The role of serum retinol activity in association with the Blood sugar level, and their link as b... more The role of serum retinol activity in association with the Blood sugar level, and their link as biochemical marker risk for lens inflammation and damage stage under pandemic, for the Retinal disease patients with cataract, hypertension, and diabetes, and in healthy for both genders. Total of seventy-five patients and thirty healthy control have been studied. Retinal disease patients were subdivided on the basis of pathological condition into three subgroups (First group was cataract, second was hypertension, and the third group was diabetes. Assessment, of serum retinol activity, and blood glucose levels were done for all groups. The concentricity of serum retinol levels is decreased in diabetic patients than control (13.147±7.195 (μmol/L) with 21.930±16.241 (μmol/L) versus P = 0.011)), while for cataract patients, they showed extremely similar concentricity of serum retinol levels to healthy (20.760±15.941 (μmol/L) with P = 0.790), whilst the retinol-activity was exhibited to be higher in hypertension patients (24.190±21.972 (μmol/L) versus P = 0.663). retinol activity is correlated significantly negatively with both diabetic patients and cataract. Moreover, blood sugar levels are increased in diabetes than control (10.256±4.119 (μmol/L) versus 5.365±1.084 (μmol/L) with P = 0.0001), in comparison with cataract (5.288±0.9560 (μmol/L) with P = 782). The retinol levels are correlated significantly negatively for diabetic and cataract patients. The purpose of this work: is to investigate association between retinal diseases with cataract hypertension & diabetes for risk of fasting at least eight hours in Ramadan and out of Ramadan time, and directly pre surgery gets started by artificial intraocular lens, and by estimation of retinol and blood sugar concentrations.
Infertility is one of the types of diseases that occur in the reproductive system. Obesity is a s... more Infertility is one of the types of diseases that occur in the reproductive system. Obesity is a state that can be occurred due to excessive fats, the progression in obesity stage results in a change in adipose tissue and the development of chronic inflammation, endocrine glands disorders and women’s reproductive system, and also increase the infection with covid-19. The study aimed to investigate the effect of the obesity, lipid-profile, and IL-6 on hormones-dysregulation in infertile-women with COVID-19 complications. The current study included 70 samples: 50 infertility-women-with-covid-19-infected, 20 healthy-women/control, the ages of both patients and healthy subjects were selected within the range 18-34 years. Levels of FBS, LH, FSH, and testosterone and lipid profile were measured in addition to calculating BMI. The result showed a significant increase in lipid profile but no HDL that revealed a considerable decline in its level (P=0.001) in patients group relative to control...
Rheumatoid arthritis (RA) is an autoimmune disorder of the joints that is characterized by extra-... more Rheumatoid arthritis (RA) is an autoimmune disorder of the joints that is characterized by extra-articular involvement in addition to inflammatory arthritis. Joint and periarticular tissue loss brought on by inflammation results in functional impairment. To lessen the significant daily challenges that patients confront and to ensure better outcomes, early detection and treatment are essential. The study's objective was to establish the use of human β-defensin-2 (HBD-2) as a RA diagnostic marker. A total of 60 RA patients and 30 healthy controls participated in the research. The ELISA technique was used to measure serum HBD-2. The following tests were performed: complete blood count (CBC), erythrocyte sedimentation rate (ESR), renal function test, and liver function test. In comparison to the healthy control group, the RA group exhibited a substantially higher blood HBD-2 levels (p ≤0.001). Additionally, there was no significant association between serum HBD-2 and urea, creatinin...
The coronavirus-pandemic has a major impact on women's-mental and physical-health. Polycystic... more The coronavirus-pandemic has a major impact on women's-mental and physical-health. Polycystic-ovary-syndrome (PCOS) has a high-predisposition to many cardiometabolic-risk factors that increase susceptibility to severe complications of COVID-19 and also exhibit an increased likelihood of subfertility. The study includes the extent of the effect of COVID-19-virus on renin-levels, glutathione-s-transferase-activity and other biochemical parameters in PCOS-women. The study included 120 samples of ladies that involved: 80 PCOS-patients, and 40 healthy-ladies. Both main groups were divided into subgroups based on COVID-19 infected or not. Blood-samples were collected from PCOS-patients in Kamal-Al-Samara Hospital, at the period between December until June. Some biochemical parameters were measured for all study-groups, which included: determination of serum renin levels by using the ELISA-technique, GST-activity, lipid-profile. FBS was assessed manually, and hormones were assessed us...
