Poster: "ECR 2016 / C-2144 / The challenge of B3 breast lesions at ultrasound-guided core ne... more Poster: "ECR 2016 / C-2144 / The challenge of B3 breast lesions at ultrasound-guided core needle biopsy: how to reduce the frequency of benign excision biopsies" by: "R. Rella, M. Giuliani, F. Patrolecco, S. E. Di Giovanni, F. Petta, M. Romani, P. Rinaldi, P. Belli, L. Bonomo; Rome/IT"
International Journal of Gynecological Cancer, 2020
Background Fusion imaging is a new diagnostic method that integrates MRI and ultrasound. It may i... more Background Fusion imaging is a new diagnostic method that integrates MRI and ultrasound. It may improve the detection and staging of locally advanced cervical cancer. Objective To evaluate the feasibility and accuracy of fusion imaging in patients with locally advanced cervical cancer. Methods Patients with suspicion of locally advanced cervical cancer at clinical examination and/or imaging, who were candidates for neoadjuvant treatment (chemotherapy or chemoradiation) followed by surgery, were prospectively enrolled between March and November 2018. MRI, ultrasound, and fusion images were obtained before and after neoadjuvant treatment. Feasibility, success of the fusion examination, and time needed to perform fusion studies were evaluated. The rates of concordance between MRI and ultrasound before and after performing fusion, using Cohen, Spearman, and McNemar tests were calculated. The agreement between MRI and ultrasound examination, and the agreement between radiologist and gyne...
The incidence of abdominal and pelvic cancer in pregnancy is low, but it's rising as the popu... more The incidence of abdominal and pelvic cancer in pregnancy is low, but it's rising as the population of pregnant women gets older. Depending on disease stage, gestational age and patient's preference, active surveillance but also surgery and chemotherapy during pregnancy are feasible options. A correct diagnosis and staging of the tumor is crucial for choosing the best therapeutic approach. Moreover, a reproducible modality to assess the treatment response is requested. Magnetic resonance imaging (MRI) is commonly used with good results for the local staging and treatment response evaluation of most abdominal and pelvic cancers in non-pregnant patients and it's considered relatively safe during pregnancy. The purpose of this article is to analyze the most relevant topics regarding the use of MRI in pregnant women with abdominal and pelvic cancer. We discuss MRI safety during pregnancy, including the use of gadolinium-based contrast agents (GBCAs), how to prepare the patie...
Ovarian cystadenofibroma is a benign ovarian tumor that is characterized by a consistent percenta... more Ovarian cystadenofibroma is a benign ovarian tumor that is characterized by a consistent percentage of masses, which remain indeterminate in ultrasonography and require magnetic resonance (MR) investigation; they may mimic borderline or malignant lesions. Three main morphologic patterns, resembling different ovarian neoplasms, can be identified in cystadenofibromas: multilocular solid lesions, unilocular cystic lesions with parietal thickening, and purely cystic masses. However, a cystoadenofibroma has typical features, such as T2-weighted hypointensity associated with no restrictions in diffusion-weighted imaging (the so-called "dark-dark appearance") and progressive post-contrast enhancement (type I perfusion curve). The purpose of this study was to review the features of ovarian cystadenofibromas in MR imaging and to suggest pearls and pitfalls regarding their correct diagnosis.
The aim of the present study was to assess the diagnostic accuracy of ultrasound-guided core need... more The aim of the present study was to assess the diagnostic accuracy of ultrasound-guided core needle biopsy (US-CNB) of breast lesions, comparing smaller needles (16- and 18-gauge) with the 14-gauge needle, and to analyze the lesion characteristics influencing US-CNB diagnostic performance. All the patients provided informed consent before the biopsy procedure. The data from breast lesions that had undergone US-CNB in our institution from January 2011 to January 2015 were retrospectively reviewed. The inclusion criterion was the surgical histopathologic examination findings of the entire lesion or radiologic follow-up data for ≥ 24 months. The exclusion criterion was the use of preoperative neoadjuvant therapy. The US-CNB results were compared with the surgical pathologic results or with the follow-up findings in the 3 needle size groups (14-, 16-, and 18-gauge). The needle size- and lesion characteristic-specific diagnostic accuracy parameters were evaluated. Statistical analysis wa...
Poster: "ECR 2018 / C-3101 / Myositis ossificans: tips and tricks to recognize it and differ... more Poster: "ECR 2018 / C-3101 / Myositis ossificans: tips and tricks to recognize it and differential diagnosis." by: "F. Petta1, M. C. Cortese1, N. Magarelli2, A. Leone2, C. Colosimo2; 1Roma/IT, 2Rome/IT"
The expanding therapeutic use of high-dose intravenous immunoglobulin (IVIg) in autoimmune diseas... more The expanding therapeutic use of high-dose intravenous immunoglobulin (IVIg) in autoimmune diseases has raised important practical and conceptual issues over the last few years. These have prompted a number of research efforts aimed at characterizing aspects of the mechanism of action of current IVIg preparations, which might lead to the development of standardized, more cost-effective agents. Although polyclonal IgG in these preparations are mostly thought to act via direct interference with disease-specific, pathogenic autoantibodies, evidence from clinical and experimental work points to the involvement of crucial checkpoints upstream of self-reactive B-cell activation and autoantibody production. Reviewed herein are the results of the most recent studies documenting the crucial role of regulatory T cells (Treg) in the immunomodulatory activity of IVIg, and the molecular mechanisms mediating the effect of specific IgG fragments and glycoforms on Treg activity and the ensuing down...
