RésuméLe concept de race a oscillé dès l'origine entre la sphère politico-sociale et la biolo... more RésuméLe concept de race a oscillé dès l'origine entre la sphère politico-sociale et la biologie. Si les perspectives sociales ont été dominantes dans la seconde moitié du XXe siècle, une nouvelle forme de naturalisation semble émerger à l’ère de l’épigénétique. Dans cet article, je montre que la conception épigénétique de la race rappelle d'anciennes perspectives externalistes et engage à articuler naturalisme, environnementalisme et constructivisme biosocial. Je souligne qu'elle fait apparaître la race comme une propriété relationnelle, plastique et accidentelle, et les groupes raciaux comme des constructions bio-sociales historiquement contingentes.
L’extension du concept d’hérédité au-delà du tout génétique a fait l’objet de nombreux débats en ... more L’extension du concept d’hérédité au-delà du tout génétique a fait l’objet de nombreux débats en biologie de l’évolution, mais elle a été relativement ignorée dans le champ de la biomédecine. L’objectif de cet article prospectif est de souligner les conséquences potentielles d’une vision renouvelée de l’hérédité sur la théorie médicale, notamment sur le concept de maladie héréditaire, ainsi que de mettre en évidence certains enjeux pratiques et sociaux connexes.
The Genotype-Phenotype (G-P) distinction was proposed in the context of Mendelian genetics, in th... more The Genotype-Phenotype (G-P) distinction was proposed in the context of Mendelian genetics, in the wake of late 19th century studies about heredity. In this paper, we provide a conceptual analysis that highlights that the G-P distinction was grounded on three pillars: observability, transmissibility, and causality. Originally, the genotype is the non-observable and transmissible cause of the phenotype, which is its observable and non-transmissible effect. We argue that the current developments of biology have called the validity of such pillars into question. First, molecular biology has unveiled the putative material substrate of the genotype (qua DNA), making it an observable object. Second, numerous findings on nongenetic heredity suggest that some phenotypic traits can be directly transmitted. Third, recent organicist approaches to biological phenomena have emphasized the reciprocal causality between parts of a biological system, which notably applies to the relations between genotypes and phenotypes. As a consequence, we submit that the G-P distinction has lost its general validity, although it can still apply to specific situations. This calls for forging new frameworks and concepts to better describe heredity and development.
Dans cet article, j’interroge les differents roles ayant ete joues par les metaphores dans les et... more Dans cet article, j’interroge les differents roles ayant ete joues par les metaphores dans les etudes consacrees a l’heredite biologique. Je soutiens plus precisement que ces roles ont eu une incidence significative sur le statut epistemologique d’un concept cle des sciences du vivant. A travers un bref parcours historique, je montre que la notion d’heredite biologique a oscille, depuis son introduction en medecine et en physiologie, entre theorie et metaphore. J’affirme en particulier que les recentes etudes sur l’heredite dite etendue mobilisent des metaphores non assumees et ramenent ainsi subtilement l’heredite biologique dans le champ des concepts metaphoriques1.
The Genotype-Phenotype (G-P) distinction was proposed in the context of Mendelian genetics, in th... more The Genotype-Phenotype (G-P) distinction was proposed in the context of Mendelian genetics, in the wake of late 19th century studies about heredity. In this paper, we provide a conceptual analysis that highlights that the G-P distinction was grounded on three pillars: observability, transmissibility, and causality. Originally, the genotype is the non-observable and transmissible cause of the phenotype, which is its observable and non-transmissible effect. We argue that the current developments of biology have called the validity of such pillars into question. First, molecular biology has unveiled the putative material substrate of the genotype (qua DNA), making it an observable object. Second, numerous findings on nongenetic heredity suggest that some phenotypic traits can be directly transmitted. Third, recent organicist approaches to biological phenomena have emphasized the reciprocal causality between parts of a biological system, which notably applies to the relations between genotypes and phenotypes. As a consequence, we submit that the G-P distinction has lost its general validity, although it can still apply to specific situations. This calls for forging new frameworks and concepts to better describe heredity and development.