Diabetes mellitus type 2 (T2DM) is a chronic and progressive condition, which affects people all ... more Diabetes mellitus type 2 (T2DM) is a chronic and progressive condition, which affects people all around the world. The risk of complications increases with age if the disease is not managed properly. Diabetic neuropathy is caused by excessive blood glucose and lipid levels, resulting in nerve damage. Apelin is a peptide hormone that is found in different human organs, including the central nervous system and adipose tissue. The aim of this study is to estimate Apelin levels in diabetes type 2 and Diabetic peripheral Neuropathy (DPN) Iraqi patients and show the extent of peripheral nerve damage. The current study included 120 participants: 40 patients with Diabetes Mellitus, 40 patients with Diabetic peripheral Neuropathy, and 40 healthy persons as control, the age range of 34-66 years, matched in age and sex. For all groups, fasting blood sugar, lipid profile (Cholesterol, Triglyceride, High-density lipoprotein, Low-density lipoprotein, and very-low-density lipoprotein), HbA1c, seru...
The role of serum retinol activity in association with the Blood sugar level, and their link as b... more The role of serum retinol activity in association with the Blood sugar level, and their link as biochemical marker risk for lens inflammation and damage stage under pandemic, for the Retinal disease patients with cataract, hypertension, and diabetes, and in healthy for both genders. Total of seventy-five patients and thirty healthy control have been studied. Retinal disease patients were subdivided on the basis of pathological condition into three subgroups (First group was cataract, second was hypertension, and the third group was diabetes. Assessment, of serum retinol activity, and blood glucose levels were done for all groups. The concentricity of serum retinol levels is decreased in diabetic patients than control (13.147±7.195 (μmol/L) with 21.930±16.241 (μmol/L) versus P = 0.011)), while for cataract patients, they showed extremely similar concentricity of serum retinol levels to healthy (20.760±15.941 (μmol/L) with P = 0.790), whilst the retinol-activity was exhibited to be hi...
Vitamin K-dependent protein (VKDP) contributes to the development of lung cancer. The purpose of ... more Vitamin K-dependent protein (VKDP) contributes to the development of lung cancer. The purpose of this research was to better understanding of the role of blood matrix Gla protein (MGP), VKDPs, Malondialdehyde (MDA), Superoxide dismutase (SOD) and Vitamin K (Vit K) in Iraqi patients with lung cancer before and after the first cycle of chemotherapy. Blood samples were collected from Al amal National Hospital for cancer treatment from October 2021 to May 2022, and a total of 80 samples were collected, divided into two groups (40 patient before taking a chemotherapy and 40 patients after taking chemotherapy), ranging in age from 20 to 45 years old. The results showed that although there were highly statistically significant differences in MDA, VKDPS, SOD, and Vit K, there was no difference in MGP serum levels between the two groups (P = 0.05). The current study found a significant positive correlation between MGP and VK1 values.Correlations before and after treatment. Based on the resul...
Baghdad Journal of Biochemistry and Applied Biological Sciences
Background and objective: Polycystic ovarian syndrome (PCOS) is a common endocrinologic disorder ... more Background and objective: Polycystic ovarian syndrome (PCOS) is a common endocrinologic disorder among women of childbearing age. Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to determine the levels of renin, d-dimer, and some relevant biomarkers in patients with PCOS (with and without COVID-19) compared with non-PCOS patients (with and without COVID-19). Methods: This cross-sectional study included 120 women [80 PCOS women (40 with COVID-19 and 40 without COVID-19) and 40 non-PCOS women (20 with COVID-19 and 20 without)] with age range of 15–40 years old. Blood samples were collected from participants, and biochemical assays were carried out. Renin and d-dimer levels were determined using the enzyme-linked-immunosorbent-assay (ELISA), lipid-profile and fasting blood glucose concentrations were assessed by using the colorimetric methods, and hormones were evaluated by ...
