✓ A schwannoma arising from the dorsum of the pontomedullary junction and presenting as an exophy... more ✓ A schwannoma arising from the dorsum of the pontomedullary junction and presenting as an exophytic mass in the fourth ventricle is described. A ventricular schwannoma has not previously been reported in the literature. The presenting clinical and radiographic features and the pathology of this tumor are summarized, and an explanation is sought for its unusual location.
The cerebral edema, as judged by computed tomographic scan, associated with supratentorial mening... more The cerebral edema, as judged by computed tomographic scan, associated with supratentorial meningiomas was assessed in 55 cases. No relationship to the occurrence or the degree of edema could be established with respect to meningioma location, histological type, tumor vascularity, cellularity, number of mitotic figures, necrosis, calcification, or cortical invasion. The larger the meningioma, the more likely the presence of and the severity of cerebral edema. The edema is a significant factor in the occurrence of clinical signs and symptoms. A biopsy of cerebral cortex and white matter underlying a transitional meningioma in a patient with associated cerebral edema demonstrated perivascular astrocytic end-feet swelling in the cortex and considerable extracellular fluid in the white matter. The ultrastructural appearance is similar to that seen with primary and metastatic brain tumors and with experimental vasogenic cerebral edema.
The X-linked form of myotubular myopathy is highly lethal in neonates. Several autopsy-derived mu... more The X-linked form of myotubular myopathy is highly lethal in neonates. Several autopsy-derived muscles from two probands of a new kindred who survived for 100 days because of intensive supportive care were analyzed by light microscopy, morphometry, enzyme histochemistry, and electron microscopy. The results were compared with a similar analysis of muscle from control fetal and neonatal subjects. The findings, in addition to the characteristic centronucleated hypotrophic myofibers, included widespread myofiber degeneration and focal contraction band necrosis that differed from the types seen in other myopathic and dystrophic muscle diseases. A high frequency of degenerating nuclei that often contained large nucleoli was observed. Because of the paradoxic nuclear morphology, nuclear failure (in migration and myofibrillogenesis) is believed to be of central importance in the pathogenesis of this disease.
Journal of Neuropathology and Experimental Neurology, 1973
Page 1. Journal of Neuropathology & Experimental Neurology Volume XXXII July 1973 Number ... more Page 1. Journal of Neuropathology & Experimental Neurology Volume XXXII July 1973 Number 3 ULTRASTRUCTURAL ALTERATIONS OF THE MOTOR END PLATE IN MYOTONIC DYSTROPHY OF THE MOUSE Ulyv/dy*) JOSEPH J. GILBERT. MD* MARTA С. ...
Five patients known to have various medical problems were found unexpectedly at autopsy to have t... more Five patients known to have various medical problems were found unexpectedly at autopsy to have typical multiple sclerosis plaques. These were most often small and in a periventricular distribution in frontal, temporal, and occipital lobes. In two cases, small plaques were found in the thalamus and brain stem. The cerebellum was not involved.
Norepinephrine was measured in postmortem cerebellar cortex of 22 non-neurological control subjec... more Norepinephrine was measured in postmortem cerebellar cortex of 22 non-neurological control subjects and nine patients with Parkinson's disease, using the high-performance liquid chromatography method with amperometric detection. In all control subjects, substantial amounts of norepinephrine was found in cerebellar cortex. There was a moderate negative correlation between age of control subjects and cerebellar norepinephrine concentration. In the patients with Parkinson's disease, the cerebellar cortical norepinephrine levels were significantly below normal. This is in accord with previously reported reduced norepinephrine levels in locus ceruleus and other regions of the parkinsonian brain. Although the main symptoms of Parkinson's disease are primarily caused by disturbed basal ganglia (dopamine) function, cerebellar dysfunction related to norepinephrine may contribute to some abnormalities of motor performance in this disorder.
✓ A schwannoma arising from the dorsum of the pontomedullary junction and presenting as an exophy... more ✓ A schwannoma arising from the dorsum of the pontomedullary junction and presenting as an exophytic mass in the fourth ventricle is described. A ventricular schwannoma has not previously been reported in the literature. The presenting clinical and radiographic features and the pathology of this tumor are summarized, and an explanation is sought for its unusual location.
The cerebral edema, as judged by computed tomographic scan, associated with supratentorial mening... more The cerebral edema, as judged by computed tomographic scan, associated with supratentorial meningiomas was assessed in 55 cases. No relationship to the occurrence or the degree of edema could be established with respect to meningioma location, histological type, tumor vascularity, cellularity, number of mitotic figures, necrosis, calcification, or cortical invasion. The larger the meningioma, the more likely the presence of and the severity of cerebral edema. The edema is a significant factor in the occurrence of clinical signs and symptoms. A biopsy of cerebral cortex and white matter underlying a transitional meningioma in a patient with associated cerebral edema demonstrated perivascular astrocytic end-feet swelling in the cortex and considerable extracellular fluid in the white matter. The ultrastructural appearance is similar to that seen with primary and metastatic brain tumors and with experimental vasogenic cerebral edema.
The X-linked form of myotubular myopathy is highly lethal in neonates. Several autopsy-derived mu... more The X-linked form of myotubular myopathy is highly lethal in neonates. Several autopsy-derived muscles from two probands of a new kindred who survived for 100 days because of intensive supportive care were analyzed by light microscopy, morphometry, enzyme histochemistry, and electron microscopy. The results were compared with a similar analysis of muscle from control fetal and neonatal subjects. The findings, in addition to the characteristic centronucleated hypotrophic myofibers, included widespread myofiber degeneration and focal contraction band necrosis that differed from the types seen in other myopathic and dystrophic muscle diseases. A high frequency of degenerating nuclei that often contained large nucleoli was observed. Because of the paradoxic nuclear morphology, nuclear failure (in migration and myofibrillogenesis) is believed to be of central importance in the pathogenesis of this disease.
Journal of Neuropathology and Experimental Neurology, 1973
Page 1. Journal of Neuropathology & Experimental Neurology Volume XXXII July 1973 Number ... more Page 1. Journal of Neuropathology & Experimental Neurology Volume XXXII July 1973 Number 3 ULTRASTRUCTURAL ALTERATIONS OF THE MOTOR END PLATE IN MYOTONIC DYSTROPHY OF THE MOUSE Ulyv/dy*) JOSEPH J. GILBERT. MD* MARTA С. ...
Five patients known to have various medical problems were found unexpectedly at autopsy to have t... more Five patients known to have various medical problems were found unexpectedly at autopsy to have typical multiple sclerosis plaques. These were most often small and in a periventricular distribution in frontal, temporal, and occipital lobes. In two cases, small plaques were found in the thalamus and brain stem. The cerebellum was not involved.
Norepinephrine was measured in postmortem cerebellar cortex of 22 non-neurological control subjec... more Norepinephrine was measured in postmortem cerebellar cortex of 22 non-neurological control subjects and nine patients with Parkinson's disease, using the high-performance liquid chromatography method with amperometric detection. In all control subjects, substantial amounts of norepinephrine was found in cerebellar cortex. There was a moderate negative correlation between age of control subjects and cerebellar norepinephrine concentration. In the patients with Parkinson's disease, the cerebellar cortical norepinephrine levels were significantly below normal. This is in accord with previously reported reduced norepinephrine levels in locus ceruleus and other regions of the parkinsonian brain. Although the main symptoms of Parkinson's disease are primarily caused by disturbed basal ganglia (dopamine) function, cerebellar dysfunction related to norepinephrine may contribute to some abnormalities of motor performance in this disorder.
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