Looking at the new and often disputed science of epigenetics, we examined the challenges faced by... more Looking at the new and often disputed science of epigenetics, we examined the challenges faced by scientists when they communicate scientific research to the public. We focused on the use of metaphors to illustrate notions of epigenetics and genetics. We studied the “encoding” by epigeneticists and “decoding” in focus groups with diverse backgrounds. We observed considerable overlap in the dominant metaphors favored by both researchers and the lay public. However, the groups differed markedly in their interpretations of which metaphors aided understanding or not. We conclude by discussing the role of metaphors and their interpretations in the context of a shift from pre-deterministic genomic metaphors to more active, dynamic and nuanced epigenetic metaphors. These reflections on the choice of metaphors and differences in encoding/decoding are important for science communication and scientific boundary-maintenance.
The British Journal for the Philosophy of Science, 2019
We develop a conceptual framework that connects biological heredity and organization. Heredity de... more We develop a conceptual framework that connects biological heredity and organization. Heredity designates the cross-generation conservation of functional elements, defined as constraints subject to organizational closure. While hereditary objects are functional constituents of biological systems, any other entity that is stable across generations—and possibly involved in the recurrence of phenotypes—belongs to their environment. The central outcome of the organizational perspective consists in extending the scope of heredity beyond the genetic domain without merging it with the broad category of cross-generation stability. After discussing some implications, we conclude with a reflection on the relationship between stability and variation.
The concept of biological inheritance has recently been extended so as to integrate, among other ... more The concept of biological inheritance has recently been extended so as to integrate, among other elements, parts of organisms’ environments. The literature refers to the trans-generational reconstruction of these parts in terms of environmental or ecological inheritance . This article’s main objective is to clarify the different meanings of "environmental inheritance," to underline so far unnoticed theoretical difficulties associated to this polysemous notion and to consequently argue that inheritance, even when extended, should be theoretically distinguished from trans-generational environmental stability. After disentangling the different meanings of environmental inheritance, I underline that studies dealing with this concept place themselves in the wake of earlier contributions about biological environment and elaborate on the role of organisms in the determination of their relevant developmental and selective surroundings. This leads me to question the legitimacy of t...
RésuméLe concept de race a oscillé dès l'origine entre la sphère politico-sociale et la biolo... more RésuméLe concept de race a oscillé dès l'origine entre la sphère politico-sociale et la biologie. Si les perspectives sociales ont été dominantes dans la seconde moitié du XXe siècle, une nouvelle forme de naturalisation semble émerger à l’ère de l’épigénétique. Dans cet article, je montre que la conception épigénétique de la race rappelle d'anciennes perspectives externalistes et engage à articuler naturalisme, environnementalisme et constructivisme biosocial. Je souligne qu'elle fait apparaître la race comme une propriété relationnelle, plastique et accidentelle, et les groupes raciaux comme des constructions bio-sociales historiquement contingentes.
L’extension du concept d’hérédité au-delà du tout génétique a fait l’objet de nombreux débats en ... more L’extension du concept d’hérédité au-delà du tout génétique a fait l’objet de nombreux débats en biologie de l’évolution, mais elle a été relativement ignorée dans le champ de la biomédecine. L’objectif de cet article prospectif est de souligner les conséquences potentielles d’une vision renouvelée de l’hérédité sur la théorie médicale, notamment sur le concept de maladie héréditaire, ainsi que de mettre en évidence certains enjeux pratiques et sociaux connexes.
The Genotype-Phenotype (G-P) distinction was proposed in the context of Mendelian genetics, in th... more The Genotype-Phenotype (G-P) distinction was proposed in the context of Mendelian genetics, in the wake of late 19th century studies about heredity. In this paper, we provide a conceptual analysis that highlights that the G-P distinction was grounded on three pillars: observability, transmissibility, and causality. Originally, the genotype is the non-observable and transmissible cause of the phenotype, which is its observable and non-transmissible effect. We argue that the current developments of biology have called the validity of such pillars into question. First, molecular biology has unveiled the putative material substrate of the genotype (qua DNA), making it an observable object. Second, numerous findings on nongenetic heredity suggest that some phenotypic traits can be directly transmitted. Third, recent organicist approaches to biological phenomena have emphasized the reciprocal causality between parts of a biological system, which notably applies to the relations between genotypes and phenotypes. As a consequence, we submit that the G-P distinction has lost its general validity, although it can still apply to specific situations. This calls for forging new frameworks and concepts to better describe heredity and development.