Ibn AL-Haitham Journal For Pure and Applied Sciences
Diabetes mellitus type 2 (T2DM) is a metabolic disorder that influences above 450 million individ... more Diabetes mellitus type 2 (T2DM) is a metabolic disorder that influences above 450 million individuals around the world. Type 2 diabetes is a lack of insulin due to pancreatic β-cell malfunction and insulin resistance. This study aimed to detect insulin resistance using homeostasis model assessment (HOMA IR) and determined the correlation with glutathione-s-transferase (GST) activity in T2DM and neuropathy patients as a predictor of oxidative stress, which occurs when the oxidation-antioxidant equilibrium is disrupted. Reactive oxygen species causes vascular injury and a series of inflammation. In the present study, the results show there is no significant difference in diabetic patients (DM) and neuropathy patients (NU) versus healthy people in insulin resistance (p> 0.05). GST activity significantly differs between the patients and healthy groups (p≤0.05). Moreover, this study has reported an improvement in insulin resistance and high activity of GST in the patient's group a...
In Iraqi patients with acromegaly the present investigation included 40 control group and 70 pati... more In Iraqi patients with acromegaly the present investigation included 40 control group and 70 patients with acromegaly divided 35 patients with Diabetic while another 35 patients without Diabetic, with ages between (29-72) years for the identification of GST activity polymorphisms by present and absent GSTM1, GSTT1, and PCR-RFLP, enzymatic digestions were carried out using BsmAI (Biolabs. England, UK) for GSTP1b and AciI (Biolabs, England, UK) for GSTP1c.the association GST Activity with GST genotype were investigated in a cohort of Iraq acromegaly patients comparing with the healthy control group. The results show a non-significant change in GSTP1b gene in both groups, while show high significantly in GSTP1c in diabetic and non-diabetic acromegaly groups.
The genus Origanum consist of different aromatic and medicinal plants some of which are used in f... more The genus Origanum consist of different aromatic and medicinal plants some of which are used in folk medicine and as food additives since ancient time. This study amid to evaluate the potential anticancer activity of Origanum majorana (marjoram) (O. marjorana) on the cancer cell lines AMN-3. This study shows that O.marjorana aqueous extract has anticancer potential and can be explored futher for active component isolation, identifaction and characterization. Keywords: Origanum marjorana, Anticancer, Cytotoxic.
This work studies the role of serum apelin-36 and Glutathione S-transferases (GST) activity in as... more This work studies the role of serum apelin-36 and Glutathione S-transferases (GST) activity in association with the hormonal, metabolic profiles and their link to the risk of cardiovascular disease (CVD) in healthy and patients' ladies with polycystic ovary syndrome (PCOS). A total of fifty-four (PCOS) patients and thirty-one healthy woman as a control have been studied. The PCOS patients were subdivided on the basis of body-mass-index (BMI), into 2-subgroups (the first group was obese-PCOS with BMI ≥ 30 and the second group was non-obese PCOS MBI<30). Fasting-insulin-levels and Lipid-profile, Homeostatic-model assessment-of-insulin-resistance (HOMA-IR), follicle-stimulating-hormone (FSH), luteinizing-hormone (LH), testosterone and serum Apelin-36 (AP-36) levels, GST-Activity were done for all groups. PCO patients showed higher concentricity of apelin-36 than healthy (160.43 ±20.81 (pg/ml) versus 85.49 ± 17.85 (pg/ml), P=0.008),while GST-activity decreased in PCOS patients an...
This study was designed to evaluate the effect of major surgery on thyroid hormones and thyrotrop... more This study was designed to evaluate the effect of major surgery on thyroid hormones and thyrotropin in patient undergoing major lower abdominal surgery. The study included fifty patients scheduled for elective major lower abdominal surgery, the serum levels of T3, T4 and TSH were determined one day preoperatively, intraoperative, one day postoperatively, two days postoperatively, and rT3 was determined one day preoperatively, and one day postoperatively. We observed that the levels of (T3, T4, TSH) increased significantly (P0.05). rT3 increased not significant (P>0.05) in one day postoperatively. It has been proposed these changes due to surgical stress that inhibits peripheral conversion of T4 to T3 by inhibiting peripheral 5'-deiodinase activity, also The absence of pituitary response to changes in serum levels of T3 and T4.According to the results of this study there is a transient abnormality in thyroid function tests in patient undergoing elective major surgery and this ...
