In this work neutral tyrosine has been generated in the gas phase by laser ablation of solid samp... more In this work neutral tyrosine has been generated in the gas phase by laser ablation of solid samples, and its most abundant conformers characterized through their rotational spectra. They were identified by comparing experimental and ab initio values of the rotational and quadrupole coupling constants. Both conformers are stabilized by an O-H•••N hydrogen bond established within the amino acid skeleton chain and an additional weak N-H•••π hydrogen bond. The observed conformers differ in the orientation of the phenolic -OH group.
This paper analyzes the thermal effects derived from the use of different screen shapes when shie... more This paper analyzes the thermal effects derived from the use of different screen shapes when shielding the magnetic field generated by underground power cables. A parametric analysis is developed to show the influence of the geometrical and the electrical parameters of the shield on the maximum temperature achieved by the power cables in order to analyze the impact of this
This paper analyzes the possibility of using compen- sated passive loops to obtain a high mitigat... more This paper analyzes the possibility of using compen- sated passive loops to obtain a high mitigation effectiveness of the magnetic field generated by underground single-core cables. With that aim, several loops arrangements are simulated in a case study, including new ones called enchained loops, whose geometry re- minds short-circuited conductors at both ends, but with the ad- vantage of requiring
Today, methane (CH4), nitrous oxide (N2O), and carbon dioxide (CO2) emissions represent approxima... more Today, methane (CH4), nitrous oxide (N2O), and carbon dioxide (CO2) emissions represent approximately 98 % of the total greenhouse gas (GHG) inventory worldwide, and their share is expected to increase significantly in this twenty-first century. CO2 represents the most important GHG with approximately 77 % of the total GHG emissions (considering its global warming potential) worldwide, while CH4 and N2O are emitted to a lesser extent (14 and 8 %, respectively) but exhibit global warming potentials 23 and 298 times higher than that of CO2, respectively. Most members of the United Nations, based on the urgent need to maintain the global average temperature 2 °C above preindustrial levels, have committed themselves to significantly reduce their GHG emissions. In this context, an active abatement of these emissions will help to achieve these target emission cuts without compromising industrial growth. Nowadays, there are sufficient empirical evidence to support that biological technolog...
The infrared and millimeter-wave spectra of isotopically pure chlorodifluoromethane (HCFC-22) hav... more The infrared and millimeter-wave spectra of isotopically pure chlorodifluoromethane (HCFC-22) have been investigated for the ν5= 1 excited state. IR spectra of CHF235Cl were recorded at room temperature with high resolution (0.0021 cm−1, Bruker IFS 120 HR) in the region between 560 and 650 cm−1. The spectral analysis of CHF2Cl allowed us to assign 7788 lines (J≤ 70) to the
HW-SW interoperability by means of standard distributed object middlewares has been proved to be ... more HW-SW interoperability by means of standard distributed object middlewares has been proved to be useful in the design of new and challenging applications for ubiquitous computing, and ambient intelligence environments. Wireless sensor networks are considered to be essential for the proper deployment of these applications, but they impose new constraints in the design of the corresponding communication infrastructure: low-cost middleware
International Conference on P2P, Parallel, Grid, Cloud and Internet Computing, 2011
Most image processing techniques are based on the idea that the information is processed in end n... more Most image processing techniques are based on the idea that the information is processed in end nodes. Our proposal is based on a slightly different idea called Process-in-Network (PIN) defined as the possibility that the network processes information as it is being transmitted, seeking to take advantage of waiting times, idle processing capacity, and the information itself. In this article,
