Neu!

Neu! (trademarked NEU! in block capitals, German: New!, pronounced [ˈnɔʏ]) was a German krautrock band formed by Klaus Dinger and Michael Rother after their split from Kraftwerk in the early 1970s. Though Neu! had minimal commercial success during its existence, the band is retrospectively considered one of the founding fathers of krautrock and a significant influence on artists including David Bowie, Sonic Youth, Camera, Brian Eno, Iggy Pop, Siouxsie and the Banshees, PiL, Joy Division, Gary Numan, Porcupine Tree, Ultravox, Simple Minds, Negativland, Stereolab, Manic Street Preachers, Boredoms, Radiohead, the Horrors, Electrelane, Kasabian, DIIV and much of the current electronic music scene.

History

(1971–1975) Main career

Neu! was formed in 1971 in Düsseldorf as an offshoot from an early line-up of another seminal krautrock band, Kraftwerk, whose early works were also produced by Conny Plank. The name ("new!") was inspired by the prevalence of the advertising business in Düsseldorf at the time, according to Dinger, who described it as "the strongest word in advertising" and even owned a pro forma advertising agency himself for the purpose of booking studios.

Neu (disambiguation)

Neu! is a German krautrock band.

Neu or NEU may also refer to:

Neu! (album)

Neu! is the debut album by German krautrock band Neu!. It was recorded in December 1971 at Windrose-Dumont-Time Studios, Hamburg, Germany, mixed at Star-Musik Studio, Hamburg, Germany, and released in 1972 by Brain Records. It was reissued by Grönland on May 29, 2001 and then licensed to Astralwerks for US distribution. This was Rother and Dinger's first recording together after they left Kraftwerk in 1971. They continued to work with Konrad "Conny" Plank, who had been producing the Kraftwerk recording sessions.

History

Having broken off from Kraftwerk, Rother and Dinger quickly began the recording sessions for what would become Neu!. The band was christened by Dinger (Rother had been against the name, preferring a more "organic" title) and a pop-art style logo created, featuring italic capitals. Dinger recalled Neu!'s logo:

The pair recorded in Star Studios in Hamburg, with the up-and-coming Krautrock producer Plank, as Dinger had with Kraftwerk. Dinger noted that Plank served as a "mediator" between the often disagreeing factions within the band.

Neuss

Neuss (German pronunciation: [ˈnɔʏs]; spelled Neuß until 1968; Limburgish: Nüss; Latin: Novaesium) is a city in North Rhine-Westphalia, Germany. It is located on the west bank of the Rhine opposing Düsseldorf. Neuss is the largest city within the Rhein-Kreis Neuss district. It is primarily known for its historic Roman sites, as well as the annual Neusser Bürger-Schützenfest. In 1984 Neuss celebrated 2000 years since its foundation. It therefore holds the title of "Germany's oldest city" alongside the city of Trier.

History

Ancient Rome

Neuss was founded by the Romans in 16 BC as a military fortification (castrum) with the current city to the north of the castrum, at the confluence of the rivers Rhine and Erft, with the name of Novaesium. Later a civil settlement was founded in the area of today's center of the town during the 1st century AD. Novaesium, together with Trier (Augusta Treverorum), is one of the three oldest Roman settlements in Germany.

Middle Ages

NEU2

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.

References

Further reading

NEU1

Sialidase 1 (lysosomal sialidase), also known as NEU1 is a mammalian lysosomal neuraminidase enzyme which in humans is encoded by the NEU1 gene.

Function

The protein encoded by this gene encodes the lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis.

Clinical significance

Deficiencies in the human enzyme NEU1 leads to sialidosis, a rare lysosomal storage disease. Sialidase has also been shown to enhance recovery from spinal cord contusion injury when injected in rats.

Interactions

NEU1 has been shown to interact with Cathepsin A.

References

Further reading