This study was designed to evaluate the effect of anesthesia on thyroid hormones (T3, T4, rT3), t... more This study was designed to evaluate the effect of anesthesia on thyroid hormones (T3, T4, rT3), thyrotropin(TSH), and cortisol levels in patients undergoing major urological surgery. The study included fifty patients scheduled for elective major urological surgery where 70% of the patients underwent general anesthesia, while30% underwent regional anesthesia. All patients were in stable control general conditions. The study showed that the thyroid hormones, thyrotropin and cortisol levels were affected with general anesthesia more than regional. The levels of these hormones responded to anesthetics and surgical stresses. This response was thought to be mainly mediated by afferent neurogenic impulses from the area of injury. Therefore, abolition of sensory as well as autonomic afferent stimuli by neurogenic blockaded types of anesthesia such as (epidural anesthesia) that may help in reducing the excretion and metabolic response to surgery.
Gestational diabetes mellitus (GDM) is a complication of gestation that is characterized by impai... more Gestational diabetes mellitus (GDM) is a complication of gestation that is characterized by impaired glucose tolerance with first recognition during gestation. It develops when ?- cell of pancreas fail to compensate the diminished insulin sensitivity during gestation. This study aims to investigate the relationship between mother adiponectin level and ?- cell dysfunction with development gestational diabetes mellitus (GDM) and other parameters in the last trimester of pregnancy. This study includes (80) subjects ( pregnant women) in the third trimester of pregnancy, (40) healthy pregnant individuals as control group aged between (17 - 42) years and (40) gestational diabetes mellitus patients with aged between (20 - 42) years. The following biochemical investigation is studied: oral glucose tolerance test (OGTT), adiponectin , insulin, C-reactive protein (CRP),body mass index (BMI), and homeostasis model assessment- insulin resistance (HOMA – IR). The adiponectin levels are significa...
The role of serum retinol activity in association with the Blood sugar level, and their link as b... more The role of serum retinol activity in association with the Blood sugar level, and their link as biochemical marker risk for lens inflammation and damage stage under pandemic, for the Retinal disease patients with cataract, hypertension, and diabetes, and in healthy for both genders. Total of seventy-five patients and thirty healthy control have been studied. Retinal disease patients were subdivided on the basis of pathological condition into three subgroups (First group was cataract, second was hypertension, and the third group was diabetes. Assessment, of serum retinol activity, and blood glucose levels were done for all groups. The concentricity of serum retinol levels is decreased in diabetic patients than control (13.147±7.195 (μmol/L) with 21.930±16.241 (μmol/L) versus P = 0.011)), while for cataract patients, they showed extremely similar concentricity of serum retinol levels to healthy (20.760±15.941 (μmol/L) with P = 0.790), whilst the retinol-activity was exhibited to be higher in hypertension patients (24.190±21.972 (μmol/L) versus P = 0.663). retinol activity is correlated significantly negatively with both diabetic patients and cataract. Moreover, blood sugar levels are increased in diabetes than control (10.256±4.119 (μmol/L) versus 5.365±1.084 (μmol/L) with P = 0.0001), in comparison with cataract (5.288±0.9560 (μmol/L) with P = 782). The retinol levels are correlated significantly negatively for diabetic and cataract patients. The purpose of this work: is to investigate association between retinal diseases with cataract hypertension &amp; diabetes for risk of fasting at least eight hours in Ramadan and out of Ramadan time, and directly pre surgery gets started by artificial intraocular lens, and by estimation of retinol and blood sugar concentrations.
