Chemica

Now-a-days preparation and study of nano particles has gain significant consideration. The common theme here is always "size matters" and over the last decades, researchers have developed exciting new materials with unique and tuneable properties. Among wide spread fields in this area, we focused on the synthesis and study of ferromagnetic iron oxides (acicular goethite) which has different application in various magnetic tapes and medical monitoring. We report synthesis of acicular goethite by using ionic liquid as a solvent and as an oxidant. With the help of [BMIM]ClO3 the reaction time was decreased from 6 h to 2 h and oxidation reaction was took place at the lower temperature (changing from 60 ºC to 40 ºC).

Introduction: Bifunctional radiosensitizer agents in which nitroaromatic moieties are attached through a linker to antineoplastic moieties have demonstrated higher cytotoxicity and radiosensitizer effects than the corresponding counterparts. This study was conducted to investigate the cytotoxicity and radiosensitizer activities of 2, 4-dinitrobenzene as a radiosensitizer moiety which connected to α, β unsaturated aryl ketones against the radioresistant human HT29 colon cancer cells. Methods: A series of bifunctional radiosensitizer derivatives that are composed of electron-affinic 2, 4-dinitrophenyl moiety and thiol reactive unsaturated conjugated ketones were prepared. The designed compounds were synthesized by the reaction of the corresponding 2, 4-dinitrobenzaldehyde, cyclohexanone and different aryl aldehydes. The cytotoxicity and radiosensitizer activity of the tested compounds were examined against HT29 colon cancer cells under aerobic condition. The IC50 value of the tested c...

Sulfuric acid functionalized Magnetic Nanocatalyst (SAMNC) has been prepared as an efficient acidic catalyst and has been applied in the one-pot preparation of 2,3-dihydroquinazolin-4(1H)-one derivatives. This catalyst has been characterized by FT-IR, SEM, VSM, TEM and TGA. According to the obtained results including time, yield and recyclability, SAMNC could be considered as an efficient catalyst for organic transformations.Sulfuric acid functionalized Magnetic Nanocatalyst (SAMNC) has been prepared as an efficient acidic catalyst and has been applied in the one-pot preparation of 2,3-dihydroquinazolin-4(1H)-one derivatives. This catalyst has been characterized by FT-IR, SEM, VSM, TEM and TGA. According to the obtained results including time, yield and recyclability, SAMNC could be considered as an efficient catalyst for organic transformations.Sulfuric acid functionalized Magnetic Nanocatalyst (SAMNC) has been prepared as an efficient acidic catalyst and has been applied in the on...

One of the important factors which influence the efficacy of antibiotics is the size of the particle that affects the permeability and penetration of antimicrobial agents in infected tissue. Vancomycin hydrochloride (VCM), as a large hydrophilic antibiotic, is unable to pass through the intestinal barrier, this antibiotic is administered intravenously to treat systemic infections. One of the approaches to increasing the absorption and permeability of drugs is reducing the size of drugs. For this reason, in this study, the intestinal permeability coefficient and the oral absorbable fraction of Vancomycin nanoparticle were assessed compared to its routine form. To analyze Permeability effectiveness (Peff), absorbable fraction, and absorption number of Vancomycin in nanoparticle and solution form at a concentration of 200, 300, and 400 µg/ml and flow rate of 0.2 ml/min for 80 min, Single-pass intestinal perfusion(SPIP) method was performed. Data showed that the Effective permeability(P...