Kolorektalni karcinom (engl. Colorectal Cancer, CRC) je treći najčešći maligni tumor na svijetu. ... more Kolorektalni karcinom (engl. Colorectal Cancer, CRC) je treći najčešći maligni tumor na svijetu. Procjenjuje se da 10-20 % pacijenata oboljelih od karcinoma umire zbog posljedica pothranjenosti, a ne zbog samog karcinoma. Nutritivni status bolesnika znatno utječe na ishod liječenja bolesnika s CRC-om, bez obzira na to je li riječ o pothranjenosti, gubitku potporne mišićne mase, normalnoj ili prekomjernoj tjelesnoj masi. Problemi s prehranom trebaju se uzeti u obzir i rješavati od vremena postavljanja dijagnoze, kirurškog liječenja te paralelno s antineoplastičnim liječenjem (kemoterapija, imunoterapija i endokrina terapija) i radioterapijom. Pri tom je važno imati multidisciplinarni tim jer postupci uključuju procjenu statusa validiranim probirnim upitnicima na malnutriciju NRS 2002 (engl. Nutritional Risk Screening 2002) i sarkopeniju SARC-F (engl. Strength, assistance with walking, rising from a chair, climbing stairs and falls), mjerenje mišićne snage i funkcije dinamometrijom šake, analizu sastava tijela bioelektričnom impedancijom, procjenu prehrambenih navika i unosa hrane te savjetovanje o prehrani. Studije daju ohrabrujuće rezultate u primjeni fitonutrijenata zelenog čaja, ekstrakta kvercetina, omega-3 masnih kiselina, probiotika, prebiotika, prehrambenih vlakana i orašastih plodova zahvaljujući njihovim protuupalnim i antioksidativnim svojstvima. Osnovni princip periopeartivne dijetoterapije je adekvatnim namirnicama smanjiti ili spriječiti pojavu nutritivnih deficita i komplikacija koje se povećavaju promjenom nutritivnog statusa, dok u poslijeoperacijskoj i terapijskoj fazi liječenja pozitivno utjecati na bolesnikov oporavak i povratak svakodnevnim aktivnostima.
INTRODUCTION Nowdays, numerous evidence are showing beneficial effects of Mediterranean diet on c... more INTRODUCTION Nowdays, numerous evidence are showing beneficial effects of Mediterranean diet on cardiovascular disease and its components. However, there are still some ambiguities and a need for more randomized studies with stronger evidence is needed. Our aim was to explore the effect of Mediterranean diet and Standard hypolipemic diet on lipid profile in obese patients in a randomized controlled study. METHODOLOGY One hundred and one subjects with a body mass index (BMI) above 30 kg/m2 were recruited from the outpatient Clinic of Department of endocrinology, diabetes and metabolism disorders at the Dubrava University Hospital in the period from November 2008 to June 2011, and were randomly assigned to either a Mediterranean diet (MD) or Standard hypolipemic diet (SHD). All subjects received education on their diet during one-week stay in Daily hospital. To determine the lipid profiles their blood samples were obtained from the antecubital vein at baseline and after 7 days, 1, 3, and 6 months. Obtained data were entered into SPSS version 20.0 (SPSS Inc, Chicago, III) and analyzed. RESULTS AND DISCUSSION The significant increase in the HDL cholesterol value of 8.59% (P=0.001) was induced by the MD group, whereas slight (1, 45%), though insignificant increase was observed by the SHD group. Cholesterol and triglycerides showed a tendency of declining throughout the first 3- month period ; however, on the last visit a discrete, unexpected increase was noted. LDL demonstrated similar behaviour ; increasing and decreasing throughout the whole 6-month period. CONCLUSIONS MD showed higher beneficial influence on HDL colesterol than SHD what supported previous study results. Positive effect on other lipid profile markers was noticed only in the first three months, while their subsequent tendency to increase should be further explored.