Infertility is one of the types of diseases that occur in the reproductive system. Obesity is a s... more Infertility is one of the types of diseases that occur in the reproductive system. Obesity is a state that can be occurred due to excessive fats, the progression in obesity stage results in a change in adipose tissue and the development of chronic inflammation, endocrine glands disorders and women’s reproductive system, and also increase the infection with covid-19. The study aimed to investigate the effect of the obesity, lipid-profile, and IL-6 on hormones-dysregulation in infertile-women with COVID-19 complications. The current study included 70 samples: 50 infertility-women-with-covid-19-infected, 20 healthy-women/control, the ages of both patients and healthy subjects were selected within the range 18-34 years. Levels of FBS, LH, FSH, and testosterone and lipid profile were measured in addition to calculating BMI. The result showed a significant increase in lipid profile but no HDL that revealed a considerable decline in its level (P=0.001) in patients group relative to control...
Rheumatoid arthritis (RA) is an autoimmune disorder of the joints that is characterized by extra-... more Rheumatoid arthritis (RA) is an autoimmune disorder of the joints that is characterized by extra-articular involvement in addition to inflammatory arthritis. Joint and periarticular tissue loss brought on by inflammation results in functional impairment. To lessen the significant daily challenges that patients confront and to ensure better outcomes, early detection and treatment are essential. The study's objective was to establish the use of human β-defensin-2 (HBD-2) as a RA diagnostic marker. A total of 60 RA patients and 30 healthy controls participated in the research. The ELISA technique was used to measure serum HBD-2. The following tests were performed: complete blood count (CBC), erythrocyte sedimentation rate (ESR), renal function test, and liver function test. In comparison to the healthy control group, the RA group exhibited a substantially higher blood HBD-2 levels (p ≤0.001). Additionally, there was no significant association between serum HBD-2 and urea, creatinin...
The coronavirus-pandemic has a major impact on women's-mental and physical-health. Polycystic... more The coronavirus-pandemic has a major impact on women's-mental and physical-health. Polycystic-ovary-syndrome (PCOS) has a high-predisposition to many cardiometabolic-risk factors that increase susceptibility to severe complications of COVID-19 and also exhibit an increased likelihood of subfertility. The study includes the extent of the effect of COVID-19-virus on renin-levels, glutathione-s-transferase-activity and other biochemical parameters in PCOS-women. The study included 120 samples of ladies that involved: 80 PCOS-patients, and 40 healthy-ladies. Both main groups were divided into subgroups based on COVID-19 infected or not. Blood-samples were collected from PCOS-patients in Kamal-Al-Samara Hospital, at the period between December until June. Some biochemical parameters were measured for all study-groups, which included: determination of serum renin levels by using the ELISA-technique, GST-activity, lipid-profile. FBS was assessed manually, and hormones were assessed us...
Diabetes mellitus type 2 (T2DM) is a chronic and progressive condition, which affects people all ... more Diabetes mellitus type 2 (T2DM) is a chronic and progressive condition, which affects people all around the world. The risk of complications increases with age if the disease is not managed properly. Diabetic neuropathy is caused by excessive blood glucose and lipid levels, resulting in nerve damage. Apelin is a peptide hormone that is found in different human organs, including the central nervous system and adipose tissue. The aim of this study is to estimate Apelin levels in diabetes type 2 and Diabetic peripheral Neuropathy (DPN) Iraqi patients and show the extent of peripheral nerve damage. The current study included 120 participants: 40 patients with Diabetes Mellitus, 40 patients with Diabetic peripheral Neuropathy, and 40 healthy persons as control, the age range of 34-66 years, matched in age and sex. For all groups, fasting blood sugar, lipid profile (Cholesterol, Triglyceride, High-density lipoprotein, Low-density lipoprotein, and very-low-density lipoprotein), HbA1c, seru...
The role of serum retinol activity in association with the Blood sugar level, and their link as b... more The role of serum retinol activity in association with the Blood sugar level, and their link as biochemical marker risk for lens inflammation and damage stage under pandemic, for the Retinal disease patients with cataract, hypertension, and diabetes, and in healthy for both genders. Total of seventy-five patients and thirty healthy control have been studied. Retinal disease patients were subdivided on the basis of pathological condition into three subgroups (First group was cataract, second was hypertension, and the third group was diabetes. Assessment, of serum retinol activity, and blood glucose levels were done for all groups. The concentricity of serum retinol levels is decreased in diabetic patients than control (13.147±7.195 (μmol/L) with 21.930±16.241 (μmol/L) versus P = 0.011)), while for cataract patients, they showed extremely similar concentricity of serum retinol levels to healthy (20.760±15.941 (μmol/L) with P = 0.790), whilst the retinol-activity was exhibited to be hi...
