Papers by Dr. M O H A M M E D Alaa
Azerbaijan Pharmaceutical and Pharmacotherapy Journal, 2023
A versatile and simple spectrophotometric technique has been presented for the detection of Ganci... more A versatile and simple spectrophotometric technique has been presented for the detection of Ganciclovir (GANCICLOVIR) in pharmaceutical formulations. The oxidation method included mixing an excessive amount of Nbromosuccinimide (NBS) with Ganciclovir in an acidic solution, then calculating the amount of unreacted NBS using methyl blue at λ 610 nm. With a superior molar absorption of 3.39 × 10 −3 L mol −1 cm −1 , the amount of NBS interacting with the colorant is equal to the amount of the drug. The Sandell's sensitivity index was 0.169 g cm −2 , the Beer-Lambert law scale was 1-35 µg mL −1 , and the recovery of the concentration was 99% with a relative standard deviation of 0.01%. The technique was successfully used to measure the drug content in pharmaceutical formulations. The precise quantification of Ganciclovir, a highly effective antiviral medication, is of considerable significance in the fields of pharmaceutical analysis and clinical practice. The objective of this study was to establish a dependable and effective approach for the quantification of Ganciclovir via an oxidation reaction employing N-bromosuccinimide (NBS) as the oxidizing agent.
Journal of the Chemical Society of Pakistan, 2023
Four different prodrugs were prepared by linking various antibiotic drugs (Ampicillin, Amoxicilli... more Four different prodrugs were prepared by linking various antibiotic drugs (Ampicillin, Amoxicillin, Ceftriaxone, and Cefotaxime) with 4-maleimidobenzoic (4-(2,5-dihydro-1H-pyrrol-1yl)benzoic acid), which is firstly converted to 4-(2,5-dihydro-1H-pyrrol-1-yl)benzoyl chloride in the presence of SOCl2 to form four maleimide derivatives [5a-d]. These derivatives were characterized by FT-IR, 1H NMR, 13CNMR, and C.H.N.S. and then studied for their antibacterial activity against E. coli and S. aureus bacteria. As well as studied the anti-cancer activities and determined their potential to reduce cell viability in the human breast cancer cell line MCF7. The findings show that the substances created in this study have a promising activity profile in terms of slowing the growth of both cancer cells and the chosen bacteria.
Chem.Soc.Pak, 2023
Four different prodrugs were prepared by linking various antibiotic drugs (Ampicillin, Amoxicilli... more Four different prodrugs were prepared by linking various antibiotic drugs (Ampicillin, Amoxicillin, Ceftriaxone, and Cefotaxime) with 4-maleimidobenzoic (4-(2,5-dihydro-1H-pyrrol-1yl)benzoic acid), which is firstly converted to 4-(2,5-dihydro-1H-pyrrol-1-yl)benzoyl chloride in the presence of SOCl2 to form four maleimide derivatives [5a-d]. These derivatives were characterized by FT-IR, 1H NMR, 13CNMR, and C.H.N.S. and then studied for their antibacterial activity against E. coli and S. aureus bacteria. As well as studied the anti-cancer activities and determined their potential to reduce cell viability in the human breast cancer cell line MCF7. The findings show that the substances created in this study have a promising activity profile in terms of slowing the growth of both cancer cells and the chosen bacteria.
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Papers by Dr. M O H A M M E D Alaa