Kolorektalni karcinom (engl. Colorectal Cancer, CRC) je treći najčešći maligni tumor na svijetu. ... more Kolorektalni karcinom (engl. Colorectal Cancer, CRC) je treći najčešći maligni tumor na svijetu. Procjenjuje se da 10-20 % pacijenata oboljelih od karcinoma umire zbog posljedica pothranjenosti, a ne zbog samog karcinoma. Nutritivni status bolesnika znatno utječe na ishod liječenja bolesnika s CRC-om, bez obzira na to je li riječ o pothranjenosti, gubitku potporne mišićne mase, normalnoj ili prekomjernoj tjelesnoj masi. Problemi s prehranom trebaju se uzeti u obzir i rješavati od vremena postavljanja dijagnoze, kirurškog liječenja te paralelno s antineoplastičnim liječenjem (kemoterapija, imunoterapija i endokrina terapija) i radioterapijom. Pri tom je važno imati multidisciplinarni tim jer postupci uključuju procjenu statusa validiranim probirnim upitnicima na malnutriciju NRS 2002 (engl. Nutritional Risk Screening 2002) i sarkopeniju SARC-F (engl. Strength, assistance with walking, rising from a chair, climbing stairs and falls), mjerenje mišićne snage i funkcije dinamometrijom šake, analizu sastava tijela bioelektričnom impedancijom, procjenu prehrambenih navika i unosa hrane te savjetovanje o prehrani. Studije daju ohrabrujuće rezultate u primjeni fitonutrijenata zelenog čaja, ekstrakta kvercetina, omega-3 masnih kiselina, probiotika, prebiotika, prehrambenih vlakana i orašastih plodova zahvaljujući njihovim protuupalnim i antioksidativnim svojstvima. Osnovni princip periopeartivne dijetoterapije je adekvatnim namirnicama smanjiti ili spriječiti pojavu nutritivnih deficita i komplikacija koje se povećavaju promjenom nutritivnog statusa, dok u poslijeoperacijskoj i terapijskoj fazi liječenja pozitivno utjecati na bolesnikov oporavak i povratak svakodnevnim aktivnostima.
INTRODUCTION Nowdays, numerous evidence are showing beneficial effects of Mediterranean diet on c... more INTRODUCTION Nowdays, numerous evidence are showing beneficial effects of Mediterranean diet on cardiovascular disease and its components. However, there are still some ambiguities and a need for more randomized studies with stronger evidence is needed. Our aim was to explore the effect of Mediterranean diet and Standard hypolipemic diet on lipid profile in obese patients in a randomized controlled study. METHODOLOGY One hundred and one subjects with a body mass index (BMI) above 30 kg/m2 were recruited from the outpatient Clinic of Department of endocrinology, diabetes and metabolism disorders at the Dubrava University Hospital in the period from November 2008 to June 2011, and were randomly assigned to either a Mediterranean diet (MD) or Standard hypolipemic diet (SHD). All subjects received education on their diet during one-week stay in Daily hospital. To determine the lipid profiles their blood samples were obtained from the antecubital vein at baseline and after 7 days, 1, 3, and 6 months. Obtained data were entered into SPSS version 20.0 (SPSS Inc, Chicago, III) and analyzed. RESULTS AND DISCUSSION The significant increase in the HDL cholesterol value of 8.59% (P=0.001) was induced by the MD group, whereas slight (1, 45%), though insignificant increase was observed by the SHD group. Cholesterol and triglycerides showed a tendency of declining throughout the first 3- month period ; however, on the last visit a discrete, unexpected increase was noted. LDL demonstrated similar behaviour ; increasing and decreasing throughout the whole 6-month period. CONCLUSIONS MD showed higher beneficial influence on HDL colesterol than SHD what supported previous study results. Positive effect on other lipid profile markers was noticed only in the first three months, while their subsequent tendency to increase should be further explored.
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Papers by Irena Martinis