Xuechen Tian
Xuechen Tian is the founder of the Science Laboratory at Wenzhou-Kean University. He currently works at Wenzhou-Kean University (WKU) as a Head for Laboratory Center. He also holds the esteemed position of Office Director at both the Zhejiang Bioinformatics International Science and Technology Cooperation Center and the Wenzhou Municipal Key Laboratory for Applied Biomedical and Biopharmaceutical Informatics. Tian is a full member of the Sigma Xi Scientific Research Honor Society and the Royal Society of Biology, UK. His international affiliations extend to being a member of the International Pangolin Research Consortium, the International Pangolin Scientific Advisory Board, and the China Pangolin Research Center. Nationally, he is recognized as a member of both the Chinese Society for Biochemistry and Molecular Biology and the Chinese Society for Cell Biology. Tian's expertise was also sought as an online review expert for the 8th College Student Life Science Competition in Zhejiang.
Tian has an extensive background in biology complemented by robust experimental research skills, hs has actively contributed to the experimental teaching of several subjects, including Principles of Biology, General Biology, Genetics, Cellular Physiology, as well as Cell and Molecular Technology. He is credited with the independent establishment of the inaugural cell physiology laboratory course (BIO4236l) at Wenzhou-Kean University, He played a pivotal role in establishing the Wenzhou-Kean teaching and research equipment platform valued at over 25 million yuan. His major accomplishments include spearheading the construction of the Comprehensive Laboratory Building, covering 1800 square meters with an investment of 20 million yuan. Furthermore, he was pivotal in the planning for the Science Building, spanning 16,000 square meters with a 150 million yuan budget. These efforts have significantly advanced the development of the biological sciences and the establishment of scientific laboratories at Wenzhou-Kean University.
In terms of research leadership, Tian has helmed a demonstration center project funded by the Wenzhou Education Bureau, a public welfare venture project by the Wenzhou Communist Youth League, and two SpS research projects at Wenzhou-Kean University. He has participated in two National Natural Science Foundation Youth Projects, one National Natural Science Foundation Foreign Youth Project, two Zhejiang Provincial Natural Science Foundation projects, and two Wenzhou City Science and Technology projects. Under his guidance, students have secured two national-level innovation and entrepreneurship projects. He has also assisted in supervising two undergraduate and two postgraduate graduation projects.
Tian's prolific academic contributions are evident in his numerous publications in top international journals such as Nature Plants, Trends in Plant Science, Molecular Plant, Conservation Letters, International Journal of Molecular Sciences, Frontiers in Microbiology, Horticulture Research, Bioinformatics and the Computational and Structural Biotechnology Journal. Notably, he has led and participated in numerous research projects, achieving remarkable outcomes. Collectively, the research team he’s on has secured research funds from national, provincial, municipal, and university sources, accumulating several million yuan. He has also been awarded provincial, municipal, and university-level honors many times for his outstanding workability and outstanding work performance.
Phone: 15088948868
Address: 88 Daxue Road，Ouhai
Tian has an extensive background in biology complemented by robust experimental research skills, hs has actively contributed to the experimental teaching of several subjects, including Principles of Biology, General Biology, Genetics, Cellular Physiology, as well as Cell and Molecular Technology. He is credited with the independent establishment of the inaugural cell physiology laboratory course (BIO4236l) at Wenzhou-Kean University, He played a pivotal role in establishing the Wenzhou-Kean teaching and research equipment platform valued at over 25 million yuan. His major accomplishments include spearheading the construction of the Comprehensive Laboratory Building, covering 1800 square meters with an investment of 20 million yuan. Furthermore, he was pivotal in the planning for the Science Building, spanning 16,000 square meters with a 150 million yuan budget. These efforts have significantly advanced the development of the biological sciences and the establishment of scientific laboratories at Wenzhou-Kean University.
In terms of research leadership, Tian has helmed a demonstration center project funded by the Wenzhou Education Bureau, a public welfare venture project by the Wenzhou Communist Youth League, and two SpS research projects at Wenzhou-Kean University. He has participated in two National Natural Science Foundation Youth Projects, one National Natural Science Foundation Foreign Youth Project, two Zhejiang Provincial Natural Science Foundation projects, and two Wenzhou City Science and Technology projects. Under his guidance, students have secured two national-level innovation and entrepreneurship projects. He has also assisted in supervising two undergraduate and two postgraduate graduation projects.