This work presents a new -based test criterion sup- ported by the characteristics of a set of exp... more This work presents a new -based test criterion sup- ported by the characteristics of a set of experimental testing measurements realized over different samples of industrial ICs and by the definition of the corresponding simulation model. Comparing the current consumptions of a specific circuit a significant correlation between measurements can be observed. The current behaviour can be divided into two
This paper presents SHAPES, a tool for hardware- software partitioning. It is based on two main p... more This paper presents SHAPES, a tool for hardware- software partitioning. It is based on two main paradigms: the implementation of the partitioning tool by means of an expert system, and the use of fuzzy logic to model the parameters involved in the process. A Formal Description of VHDL-AMS Analogue Systems83590916abs.htm Tom KazmierskiUniversity of SouthamptonA formal definition of the general VHDL-AMS
Toll-like receptor-3 (TLR3) is a cellular receptor that may recognize double-stranded RNA (dsRNA)... more Toll-like receptor-3 (TLR3) is a cellular receptor that may recognize double-stranded RNA (dsRNA) from viruses, resulting in production of proinflammatory cytokines and interferons, which are important for the adaptive immune response. To analyze the association between Toll-like receptor-3 (TLR3) polymorphisms (rs3775291 and rs13126816) and virologic response to pegylated interferon-alpha plus ribavirin (pegIFNα/RBV) therapy in HIV/HCV coinfected patients. We performed a retrospective study in 321 naïve patients treated with pegIFNα/RBV. Genotyping was performed by using the GoldenGate(®) assay with VeraCode(®). The outcome variables were early virologic response (EVR) and sustained virologic response (SVR). In a multivariate analysis, rs3775291 A allele decreased the likelihood of achieving EVR (aOR=0.20; p=0.018) and SVR (aOR=0.38; p=0.024). Regarding rs13126816, the percentage of EVR decreased with each minor A allele (p=0.034) in HCV-GT2/3 patients, although no significant association was obtained in the multivariate analysis (p=0.076). Regarding TLR3 haplotypes (comprised of rs3775291 and rs13126816), GT2/3 patients with AA haplotype had decreased odds of achieving EVR (p=0.030), whereas GG haplotype increased the likelihood (p=0.018). Regarding SVR, GG haplotype carriers had increased odds of achieving SVR (p=0.019, p=0.043 and p=0.070 for all, GT2/3 and GT1/4 patients, respectively). Besides, GT1/4 patients with GA haplotype had lower odds of achieving SVR (p=0.039). Our study shows the first evidence that two TLR3 polymorphisms (rs3775291 and rs13126816) seem to be related to the HCV therapy response in HCV/HIV coinfected patients.
This review resumes different basic aspects of the protein family called Metalloproteases- Disint... more This review resumes different basic aspects of the protein family called Metalloproteases- Disintegrins (ADAMS: A Metalloprotease and Disintegrins). Because the high extension of the topic, in relationship with the multiple functions that they develop in biological organisms, it could be so extents to make a total recompilation of all aspects from this protein family where it is involved. However, it
Laser ablation in combination with molecular beam Fourier transform microwave spectroscopy has be... more Laser ablation in combination with molecular beam Fourier transform microwave spectroscopy has been used to establish unambiguously the presence of the diketo form of thymine in the gas phase and to obtain its structure.
Physical chemistry chemical physics : PCCP, Jan 21, 2015
2-Azetidinone-water clusters can be considered as appropriate models for investigating the intera... more 2-Azetidinone-water clusters can be considered as appropriate models for investigating the interaction of the peptide functional group with water. The rotational spectra of 2-azetidinone-(H2O)n (n = 1, 2) complexes have been studied in the 6-18 GHz frequency range using a molecular beam Fourier transform microwave spectrometer. Two different isomers have been observed for the 1 : 1 adduct. The most stable (1 : 1a) is stabilized by two hydrogen bonds O-HO[double bond, length as m-dash]C and N-HO with water closing a ring with the peptide group. For the other conformer (1 : 1b), water is placed on the other side of the carbonyl group stabilized by O-HO[double bond, length as m-dash]C and C-HO hydrogen bonds. In 2-azetidinone-(H2O)2 the water molecules close a ring with the peptide group forming three different hydrogen bonds: O-HO[double bond, length as m-dash]C, O-HO and N-HO. The spectra of the parent and several isotopologues of each cluster have been investigated in order to deter...
