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David de Lorenzo

Pompeu Fabra University, CEXS, Associate Professor

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Dr. David de Lorenzo is a scientist with a multidisciplinary education in Genomics and Evolutionary Genomics, with special emphasis in Nutritional Genomics.
He has a 10-year experience in teaching and research in the United States of America and Germany. After recently returning to Spain, his research interests are centered on the understanding of the biological and environmental mechanisms underlying Human Complex Traits, Behavior and Diseases, establishing national and international collaborations in the field of Nutrigenomics.
Dr. de Lorenzo plays also a leading role in the development of R&D projects, as co-director of the Nutren-Nutrigenomics technology transfer center.

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Papers by David de Lorenzo

Perspectivas presentes y futuras de la Nutrigenómica y la Nutrigenética en la medicina preventiva

Nutricion Clinica Y Dietetica Hospitalaria, 2012

A genetic-based algorithm for personalized resistance training

by Craig Pickering and David de Lorenzo

Nutrigenómica y nutrigenética en la farmacia

Aula De La Farmacia Revista Profesional De Formacion Continuada, 2012

A genetic-based algorithm for personalized resistance-training

by David de Lorenzo, Bruce Suraci, and keith Grimaldi

Biology of Sport, 2016

Association studies have identified dozens of genetic variants linked to training responses and s... more Association studies have identified dozens of genetic variants linked to training responses and sport-related traits. However, no intervention studies utilizing the idea of personalised training based on athlete&amp;amp;#39;s genetic profile have been conducted. Here we propose an algorithm that allows achieving greater results in response to high- or low-intensity resistance training programs by predicting athlete&amp;amp;#39;s potential for the development of power and endurance qualities with the panel of 15 performance-associated gene polymorphisms. To develop and validate such an algorithm we performed two studies in independent cohorts of male athletes (study 1: athletes from different sports (n = 28); study 2: soccer players (n = 39)). In both studies athletes completed an eight-week high- or low-intensity resistance training program, which either matched or mismatched their individual genotype. Two variables of explosive power and aerobic fitness, as measured by the countermovement jump (CMJ) and aerobic 3-min cycle test (Aero3) were assessed pre and post 8 weeks of resistance training. In study 1, the athletes from the matched groups (i.e. high-intensity trained with power genotype or low-intensity trained with endurance genotype) significantly increased results in CMJ (P = 0.0005) and Aero3 (P = 0.0004). Whereas, athletes from the mismatched group (i.e. high-intensity trained with endurance genotype or low-intensity trained with power genotype) demonstrated non-significant improvements in CMJ (P = 0.175) and less prominent results in Aero3 (P = 0.0134). In study 2, soccer players from the matched group also demonstrated significantly greater (P &amp;amp;lt; 0.0001) performance changes in both tests compared to the mismatched group. Among non- or low responders of both studies, 82% of athletes (both for CMJ and Aero3) were from the mismatched group (P &amp;amp;lt; 0.0001). Our results indicate that matching the individual&amp;amp;#39;s genotype with the appropriate training modality leads to more effective resistance training. The developed algorithm may be used to guide individualised resistance-training interventions.

Ciencia y Universidad en Cataluña. Proyección de futuro

Binomios: el m�todo cient�fico y los alimentos transg�nicos

Ciència i universitat a Catalunya

Ciència i universitat a Catalunya. Projecció de futur.

Vitamin D receptor BsmI polymorphism modulates soy intake and 25-hydroxyvitamin D supplementation benefits in cardiovascular disease risk factors profile

Genes & nutrition, 2013

D. de Lorenzo, Vita (Diari Segre), 2009

D. de Lorenzo, InfoTabac, Vol 15, 15:7:2009

D. de Lorenzo, Treballs SCB, Vol 50, 2000

D. de Lorenzo, EKKE, Vol 3, 2008

Stephan and de Lorenzo, Bioforum, Vol 5, 2004

D. de Lorenzo, Revista Estar Bien, Vol 109, 2010

D. de Lorenzo, Butlleti Medic COMLL, Vol 76, 2009

Nutrición Clínica y Dietética Hospitalaria, Vol 32, 2/2012

Impulsive-disinhibited personality and serotonin transporter gene polymorphisms: Association study in an inmate’s sample

by David de Lorenzo and Angel Blanch

Journal of Psychiatric Research, 2009

Binomios: el método científico y los alimentos transgénicos

Distinctly different sex ratios in African and European populations of Drosophila melanogaster inferred from chromosome-wide SNP data

