the use of PLT concentrates. When talking about PLTs and their products, a great number of variables have to be considered. These variables are mainly related to PRP preparation methods, the type of activators, intra- and inter-species variability, types of pathology to be treated, the ways and times of administration and the association of PRP or PG with other treatments. This review considers and discusses these causes of variability with particular attention to orthopaedic implications. The possibility of improving the knowledge on variables affecting therapeutic efficacy will surely help in ...
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    Hyalograft C is an innovative tissue-engineering approach for the treatment of knee cartilage defects involving the implantation of laboratory expanded autologous chondrocytes grown on a three-dimensional hyaluronan-based scaffold. This... more
    Hyalograft C is an innovative tissue-engineering approach for the treatment of knee cartilage defects involving the implantation of laboratory expanded autologous chondrocytes grown on a three-dimensional hyaluronan-based scaffold. This technique has recently been introduced into clinical practice, with more than 600 patients treated so far. Because no periosteal coverage is required to keep the graft in place, surgical time and morbidity are reduced, and handling of the graft is much simpler than currently available autologous chondrocyte implantation techniques. The safety profile of the treatment appears positive, with a limited number of adverse events reported. Here we discuss the clinical, arthroscopic and histological results from a cohort of 67 patients treated with Hyalograft C (mean follow-up time from implantation of 17.5 months). Results are reported based on four endpoints: patients' subjective evaluation of knee conditions (97% of patients improved) and quality of life (94% improved), surgeons' knee functional test (87% of patients with the best scores), arthroscopic evaluation of cartilage repair (96.7% biologically acceptable) and histological assessment of the grafted site (majority of specimens hyaline-like). The positive clinical results obtained indicate that Hyalograft C may be a viable therapeutic option for the treatment of acute cartilage lesions.
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    ... Hajime Ohgushi, Jun Miyake andTetsuyaTateishi Mesenchymal stem cells and bioceramics: strategies to regenerate the skeleton 118 Discussion 127 Ranieri Cancedda, Maddalena Mastrogiacomo, Giordano Bianchi, Anna Derubeis, Anita Muraglia... more
    ... Hajime Ohgushi, Jun Miyake andTetsuyaTateishi Mesenchymal stem cells and bioceramics: strategies to regenerate the skeleton 118 Discussion 127 Ranieri Cancedda, Maddalena Mastrogiacomo, Giordano Bianchi, Anna Derubeis, Anita Muraglia andRodolfoQuarto Bone ...
    ... Elizaveta Kon, MD, Giuseppe Filardo, MD, and Maurilio Marcacci, MD, can be reached at the Biomechanics Laboratory – III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano 1/10 – 40136 Bologna, Italy; +39-051-6366567; e-mail:... more
    ... Elizaveta Kon, MD, Giuseppe Filardo, MD, and Maurilio Marcacci, MD, can be reached at the Biomechanics Laboratory – III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano 1/10 – 40136 Bologna, Italy; +39-051-6366567; e-mail: e.kon@biomec.ior.it, g.filardo@biomec.ior.it ...
    We describe an arthroscopic surgical technique for tissue engineered cartilage grafting. A three-dimensional hyaluronic acid support is used for autologous chondrocyte culturing. The technique reduces morbidity of classic autologous... more
    We describe an arthroscopic surgical technique for tissue engineered cartilage grafting. A three-dimensional hyaluronic acid support is used for autologous chondrocyte culturing. The technique reduces morbidity of classic autologous implant and avoids open surgery and the use of a periosteal flap. The procedure includes the advantages of arthroscopic osteochondral grafting without donor site morbidity. With this technique is possible to reduce the patient morbidity, time and cost of surgery.
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    ABSTRACT A biodegradable, hyaluronian-based biocompatible scaff old is used for autologous chondrocyte implantation (ACI) for the treatment of articular cartilage lesions. This procedure consists of two steps: the fi rst one is an... more
    ABSTRACT A biodegradable, hyaluronian-based biocompatible scaff old is used for autologous chondrocyte implantation (ACI) for the treatment of articular cartilage lesions. This procedure consists of two steps: the fi rst one is an arthroscopic biopsy of healthy cartilage for chondrocyte cell culture. After 6 weeks, the bioengineered tissue obtained can be implanted trough a mini-open procedure or arthroscopic technique.
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    ABSTRACT Cartilage injuries have a high impact on society, and their incidence is increasing over time. For this reason, in the last twenty years numerous treatments have been proposed for the management of such injuries, including... more
    ABSTRACT Cartilage injuries have a high impact on society, and their incidence is increasing over time. For this reason, in the last twenty years numerous treatments have been proposed for the management of such injuries, including conservative and surgical approaches, which can vary from purely reparative procedures to others, characterized also by a regenerative potential. Concerning conservative therapies, they represent the first approach to consider when treating small cartilage defects, but there is no evidence of their ability to alter the degeneration processes of the joint, and they can provide only a short-term pain release. With regard to surgical procedures, they are considered for the treatment of large cartilage lesions or after the failure of conservative management, in order to restore the cartilage surface. Despite the numerous studies performed in this field, the contradictory results reported in the literature prevent to demonstrate the effectiveness of the surgical approach. In this context, the orthopedic surgeon often decide which procedure to perform more as a consequence of his personal experience than following any scientific evidence. This article has the aim to briefly describe the available options for the treatment of cartilage lesions, trying to give an overview of our experience, and to better define the rational and indications of each procedure, thus providing a useful tool for the orthopedic surgeon to decide the procedure to use and when on the basis of scientific data.
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