Recent research has shown that rat surfactant apoproteins (26-38 kDa) are vitamin K-dependent [Ra... more Recent research has shown that rat surfactant apoproteins (26-38 kDa) are vitamin K-dependent [Rannels, Gallaher, Wallin & Rannels (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 5952-5956]. We have investigated the effect of the vitamin K antagonist warfarin on this family of apoproteins in surfactant from dog lung. Our data suggest that warfarin does not interfere with synthesis and secretion of these proteins into dog lung surfactant. Abnormal surfactant apoproteins, produced in response to warfarin treatment of the dog, were also not found in lung surfactant. 4-Carboxyglutamic acid analysis of purified dog apoproteins also failed to detect the vitamin K-modification. When vitamin K-dependent 14C labelling of precursors of vitamin K-dependent proteins was carried out, fluorography of these precursors, when electrophoresed into SDS/polyacrylamide gels, revealed 14C-labelled proteins of apparent molecular mass 74, 46, 42, 34, 31 and 23 kDa. Antibodies produced against purified dog surfactant apoproteins recognized precursors of the surfactant apoproteins in lung microsomes but did not recognize any 14C-labelled carboxylase substrates. These precursors appeared on immunoblots with apparent molecular mass 29, 32, 33 and 50 kDa. Our data suggest that there are significant differences between this class of surfactant apoproteins in the rat and the dog.
ABSTRACT Domain decomposition of dissipative particle dynamics is complicated by the use of rando... more ABSTRACT Domain decomposition of dissipative particle dynamics is complicated by the use of random pairwise forces as a component of a momentum-conserving thermostat. The conventional use of a pseudorandom number generator for each processor core leads to the need for an additional communication step to correctly assign random forces to particles in boundary halos. To circumvent this communication, the use of a three-seed pseudorandom number generator is proposed to allow multiple processor cores to evaluate the same forces. This kind of pseudorandom number generator will be applied to the general-purpose mesoscale modelling package DL_MESO to improve its parallel scalability for large processor core counts.
Cutaneous wound healing in the pig is frequently used as a model for human cutaneous wound healin... more Cutaneous wound healing in the pig is frequently used as a model for human cutaneous wound healing. In this review, we examine the appropriateness of this model for studying normal and pathological wound healing, and describe models for chronic nonhealing wounds, diabetic wounds, burns, and hypertrophic scars. In addition, we focus on studies that have used pigs to evaluate wound-healing therapies, and discuss genetic engineering technology in the pig that may advance our knowledge of wound healing. We conclude that, although not perfect, the pig offers a versatile model that can be adjusted to mimic a wide range of clinical scenarios.
Nicotine metabolism is exceedingly sensitive to perturbation by numerous host factors. To reduce ... more Nicotine metabolism is exceedingly sensitive to perturbation by numerous host factors. To reduce the large variations and discrepancies in the literature pertaining to nicotine metabolism, investigators in future studies need to recognize and better control these host factors. Recent advances in the understanding of nicotine metabolism have suggested new approaches to elucidating underlying mechanisms of certain toxic effects associated with cigarette smoking.
ABSTRACT We have created a patient tracking system within the web-based HIV-EMR to minimize loss-... more ABSTRACT We have created a patient tracking system within the web-based HIV-EMR to minimize loss-to-follow-up among HIV patients which has been estimated to be as high as 62% in programs in Africa. This system generates a graphical representation of the status of each patients visits and medication pick-ups. By identifying missing patients early, the system allows physicians to contact patients and minimize loss-to-follow-up.
Electronic effects are believed to be important in high-energy radiation damage processes where h... more Electronic effects are believed to be important in high-energy radiation damage processes where high electronic temperature is expected, yet their effects are not currently understood. Here, we perform molecular dynamics simulations of high-energy collision cascades in α-iron using the coupled two-temperature molecular dynamics (2T-MD) model that incorporates both effects of electronic stopping and electron-ion interaction. We subsequently compare it with the model employing the electronic stopping only, and find several interesting novel insights. The 2T-MD results in both decreased damage production in the thermal spike and faster relaxation of the damage at short times. Notably, the 2T-MD model gives a similar amount of the final damage at longer times, which we interpret to be the result of two competing effects: smaller amount of short-time damage and shorter time available for damage recovery.