Vitamin K-dependent protein (VKDP) contributes to the development of lung cancer. The purpose of ... more Vitamin K-dependent protein (VKDP) contributes to the development of lung cancer. The purpose of this research was to better understanding of the role of blood matrix Gla protein (MGP), VKDPs, Malondialdehyde (MDA), Superoxide dismutase (SOD) and Vitamin K (Vit K) in Iraqi patients with lung cancer before and after the first cycle of chemotherapy. Blood samples were collected from Al amal National Hospital for cancer treatment from October 2021 to May 2022, and a total of 80 samples were collected, divided into two groups (40 patient before taking a chemotherapy and 40 patients after taking chemotherapy), ranging in age from 20 to 45 years old. The results showed that although there were highly statistically significant differences in MDA, VKDPS, SOD, and Vit K, there was no difference in MGP serum levels between the two groups (P = 0.05). The current study found a significant positive correlation between MGP and VK1 values.Correlations before and after treatment. Based on the resul...
Baghdad Journal of Biochemistry and Applied Biological Sciences
Background and objective: Polycystic ovarian syndrome (PCOS) is a common endocrinologic disorder ... more Background and objective: Polycystic ovarian syndrome (PCOS) is a common endocrinologic disorder among women of childbearing age. Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to determine the levels of renin, d-dimer, and some relevant biomarkers in patients with PCOS (with and without COVID-19) compared with non-PCOS patients (with and without COVID-19). Methods: This cross-sectional study included 120 women [80 PCOS women (40 with COVID-19 and 40 without COVID-19) and 40 non-PCOS women (20 with COVID-19 and 20 without)] with age range of 15–40 years old. Blood samples were collected from participants, and biochemical assays were carried out. Renin and d-dimer levels were determined using the enzyme-linked-immunosorbent-assay (ELISA), lipid-profile and fasting blood glucose concentrations were assessed by using the colorimetric methods, and hormones were evaluated by ...
Ibn AL-Haitham Journal For Pure and Applied Sciences
Diabetes mellitus type 2 (T2DM) is a metabolic disorder that influences above 450 million individ... more Diabetes mellitus type 2 (T2DM) is a metabolic disorder that influences above 450 million individuals around the world. Type 2 diabetes is a lack of insulin due to pancreatic β-cell malfunction and insulin resistance. This study aimed to detect insulin resistance using homeostasis model assessment (HOMA IR) and determined the correlation with glutathione-s-transferase (GST) activity in T2DM and neuropathy patients as a predictor of oxidative stress, which occurs when the oxidation-antioxidant equilibrium is disrupted. Reactive oxygen species causes vascular injury and a series of inflammation. In the present study, the results show there is no significant difference in diabetic patients (DM) and neuropathy patients (NU) versus healthy people in insulin resistance (p> 0.05). GST activity significantly differs between the patients and healthy groups (p≤0.05). Moreover, this study has reported an improvement in insulin resistance and high activity of GST in the patient's group a...
In Iraqi patients with acromegaly the present investigation included 40 control group and 70 pati... more In Iraqi patients with acromegaly the present investigation included 40 control group and 70 patients with acromegaly divided 35 patients with Diabetic while another 35 patients without Diabetic, with ages between (29-72) years for the identification of GST activity polymorphisms by present and absent GSTM1, GSTT1, and PCR-RFLP, enzymatic digestions were carried out using BsmAI (Biolabs. England, UK) for GSTP1b and AciI (Biolabs, England, UK) for GSTP1c.the association GST Activity with GST genotype were investigated in a cohort of Iraq acromegaly patients comparing with the healthy control group. The results show a non-significant change in GSTP1b gene in both groups, while show high significantly in GSTP1c in diabetic and non-diabetic acromegaly groups.
The genus Origanum consist of different aromatic and medicinal plants some of which are used in f... more The genus Origanum consist of different aromatic and medicinal plants some of which are used in folk medicine and as food additives since ancient time. This study amid to evaluate the potential anticancer activity of Origanum majorana (marjoram) (O. marjorana) on the cancer cell lines AMN-3. This study shows that O.marjorana aqueous extract has anticancer potential and can be explored futher for active component isolation, identifaction and characterization. Keywords: Origanum marjorana, Anticancer, Cytotoxic.
