Background: Together with women giving birth, healthcare professionals involved in perinatal care... more Background: Together with women giving birth, healthcare professionals involved in perinatal care faced significant challenges due to Covid-19 restrictions. The birth environment has been affected, influencing the quality and nature of interactions between care providers, women, and their families as well as the quality of care provided to women. Aim: To identify, categorize and reflect on the most relevant aspects of the experience of healthcare workers, especially obstetricians and gynecologists, involved in the peripartum period, after the first wave of the Covid-19 pandemic up till now. Methods: A scoping review was conducted. After conducting a literature search using a variety of online data- bases, 22 articles were included, and the main/recurrent themes were identified. Results: The following main themes were described: fear of the virus, changes in the way care is provided, increase in the workload, mental health, psychological distress, support strategies, university educa...
Although the COVID-19 pandemic appears to be diminishing, the emergence of SARS-CoV-2 variants re... more Although the COVID-19 pandemic appears to be diminishing, the emergence of SARS-CoV-2 variants represents a threat to humans due to its inherent transmissibility, immunological evasion, virulence, and invulnerability to existing therapies. The previous COVID-19 pandemic affected more than 500 million people and caused over 6 million deaths. Vaccines are essential, but in circumstances when vaccination is not accessible or in individuals with compromised immune systems, drugs can give additional protection. Targeting host signaling pathways is recommended due to their genomic stability and resistance barriers. Plant-derived products, which have been used in traditional medicine for treating pathological conditions, offer structurally novel therapeutic compounds including anti-viral. In addition, plant-derived bioactive substances might serve as the ideal basis for developing sustainable/efficient/cost-effective anti-viral alternatives. Epigenetic modifications in the genome can affec...
Due to increased global use, acute and chronic exposures to pyrethroid insecticides in humans are... more Due to increased global use, acute and chronic exposures to pyrethroid insecticides in humans are of clinical concern. Pyrethroids have a primary mode of action that involves interference with the sodium and calcium channels in excitable cells, which may include cardiac myocytes. Here, we investigated the possible cardiac toxicity of permethrin metabolites (METP), 3-phenoxy-benzyl alcohol (3PBA), 3-phenoxy-benzaldehyde (3PBALD), and 3-phenoxybenzoic acid (3PBACID). Plasma membrane fluidity, polarity, lipid, and protein oxidation were studied in isolated rat heart cells. Laurdan was chosen as probe to detect the lateral mobility and polarity of its environment and thus water penetration into the hydrophobic part of the bilayer, while 1,6-diphenyl-1,3,5-hexatriene permits to measure changes in fluidity in the inner part of the bilayer. Results show that METP can change membrane fluidity at different depths of the bilayer according to their partition coefficient. Consequently, 3PBA, at all concentration used, decreases membrane fluidity and polarity in the hydrophilic-hydrophobic region of the bilayer, and similar effect was observed with 20 μM 3PBALD or 10 or 20 μM 3 PBACID. Membrane dynamics in the hydrophobic core resulted decreased by 3PBALD, while it was increased by 20 μM 3PBACID. All METP increase protein and lipid oxidation, and the peroxidative lipid damage decreases with the type of METP produced during the transformation pathway from parent compound to 3PBACID. Consequently, 3PBA induced the highest lipid peroxidation, while 3PBACID was the stronger inducer of protein damage.
Background: Together with women giving birth, healthcare professionals involved in perinatal care... more Background: Together with women giving birth, healthcare professionals involved in perinatal care faced significant challenges due to Covid-19 restrictions. The birth environment has been affected, influencing the quality and nature of interactions between care providers, women, and their families as well as the quality of care provided to women. Aim: To identify, categorize and reflect on the most relevant aspects of the experience of healthcare workers, especially obstetricians and gynecologists, involved in the peripartum period, after the first wave of the Covid-19 pandemic up till now. Methods: A scoping review was conducted. After conducting a literature search using a variety of online data- bases, 22 articles were included, and the main/recurrent themes were identified. Results: The following main themes were described: fear of the virus, changes in the way care is provided, increase in the workload, mental health, psychological distress, support strategies, university educa...
Although the COVID-19 pandemic appears to be diminishing, the emergence of SARS-CoV-2 variants re... more Although the COVID-19 pandemic appears to be diminishing, the emergence of SARS-CoV-2 variants represents a threat to humans due to its inherent transmissibility, immunological evasion, virulence, and invulnerability to existing therapies. The previous COVID-19 pandemic affected more than 500 million people and caused over 6 million deaths. Vaccines are essential, but in circumstances when vaccination is not accessible or in individuals with compromised immune systems, drugs can give additional protection. Targeting host signaling pathways is recommended due to their genomic stability and resistance barriers. Plant-derived products, which have been used in traditional medicine for treating pathological conditions, offer structurally novel therapeutic compounds including anti-viral. In addition, plant-derived bioactive substances might serve as the ideal basis for developing sustainable/efficient/cost-effective anti-viral alternatives. Epigenetic modifications in the genome can affec...
Due to increased global use, acute and chronic exposures to pyrethroid insecticides in humans are... more Due to increased global use, acute and chronic exposures to pyrethroid insecticides in humans are of clinical concern. Pyrethroids have a primary mode of action that involves interference with the sodium and calcium channels in excitable cells, which may include cardiac myocytes. Here, we investigated the possible cardiac toxicity of permethrin metabolites (METP), 3-phenoxy-benzyl alcohol (3PBA), 3-phenoxy-benzaldehyde (3PBALD), and 3-phenoxybenzoic acid (3PBACID). Plasma membrane fluidity, polarity, lipid, and protein oxidation were studied in isolated rat heart cells. Laurdan was chosen as probe to detect the lateral mobility and polarity of its environment and thus water penetration into the hydrophobic part of the bilayer, while 1,6-diphenyl-1,3,5-hexatriene permits to measure changes in fluidity in the inner part of the bilayer. Results show that METP can change membrane fluidity at different depths of the bilayer according to their partition coefficient. Consequently, 3PBA, at all concentration used, decreases membrane fluidity and polarity in the hydrophilic-hydrophobic region of the bilayer, and similar effect was observed with 20 μM 3PBALD or 10 or 20 μM 3 PBACID. Membrane dynamics in the hydrophobic core resulted decreased by 3PBALD, while it was increased by 20 μM 3PBACID. All METP increase protein and lipid oxidation, and the peroxidative lipid damage decreases with the type of METP produced during the transformation pathway from parent compound to 3PBACID. Consequently, 3PBA induced the highest lipid peroxidation, while 3PBACID was the stronger inducer of protein damage.
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Papers by Rosita Gabbianelli