... Isidro S. Marcos, Isabel M. Oliva, David Díez, Pilar Basabe, Anna M. Lithgow, Rosalina F. Moro, Narciso M. Garrido and Julio G. Urones *. ... BN Zhou, BP Ying, GQ Song, ZX Chen, J. Han and YF Yan, Planta Medica 47 (1983), pp. 3538. ...
These results prompted us to communicate our observations in this area. As can be seen, all the above catalysts are either monosubstituted in the pyrrolidine ring or disubstituted with a single protected hydroxyl group substituent. It is... more
These results prompted us to communicate our observations in this area. As can be seen, all the above catalysts are either monosubstituted in the pyrrolidine ring or disubstituted with a single protected hydroxyl group substituent. It is known that a subtle change in the ...
... a Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Salamanca,Plaza de los Caídos 1-5 ... which would then not correspond to that of ent-halimic acid methyl ester 3. ... 16 Urones JG, Pascual Teresa J,... more
... a Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Salamanca,Plaza de los Caídos 1-5 ... which would then not correspond to that of ent-halimic acid methyl ester 3. ... 16 Urones JG, Pascual Teresa J, Marcos IS, Díez D, Garrido NM, Guerra RA ...
... Julio G. Urones, Isidro S. Marcos, Belen Gómez Pérez, Anna M. Lithgow, David Díez Patricio M. Gómez, Pilar Basabe, Narciso M. Garrido. ... IR = H, polygodial 3 4 2 R = OH, warburganal Scheme 1. Retrosynthetic Analysis 1845 1846 JG... more
... Julio G. Urones, Isidro S. Marcos, Belen Gómez Pérez, Anna M. Lithgow, David Díez Patricio M. Gómez, Pilar Basabe, Narciso M. Garrido. ... IR = H, polygodial 3 4 2 R = OH, warburganal Scheme 1. Retrosynthetic Analysis 1845 1846 JG URONES et al. ...
... Narciso M. Garrido*, David Díez, Sara H. Domínguez, M. Rosa Sánchez, Mercedes Garcíaand Julio G. Urones ... lithium amide [(R)-1] Michael addition to diendioate esters 2 and 3 respectively (Scheme 1) [6]. While addition to... more
... Narciso M. Garrido*, David Díez, Sara H. Domínguez, M. Rosa Sánchez, Mercedes Garcíaand Julio G. Urones ... lithium amide [(R)-1] Michael addition to diendioate esters 2 and 3 respectively (Scheme 1) [6]. While addition to (E,E)-octa-2,6-diendioate gave the cyclopentane ...
The use of hydrotalcites for the synthesis of two chiral building blocks in a simple way is described as a new and green methodology. The synthesis of these compounds implies a regioselective Baeyer-Villiger reaction in a very selective... more
The use of hydrotalcites for the synthesis of two chiral building blocks in a simple way is described as a new and green methodology. The synthesis of these compounds implies a regioselective Baeyer-Villiger reaction in a very selective way with ulterior opening and lactonisation. This methodology should be considered green for the use of hydrogen peroxide as the only oxidant and hydrotalcites as the catalyst, and because no residues are produced apart from water. The procedure is very adequate for using in gram scale, in order to increase the value of the obtained compounds. The conditions are excellent and can be applied for nonstable compounds, as they are very mild. The synthesised compounds are magnific starting materials for the synthesis of biologically active or natural compounds. The use of a cheap, commercial and chiral compound as carvone disposable in both enantiomeric forms adds an extra value to this methodology.
The title compound, C14H19NO5S, was prepared by nucleophilic addition of the lithium derivative of methylphenylsulfone to (3S,4R)-3,4-isopropylidenedioxypyrroline 1-oxide. There are four molecules in the asymmetric unit. The crystal... more
The title compound, C14H19NO5S, was prepared by nucleophilic addition of the lithium derivative of methylphenylsulfone to (3S,4R)-3,4-isopropylidenedioxypyrroline 1-oxide. There are four molecules in the asymmetric unit. The crystal structure determination confirms the configuration of the chiral centres as 2R,3S,4R. In the crystal, pairs of O—H...N hydrogen bonds link the molecules into dimers.
