In severe, neutrophilic asthma, neutrophils are thought to have an important role in both the mai... more In severe, neutrophilic asthma, neutrophils are thought to have an important role in both the maintenance of the disease and during exacerbations. These patients often display excessive, mucosal airway inflammation with unresolving neutrophilia. Because this variant of asthma is poorly controlled by glucocorticoids, specific pharmacologic targeting of neutrophils seems a plausible therapeutic approach. However, most attempts with this approach have failed in the clinic. We propose that this could be attributed, in part, to an incomplete understanding of the emerging new insights underlying neutrophil homeostasis and life span, neutrophil reverse transmigration, neutrophil phenotypes, and neutrophil transdifferentiation in human health and disease. Of clinical relevance, recent translational studies have started to uncover distinct neutrophil subsets in humans, namely mature and hypersegmented phenotypes that have bimodal immunomodulatory functions during an acute inflammatory respon...
When the patch test reaction to aeroallergens in atopic dermatitis (AD) patients is considered a ... more When the patch test reaction to aeroallergens in atopic dermatitis (AD) patients is considered a representative model to study its pathogenesis, then eosinophils may really be involved in the pathogenesis of AD. They actively infiltrate the dermis and the epidermis after patch testing with aeroallergens and even release part of their granular constituents. The role eosinophils play in the pathogenesis of AD is still open for discussion. The granular components of the eosinophil may certainly contribute to a situation of chronic inflammation. On the other hand one should seriously consider the possibility of a beneficial role also, i.e. modulation of the lymphoproliferative response.
International Archives of Allergy and Immunology, 1989
So far, the role of antigen-presenting cells in atopic disorders has been underestimated. Recent ... more So far, the role of antigen-presenting cells in atopic disorders has been underestimated. Recent observations, made in the skin of patients with atopic dermatitis and in the nasal mucosa of patients with allergic rhinitis suggest that Langerhans cells, being tissue-specific dendritic cells with potent antigen-presenting capacity, play an important role in the allergic inflammatory response. Evidence is presented that Langerhans cells even play a crucial role in directing the type of the allergic reaction mechanism.
In severe, neutrophilic asthma, neutrophils are thought to have an important role in both the mai... more In severe, neutrophilic asthma, neutrophils are thought to have an important role in both the maintenance of the disease and during exacerbations. These patients often display excessive, mucosal airway inflammation with unresolving neutrophilia. Because this variant of asthma is poorly controlled by glucocorticoids, specific pharmacologic targeting of neutrophils seems a plausible therapeutic approach. However, most attempts with this approach have failed in the clinic. We propose that this could be attributed, in part, to an incomplete understanding of the emerging new insights underlying neutrophil homeostasis and life span, neutrophil reverse transmigration, neutrophil phenotypes, and neutrophil transdifferentiation in human health and disease. Of clinical relevance, recent translational studies have started to uncover distinct neutrophil subsets in humans, namely mature and hypersegmented phenotypes that have bimodal immunomodulatory functions during an acute inflammatory respon...
When the patch test reaction to aeroallergens in atopic dermatitis (AD) patients is considered a ... more When the patch test reaction to aeroallergens in atopic dermatitis (AD) patients is considered a representative model to study its pathogenesis, then eosinophils may really be involved in the pathogenesis of AD. They actively infiltrate the dermis and the epidermis after patch testing with aeroallergens and even release part of their granular constituents. The role eosinophils play in the pathogenesis of AD is still open for discussion. The granular components of the eosinophil may certainly contribute to a situation of chronic inflammation. On the other hand one should seriously consider the possibility of a beneficial role also, i.e. modulation of the lymphoproliferative response.
International Archives of Allergy and Immunology, 1989
So far, the role of antigen-presenting cells in atopic disorders has been underestimated. Recent ... more So far, the role of antigen-presenting cells in atopic disorders has been underestimated. Recent observations, made in the skin of patients with atopic dermatitis and in the nasal mucosa of patients with allergic rhinitis suggest that Langerhans cells, being tissue-specific dendritic cells with potent antigen-presenting capacity, play an important role in the allergic inflammatory response. Evidence is presented that Langerhans cells even play a crucial role in directing the type of the allergic reaction mechanism.
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