Recent research has shown that rat surfactant apoproteins (26-38 kDa) are vitamin K-dependent [Ra... more Recent research has shown that rat surfactant apoproteins (26-38 kDa) are vitamin K-dependent [Rannels, Gallaher, Wallin & Rannels (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 5952-5956]. We have investigated the effect of the vitamin K antagonist warfarin on this family of apoproteins in surfactant from dog lung. Our data suggest that warfarin does not interfere with synthesis and secretion of these proteins into dog lung surfactant. Abnormal surfactant apoproteins, produced in response to warfarin treatment of the dog, were also not found in lung surfactant. 4-Carboxyglutamic acid analysis of purified dog apoproteins also failed to detect the vitamin K-modification. When vitamin K-dependent 14C labelling of precursors of vitamin K-dependent proteins was carried out, fluorography of these precursors, when electrophoresed into SDS/polyacrylamide gels, revealed 14C-labelled proteins of apparent molecular mass 74, 46, 42, 34, 31 and 23 kDa. Antibodies produced against purified dog surfactant apoproteins recognized precursors of the surfactant apoproteins in lung microsomes but did not recognize any 14C-labelled carboxylase substrates. These precursors appeared on immunoblots with apparent molecular mass 29, 32, 33 and 50 kDa. Our data suggest that there are significant differences between this class of surfactant apoproteins in the rat and the dog.
ABSTRACT Domain decomposition of dissipative particle dynamics is complicated by the use of rando... more ABSTRACT Domain decomposition of dissipative particle dynamics is complicated by the use of random pairwise forces as a component of a momentum-conserving thermostat. The conventional use of a pseudorandom number generator for each processor core leads to the need for an additional communication step to correctly assign random forces to particles in boundary halos. To circumvent this communication, the use of a three-seed pseudorandom number generator is proposed to allow multiple processor cores to evaluate the same forces. This kind of pseudorandom number generator will be applied to the general-purpose mesoscale modelling package DL_MESO to improve its parallel scalability for large processor core counts.
Nicotine metabolism is exceedingly sensitive to perturbation by numerous host factors. To reduce ... more Nicotine metabolism is exceedingly sensitive to perturbation by numerous host factors. To reduce the large variations and discrepancies in the literature pertaining to nicotine metabolism, investigators in future studies need to recognize and better control these host factors. Recent advances in the understanding of nicotine metabolism have suggested new approaches to elucidating underlying mechanisms of certain toxic effects associated with cigarette smoking.
ABSTRACT We have created a patient tracking system within the web-based HIV-EMR to minimize loss-... more ABSTRACT We have created a patient tracking system within the web-based HIV-EMR to minimize loss-to-follow-up among HIV patients which has been estimated to be as high as 62% in programs in Africa. This system generates a graphical representation of the status of each patients visits and medication pick-ups. By identifying missing patients early, the system allows physicians to contact patients and minimize loss-to-follow-up.
IEEE International Carnahan Conference on Security Technology, Crime Countermeasures, 1990
Historically, Operations with people, property, and operations at risk have attempted to monitor ... more Historically, Operations with people, property, and operations at risk have attempted to monitor and control the flow of people and items into their installations and at restricted sites within their property by issuing documents purported to identify the bearer as an authorized ...
Radio continuum flux spectra S, depend on electron temperatures Te and on angular areas (E) which... more Radio continuum flux spectra S, depend on electron temperatures Te and on angular areas (E) which enclose contours of constant emission measure E. Different methods of analyzing observations are discussed.
