Game Boy Advance

The Game Boy Advance (Japanese: ゲームボーイアドバンス, Hepburn: Gēmu Bōi Adobansu), often shortened to GBA, is a 32-bit handheld video game console developed, manufactured and marketed by Nintendo. It is the successor to the Game Boy Color. It was released in Japan on March 21, 2001; in North America on June 11, 2001; in Australia and Europe on June 22, 2001; and in the People's Republic of China on June 8, 2004 (excluding Hong Kong).

Nintendo's competitors in the handheld market were the Neo Geo Pocket Color, WonderSwan, GP32, Tapwave Zodiac, and the N-Gage. Despite the competitors' best efforts, Nintendo maintained a majority market share with the Game Boy Advance.

As of June 30, 2010, the Game Boy Advance series has sold 81.51 million units worldwide. Its successor, the Nintendo DS, was released in November 2004.

History

Contrary to the previous Game Boy models, which were all following the "portrait" form factor of the original Game Boy (designed by Gunpei Yokoi), the Game Boy Advance was designed in a "landscape" form factor, putting the buttons to the sides of the device instead of below the screen. The Game Boy Advance was designed by the French designer Gwénaël Nicolas and his Tokyo-based design studio Curiosity Inc.

GBA2

Non-lysosomal glucosylceramidase is an enzyme that in humans is encoded by the GBA2 gene. It has glucosylceramidase (EC 3.2.1.45) activity.

Function

This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism.

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GBA3

Cytosolic beta-glucosidase, also known as cytosolic beta-glucosidase-like protein 1, is a beta-glucosidase (EC 3.2.1.21) enzyme that in humans is encoded by the GBA3 gene.

Function

Cytosolic beta-glucosidase is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides. GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a non-lysosomal catabolic pathway of glucosylceramide metabolism.

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