Dans cet article, j’interroge les differents roles ayant ete joues par les metaphores dans les et... more Dans cet article, j’interroge les differents roles ayant ete joues par les metaphores dans les etudes consacrees a l’heredite biologique. Je soutiens plus precisement que ces roles ont eu une incidence significative sur le statut epistemologique d’un concept cle des sciences du vivant. A travers un bref parcours historique, je montre que la notion d’heredite biologique a oscille, depuis son introduction en medecine et en physiologie, entre theorie et metaphore. J’affirme en particulier que les recentes etudes sur l’heredite dite etendue mobilisent des metaphores non assumees et ramenent ainsi subtilement l’heredite biologique dans le champ des concepts metaphoriques1.
The Genotype-Phenotype (G-P) distinction was proposed in the context of Mendelian genetics, in th... more The Genotype-Phenotype (G-P) distinction was proposed in the context of Mendelian genetics, in the wake of late 19th century studies about heredity. In this paper, we provide a conceptual analysis that highlights that the G-P distinction was grounded on three pillars: observability, transmissibility, and causality. Originally, the genotype is the non-observable and transmissible cause of the phenotype, which is its observable and non-transmissible effect. We argue that the current developments of biology have called the validity of such pillars into question. First, molecular biology has unveiled the putative material substrate of the genotype (qua DNA), making it an observable object. Second, numerous findings on nongenetic heredity suggest that some phenotypic traits can be directly transmitted. Third, recent organicist approaches to biological phenomena have emphasized the reciprocal causality between parts of a biological system, which notably applies to the relations between genotypes and phenotypes. As a consequence, we submit that the G-P distinction has lost its general validity, although it can still apply to specific situations. This calls for forging new frameworks and concepts to better describe heredity and development.
Looking at the new and often disputed science of epigenetics, we examined the challenges faced by... more Looking at the new and often disputed science of epigenetics, we examined the challenges faced by scientists when they communicate scientific research to the public. We focused on the use of metaphors to illustrate notions of epigenetics and genetics. We studied the “encoding” by epigeneticists and “decoding” in focus groups with diverse backgrounds. We observed considerable overlap in the dominant metaphors favored by both researchers and the lay public. However, the groups differed markedly in their interpretations of which metaphors aided understanding or not. We conclude by discussing the role of metaphors and their interpretations in the context of a shift from pre-deterministic genomic metaphors to more active, dynamic and nuanced epigenetic metaphors. These reflections on the choice of metaphors and differences in encoding/decoding are important for science communication and scientific boundary-maintenance.
The British Journal for the Philosophy of Science, 2019
We develop a conceptual framework that connects biological heredity and organization. Heredity de... more We develop a conceptual framework that connects biological heredity and organization. Heredity designates the cross-generation conservation of functional elements, defined as constraints subject to organizational closure. While hereditary objects are functional constituents of biological systems, any other entity that is stable across generations—and possibly involved in the recurrence of phenotypes—belongs to their environment. The central outcome of the organizational perspective consists in extending the scope of heredity beyond the genetic domain without merging it with the broad category of cross-generation stability. After discussing some implications, we conclude with a reflection on the relationship between stability and variation.
The concept of biological inheritance has recently been extended so as to integrate, among other ... more The concept of biological inheritance has recently been extended so as to integrate, among other elements, parts of organisms’ environments. The literature refers to the trans-generational reconstruction of these parts in terms of environmental or ecological inheritance . This article’s main objective is to clarify the different meanings of "environmental inheritance," to underline so far unnoticed theoretical difficulties associated to this polysemous notion and to consequently argue that inheritance, even when extended, should be theoretically distinguished from trans-generational environmental stability. After disentangling the different meanings of environmental inheritance, I underline that studies dealing with this concept place themselves in the wake of earlier contributions about biological environment and elaborate on the role of organisms in the determination of their relevant developmental and selective surroundings. This leads me to question the legitimacy of t...
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Papers by Gaelle Pontarotti