Understanding and predicting a material's performance in response to high-energy radiation damage... more Understanding and predicting a material's performance in response to high-energy radiation damage, as well as designing future materials to be used in intense radiation environments, requires the knowledge of the structure, morphology and amount of radiation-induced structural changes 1-5 . We report the results of molecular dynamics simulations of high-energy radiation damage in iron in the range 0.2-0.5 MeV. We analyze and quantify the nature of collision cascades both at the global and local scale. We find that the structure of high-energy collision cascades becomes increasingly continuous as opposed to showing sub-cascade branching reported previously. At the local length scale, we find large defect clusters and novel small vacancy and interstitial clusters. These features form the basis for physical models aimed at understanding the effects of high energy radiation damage in structural materials.
IEEE International Carnahan Conference on Security Technology, Crime Countermeasures, 1990
Historically, Operations with people, property, and operations at risk have attempted to monitor ... more Historically, Operations with people, property, and operations at risk have attempted to monitor and control the flow of people and items into their installations and at restricted sites within their property by issuing documents purported to identify the bearer as an authorized ...
Radio continuum flux spectra S, depend on electron temperatures Te and on angular areas (E) which... more Radio continuum flux spectra S, depend on electron temperatures Te and on angular areas (E) which enclose contours of constant emission measure E. Different methods of analyzing observations are discussed.
The aims of the international collaborations, Opacity Project (OP), the IRON Project (IP), and th... more The aims of the international collaborations, Opacity Project (OP), the IRON Project (IP), and the RmaX Network (The Opacity Project Team, Vol.1,2), IOPP, Bristol (1995,1996); Hummer et al., Astron. Astrophys. 279, 298 (1993) are to obtain accurate atomic data for radiative and collisional processes, and plasma opacities for astrophysical applications. A new, considerably enlarged, version of the existing electronic database
Recent research has shown that rat surfactant apoproteins (26-38 kDa) are vitamin K-dependent [Ra... more Recent research has shown that rat surfactant apoproteins (26-38 kDa) are vitamin K-dependent [Rannels, Gallaher, Wallin & Rannels (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 5952-5956]. We have investigated the effect of the vitamin K antagonist warfarin on this family of apoproteins in surfactant from dog lung. Our data suggest that warfarin does not interfere with synthesis and secretion of these proteins into dog lung surfactant. Abnormal surfactant apoproteins, produced in response to warfarin treatment of the dog, were also not found in lung surfactant. 4-Carboxyglutamic acid analysis of purified dog apoproteins also failed to detect the vitamin K-modification. When vitamin K-dependent 14C labelling of precursors of vitamin K-dependent proteins was carried out, fluorography of these precursors, when electrophoresed into SDS/polyacrylamide gels, revealed 14C-labelled proteins of apparent molecular mass 74, 46, 42, 34, 31 and 23 kDa. Antibodies produced against purified dog surfactant apoproteins recognized precursors of the surfactant apoproteins in lung microsomes but did not recognize any 14C-labelled carboxylase substrates. These precursors appeared on immunoblots with apparent molecular mass 29, 32, 33 and 50 kDa. Our data suggest that there are significant differences between this class of surfactant apoproteins in the rat and the dog.
ABSTRACT Domain decomposition of dissipative particle dynamics is complicated by the use of rando... more ABSTRACT Domain decomposition of dissipative particle dynamics is complicated by the use of random pairwise forces as a component of a momentum-conserving thermostat. The conventional use of a pseudorandom number generator for each processor core leads to the need for an additional communication step to correctly assign random forces to particles in boundary halos. To circumvent this communication, the use of a three-seed pseudorandom number generator is proposed to allow multiple processor cores to evaluate the same forces. This kind of pseudorandom number generator will be applied to the general-purpose mesoscale modelling package DL_MESO to improve its parallel scalability for large processor core counts.