This work studies the role of serum apelin-36 and Glutathione S-transferases (GST) activity in as... more This work studies the role of serum apelin-36 and Glutathione S-transferases (GST) activity in association with the hormonal, metabolic profiles and their link to the risk of cardiovascular disease (CVD) in healthy and patients' ladies with polycystic ovary syndrome (PCOS). A total of fifty-four (PCOS) patients and thirty-one healthy woman as a control have been studied. The PCOS patients were subdivided on the basis of body-mass-index (BMI), into 2-subgroups (the first group was obese-PCOS with BMI ≥ 30 and the second group was non-obese PCOS MBI<30). Fasting-insulin-levels and Lipid-profile, Homeostatic-model assessment-of-insulin-resistance (HOMA-IR), follicle-stimulating-hormone (FSH), luteinizing-hormone (LH), testosterone and serum Apelin-36 (AP-36) levels, GST-Activity were done for all groups. PCO patients showed higher concentricity of apelin-36 than healthy (160.43 ±20.81 (pg/ml) versus 85.49 ± 17.85 (pg/ml), P=0.008),while GST-activity decreased in PCOS patients an...
This study was designed to evaluate the effect of major surgery on thyroid hormones and thyrotrop... more This study was designed to evaluate the effect of major surgery on thyroid hormones and thyrotropin in patient undergoing major lower abdominal surgery. The study included fifty patients scheduled for elective major lower abdominal surgery, the serum levels of T3, T4 and TSH were determined one day preoperatively, intraoperative, one day postoperatively, two days postoperatively, and rT3 was determined one day preoperatively, and one day postoperatively. We observed that the levels of (T3, T4, TSH) increased significantly (P0.05). rT3 increased not significant (P>0.05) in one day postoperatively. It has been proposed these changes due to surgical stress that inhibits peripheral conversion of T4 to T3 by inhibiting peripheral 5'-deiodinase activity, also The absence of pituitary response to changes in serum levels of T3 and T4.According to the results of this study there is a transient abnormality in thyroid function tests in patient undergoing elective major surgery and this ...
This study was designed to evaluate the effect of anesthesia on thyroid hormones (T3, T4, rT3), t... more This study was designed to evaluate the effect of anesthesia on thyroid hormones (T3, T4, rT3), thyrotropin(TSH), and cortisol levels in patients undergoing major urological surgery. The study included fifty patients scheduled for elective major urological surgery where 70% of the patients underwent general anesthesia, while30% underwent regional anesthesia. All patients were in stable control general conditions. The study showed that the thyroid hormones, thyrotropin and cortisol levels were affected with general anesthesia more than regional. The levels of these hormones responded to anesthetics and surgical stresses. This response was thought to be mainly mediated by afferent neurogenic impulses from the area of injury. Therefore, abolition of sensory as well as autonomic afferent stimuli by neurogenic blockaded types of anesthesia such as (epidural anesthesia) that may help in reducing the excretion and metabolic response to surgery.
Gestational diabetes mellitus (GDM) is a complication of gestation that is characterized by impai... more Gestational diabetes mellitus (GDM) is a complication of gestation that is characterized by impaired glucose tolerance with first recognition during gestation. It develops when ?- cell of pancreas fail to compensate the diminished insulin sensitivity during gestation. This study aims to investigate the relationship between mother adiponectin level and ?- cell dysfunction with development gestational diabetes mellitus (GDM) and other parameters in the last trimester of pregnancy. This study includes (80) subjects ( pregnant women) in the third trimester of pregnancy, (40) healthy pregnant individuals as control group aged between (17 - 42) years and (40) gestational diabetes mellitus patients with aged between (20 - 42) years. The following biochemical investigation is studied: oral glucose tolerance test (OGTT), adiponectin , insulin, C-reactive protein (CRP),body mass index (BMI), and homeostasis model assessment- insulin resistance (HOMA – IR). The adiponectin levels are significa...
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Papers by fayhaa M. Khaleel