Tian's prolific academic contributions are evident in his numerous publications in top international journals such as Nature Plants, Trends in Plant Science, Molecular Plant, Conservation Letters, International Journal of Molecular Sciences, Frontiers in Microbiology, Horticulture Research, Bioinformatics and the Computational and Structural Biotechnology Journal. Notably, he has led and participated in numerous research projects, achieving remarkable outcomes. Collectively, the research team he’s on has secured research funds from national, provincial, municipal, and university sources, accumulating several million yuan. He has also been awarded provincial, municipal, and university-level honors many times for his outstanding workability and outstanding work performance.
Phone: 15088948868
Address: 88 Daxue Road，Ouhai
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Papers by Xuechen Tian
Schaalia species are primarily found among the oral microbiota of humans and other animals. They have been associated with various infections through their involvement in biofilm formation, modulation of host responses, and interaction with other microorganisms. In this study, two strains previously indicated as Actinomyces spp. were found to be novel members of the genus Schaalia based on their whole genome sequences.
Results
Whole-genome sequencing revealed both strains with a genome size of 2.3 Mbp and GC contents of 65.5%. Phylogenetics analysis for taxonomic placement revealed strains NCTC 9931 and C24 as distinct species within the genus Schaalia. Overall genome-relatedness indices including digital DNA-DNA hybridization (dDDH), and average nucleotide/amino acid identity (ANI/AAI) confirmed both strains as distinct species, with values below the species boundary thresholds (dDDH < 70%, and ANI and AAI < 95%) when compared to nearest type strain Schaalia odontolytica NCTC 9935 T. Pangenome and orthologous analyses highlighted their differences in gene properties and biological functions compared to existing type strains. Additionally, the identification of genomic islands (GIs) and virulence-associated factors indicated their genetic diversity and potential adaptive capabilities, as well as potential implications for human health. Notably, CRISPR-Cas systems in strain NCTC 9931 underscore its adaptive immune mechanisms compared to strain C24.
Conclusions
Based on these findings, strain NCTC 9931 T (= ATCC 17982 T = DSM 43331 T = CIP 104728 T = CCUG 18309 T = NCTC 14978 T = CGMCC 1.90328 T) represents a novel species, for which the name Schaalia dentiphila subsp. dentiphila sp. nov. subsp. nov. is proposed, while strain C24 T (= NCTC 14980 T = CGMCC 1.90329 T) represents a distinct novel subspecies, for which the name Schaalia dentiphila subsp. denticola. subsp. nov. is proposed. This study enriches our understanding of the genomic diversity of Schaalia species and paves the way for further investigations into their roles in oral health.
Schaalia species are primarily found among the oral microbiota of humans and other animals. They have been associated with various infections through their involvement in biofilm formation, modulation of host responses, and interaction with other microorganisms. In this study, two strains previously indicated as Actinomyces spp. were found to be novel members of the genus Schaalia based on their whole genome sequences.
Results
Whole-genome sequencing revealed both strains with a genome size of 2.3 Mbp and GC contents of 65.5%. Phylogenetics analysis for taxonomic placement revealed strains NCTC 9931 and C24 as distinct species within the genus Schaalia. Overall genome-relatedness indices including digital DNA-DNA hybridization (dDDH), and average nucleotide/amino acid identity (ANI/AAI) confirmed both strains as distinct species, with values below the species boundary thresholds (dDDH < 70%, and ANI and AAI < 95%) when compared to nearest type strain Schaalia odontolytica NCTC 9935 T. Pangenome and orthologous analyses highlighted their differences in gene properties and biological functions compared to existing type strains. Additionally, the identification of genomic islands (GIs) and virulence-associated factors indicated their genetic diversity and potential adaptive capabilities, as well as potential implications for human health. Notably, CRISPR-Cas systems in strain NCTC 9931 underscore its adaptive immune mechanisms compared to strain C24.
Conclusions
Based on these findings, strain NCTC 9931 T (= ATCC 17982 T = DSM 43331 T = CIP 104728 T = CCUG 18309 T = NCTC 14978 T = CGMCC 1.90328 T) represents a novel species, for which the name Schaalia dentiphila subsp. dentiphila sp. nov. subsp. nov. is proposed, while strain C24 T (= NCTC 14980 T = CGMCC 1.90329 T) represents a distinct novel subspecies, for which the name Schaalia dentiphila subsp. denticola. subsp. nov. is proposed. This study enriches our understanding of the genomic diversity of Schaalia species and paves the way for further investigations into their roles in oral health.