short-paper

Predicting candidate epitopes on Ebolaviruse for possible vaccine development

Authors:

Maryam Hemmati,

Hossein EinAbadi,

Hossein FallahiAuthors Info & Claims

ASONAM '15: Proceedings of the 2015 IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining 2015

Pages 1083 - 1088

https://doi.org/10.1145/2808797.2809370

Published: 25 August 2015 Publication History

Abstract

Zaire ebolavirus a member of family Filoviridae is the cause of hemorrhagic fever. Due to lack of appropriate anti-viral or vaccine, this disease is very lethal. In this study we tried to find epitopes for superficial glycoprotein of Zaire ebolavirus (that have high antigenicity for MHC I, II and B cells) with use of in-silico methods and immunoinformatics approach. By use of CTLPred, SYFPEITHI and Propred web applications for MHC class I and SYFPEITHI and Propred1web applications for MHC class II we had been able to find epitopes (peptides) that have highest score. Also ElliPro, IgPred and Discotope web tools had been performed to predict B cells epitopes. The sequence "SRFTPQFLL" and "IFFLYDRLAS" were selected to be epitopes for MHCs molecules. The region 255 to 310 was selected for B cell epitope. It was expected these peptides could be stimulated immune response and used for designing multi-peptide vaccine against ZEV but these results should be reliable with experimental analysis.

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Cited By

Raoufi EBahramimeimandi BDarestanifarahani MHosseini FSalehi-Shadkami MRaoufi HAfzalipour R(2021)Docking-Based Screening of Cell-Penetrating Peptides with Antiviral Features and Ebola Virus Proteins as a Drug Discovery Approach to Develop a Treatment for Ebola Virus DiseaseViral Outbreaks [Working Title]10.5772/intechopen.97222Online publication date: 16-Apr-2021
https://doi.org/10.5772/intechopen.97222
Raoufi EBahramimeimandi BSalehi-Shadkami MChaosri PMozafari M(2021)Methodical Design of Viral Vaccines Based on Avant-Garde Nanocarriers: A Multi-Domain Narrative ReviewBiomedicines10.3390/biomedicines90505209:5(520)Online publication date: 6-May-2021
https://doi.org/10.3390/biomedicines9050520
Zinsli LStierlin NLoessner MSchmelcher M(2021)Deimmunization of protein therapeutics – Recent advances in experimental and computational epitope prediction and deletionComputational and Structural Biotechnology Journal10.1016/j.csbj.2020.12.02419(315-329)Online publication date: 2021
https://doi.org/10.1016/j.csbj.2020.12.024
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Predicting candidate epitopes on Ebolaviruse for possible vaccine development
1. Applied computing
  1. Life and medical sciences
2. Human-centered computing
  1. Human computer interaction (HCI)
    1. Interaction paradigms

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cover image ACM Conferences

ASONAM '15: Proceedings of the 2015 IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining 2015

August 2015

835 pages

ISBN:9781450338547

DOI:10.1145/2808797

Copyright © 2015 ACM.

Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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Published: 25 August 2015

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ASONAM '15: Advances in Social Networks Analysis and Mining 2015

August 25 - 28, 2015

Paris, France

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Overall Acceptance Rate 116 of 549 submissions, 21%

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Cited By

Raoufi EBahramimeimandi BDarestanifarahani MHosseini FSalehi-Shadkami MRaoufi HAfzalipour R(2021)Docking-Based Screening of Cell-Penetrating Peptides with Antiviral Features and Ebola Virus Proteins as a Drug Discovery Approach to Develop a Treatment for Ebola Virus DiseaseViral Outbreaks [Working Title]10.5772/intechopen.97222Online publication date: 16-Apr-2021
https://doi.org/10.5772/intechopen.97222
Raoufi EBahramimeimandi BSalehi-Shadkami MChaosri PMozafari M(2021)Methodical Design of Viral Vaccines Based on Avant-Garde Nanocarriers: A Multi-Domain Narrative ReviewBiomedicines10.3390/biomedicines90505209:5(520)Online publication date: 6-May-2021
https://doi.org/10.3390/biomedicines9050520
Zinsli LStierlin NLoessner MSchmelcher M(2021)Deimmunization of protein therapeutics – Recent advances in experimental and computational epitope prediction and deletionComputational and Structural Biotechnology Journal10.1016/j.csbj.2020.12.02419(315-329)Online publication date: 2021
https://doi.org/10.1016/j.csbj.2020.12.024
Raoufi EHemmati MEftekhari SKhaksaran KMahmodi ZFarajollahi MMohsenzadegan M(2019)Epitope Prediction by Novel Immunoinformatics Approach: A State-of-the-art ReviewInternational Journal of Peptide Research and Therapeutics10.1007/s10989-019-09918-zOnline publication date: 20-Aug-2019
https://doi.org/10.1007/s10989-019-09918-z
Hemmati MRaoufi EFallahi H(2018)Predicting Candidate Epitopes on Ebola Virus for Possible Vaccine DevelopmentAdvances in Ebola Control10.5772/intechopen.72413Online publication date: 26-Apr-2018
https://doi.org/10.5772/intechopen.72413

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