Background: Central mucoepidermoid carcinoma is a rare malignant salivary neoplasm arising inside... more Background: Central mucoepidermoid carcinoma is a rare malignant salivary neoplasm arising inside the bone of the jaws. We report a rare case of central mucoepidermoid carcinoma of a 16-year-old girl arising in the maxilla. Clinical and radiological analyses were shown and discussed, as well as the surgical treatment. Methods: A left maxillectomy from the last molar to the first premolar was performed, and the site was reconstructed using a fibula free flap stabilized with titanium plates. Results: The young patient was followed up for more than 6 years, and to date no recurrence was observed. A literature review of the 11 rare previous cases was provided to guide the clinician in the diagnosis and management of this unusual glandular tumor. Conclusion: It is of immense importance to differentiate the central mucoepidermoid from other osteolytic lesion and odontogenic cysts because of his malignancy and local aggressiveness. The treatment option is the radical excision, with the evaluation of neck nodes, and radiotherapy is only recommended in the most aggressive of cases.
A retrospective longitudinal study was conducted to identify the cutoff value of infiltration dep... more A retrospective longitudinal study was conducted to identify the cutoff value of infiltration depth for predicting the risk of lymph node metastasis of the neck in a well-defined population of surgically treated patients affected by stage T1 to T2 oral squamous cell carcinoma of the tongue. Sixty-seven patients were enrolled in this study. Forty-four patients (65.5%) had pN0 status and 23 (34.5%) had pN(+) status. Thirty-five positive lymph nodes were analyzed. The median follow-up for these patients was 51.4 months. The mean infiltration depth of the N-negative group was 2.4 mm; this was substantially different from the mean value observed in the N-positive group at 5.5 mm. A meaningful cutoff was identified at an infiltration depth value of 4 mm. Infiltration depth was identified as an important predictor for neck nodal status. In this specific population, mortality was associated with increasing tumor infiltration depth.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, Jan 19, 2015
Modern planning techniques, including computer-aided design/computer-aided manufacturing (CAD-CAM... more Modern planning techniques, including computer-aided design/computer-aided manufacturing (CAD-CAM) can be used to plan reconstructive surgery, optimising aesthetic outcomes and functional rehabilitation. However, although many such applications are available, no systematic protocol yet describes the entire reconstructive procedure, which must include virtual planning, custom manufacture, and a reconstructive algorithm. We reviewed current practices in this novel field, analysed case series described in the literature, and developed a new, defect-based reconstructive algorithm. We also evaluated methods of mandibular reconstruction featuring virtual planning, the use of surgical guides, and laser printing of custom titanium bony plates to support composite free flaps, and evaluated their utility.
Ghost cell odontogenic carcinomas are rare neoplasms that arise in the maxillary bones either fro... more Ghost cell odontogenic carcinomas are rare neoplasms that arise in the maxillary bones either from a calcifying odontogenic cyst or de novo. They are aggressive locally and can metastasize. We report herein a case of a ghost cell odontogenic carcinoma arising in the mandible of a Caucasian male 86 years of age. We have described the clinical and radiographic features, histological characteristics, immunohistochemistry findings, and surgical treatment. We especially focused on how Ki-67 expression guides the treatment choice. Finally, we reviewed 32 cases described in the literature and compared them with the cases described up until 2014 to help clinicians identify the diagnostic characteristics of and select appropriate treatment modalities for ghost cell odontogenic carcinomas.
Background: Central mucoepidermoid carcinoma is a rare malignant salivary neoplasm arising inside... more Background: Central mucoepidermoid carcinoma is a rare malignant salivary neoplasm arising inside the bone of the jaws. We report a rare case of central mucoepidermoid carcinoma of a 16-year-old girl arising in the maxilla. Clinical and radiological analyses were shown and discussed, as well as the surgical treatment. Methods: A left maxillectomy from the last molar to the first premolar was performed, and the site was reconstructed using a fibula free flap stabilized with titanium plates. Results: The young patient was followed up for more than 6 years, and to date no recurrence was observed. A literature review of the 11 rare previous cases was provided to guide the clinician in the diagnosis and management of this unusual glandular tumor. Conclusion: It is of immense importance to differentiate the central mucoepidermoid from other osteolytic lesion and odontogenic cysts because of his malignancy and local aggressiveness. The treatment option is the radical excision, with the evaluation of neck nodes, and radiotherapy is only recommended in the most aggressive of cases.
A retrospective longitudinal study was conducted to identify the cutoff value of infiltration dep... more A retrospective longitudinal study was conducted to identify the cutoff value of infiltration depth for predicting the risk of lymph node metastasis of the neck in a well-defined population of surgically treated patients affected by stage T1 to T2 oral squamous cell carcinoma of the tongue. Sixty-seven patients were enrolled in this study. Forty-four patients (65.5%) had pN0 status and 23 (34.5%) had pN(+) status. Thirty-five positive lymph nodes were analyzed. The median follow-up for these patients was 51.4 months. The mean infiltration depth of the N-negative group was 2.4 mm; this was substantially different from the mean value observed in the N-positive group at 5.5 mm. A meaningful cutoff was identified at an infiltration depth value of 4 mm. Infiltration depth was identified as an important predictor for neck nodal status. In this specific population, mortality was associated with increasing tumor infiltration depth.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, Jan 19, 2015
Modern planning techniques, including computer-aided design/computer-aided manufacturing (CAD-CAM... more Modern planning techniques, including computer-aided design/computer-aided manufacturing (CAD-CAM) can be used to plan reconstructive surgery, optimising aesthetic outcomes and functional rehabilitation. However, although many such applications are available, no systematic protocol yet describes the entire reconstructive procedure, which must include virtual planning, custom manufacture, and a reconstructive algorithm. We reviewed current practices in this novel field, analysed case series described in the literature, and developed a new, defect-based reconstructive algorithm. We also evaluated methods of mandibular reconstruction featuring virtual planning, the use of surgical guides, and laser printing of custom titanium bony plates to support composite free flaps, and evaluated their utility.
Ghost cell odontogenic carcinomas are rare neoplasms that arise in the maxillary bones either fro... more Ghost cell odontogenic carcinomas are rare neoplasms that arise in the maxillary bones either from a calcifying odontogenic cyst or de novo. They are aggressive locally and can metastasize. We report herein a case of a ghost cell odontogenic carcinoma arising in the mandible of a Caucasian male 86 years of age. We have described the clinical and radiographic features, histological characteristics, immunohistochemistry findings, and surgical treatment. We especially focused on how Ki-67 expression guides the treatment choice. Finally, we reviewed 32 cases described in the literature and compared them with the cases described up until 2014 to help clinicians identify the diagnostic characteristics of and select appropriate treatment modalities for ghost cell odontogenic carcinomas.
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Papers by Giacomo Del Corso