Cutaneous wound healing in the pig is frequently used as a model for human cutaneous wound healin... more Cutaneous wound healing in the pig is frequently used as a model for human cutaneous wound healing. In this review, we examine the appropriateness of this model for studying normal and pathological wound healing, and describe models for chronic nonhealing wounds, diabetic wounds, burns, and hypertrophic scars. In addition, we focus on studies that have used pigs to evaluate wound-healing therapies, and discuss genetic engineering technology in the pig that may advance our knowledge of wound healing. We conclude that, although not perfect, the pig offers a versatile model that can be adjusted to mimic a wide range of clinical scenarios.
Nicotine metabolism is exceedingly sensitive to perturbation by numerous host factors. To reduce ... more Nicotine metabolism is exceedingly sensitive to perturbation by numerous host factors. To reduce the large variations and discrepancies in the literature pertaining to nicotine metabolism, investigators in future studies need to recognize and better control these host factors. Recent advances in the understanding of nicotine metabolism have suggested new approaches to elucidating underlying mechanisms of certain toxic effects associated with cigarette smoking.
ABSTRACT We have created a patient tracking system within the web-based HIV-EMR to minimize loss-... more ABSTRACT We have created a patient tracking system within the web-based HIV-EMR to minimize loss-to-follow-up among HIV patients which has been estimated to be as high as 62% in programs in Africa. This system generates a graphical representation of the status of each patients visits and medication pick-ups. By identifying missing patients early, the system allows physicians to contact patients and minimize loss-to-follow-up.
Electronic effects are believed to be important in high-energy radiation damage processes where h... more Electronic effects are believed to be important in high-energy radiation damage processes where high electronic temperature is expected, yet their effects are not currently understood. Here, we perform molecular dynamics simulations of high-energy collision cascades in α-iron using the coupled two-temperature molecular dynamics (2T-MD) model that incorporates both effects of electronic stopping and electron-ion interaction. We subsequently compare it with the model employing the electronic stopping only, and find several interesting novel insights. The 2T-MD results in both decreased damage production in the thermal spike and faster relaxation of the damage at short times. Notably, the 2T-MD model gives a similar amount of the final damage at longer times, which we interpret to be the result of two competing effects: smaller amount of short-time damage and shorter time available for damage recovery.
Understanding and predicting a material's performance in response to high-energy radiation damage... more Understanding and predicting a material's performance in response to high-energy radiation damage, as well as designing future materials to be used in intense radiation environments, requires the knowledge of the structure, morphology and amount of radiation-induced structural changes 1-5 . We report the results of molecular dynamics simulations of high-energy radiation damage in iron in the range 0.2-0.5 MeV. We analyze and quantify the nature of collision cascades both at the global and local scale. We find that the structure of high-energy collision cascades becomes increasingly continuous as opposed to showing sub-cascade branching reported previously. At the local length scale, we find large defect clusters and novel small vacancy and interstitial clusters. These features form the basis for physical models aimed at understanding the effects of high energy radiation damage in structural materials.
IEEE International Carnahan Conference on Security Technology, Crime Countermeasures, 1990
Historically, Operations with people, property, and operations at risk have attempted to monitor ... more Historically, Operations with people, property, and operations at risk have attempted to monitor and control the flow of people and items into their installations and at restricted sites within their property by issuing documents purported to identify the bearer as an authorized ...
Radio continuum flux spectra S, depend on electron temperatures Te and on angular areas (E) which... more Radio continuum flux spectra S, depend on electron temperatures Te and on angular areas (E) which enclose contours of constant emission measure E. Different methods of analyzing observations are discussed.
The aims of the international collaborations, Opacity Project (OP), the IRON Project (IP), and th... more The aims of the international collaborations, Opacity Project (OP), the IRON Project (IP), and the RmaX Network (The Opacity Project Team, Vol.1,2), IOPP, Bristol (1995,1996); Hummer et al., Astron. Astrophys. 279, 298 (1993) are to obtain accurate atomic data for radiative and collisional processes, and plasma opacities for astrophysical applications. A new, considerably enlarged, version of the existing electronic database
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Papers by M. Seaton