The aims of the international collaborations, Opacity Project (OP), the IRON Project (IP), and th... more The aims of the international collaborations, Opacity Project (OP), the IRON Project (IP), and the RmaX Network (The Opacity Project Team, Vol.1,2), IOPP, Bristol (1995,1996); Hummer et al., Astron. Astrophys. 279, 298 (1993) are to obtain accurate atomic data for radiative and collisional processes, and plasma opacities for astrophysical applications. A new, considerably enlarged, version of the existing electronic database
Recent research has shown that rat surfactant apoproteins (26-38 kDa) are vitamin K-dependent [Ra... more Recent research has shown that rat surfactant apoproteins (26-38 kDa) are vitamin K-dependent [Rannels, Gallaher, Wallin & Rannels (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 5952-5956]. We have investigated the effect of the vitamin K antagonist warfarin on this family of apoproteins in surfactant from dog lung. Our data suggest that warfarin does not interfere with synthesis and secretion of these proteins into dog lung surfactant. Abnormal surfactant apoproteins, produced in response to warfarin treatment of the dog, were also not found in lung surfactant. 4-Carboxyglutamic acid analysis of purified dog apoproteins also failed to detect the vitamin K-modification. When vitamin K-dependent 14C labelling of precursors of vitamin K-dependent proteins was carried out, fluorography of these precursors, when electrophoresed into SDS/polyacrylamide gels, revealed 14C-labelled proteins of apparent molecular mass 74, 46, 42, 34, 31 and 23 kDa. Antibodies produced against purified dog surfactant apoproteins recognized precursors of the surfactant apoproteins in lung microsomes but did not recognize any 14C-labelled carboxylase substrates. These precursors appeared on immunoblots with apparent molecular mass 29, 32, 33 and 50 kDa. Our data suggest that there are significant differences between this class of surfactant apoproteins in the rat and the dog.
ABSTRACT Domain decomposition of dissipative particle dynamics is complicated by the use of rando... more ABSTRACT Domain decomposition of dissipative particle dynamics is complicated by the use of random pairwise forces as a component of a momentum-conserving thermostat. The conventional use of a pseudorandom number generator for each processor core leads to the need for an additional communication step to correctly assign random forces to particles in boundary halos. To circumvent this communication, the use of a three-seed pseudorandom number generator is proposed to allow multiple processor cores to evaluate the same forces. This kind of pseudorandom number generator will be applied to the general-purpose mesoscale modelling package DL_MESO to improve its parallel scalability for large processor core counts.
Nicotine metabolism is exceedingly sensitive to perturbation by numerous host factors. To reduce ... more Nicotine metabolism is exceedingly sensitive to perturbation by numerous host factors. To reduce the large variations and discrepancies in the literature pertaining to nicotine metabolism, investigators in future studies need to recognize and better control these host factors. Recent advances in the understanding of nicotine metabolism have suggested new approaches to elucidating underlying mechanisms of certain toxic effects associated with cigarette smoking.
ABSTRACT We have created a patient tracking system within the web-based HIV-EMR to minimize loss-... more ABSTRACT We have created a patient tracking system within the web-based HIV-EMR to minimize loss-to-follow-up among HIV patients which has been estimated to be as high as 62% in programs in Africa. This system generates a graphical representation of the status of each patients visits and medication pick-ups. By identifying missing patients early, the system allows physicians to contact patients and minimize loss-to-follow-up.
IEEE International Carnahan Conference on Security Technology, Crime Countermeasures, 1990
Historically, Operations with people, property, and operations at risk have attempted to monitor ... more Historically, Operations with people, property, and operations at risk have attempted to monitor and control the flow of people and items into their installations and at restricted sites within their property by issuing documents purported to identify the bearer as an authorized ...
Radio continuum flux spectra S, depend on electron temperatures Te and on angular areas (E) which... more Radio continuum flux spectra S, depend on electron temperatures Te and on angular areas (E) which enclose contours of constant emission measure E. Different methods of analyzing observations are discussed.
The aims of the international collaborations, Opacity Project (OP), the IRON Project (IP), and th... more The aims of the international collaborations, Opacity Project (OP), the IRON Project (IP), and the RmaX Network (The Opacity Project Team, Vol.1,2), IOPP, Bristol (1995,1996); Hummer et al., Astron. Astrophys. 279, 298 (1993) are to obtain accurate atomic data for radiative and collisional processes, and plasma opacities for astrophysical applications. A new, considerably enlarged, version of the existing electronic database
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