A comparative study was performed on the venoms of adult specimens of the neotropical rattlesnake... more A comparative study was performed on the venoms of adult specimens of the neotropical rattlesnake, Crotalus durissus, from Guatemala, Costa Rica, Venezuela and Brazil, together with the venom of newborn specimens of C. d. durissus from Costa Rica. Venoms from Brazil (C. d. terrificus) and from newborn specimens of C. d. durissus presented an electrophoretic pattern characterized by the predominance of bands with molecular mass of 36 and 15 kDa, whereas those of adult specimens of C. d. durissus from Guatemala and Costa Rica, and C. d. cumanensis from Venezuela, showed a conspicuous band of 62 kDa, and additional bands of 36, 29 and 15 kDa. Moreover, venoms from C. d. terrificus and C. d. cumanensis showed a prominent band of < 10 kDa that probably corresponds to crotamine, since a 'crotamine-like' activity was detected in these venoms upon intraperitoneal injection in mice. Venoms of C. d. terrificus, C. d cumanensis and newborn C. d. durissus induced higher lethal and my...
A digital signal processing training module (DSPTM) is constructed around a TMS320C6211 starter k... more A digital signal processing training module (DSPTM) is constructed around a TMS320C6211 starter kit. The DSP target system is enclosed in a portable case with the necessary accessories: A host port interface connector, power supply, function generator, audio amplifier, speaker, input/output audio sockets and selector switches. DSP demonstration software is bundled with custom windows 98/XP virtual instrumentation programs that run
Although there exists formal development support, as well as informal de- sign guidelines, a lot ... more Although there exists formal development support, as well as informal de- sign guidelines, a lot of protocols, whether recent or not, are faulty. Further aid for protocol development is thus required. We have developed Shrimp, a Smart metHod for Repairing IMperfect security Protocols, aims at speeding up the formal software development cycle, bridging the gap between design and anal- ysis
In this work neutral tyrosine has been generated in the gas phase by laser ablation of solid samp... more In this work neutral tyrosine has been generated in the gas phase by laser ablation of solid samples, and its most abundant conformers characterized through their rotational spectra. They were identified by comparing experimental and ab initio values of the rotational and quadrupole coupling constants. Both conformers are stabilized by an O-H•••N hydrogen bond established within the amino acid skeleton chain and an additional weak N-H•••π hydrogen bond. The observed conformers differ in the orientation of the phenolic -OH group.
This paper analyzes the thermal effects derived from the use of different screen shapes when shie... more This paper analyzes the thermal effects derived from the use of different screen shapes when shielding the magnetic field generated by underground power cables. A parametric analysis is developed to show the influence of the geometrical and the electrical parameters of the shield on the maximum temperature achieved by the power cables in order to analyze the impact of this
This paper analyzes the possibility of using compen- sated passive loops to obtain a high mitigat... more This paper analyzes the possibility of using compen- sated passive loops to obtain a high mitigation effectiveness of the magnetic field generated by underground single-core cables. With that aim, several loops arrangements are simulated in a case study, including new ones called enchained loops, whose geometry re- minds short-circuited conductors at both ends, but with the ad- vantage of requiring
Today, methane (CH4), nitrous oxide (N2O), and carbon dioxide (CO2) emissions represent approxima... more Today, methane (CH4), nitrous oxide (N2O), and carbon dioxide (CO2) emissions represent approximately 98 % of the total greenhouse gas (GHG) inventory worldwide, and their share is expected to increase significantly in this twenty-first century. CO2 represents the most important GHG with approximately 77 % of the total GHG emissions (considering its global warming potential) worldwide, while CH4 and N2O are emitted to a lesser extent (14 and 8 %, respectively) but exhibit global warming potentials 23 and 298 times higher than that of CO2, respectively. Most members of the United Nations, based on the urgent need to maintain the global average temperature 2 °C above preindustrial levels, have committed themselves to significantly reduce their GHG emissions. In this context, an active abatement of these emissions will help to achieve these target emission cuts without compromising industrial growth. Nowadays, there are sufficient empirical evidence to support that biological technolog...