Poster: "ECR 2016 / C-2144 / The challenge of B3 breast lesions at ultrasound-guided core ne... more Poster: "ECR 2016 / C-2144 / The challenge of B3 breast lesions at ultrasound-guided core needle biopsy: how to reduce the frequency of benign excision biopsies" by: "R. Rella, M. Giuliani, F. Patrolecco, S. E. Di Giovanni, F. Petta, M. Romani, P. Rinaldi, P. Belli, L. Bonomo; Rome/IT"
International Journal of Gynecological Cancer, 2020
Background Fusion imaging is a new diagnostic method that integrates MRI and ultrasound. It may i... more Background Fusion imaging is a new diagnostic method that integrates MRI and ultrasound. It may improve the detection and staging of locally advanced cervical cancer. Objective To evaluate the feasibility and accuracy of fusion imaging in patients with locally advanced cervical cancer. Methods Patients with suspicion of locally advanced cervical cancer at clinical examination and/or imaging, who were candidates for neoadjuvant treatment (chemotherapy or chemoradiation) followed by surgery, were prospectively enrolled between March and November 2018. MRI, ultrasound, and fusion images were obtained before and after neoadjuvant treatment. Feasibility, success of the fusion examination, and time needed to perform fusion studies were evaluated. The rates of concordance between MRI and ultrasound before and after performing fusion, using Cohen, Spearman, and McNemar tests were calculated. The agreement between MRI and ultrasound examination, and the agreement between radiologist and gyne...
The incidence of abdominal and pelvic cancer in pregnancy is low, but it's rising as the popu... more The incidence of abdominal and pelvic cancer in pregnancy is low, but it's rising as the population of pregnant women gets older. Depending on disease stage, gestational age and patient's preference, active surveillance but also surgery and chemotherapy during pregnancy are feasible options. A correct diagnosis and staging of the tumor is crucial for choosing the best therapeutic approach. Moreover, a reproducible modality to assess the treatment response is requested. Magnetic resonance imaging (MRI) is commonly used with good results for the local staging and treatment response evaluation of most abdominal and pelvic cancers in non-pregnant patients and it's considered relatively safe during pregnancy. The purpose of this article is to analyze the most relevant topics regarding the use of MRI in pregnant women with abdominal and pelvic cancer. We discuss MRI safety during pregnancy, including the use of gadolinium-based contrast agents (GBCAs), how to prepare the patie...
Ovarian cystadenofibroma is a benign ovarian tumor that is characterized by a consistent percenta... more Ovarian cystadenofibroma is a benign ovarian tumor that is characterized by a consistent percentage of masses, which remain indeterminate in ultrasonography and require magnetic resonance (MR) investigation; they may mimic borderline or malignant lesions. Three main morphologic patterns, resembling different ovarian neoplasms, can be identified in cystadenofibromas: multilocular solid lesions, unilocular cystic lesions with parietal thickening, and purely cystic masses. However, a cystoadenofibroma has typical features, such as T2-weighted hypointensity associated with no restrictions in diffusion-weighted imaging (the so-called "dark-dark appearance") and progressive post-contrast enhancement (type I perfusion curve). The purpose of this study was to review the features of ovarian cystadenofibromas in MR imaging and to suggest pearls and pitfalls regarding their correct diagnosis.
The aim of the present study was to assess the diagnostic accuracy of ultrasound-guided core need... more The aim of the present study was to assess the diagnostic accuracy of ultrasound-guided core needle biopsy (US-CNB) of breast lesions, comparing smaller needles (16- and 18-gauge) with the 14-gauge needle, and to analyze the lesion characteristics influencing US-CNB diagnostic performance. All the patients provided informed consent before the biopsy procedure. The data from breast lesions that had undergone US-CNB in our institution from January 2011 to January 2015 were retrospectively reviewed. The inclusion criterion was the surgical histopathologic examination findings of the entire lesion or radiologic follow-up data for ≥ 24 months. The exclusion criterion was the use of preoperative neoadjuvant therapy. The US-CNB results were compared with the surgical pathologic results or with the follow-up findings in the 3 needle size groups (14-, 16-, and 18-gauge). The needle size- and lesion characteristic-specific diagnostic accuracy parameters were evaluated. Statistical analysis wa...
Poster: "ECR 2018 / C-3101 / Myositis ossificans: tips and tricks to recognize it and differ... more Poster: "ECR 2018 / C-3101 / Myositis ossificans: tips and tricks to recognize it and differential diagnosis." by: "F. Petta1, M. C. Cortese1, N. Magarelli2, A. Leone2, C. Colosimo2; 1Roma/IT, 2Rome/IT"
The expanding therapeutic use of high-dose intravenous immunoglobulin (IVIg) in autoimmune diseas... more The expanding therapeutic use of high-dose intravenous immunoglobulin (IVIg) in autoimmune diseases has raised important practical and conceptual issues over the last few years. These have prompted a number of research efforts aimed at characterizing aspects of the mechanism of action of current IVIg preparations, which might lead to the development of standardized, more cost-effective agents. Although polyclonal IgG in these preparations are mostly thought to act via direct interference with disease-specific, pathogenic autoantibodies, evidence from clinical and experimental work points to the involvement of crucial checkpoints upstream of self-reactive B-cell activation and autoantibody production. Reviewed herein are the results of the most recent studies documenting the crucial role of regulatory T cells (Treg) in the immunomodulatory activity of IVIg, and the molecular mechanisms mediating the effect of specific IgG fragments and glycoforms on Treg activity and the ensuing down...
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Papers by Federica Petta