La comprensió dels mecanismes de l'evoluci

Perspectivas presentes y futuras de la Nutrigenómica y la Nutrigenética en la medicina preventiva

Nutricion Clinica Y Dietetica Hospitalaria, 2012

A genetic-based algorithm for personalized resistance training

by Craig Pickering and David de Lorenzo

Nutrigenómica y nutrigenética en la farmacia

Aula De La Farmacia Revista Profesional De Formacion Continuada, 2012

A genetic-based algorithm for personalized resistance-training

by David de Lorenzo, Bruce Suraci, and keith Grimaldi

Biology of Sport, 2016

Association studies have identified dozens of genetic variants linked to training responses and s... more Association studies have identified dozens of genetic variants linked to training responses and sport-related traits. However, no intervention studies utilizing the idea of personalised training based on athlete&amp;amp;#39;s genetic profile have been conducted. Here we propose an algorithm that allows achieving greater results in response to high- or low-intensity resistance training programs by predicting athlete&amp;amp;#39;s potential for the development of power and endurance qualities with the panel of 15 performance-associated gene polymorphisms. To develop and validate such an algorithm we performed two studies in independent cohorts of male athletes (study 1: athletes from different sports (n = 28); study 2: soccer players (n = 39)). In both studies athletes completed an eight-week high- or low-intensity resistance training program, which either matched or mismatched their individual genotype. Two variables of explosive power and aerobic fitness, as measured by the countermovement jump (CMJ) and aerobic 3-min cycle test (Aero3) were assessed pre and post 8 weeks of resistance training. In study 1, the athletes from the matched groups (i.e. high-intensity trained with power genotype or low-intensity trained with endurance genotype) significantly increased results in CMJ (P = 0.0005) and Aero3 (P = 0.0004). Whereas, athletes from the mismatched group (i.e. high-intensity trained with endurance genotype or low-intensity trained with power genotype) demonstrated non-significant improvements in CMJ (P = 0.175) and less prominent results in Aero3 (P = 0.0134). In study 2, soccer players from the matched group also demonstrated significantly greater (P &amp;amp;lt; 0.0001) performance changes in both tests compared to the mismatched group. Among non- or low responders of both studies, 82% of athletes (both for CMJ and Aero3) were from the mismatched group (P &amp;amp;lt; 0.0001). Our results indicate that matching the individual&amp;amp;#39;s genotype with the appropriate training modality leads to more effective resistance training. The developed algorithm may be used to guide individualised resistance-training interventions.

Ciencia y Universidad en Cataluña. Proyección de futuro

Binomios: el m�todo cient�fico y los alimentos transg�nicos

Ciència i universitat a Catalunya

Ciència i universitat a Catalunya. Projecció de futur.

Vitamin D receptor BsmI polymorphism modulates soy intake and 25-hydroxyvitamin D supplementation benefits in cardiovascular disease risk factors profile

Genes & nutrition, 2013

D. de Lorenzo, Vita (Diari Segre), 2009

D. de Lorenzo, InfoTabac, Vol 15, 15:7:2009

D. de Lorenzo, Treballs SCB, Vol 50, 2000

D. de Lorenzo, EKKE, Vol 3, 2008

Stephan and de Lorenzo, Bioforum, Vol 5, 2004

D. de Lorenzo, Revista Estar Bien, Vol 109, 2010

D. de Lorenzo, Butlleti Medic COMLL, Vol 76, 2009

Nutrición Clínica y Dietética Hospitalaria, Vol 32, 2/2012

Impulsive-disinhibited personality and serotonin transporter gene polymorphisms: Association study in an inmate’s sample

by David de Lorenzo and Angel Blanch

Journal of Psychiatric Research, 2009

Binomios: el método científico y los alimentos transgénicos

Distinctly different sex ratios in African and European populations of Drosophila melanogaster inferred from chromosome-wide SNP data

La comprensió dels mecanismes de l'evoluci