The infrared and millimeter-wave spectra of isotopically pure chlorodifluoromethane (HCFC-22) hav... more The infrared and millimeter-wave spectra of isotopically pure chlorodifluoromethane (HCFC-22) have been investigated for the ν5= 1 excited state. IR spectra of CHF235Cl were recorded at room temperature with high resolution (0.0021 cm−1, Bruker IFS 120 HR) in the region between 560 and 650 cm−1. The spectral analysis of CHF2Cl allowed us to assign 7788 lines (J≤ 70) to the
HW-SW interoperability by means of standard distributed object middlewares has been proved to be ... more HW-SW interoperability by means of standard distributed object middlewares has been proved to be useful in the design of new and challenging applications for ubiquitous computing, and ambient intelligence environments. Wireless sensor networks are considered to be essential for the proper deployment of these applications, but they impose new constraints in the design of the corresponding communication infrastructure: low-cost middleware
International Conference on P2P, Parallel, Grid, Cloud and Internet Computing, 2011
Most image processing techniques are based on the idea that the information is processed in end n... more Most image processing techniques are based on the idea that the information is processed in end nodes. Our proposal is based on a slightly different idea called Process-in-Network (PIN) defined as the possibility that the network processes information as it is being transmitted, seeking to take advantage of waiting times, idle processing capacity, and the information itself. In this article,
This work presents a new -based test criterion sup- ported by the characteristics of a set of exp... more This work presents a new -based test criterion sup- ported by the characteristics of a set of experimental testing measurements realized over different samples of industrial ICs and by the definition of the corresponding simulation model. Comparing the current consumptions of a specific circuit a significant correlation between measurements can be observed. The current behaviour can be divided into two
This paper presents SHAPES, a tool for hardware- software partitioning. It is based on two main p... more This paper presents SHAPES, a tool for hardware- software partitioning. It is based on two main paradigms: the implementation of the partitioning tool by means of an expert system, and the use of fuzzy logic to model the parameters involved in the process. A Formal Description of VHDL-AMS Analogue Systems83590916abs.htm Tom KazmierskiUniversity of SouthamptonA formal definition of the general VHDL-AMS
Toll-like receptor-3 (TLR3) is a cellular receptor that may recognize double-stranded RNA (dsRNA)... more Toll-like receptor-3 (TLR3) is a cellular receptor that may recognize double-stranded RNA (dsRNA) from viruses, resulting in production of proinflammatory cytokines and interferons, which are important for the adaptive immune response. To analyze the association between Toll-like receptor-3 (TLR3) polymorphisms (rs3775291 and rs13126816) and virologic response to pegylated interferon-alpha plus ribavirin (pegIFNα/RBV) therapy in HIV/HCV coinfected patients. We performed a retrospective study in 321 naïve patients treated with pegIFNα/RBV. Genotyping was performed by using the GoldenGate(®) assay with VeraCode(®). The outcome variables were early virologic response (EVR) and sustained virologic response (SVR). In a multivariate analysis, rs3775291 A allele decreased the likelihood of achieving EVR (aOR=0.20; p=0.018) and SVR (aOR=0.38; p=0.024). Regarding rs13126816, the percentage of EVR decreased with each minor A allele (p=0.034) in HCV-GT2/3 patients, although no significant association was obtained in the multivariate analysis (p=0.076). Regarding TLR3 haplotypes (comprised of rs3775291 and rs13126816), GT2/3 patients with AA haplotype had decreased odds of achieving EVR (p=0.030), whereas GG haplotype increased the likelihood (p=0.018). Regarding SVR, GG haplotype carriers had increased odds of achieving SVR (p=0.019, p=0.043 and p=0.070 for all, GT2/3 and GT1/4 patients, respectively). Besides, GT1/4 patients with GA haplotype had lower odds of achieving SVR (p=0.039). Our study shows the first evidence that two TLR3 polymorphisms (rs3775291 and rs13126816) seem to be related to the HCV therapy response in HCV/HIV coinfected patients.
This review resumes different basic aspects of the protein family called Metalloproteases- Disint... more This review resumes different basic aspects of the protein family called Metalloproteases- Disintegrins (ADAMS: A Metalloprotease and Disintegrins). Because the high extension of the topic, in relationship with the multiple functions that they develop in biological organisms, it could be so extents to make a total recompilation of all aspects from this protein family where it is involved. However, it
Laser ablation in combination with molecular beam Fourier transform microwave spectroscopy has be... more Laser ablation in combination with molecular beam Fourier transform microwave spectroscopy has been used to establish unambiguously the presence of the diketo form of thymine in the gas phase and to obtain its structure.
Physical chemistry chemical physics : PCCP, Jan 21, 2015
2-Azetidinone-water clusters can be considered as appropriate models for investigating the intera... more 2-Azetidinone-water clusters can be considered as appropriate models for investigating the interaction of the peptide functional group with water. The rotational spectra of 2-azetidinone-(H2O)n (n = 1, 2) complexes have been studied in the 6-18 GHz frequency range using a molecular beam Fourier transform microwave spectrometer. Two different isomers have been observed for the 1 : 1 adduct. The most stable (1 : 1a) is stabilized by two hydrogen bonds O-HO[double bond, length as m-dash]C and N-HO with water closing a ring with the peptide group. For the other conformer (1 : 1b), water is placed on the other side of the carbonyl group stabilized by O-HO[double bond, length as m-dash]C and C-HO hydrogen bonds. In 2-azetidinone-(H2O)2 the water molecules close a ring with the peptide group forming three different hydrogen bonds: O-HO[double bond, length as m-dash]C, O-HO and N-HO. The spectra of the parent and several isotopologues of each cluster have been investigated in order to deter...
A comparative study was performed on the venoms of adult specimens of the neotropical rattlesnake... more A comparative study was performed on the venoms of adult specimens of the neotropical rattlesnake, Crotalus durissus, from Guatemala, Costa Rica, Venezuela and Brazil, together with the venom of newborn specimens of C. d. durissus from Costa Rica. Venoms from Brazil (C. d. terrificus) and from newborn specimens of C. d. durissus presented an electrophoretic pattern characterized by the predominance of bands with molecular mass of 36 and 15 kDa, whereas those of adult specimens of C. d. durissus from Guatemala and Costa Rica, and C. d. cumanensis from Venezuela, showed a conspicuous band of 62 kDa, and additional bands of 36, 29 and 15 kDa. Moreover, venoms from C. d. terrificus and C. d. cumanensis showed a prominent band of < 10 kDa that probably corresponds to crotamine, since a 'crotamine-like' activity was detected in these venoms upon intraperitoneal injection in mice. Venoms of C. d. terrificus, C. d cumanensis and newborn C. d. durissus induced higher lethal and my...
A digital signal processing training module (DSPTM) is constructed around a TMS320C6211 starter k... more A digital signal processing training module (DSPTM) is constructed around a TMS320C6211 starter kit. The DSP target system is enclosed in a portable case with the necessary accessories: A host port interface connector, power supply, function generator, audio amplifier, speaker, input/output audio sockets and selector switches. DSP demonstration software is bundled with custom windows 98/XP virtual instrumentation programs that run
Although there exists formal development support, as well as informal de- sign guidelines, a lot ... more Although there exists formal development support, as well as informal de- sign guidelines, a lot of protocols, whether recent or not, are faulty. Further aid for protocol development is thus required. We have developed Shrimp, a Smart metHod for Repairing IMperfect security Protocols, aims at speeding up the formal software development cycle, bridging the gap between design and anal- ysis
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